LOCUS       NM_177084               4028 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 4 (Slc9a4), mRNA.
ACCESSION   NM_177084 XM_979950
VERSION     NM_177084.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4028)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4028)
  AUTHORS   Sakuta,H., Lin,C.H., Hiyama,T.Y., Matsuda,T., Yamaguchi,K.,
            Shigenobu,S., Kobayashi,K. and Noda,M.
  TITLE     SLC9A4 in the organum vasculosum of the lamina terminalis is a
            [Na+] sensor for the control of water intake
  JOURNAL   Pflugers Arch 472 (5), 609-624 (2020)
   PUBMED   32372285
  REMARK    GeneRIF: SLC9A4 in the organum vasculosum of the lamina terminalis
            is a [Na(+)] sensor for the control of water intake.
REFERENCE   3  (bases 1 to 4028)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4028)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4028)
  AUTHORS   Siyanov,V. and Baltz,J.M.
  TITLE     NHE1 is the sodium-hydrogen exchanger active in acute intracellular
            pH regulation in preimplantation mouse embryos
  JOURNAL   Biol Reprod 88 (6), 157 (2013)
   PUBMED   23677982
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4028)
  AUTHORS   Lee,M.G., Ahn,W., Choi,J.Y., Luo,X., Seo,J.T., Schultheis,P.J.,
            Shull,G.E., Kim,K.H. and Muallem,S.
  TITLE     Na(+)-dependent transporters mediate HCO(3)(-) salvage across the
            luminal membrane of the main pancreatic duct
  JOURNAL   J Clin Invest 105 (11), 1651-1658 (2000)
   PUBMED   10841524
REFERENCE   7  (bases 1 to 4028)
  AUTHORS   Praetorius,J., Andreasen,D., Jensen,B.L., Ainsworth,M.A.,
            Friis,U.G. and Johansen,T.
  TITLE     NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH
            in murine duodenal epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (2), G197-G206 (2000)
   PUBMED   10666043
REFERENCE   8  (bases 1 to 4028)
  AUTHORS   Shull,G.E., Miller,M.L. and Schultheis,P.J.
  TITLE     Lessons from genetically engineered animal models VIII. Absorption
            and secretion of ions in the gastrointestinal tract
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (2), G185-G190 (2000)
   PUBMED   10666041
  REMARK    Review article
REFERENCE   9  (bases 1 to 4028)
  AUTHORS   Barr,K.J., Garrill,A., Jones,D.H., Orlowski,J. and Kidder,G.M.
  TITLE     Contributions of Na+/H+ exchanger isoforms to preimplantation
            development of the mouse
  JOURNAL   Mol Reprod Dev 50 (2), 146-153 (1998)
   PUBMED   9590530
REFERENCE   10 (bases 1 to 4028)
  AUTHORS   Pathak,B.G., Shull,G.E., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mouse chromosomal location of four Na/H exchanger isoform genes
  JOURNAL   Genomics 31 (2), 261-263 (1996)
   PUBMED   8824815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138210.10.
            
            On Oct 31, 2022 this sequence version replaced NM_177084.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141534.1, AK085681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC138210.10        89555-90008         c
            455-918             AC138210.10        86004-86467         c
            919-1178            AC138210.10        69297-69556         c
            1179-1396           AC138210.10        67256-67473         c
            1397-1599           AC138210.10        63115-63317         c
            1600-1686           AC138210.10        62491-62577         c
            1687-1757           AC138210.10        59939-60009         c
            1758-1919           AC138210.10        58042-58203         c
            1920-2016           AC138210.10        51190-51286         c
            2017-2148           AC138210.10        46802-46933         c
            2149-2236           AC138210.10        46025-46112         c
            2237-4028           AC138210.10        39298-41089         c
FEATURES             Location/Qualifiers
     source          1..4028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.51 cM"
     gene            1..4028
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 4"
                     /db_xref="GeneID:110895"
                     /db_xref="MGI:MGI:105074"
     exon            1..454
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2592
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="sodium/hydrogen exchanger 4; NHE-4; solute carrier
                     family 9 member 4; Na(+)/H(+) exchanger 4"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 4 precursor"
                     /protein_id="NP_796058.1"
                     /db_xref="CCDS:CCDS14913.1"
                     /db_xref="GeneID:110895"
                     /db_xref="MGI:MGI:105074"
                     /translation="MGPAMFMAFRLWNWLLLLAVLTRSEATSYVNESSNPTAQQAPDA
                     RFAASSSDPDEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCL
                     LIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILW
                     WAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEA
                     RVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCG
                     GVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVT
                     MKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWNWAFICFTLLF
                     CQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKK
                     LFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHSRLMDHLKAGIEDV
                     CGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKSSIVSLYKKLEMKQAIEMVETGILSS
                     VASPTPYQSERIQGIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQTSEKQA
                     KEILIRRQNTLRESMRKGQSLPWGKPAGTKNFRYLSFPYSNPQAARREARAAEPTDDD
                     GTDSGFQPLMFSIHSRAGSLQERRQTQAVIPMKRLQRGEKALSFSYRSNTSWEDQAGW
                     RRMDVLRPKPLFYAVAEEYDSGEQTEEETSAILSRWTAEHRHSTEHHKSHSPLLHRK"
     exon            455..918
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1178
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1396
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1599
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1686
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1757
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1919
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2016
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2148
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2236
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..4028
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3398..3403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="hexamer: AATATA"
     polyA_site      3424
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
     regulatory      3694..3699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="hexamer: AATAAA"
     polyA_site      3726
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="major polyA site"
     regulatory      4005..4010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
                     /note="hexamer: AATAAA"
     polyA_site      4028
                     /gene="Slc9a4"
                     /gene_synonym="D730009J23Rik; NHE4"
ORIGIN      
        1 gagctgcctg aacacagtag attttaagaa gatttgaaag gacgcacctg cagagtcatc
       61 gcaccggacc tctttggaaa tgacttctgg attgcaaata gattgcctct cggtcagata
      121 gtgcagctgg aaactcacct gtgccgcaga ggcgtggcat acatcaggac ccaggtgcga
      181 agtcagagtc gcacaggcat gggtcctgca atgtttatgg cttttcgttt atggaactgg
      241 ttactactgc tggcggtcct tacacgttcc gaagcaacat cgtatgttaa tgagtcctcc
      301 aatcccactg cccagcaggc acctgatgct cggtttgctg cttctagctc agaccccgat
      361 gaagggatat ctgtttttga actggattat gactatgttc aaatccctta tgaagtcacc
      421 ctctggatac tgctcgcatc tcttgccaag ataggtttcc atctttacca caggctgccg
      481 cacctcatgc cagagagctg cctcctcatc atcgtgggag ctctggtggg cggcatcatt
      541 tttggcaccc accacaaatc gcctccggtc atggattcaa gcatttactt cctctacctt
      601 ctcccaccta ttgtgttgga aagcggctac ttcatgccca ccaggccctt ctttgagaat
      661 attggctcca tcctgtggtg ggcaggcctg ggagccctga tcaatgcctt tggcattggg
      721 ctctctctct acttcatctg tcagatcaag gcctttggcc ttggtgacat caacctgcta
      781 cacaatctgc tatttggcag cctcatctca gcggtcgacc ccgtggctgt gctggctgtt
      841 tttgaggagg cacgtgtgaa tgaacagctt tacatgatga tcttcgggga ggccctgctc
      901 aatgatggaa tcagcgtggt cttatacaac atactaattg ccttcactaa gatgcacaaa
      961 tttgaggaca tagaagcggt ggacattttg gctgggtgtg ccagattcgt catcgtgggg
     1021 tgcgggggag tatttttcgg catcatattt ggattcattt ccgcatttat cacacgtttc
     1081 actcagaaca tctctgcgat tgagcccctc atcgtcttca tgttcagcta tctgtcttac
     1141 ttagcagccg agacgcttta tctctcagga atcctggcca tcacagcttg cgcagtgacc
     1201 atgaaaaagt acgtggaaga gaacgtgtcc cagacatcat acacgaccat caagtacttc
     1261 atgaagatgc tgagcagcgt gagtgagacc ctgatcttca tcttcatggg cgtgtccacc
     1321 attgggaaga accatgagtg gaactgggct ttcatctgct tcactctgct cttctgccag
     1381 atctggagag caatcagcgt atttaccctc ttctatgtca gtaaccagtt tcggactttc
     1441 cccttctcca tcaaggacca gttcataata ttctacagcg gtgtgagagg agcaggaagc
     1501 ttctcccttg cgtttttgct tcctctgtcc ctttttccta ggaagaaact gtttgttacg
     1561 gcaactttag tagttacata ctttactgta ttttttcagg gaatcacaat tggcccactg
     1621 gtcaggtatc tggatgtcag aaagaccaat aaaaaagaat ccatcaacga agagcttcac
     1681 agccgtctta tggatcatct gaaggctggg attgaagatg tgtgtgggca gtggagtcac
     1741 taccaagtga gagataagtt caagaagttt gaccatagat atttacggaa aattctaatc
     1801 cggaggaacc tgccaaaatc aagcatcgtt tctttgtata agaagctgga gatgaaacag
     1861 gccattgaga tggtagagac tgggatactg agctctgtgg cttctcccac accctatcag
     1921 tctgagagga tacagggaat caagcggctt tctcctgaag acgtggagtc catgcgggac
     1981 attctgacaa gaagcatgta ccaagttcga caaagaaccc tatcctacaa caaatacaac
     2041 ctcaaacccc aaacaagtga gaagcaagcc aaagagattc tgatccgtcg ccagaacacc
     2101 ttgagggaga gcatgcggaa aggccagagt ctgccctggg gaaagccggc aggcaccaag
     2161 aactttcgat atctctcctt tccttatagc aatcctcagg cagcaaggag agaggcaagg
     2221 gctgctgaac ccacagatga tgatggcact gattcaggat tccagccctt gatgttcagc
     2281 atacactcaa gagcagggtc ccttcaggaa aggcgacaga cccaggcagt gatccctatg
     2341 aagaggctgc agagaggaga gaaggcgctt agcttcagct accgaagcaa caccagctgg
     2401 gaggaccagg ccggatggcg caggatggat gtcctccggc ccaagccgct gttctatgca
     2461 gtagccgagg agtatgactc tggagagcag acggaggagg agacctcagc aatcctgtcc
     2521 agatggacag ctgaacacag acacagcaca gagcaccaca agtcccacag tcctttgctc
     2581 cataggaaat agcttattat tctcagatgg ctgttggttc tttccagagt cccaaatcct
     2641 attttataaa acgaaaattc ccacagtctg gaacatttac caagtttgca tttttttttg
     2701 aaacttccag acaccattct acagggtaag ctctcagtga acttaaaggc tgagccacac
     2761 tcttgtacct ttgtagatga attctgtgtg cagcagaaca tcaccgcttc tcagagtaac
     2821 cagtcatctc tgaggattgc agaaatccat caagcactct tggtttcctc ctagacgtca
     2881 agagggatgc tgggatttgg agatacctaa tgatggaagc cattagaaaa tcccacctct
     2941 gagaaaagaa ccaaagaaca aaggcatctt catttagaat tcataggaac cttctatcac
     3001 aaccctctga tctgtggcat atatccagaa ctacatgtgc tcggtcagca attcctataa
     3061 gttgtatgga tatgcaattt gtaatcactt agaaacggca gggctcttta aattcatctg
     3121 gctcagcccc tggcatttgc agattgagac acattgacaa gatctcctga aatattggtc
     3181 accttgcaag ttgtatgcct tggctttaat ttttttcaaa tgaactcctt tgttttcaaa
     3241 gatacaatag tatacctcaa atgagagata aaatttgttc cacactgtta tgtttaatca
     3301 gtgatgttga tagacatgat ctgtactcta ggggctgatc ttacgaatct atatactatt
     3361 tttataatta gaatgtcaat ttaaaataaa ttgtagcaat ataagagcta cagtttaata
     3421 acgatggcat gaataataga atttatctgc tgtgtgttta taacttgtga agttttgctc
     3481 tggagtttag taactattct tcagttgagt tgtgcaccat ggttattcca aacctgactt
     3541 tggacttcac agtttagctt gctaattttc ccagctactc tttatctctc ttcctacctt
     3601 acccttccct tctgtctctg catctatagg tgaatagaca tgtctgaaat gttacttact
     3661 gtgccagata actagatcta tggcaaccag atcaataaat atcctttgcc atcatggctt
     3721 aatccatctc tgccaggccc atctgactta atcaagaaca catttcagct gccttgaccc
     3781 ttgaggtcct ctgtgctcct cttggtgggt aaggggttgg gggacttggc ttgtcctctg
     3841 ggcacatgtg tttagtcttg tggcccaaag gacaaaggag gacagtttga ttgatttgcc
     3901 atttgtccat ttatcaggtg caactttttc cttctttccc tttttattgt gtatttgact
     3961 tccaccaact ttcctctatt atcattgtgt cttcgacatg gaagaataaa catggatgct
     4021 gaatggaa
//
