LOCUS       NM_172780               4916 bp    mRNA    linear   ROD 14-MAR-2023
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 6 (Slc9a6), transcript variant 1, mRNA.
ACCESSION   NM_172780
VERSION     NM_172780.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4916)
  AUTHORS   Sekulic-Jablanovic M, Paproth J, Sgambato C, Albano G, Fuster DG,
            Bodmer D and Petkovic V.
  TITLE     Lack of NHE6 and Inhibition of NKCC1 Associated With Increased
            Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell
            Layer
  JOURNAL   Front Cell Neurosci 16, 862119 (2022)
   PUBMED   35496913
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4916)
  AUTHORS   Schnyder D, Albano G, Kucharczyk P, Dolder S, Siegrist M, Anderegg
            M, Pathare G, Hofstetter W, Baron R and Fuster DG.
  TITLE     Deletion of the sodium/hydrogen exchanger 6 causes low bone volume
            in adult mice
  JOURNAL   Bone 153, 116178 (2021)
   PUBMED   34508879
  REMARK    GeneRIF: Deletion of the sodium/hydrogen exchanger 6 causes low
            bone volume in adult mice.
REFERENCE   3  (bases 1 to 4916)
  AUTHORS   Pescosolido MF, Ouyang Q, Liu JS and Morrow EM.
  TITLE     Loss of Christianson Syndrome Na+/H+ Exchanger 6 (NHE6) Causes
            Abnormal Endosome Maturation and Trafficking Underlying Lysosome
            Dysfunction in Neurons
  JOURNAL   J Neurosci 41 (44), 9235-9256 (2021)
   PUBMED   34526390
  REMARK    GeneRIF: Loss of Christianson Syndrome Na(+)/H(+) Exchanger 6
            (NHE6) Causes Abnormal Endosome Maturation and Trafficking
            Underlying Lysosome Dysfunction in Neurons.
REFERENCE   4  (bases 1 to 4916)
  AUTHORS   Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido
            TC, Evers BM, White CL 3rd, Connor J, Hammer RE and Herz J.
  TITLE     NHE6 depletion corrects ApoE4-mediated synaptic impairments and
            reduces amyloid plaque load
  JOURNAL   Elife 10, e72034 (2021)
   PUBMED   34617884
  REMARK    GeneRIF: NHE6 depletion corrects ApoE4-mediated synaptic
            impairments and reduces amyloid plaque load.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4916)
  AUTHORS   Kucharava K, Brand Y, Albano G, Sekulic-Jablanovic M, Glutz A, Xian
            X, Herz J, Bodmer D, Fuster DG and Petkovic V.
  TITLE     Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing
            loss, via reduced endosomal signalling through the BDNF/Trk pathway
  JOURNAL   Sci Rep 10 (1), 3609 (2020)
   PUBMED   32107410
  REMARK    GeneRIF: Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to
            hearing loss, via reduced endosomal signalling through the BDNF/Trk
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4916)
  AUTHORS   Ohgaki R, van IJzendoorn SC, Matsushita M, Hoekstra D and Kanazawa
            H.
  TITLE     Organellar Na+/H+ exchangers: novel players in organelle pH
            regulation and their emerging functions
  JOURNAL   Biochemistry 50 (4), 443-450 (2011)
   PUBMED   21171650
  REMARK    GeneRIF: This review describes Nhe6 knockout mice, which partially
            mimic phenotypical features of patients suffering from mental
            disorders including motor hyperactivity and a lowered threshold for
            pharmacologically induced seizures.
            Review article
REFERENCE   7  (bases 1 to 4916)
  AUTHORS   Hill JK, Brett CL, Chyou A, Kallay LM, Sakaguchi M, Rao R and
            Gillespie PG.
  TITLE     Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers
            NHE6 and NHE9
  JOURNAL   J Neurosci 26 (39), 9944-9955 (2006)
   PUBMED   17005858
  REMARK    GeneRIF: NHE6 is expressed in the inner ear
REFERENCE   8  (bases 1 to 4916)
  AUTHORS   Nakamura N, Tanaka S, Teko Y, Mitsui K and Kanazawa H.
  TITLE     Four Na+/H+ exchanger isoforms are distributed to Golgi and
            post-Golgi compartments and are involved in organelle pH regulation
  JOURNAL   J Biol Chem 280 (2), 1561-1572 (2005)
   PUBMED   15522866
REFERENCE   9  (bases 1 to 4916)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 4916)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137460.1, BC130221.1, AK028350.1 and BE197183.1.
            
            [WARNING] On Apr 12, 2023 this sequence was replaced by
            NM_172780.5.
            
            On Dec 12, 2017 this sequence version replaced NM_172780.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.109228.1,
                                           SRR1660815.7111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY137460.1         2-24
            24-2228             BC130221.1         9-2213
            2229-4515           AK028350.1         488-2774
            4516-4916           BE197183.1         5-405               c
FEATURES             Location/Qualifiers
     source          1..4916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X"
     gene            1..4916
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 6"
                     /db_xref="GeneID:236794"
                     /db_xref="MGI:MGI:2443511"
     exon            1..353
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2134
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Na(+)/H(+) exchanger 6; sodium/hydrogen exchanger; solute
                     carrier family 9 member 6; sodium/hydrogen exchanger 6"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 6 isoform 1"
                     /protein_id="NP_766368.2"
                     /db_xref="CCDS:CCDS40979.1"
                     /db_xref="GeneID:236794"
                     /db_xref="MGI:MGI:2443511"
                     /translation="MAGARRGWRLAPVRRGVCGPRARPLMRPLWLLFAVSFFGWTGAL
                     DGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHE
                     TGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEI
                     SSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFL
                     GTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQ
                     VDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSG
                     SFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCG
                     ITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGA
                     FIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYAR
                     QMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAW
                     LFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDL
                     ILNDGDISLTYGDSTVNTESATASAPRRFMGNSSEDALDRELTFGDHELVIRGTRLVL
                     PMDDSEPALNSLDDTRHSPA"
     exon            354..553
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            554..631
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            632..708
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            709..821
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            822..927
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1069
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1175
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1264
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1378
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1490
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1644
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1675
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1755
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1861
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..4916
                     /gene="Slc9a6"
                     /gene_synonym="3732426M05; 6430520C02Rik; mKIAA0267;
                     NHE-6; NHE6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggggcagg gggtgggggg aagacatggc tggggctcgg cgcggctggc ggctggcgcc
       61 cgttcgccgt ggcgtctgcg ggccccgggc gcgtccgctc atgcggcccc tttggttgct
      121 cttcgcagtg agcttctttg gctggaccgg ggctctggac ggctccgggg gaacgaccag
      181 agccatggac gaggagatcg tgtccgagaa gcaggcggag gagagccatc ggcaggacag
      241 cgccaacctg ctcatcttca tcctgctgct caccctcacc attctgacga tctggctctt
      301 caagcaccgc cgggcccgct tcctgcacga aaccggcctt gctatgattt atggtctttt
      361 ggtaggcctc gtgcttcggt acggcattca tgttccaagc gatgtgaata atgtgactct
      421 gagctgtgaa gtgcagtcaa gtccaactac cttgttggtc aacgtcagtg gaaaatttta
      481 tgagtatacg ctgaaaggag agattagctc acatgaactc aacaatgttc aagataatga
      541 aatgcttagg aaggttactt ttgatccaga agtctttttc aacatactgc ttcctcctat
      601 catattttat gcagggtaca gtctcaaaag gagacatttc ttccggaacc ttgggtctat
      661 cttagcatat gcctttcttg gaacagcaat ttcttgtttc gttattgggt ccatcatgta
      721 tggctgtgta accctgatga aggtgaccgg gcagctcgcg ggagattttt actttacaga
      781 ttgcttgctg tttggtgcca ttgtttcagc caccgaccca gtgactgttc ttgccatctt
      841 ccatgagctt caagttgacg ttgaactcta cgctcttctc ttcggggaaa gtgtcctcaa
      901 tgacgcggtt gccatagtgc tgtcctcctc aatagtggca taccagccag cgggagacaa
      961 cagccacacc tttgacgtta cagccatgtt caaatctatt ggaatcttcc ttgggatctt
     1021 cagtggatct tttgcaatgg gtgctgcaac aggcgtggta acagctttag tgacaaagtt
     1081 cacaaagctg agagagttcc agctgttgga gacaggcctt ttcttcttga tgtcctggag
     1141 cacctttctt ctggctgaag catggggttt cacaggtgtg gttgcagtat tgttttgtgg
     1201 catcacacaa gcacattaca cgtacaataa tttgtctaca gagtctcagc atagaacaaa
     1261 gcagttgttt gagcttctca attttttagc ggagaatttc atcttttcct acatggggct
     1321 gacgctgttc accttccaga atcacgtctt taacccaaca tttgtcgtag gagcattcat
     1381 tgctattttc ttgggaagag ctgccaatat ttatcccttg tctctcttac ttaatttggg
     1441 tagaagaagt aagattggat caaattttca acacatgatg atgtttgctg gtcttcgtgg
     1501 tgcaatggca tttgccttgg ccattcgaga tactgccact tatgcacgac aaatgatgtt
     1561 cagcaccaca cttctgatcg tgttttttac tgtgtgggta tttggtggtg gcaccactgc
     1621 catgctgtca tgcctgcata taagggttgg tgttgattca gaccaagaac atttgggtgt
     1681 tcctgacaac gaaaggagaa ccaccaaagc agagagtgcc tggctctttc ggatgtggta
     1741 caacttcgat cataactatc tgaagcccct gctgacccac agtgggcctc ctctgactac
     1801 cacactccca gcctgctgtg ggccaatcgc caggtgcctg accagccccc aagcatatga
     1861 aaaccaggag cagttgaaag atgatgactc tgatctcatt ctcaatgatg gtgatatcag
     1921 tctgacatat ggggattcta ctgtgaacac cgagtccgca acagccagcg ccccaaggag
     1981 atttatgggc aacagttctg aagatgcctt ggaccgggag cttacatttg gggaccacga
     2041 actagtcatt cgtggcacac gcctggttct tccgatggat gattctgaac ctgcgttaaa
     2101 ttcattagat gatacgagac acagtccggc ctaagcgctc tgatgctcag ttagtggttt
     2161 gtaaactttg cacatgtgat tgtgaagaaa tgtgtactac ctacaagtcc tagtgcatgt
     2221 ctctgaatgt gtaagctata taaatgccgt ttatatggca taggaagaat ataaataccc
     2281 tgtacaaggc agattgtgaa aaaactgttc tcttaagttt ttctggcttt actacatatt
     2341 ggccagatct gttttagaaa cttactttca cagtgatgtt ctgtgttctg ttacttttat
     2401 gtttcagtta aagcataaaa agtgacggat tgactctttc ttatatttat ctgagtaccg
     2461 agttcttgtg ctgtgagtta atttgtgtgt ggcagggaag gggagggaag ggggagctgt
     2521 tattccctcg ggaacccggg aggagaggtt cctttgttgg aaaaactttt gttgattgct
     2581 gctgcctttg tcgtgacttt ttctttccct tttctctggt ggccctttgt ggtgcaagga
     2641 gctgatggca ttttgatctc accccattca ggttggggac tgaagtgtgg gggccgtttt
     2701 cccccattga tgtgaaagaa cagatttctt gactacagta cattgatgct ctgagaaaga
     2761 aggctacaaa tgacctccaa gaccttattt cttttctttc acaccaagac cataggaatt
     2821 gcatccagct ggcttagcta aaatacaggt gtatatcgtt cagggcactt gttacagatt
     2881 tgagggcgct ggagcaagtg gacatgggga tagtggtgtt ggaggtctct cttcccaaat
     2941 atgtaaatag tctataccag ataagttgaa ataggaaatg tacttgctgc ttcatttttg
     3001 attatgttca ttgtgtgtat agcaagcctt gtcaccagaa gtttttttta tatcaactta
     3061 aatcgctgct ctttagcagc caaacaggag caaaatgtaa aatttttaaa ctcgttatgt
     3121 ttaaaggtca cttgttagtt gatagttaat gttaaaagtt aatttatgaa cccacacctg
     3181 ttctgtactg caccagaggc ggccgtgaga gggatgcagt gttctgcatt ctttgaaggg
     3241 attctcctgg tgtaaagtgg gtgcgcttgt tgtcttcatt gtcgtgttac tttttaataa
     3301 tagacaccta agctgccatg tgttactttt tgatggtttt tgaggaagag cacagaacaa
     3361 attttcattt catattcata gtatgaaagt ggtttctatt ttgtaatgct gcaaatacct
     3421 aaaggtacat tgaacacttg gaagggaaca ctttttgatg ctgattctga cctgtttctg
     3481 attcaggaga aaaagataca aatcttgtgg atttttctcc ctcaggtcca agtagcattg
     3541 ccttaaatct aacccaatta gaaacttgat tacttatgtg acgttcaaat tttccactga
     3601 aaaataccct tccaaacaaa gcacgcactt actctcaaaa gggttctgtg ccattgccaa
     3661 cactccttga gactttacag gaattctcat ggtgtaccct tcgtggcagc cttgactgtt
     3721 ggcatagcca tttgttatgt agtggtagtg actttcctgc tatgcaggaa caactcctgt
     3781 gaagtgtacg ttttatatga tgcgtggctc ttcatgcagt aaataatttc tttgttaatg
     3841 tatgtttgag gggttttgaa tgtcagcatc attgacccac aaagttattc aagttgtaaa
     3901 agggtataca gtgatttaac tactatcttt tttattctgt caggttactg agctcacctt
     3961 atgaaaatgg ctataaatac ttagcatgac aaattatatg taacctgtct ctttttagca
     4021 tgcataagat ttctcattaa ggaaactgat aacgcttgag tccactaaat ctgccttcag
     4081 tactttatca aaggagaacg aagcttgttg tacttatgta ttcatctgga agcctttttt
     4141 tccccctctc ttgtctgtgt acagcatccc catgcataga gcaaagcatc tctgttgaga
     4201 cagtcattag aattaagcac ctcaatgaac tttgatgaag tacagtgtga gttaccatca
     4261 tgcatgagtg aacgcttgtg gacctgtttt tctgttgttt gtggaaccta tgtgtttgat
     4321 tgacttgaac actgcatctc tcagagttgt ttttaaggtc tcttggcatt tatcctagtc
     4381 tgtgtttggc agcgtgctgt taaagtacta gacttctaat ctgtacgtgc tttctgtttt
     4441 cccttggagt actgggaaag atgttctagt ggtttctttt aggaaaatct gtcattaaaa
     4501 aaattatagc cttgcaaata accattcact gttatttgag tcacagttta ttctagagag
     4561 acataaagaa tgctgacttc atttattttt ctacctatat acatactgga aaaggggaag
     4621 ggctggtgtt gtaaaaagaa acatgacaga aaacttatga ggtggcagag ttggggtgct
     4681 taggtataag ggtggatgta tttgcttatg gtcacaattg taccatttaa gaaatactgg
     4741 tcaaagccat caagttccat tacattgatt tgtagcttgt tagcacaata gcagaaaatg
     4801 tcgtgaaaat agttgtattg tacagcaggc aggatggctg tgaactgggt taagtagaaa
     4861 ggcagttcca ggtttgcctg taaagtatga ccattaaatc tttcatgtta aaggta
//
