LOCUS       NM_001081332            4770 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 5 (Slc9a5), transcript variant 1, mRNA.
ACCESSION   NM_001081332 XM_894890
VERSION     NM_001081332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4770)
  AUTHORS   Chen,X., Wang,X., Tang,L., Wang,J., Shen,C., Liu,J., Lu,S.,
            Zhang,H., Kuang,Y., Fei,J. and Wang,Z.
  TITLE     Nhe5 deficiency enhances learning and memory via upregulating
            Bdnf/TrkB signaling in mice
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 174 (8), 828-838 (2017)
   PUBMED   28981195
  REMARK    GeneRIF: Nhe5 deficiency is associated with enhanced learning and
            memory by upregulating Bdnf and TrkB signaling.
REFERENCE   3  (bases 1 to 4770)
  AUTHORS   Jinadasa,T., Szabo,E.Z., Numat,M. and Orlowski,J.
  TITLE     Activation of AMP-activated protein kinase regulates hippocampal
            neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell
            surface
  JOURNAL   J Biol Chem 289 (30), 20879-20897 (2014)
   PUBMED   24936055
  REMARK    GeneRIF: These data reveal a unique role for AMPK and NHE5 in
            regulating the pH homeostasis of hippocampal neurons during
            metabolic stress.
REFERENCE   4  (bases 1 to 4770)
  AUTHORS   Siyanov,V. and Baltz,J.M.
  TITLE     NHE1 is the sodium-hydrogen exchanger active in acute intracellular
            pH regulation in preimplantation mouse embryos
  JOURNAL   Biol Reprod 88 (6), 157 (2013)
   PUBMED   23677982
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4770)
  AUTHORS   Lukashova,V., Jinadasa,T., Ilie,A., Verbich,D., Cooper,E. and
            Orlowski,J.
  TITLE     The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular
            vesicles in the central and peripheral nervous systems
  JOURNAL   Adv Exp Med Biol 961, 397-410 (2013)
   PUBMED   23224898
  REMARK    GeneRIF: NHE5 partitions into a unique vesicular pool in neurons
            that shares some characteristics of recycling endosomes where it
            may serve as an important regulated store of functional
            transporters required to maintain cytoplasmic pH homeostasis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On Apr 9, 2022 this sequence version replaced NM_001081332.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151197.1, SRR7974084.19996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1397              AC124584.5         43907-45303         c
            1398-1700           AC124584.5         39754-40056         c
            1701-1864           AC124584.5         38172-38335         c
            1865-1943           AC124584.5         37930-38008         c
            1944-2121           AC124584.5         37455-37632         c
            2122-2342           AC124584.5         36728-36948         c
            2343-2545           AC124584.5         36306-36508         c
            2546-2635           AC124584.5         35996-36085         c
            2636-2706           AC124584.5         35828-35898         c
            2707-2836           AC124584.5         34976-35105         c
            2837-2925           AC124584.5         34299-34387         c
            2926-3052           AC124584.5         34026-34152         c
            3053-3223           AC124584.5         30046-30216         c
            3224-3293           AC124584.5         29473-29542         c
            3294-3428           AC124584.5         28663-28797         c
            3429-4770           AC124584.5         24132-25473         c
FEATURES             Location/Qualifiers
     source          1..4770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..4770
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 5"
                     /db_xref="GeneID:277973"
                     /db_xref="MGI:MGI:2685542"
     exon            1..1397
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1202..3898
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /note="Na(+)/H(+) exchanger 5; sodium/hydrogen exchanger;
                     solute carrier family 9 member 5; sodium/hydrogen
                     exchanger 5"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 5 precursor"
                     /protein_id="NP_001074801.1"
                     /db_xref="CCDS:CCDS40457.1"
                     /db_xref="GeneID:277973"
                     /db_xref="MGI:MGI:2685542"
                     /translation="MLSAALLLLPGLPLAGAGATEEPTQESGPLGEPPPGLALFRWQW
                     HEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAE
                     YQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGL
                     QQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNQTLFIIIFGESLLNDA
                     VTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTK
                     RVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTAVKYT
                     MKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQTWALNQF
                     RLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGL
                     TIKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDK
                     KYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSV
                     AETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCGR
                     HFISEDAQERQDKEIFQQNMKRRLESFKSTKHNICFTKSKPRPRKTSHKKKDGVANPE
                     ATNGKPPRDLGFQDTAAVILTVESEEEEESDSSETEKEDDEGIIFVARATSEVLQEGK
                     VSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSI
                     SSLESLASPPCTQPPTLTRLPPHPLVTEEPQVPIDLSSDPRSSFAFPPSLAKAGRSRS
                     ESSADIPQQELQPLMGHKDHTHLSPGTANSHWCIQFNRGGRL"
     exon            1398..1700
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1864
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1943
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2121
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2342
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2545
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2635
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2706
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2836
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2925
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3052
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3223
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3293
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3428
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..4770
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4750..4755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /note="hexamer: ATTAAA"
     polyA_site      4770
                     /gene="Slc9a5"
                     /gene_synonym="Gm696; NHE-5"
                     /note="major polyA site"
ORIGIN      
        1 ctttagattt ggtatgggcg aggctgcagc ggatctttgt aaggattttt agggcagatg
       61 gggggggggg ggtaaatctc ttcggataat ctgggtagct gggccactct caagggacga
      121 gatgggacta attgctagct tgaaagacaa atgaaagcat ttctctcatt tggggaaagc
      181 agtaagaaga atctctttca atgtggaata agaagtggaa atagatttta tatttgaaag
      241 aagaggtgga ttcagtcccc tttagctgtg ggggcaaaaa aaaagaggac gggtgctctt
      301 tctcgaaaaa gaatgggatg agtcactgtg aggaggcagg tagcacatgt tttttcggct
      361 tgggtgatga atgaaaagtg gagacattct tcggtttggg gcgagatgag tcaaatgccc
      421 caagttgttc ctaatttaaa gggaattcca taaggtcctc tcagatccat ggaataggca
      481 aacagttccc tgtagtttga aggaaaggga aggcggcgcc tctgggctct ggagagatga
      541 ggaatagcca gcttttcagc ctggaaagag ccgggtccgt cccggccttg aggtttctgg
      601 gtacgttgag agcaccgttg tccattaggc tttctgggtg tgcccagtgc gcgtgcgcag
      661 ctgtggtccg gtaggggggt cccaggtttt ggagatcgtg ctggaaggcg gcagcgcacc
      721 gccccctgcg gttttctcag cttagcactg ggacccgcag cctgagcacc tgggacgggt
      781 ggcccgctgc tgggcggtgt tctgcagtag ctgcgcttgt ctctgcttcc cgagaccccc
      841 gtccttcttg gtgctccggg acgcggtggc tggtcacctt tctgaatccg gaggagaggc
      901 ggtttaggag agcacactcg aaagagtggg tttcaggact cgaggggtta ggagggttat
      961 gctggggaat ttccggagat gagattaacc tagaagagat ggaggagggg atcctaactg
     1021 ctaggatcct gggcagggtc tcggggtccg gacctggcct gggggtatcg gagctcggat
     1081 tggggggagt gagccccacg tgcctgtgac gcgggggcgc cgggtaggcg gcggcagcgg
     1141 cggcggcggc ggcggcagcg acgcggggcc ggcggccgtg cagtgcccgg aggacagcaa
     1201 gatgctgagc gccgcactgc ttcttctgcc cgggttgccc ctggcggggg cgggggccac
     1261 agaagaaccc acccaggagt ccgggccgtt gggtgagcct cctccaggct tggcgctctt
     1321 ccgctggcag tggcacgagg tggaggcgcc ctacctggtg gccctgtgga tcctggtggc
     1381 cagcttagcc aaaatcgtgt tccacctgtc ccggaaggta acatctctgg tccctgagag
     1441 ctgcctgctg attttgctgg gcctggtgct agggggcatt gtcttagccg tggccaagaa
     1501 ggctgagtac cagctggagc cggggacctt cttccttttc ctgctccctc ccatcgtgct
     1561 agactcaggc tatttcatgc ccagccggct gttttttgac aacttgggtg ccatcctcac
     1621 ctacgccgtg gtgggcacac tctggaatgc cttcacaaca ggtgttgccc tttggggcct
     1681 gcagcaggct ggacttgtgg ctcctagggt acaggctggc ctgctggatt tcttgctgtt
     1741 tgggagtctc atctcagcag tggaccctgt ggccgtgttg gccgtctttg aggaggtgca
     1801 tgtcaatcag accctcttta tcatcatctt cggcgagtct ctgctcaatg atgcagtaac
     1861 tgtggtgctg tacaaggtct gcaactcctt tgtggagatg ggctctgcca acgtgcaggc
     1921 cactgactac ctaaagggcg tcgcctccct gtttgtggtc agtctgggcg gggcagcggt
     1981 gggcttagtc tttgccttcc tcctggccct gaccacacgc ttcaccaagc gggtccgcat
     2041 catcgagccg ttgctggtct tcctcctcgc ctacgcagcc tacctcactg ctgagatggc
     2101 ctcgttgtcc gccattcttg cggtgaccat gtgtggcctg ggatgtaaga aatacgtgga
     2161 agccaacatc tcccataagt cccgcacggc tgtcaagtac acgatgaaaa cactcgccag
     2221 ctgtgccgaa acggtcatct tcatgttact tggcatctcg gccgtggact cttccaaatg
     2281 ggcctgggac tctgggctgg tgctgggcac cctcttcttc atcctgttct tccgagccct
     2341 cggcgtggtc ttgcagacgt gggcgctgaa tcagttccgg ctggtccctc tggacaagat
     2401 tgaccaggtg gtgatgtcct atgggggcct tcggggggct gtggcctttg ctctcgtcat
     2461 cctcctggac aggaccaaag tccctgccaa ggactacttt gtggccacca ctattgtggt
     2521 ggtcttcttc accgtcatcg tgcagggttt gaccatcaag ccactggtca agtggctgag
     2581 ggtgaagagg agtgattacc acaaacccac cttgaaccag gagctgcatg agcacacttt
     2641 tgaccacatt ctggccgcag tggaggacgt tgtggggcac catggctacc actactggag
     2701 ggacaggtgg gaacagtttg acaagaagta cctgagtcag ctcttgatgc ggcggtcagc
     2761 ctatcgtatc cgcgaccaga tctgggatgt gtactacaga ctcaacatcc gagatgccat
     2821 cagctttgtg gaccagggag gccatgtctt gtcctccaca ggactcactc tgccctctat
     2881 gcctagcaga aattctgtgg cagagacctc tgtcaccaac ctgttgaggg agagcggcag
     2941 tggagcgtgt ctggatctgc aggtgattga cacggtgcgc agcggccgag accgggagga
     3001 tgccgtgatg catcatctgc tctgtggagg cctctacaag ccacggcgca ggtacaaagc
     3061 tagctgcggc cgccacttca tctcagagga tgcccaggag cgacaggaca aggagatctt
     3121 ccagcagaac atgaagcgac ggcttgagtc ctttaagtcc accaaacata acatctgttt
     3181 caccaagagc aaacctcggc cccgaaagac cagccataag aagaaggatg gtgtggctaa
     3241 tcccgaagct accaatggga agcctcctcg agacctgggc tttcaggaca cagctgcagt
     3301 gatactaacc gtggagtctg aggaggagga agaaagcgac agttcagaga cagagaaaga
     3361 ggacgatgaa gggatcatct ttgtggctcg tgccaccagt gaggttctcc aggaaggcaa
     3421 ggtctcagga agccttgagg tgtgtccaag cccacgcatc attcccccat ccccaacctg
     3481 tgcagagaag gagttaccct ggaagagtgg gcagggagac ctggctgtgt atgtgtcttc
     3541 agaaacaacc aagatcgtgc ctgtggacat gcagacaggc tggaaccaga gcatctcgtc
     3601 cctggagagc ctggcatccc ctccctgcac ccagcccccg actttaaccc gcttaccccc
     3661 ccaccctctg gtcactgaag agccccaggt tcctattgac ctgtcttctg accctcgctc
     3721 tagctttgcc ttccccccaa gcctggccaa agctggtcgt tctcgaagtg agagcagcgc
     3781 tgacatcccc cagcaggagt tgcagcccct catgggccac aaggaccaca ctcaccttag
     3841 tccgggcact gccaactccc actggtgcat ccagttcaac cgaggaggca ggctgtagcc
     3901 caggcctcag gggggagcag gagtggagcc cctgtgggga gtgctcttca gcctgggcag
     3961 aggagcctac ccagcctgga ctgaagtggt aacggcctcc ttgggactgg tcagaagggt
     4021 ttcctgggct ggtcctcaca gggacccttc tcccctctct ccctgccctc aacccttccc
     4081 acttttcatt tcgaaaaatg gctcaggatc cagtccagag ttctaaggga taggccccca
     4141 agctgctgtc ccttccctag ggcgtctttc tggacttagt gttggcagct gttcctcccc
     4201 acaaaccatc attcttcagt ggacactggt cccccctgac ctccaccctc tcccctgcac
     4261 caggtcagga tcattgccct ggcagcgagg ctgtcggagg ggctggtcct cagagcagct
     4321 gggctaggag agagctcagt caggtcagct aacttgtggg gtcagccaca cgagtaccac
     4381 atcttgcttt aaccctttcc ctctgctttc agttattgag gtcatggtga gtctttttct
     4441 aggacctagg cgctgggcca ggctttcctt cagagctgct ttatagccag tctactgcat
     4501 taggtctaaa tctgaacttt ctgaggcttg gatctgagat ttttttagag taggagacag
     4561 gtctctgggc ccgtcaccac ctcagaattt tcccaaaggg agaagggacc aagtctccca
     4621 gggccagtgc accgttcctg gtggagctgg gatgcctggc tgcaatgttt gggggcagct
     4681 agctgactaa caggtgactt tcccggggtt agcccctgcc gtgtgttttg taccttaaac
     4741 ccgagataca ttaaacatct ctcagatgaa
//
