LOCUS       NM_001081060            5970 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 3 (Slc9a3), mRNA.
ACCESSION   NM_001081060 XM_127434
VERSION     NM_001081060.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5970)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 5970)
  AUTHORS   Luo,M., Liu,Y., Nikolovska,K., Riederer,B., Patrucco,E., Hofmann,F.
            and Seidler,U.
  TITLE     cGMP-dependent kinase 2, Na+/H+ exchanger NHE3, and PDZ-adaptor
            NHERF2 co-assemble in apical membrane microdomains
  JOURNAL   Acta Physiol (Oxf) 240 (4), e14125 (2024)
   PUBMED   38533975
  REMARK    GeneRIF: cGMP-dependent kinase 2, Na[+]/H[+] exchanger NHE3, and
            PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains.
REFERENCE   3  (bases 1 to 5970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5970)
  AUTHORS   Goto,S., Yoshida,Y., Hosojima,M., Kuwahara,S., Kabasawa,H.,
            Aoki,H., Iida,T., Sawada,R., Ugamura,D., Yoshizawa,Y., Takemoto,K.,
            Komochi,K., Kobayashi,R., Kaseda,R., Yaoita,E., Nagatoishi,S.,
            Narita,I., Tsumoto,K. and Saito,A.
  TITLE     Megalin is involved in angiotensinogen-induced, angiotensin
            II-mediated ERK1/2 signaling to activate Na + -H + exchanger 3 in
            proximal tubules
  JOURNAL   J Hypertens 41 (11), 1831-1843 (2023)
   PUBMED   37682076
  REMARK    GeneRIF: Megalin is involved in angiotensinogen-induced,
            angiotensin II-mediated ERK1/2 signaling to activate Na + -H +
            exchanger 3 in proximal tubules.
REFERENCE   5  (bases 1 to 5970)
  AUTHORS   Oh,Y., Kasu,M., Bottoms,C.J., Douglas,J.C., Sekulovski,N.,
            Hayashi,K. and MacLean Ii,J.A.
  TITLE     Rhox8 homeobox gene ablation leads to rete testis abnormality and
            male subfertility in micedagger
  JOURNAL   Biol Reprod 109 (4), 520-532 (2023)
   PUBMED   37471646
REFERENCE   6  (bases 1 to 5970)
  AUTHORS   Barr,K.J., Garrill,A., Jones,D.H., Orlowski,J. and Kidder,G.M.
  TITLE     Contributions of Na+/H+ exchanger isoforms to preimplantation
            development of the mouse
  JOURNAL   Mol Reprod Dev 50 (2), 146-153 (1998)
   PUBMED   9590530
REFERENCE   7  (bases 1 to 5970)
  AUTHORS   Schultheis,P.J., Clarke,L.L., Meneton,P., Harline,M., Boivin,G.P.,
            Stemmermann,G., Duffy,J.J., Doetschman,T., Miller,M.L. and
            Shull,G.E.
  TITLE     Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene
            causes reduced viability of gastric parietal cells and loss of net
            acid secretion
  JOURNAL   J Clin Invest 101 (6), 1243-1253 (1998)
   PUBMED   9502765
REFERENCE   8  (bases 1 to 5970)
  AUTHORS   Tamimi,R.M., Steingrimsson,E., Montgomery-Dyer,K., Copeland,N.G.,
            Jenkins,N.A. and Tapscott,S.J.
  TITLE     NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and
            5q23-q31 and mouse chromosomes 11 and 13, respectively
  JOURNAL   Genomics 40 (2), 355-357 (1997)
   PUBMED   9119405
REFERENCE   9  (bases 1 to 5970)
  AUTHORS   Pathak,B.G., Shull,G.E., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mouse chromosomal location of four Na/H exchanger isoform genes
  JOURNAL   Genomics 31 (2), 261-263 (1996)
   PUBMED   8824815
REFERENCE   10 (bases 1 to 5970)
  AUTHORS   Kuhn,R., Lohler,J., Rennick,D., Rajewsky,K. and Muller,W.
  TITLE     Interleukin-10-deficient mice develop chronic enterocolitis
  JOURNAL   Cell 75 (2), 263-274 (1993)
   PUBMED   8402911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154839.3.
            
            On Nov 15, 2022 this sequence version replaced NM_001081060.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849378 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC154839.3         71814-72111         c
            299-601             AC154839.3         42562-42864         c
            602-762             AC154839.3         38275-38435         c
            763-841             AC154839.3         36461-36539         c
            842-1019            AC154839.3         35742-35919         c
            1020-1240           AC154839.3         34629-34849         c
            1241-1443           AC154839.3         34093-34295         c
            1444-1533           AC154839.3         33214-33303         c
            1534-1604           AC154839.3         33027-33097         c
            1605-1734           AC154839.3         31698-31827         c
            1735-1850           AC154839.3         30389-30504         c
            1851-1980           AC154839.3         29712-29841         c
            1981-2157           AC154839.3         29184-29360         c
            2158-2230           AC154839.3         28928-29000         c
            2231-2338           AC154839.3         28119-28226         c
            2339-5970           AC154839.3         24082-27713         c
FEATURES             Location/Qualifiers
     source          1..5970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..5970
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 3"
                     /db_xref="GeneID:105243"
                     /db_xref="MGI:MGI:105064"
     exon            1..298
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2592
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /note="sodium/hydrogen exchanger 3"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 3 precursor"
                     /protein_id="NP_001074529.1"
                     /db_xref="CCDS:CCDS36731.1"
                     /db_xref="GeneID:105243"
                     /db_xref="MGI:MGI:105064"
                     /translation="MWHRALGPGWKLLLALALTSLQGARGAEEEPSSDGSFQVVTFKW
                     HHVQDPYIIALWILVASLAKIVFHLSHKVTSIVPESALLIVLGLVLGGIVWAADHIAS
                     FTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGV
                     FLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAV
                     TVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKH
                     VRIIEPGFVFVISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTM
                     KMLASGAETIIFMFLGISAVNPDIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYR
                     MVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLT
                     IKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRK
                     FLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVD
                     FNTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPR
                     QEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERA
                     QKRRNSSIPNGKLPMENLAHNYTIKEKDLELSEHEEATNYEEISGGIEFLASVTQDVA
                     SDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTP
                     FRLSNKSVDSFLQADGHEEQLQPAAPESTHM"
     exon            299..601
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..762
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..841
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1019
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1240
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1443
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1533
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1604
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1734
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1850
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1980
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2157
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2230
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2338
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..5970
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5951..5956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /note="hexamer: ATTAAA"
     polyA_site      5970
                     /gene="Slc9a3"
                     /gene_synonym="9030624O13Rik; NHE-3; NHE3"
                     /note="major polyA site"
ORIGIN      
        1 ctgactgctg ccagctccgg gctcgcgcag agggctgcga cggagagcgc agcaggtact
       61 caccaaggta tgcgtgttgg ctcccggagc tgagcagcag cgatgtggca ccgggctctg
      121 ggaccagggt ggaagctgct gctggccctg gcgctgacca gcctgcaagg cgcgaggggg
      181 gctgaggagg aaccgagcag tgatgggagc ttccaggtgg tcaccttcaa atggcaccac
      241 gtccaggatc catacatcat tgcgctctgg atcctcgtgg ccagcttggc caaaatcgtc
      301 tttcacctgt cccacaaggt caccagtatc gtccccgaga gtgctctact catcgttctg
      361 ggcctggtgt tgggtggcat cgtctgggca gctgaccaca tcgcctcctt cacactcaca
      421 cccacgctct tcttcttcta cctgctgccc cctattgtgt tggatgctgg atacttcatg
      481 cccaatcgac tcttctttgg caacctgggc accattctgc tatatgctgt cattggcact
      541 atatggaatg cagccaccac aggattgtcc ctctatggtg tcttcctcag tggcttgatg
      601 ggtgaactga aaattggact cctggatttc ttgctgtttg gtagcctcat tgcagctgtg
      661 gacccagtgg ctgtgctggc tgtgtttgag gaagtccatg tcaatgaagt cctcttcatc
      721 attgtctttg gggagtcact gctgaatgat gcagtgactg tggtcttgta caatgttttt
      781 gagtcttttg tgacactggg tggtgacgca gtgactggcg tggattgtgt gaaaggcata
      841 gtgtccttct tcgtggtgag cctggggggc actctggtgg gtgttatctt cgccttcctg
      901 ctgtccttgg tgactcgctt caccaagcat gtgcgtatca tcgagcctgg cttcgtcttt
      961 gtcatttcct acctgtccta tctgacctcc gagatgctgt ctttgtcatc catcctggcc
     1021 atcacctttt gcggcatctg ctgtcagaag tacgtgaagg ccaacatctc agagcagtcg
     1081 gccaccactg tgcgctacac tatgaagatg ctggccagtg gagcagagac cattatcttt
     1141 atgttcctgg gtatctcagc tgtgaacccc gacatctgga catggaacac agcttttgtg
     1201 ttgctgacac tggtcttcat ttctgtatat cgagccattg gtgttgttct gcagacctgg
     1261 atcctgaatc gctacagaat ggtgcagcta gaaaccattg accaggtggt catgtcctat
     1321 ggtggcctgc gtggggcagt ggcctatgcc ttggtggtac ttctggatga gaagaaagtc
     1381 aaggagaaaa atctgtttgt cagcaccact ctcattgtgg ttttcttcac agtcatcttt
     1441 cagggcctga ccattaagcc cctggtgcag tggctgaagg tgaagaggag cgagcatcgt
     1501 gagccaaagc tcaatgagaa gctacatggc cgggctttcg accacatcct ctcagccatt
     1561 gaggacatct caggacaaat tggacacaat tacctcagag ataagtggtc caattttgac
     1621 cggaagttcc tcagcaaagt cctcatgaga agatctgctc aaaaatctcg agatcggatc
     1681 ctgaatgttt tccatgagct gaatttgaag gatgctatca gctatgtggc tgagggagag
     1741 cgccgtgggt ccctggcctt cattcgctcc ccaagtacgg acaatatggt caatgtggac
     1801 ttcaacacac cccgcccatc tactgtggag gcgtctgtct catatttctt gagggaaaat
     1861 gtcagtgctg tatgcctgga catgcagtcc ttggaacaga ggcggaggag catccgtgac
     1921 accgaggaca tggtcaccca ccacacactg caacagtacc tgtacaagcc tcggcaggag
     1981 tacaagcatc tctatagtcg gcacgagcta acacccaatg aggatgaaaa gcaggacaag
     2041 gaaatctttc acagaaccat gaggaagcgc ctggagtcct ttaagtcagc taagctaggc
     2101 atcaaccaga ataagaaggc ggccaagctg tacaagaggg agcgcgcaca gaagcggagg
     2161 aatagcagca ttcctaatgg gaaactgcct atggagaacc tggcacacaa ctacaccatc
     2221 aaggagaaag atttggaact ttcagagcat gaggaggcca ccaactatga agagatcagt
     2281 ggaggcattg agtttctggc cagtgtcacc caggatgtag cctctgactc tggggcagga
     2341 attgataatc ccgtgttctc ccctgatgag gatctggacc caagcatcct atccagggtg
     2401 ccaccctggc tgtcccctgg ggagaccgtg gtgccctccc agagggcccg tgttcagatt
     2461 ccaaactctc ccagcaactt ccgccgcctg acaccattcc gcctcagcaa caaatccgtg
     2521 gattccttcc tgcaggctga tggccacgag gaacagctcc aaccggctgc ccccgagtcc
     2581 acacacatgt aactgctttc ctcctctaac gcgttctttc ttcccagctg ttgccgtcag
     2641 gtgtacctgc actttttcag actttgcagc agctgtcttc actctgcaaa ccctgtcttg
     2701 gtcatctgtc cagctgtata tttcttagaa cctgcttgtc cacagagctc ttccacctgc
     2761 tctttgcttc tgtctctcgg cttgcccccg cttccaccct tttcgacagg gtttccctga
     2821 gcagctctgg ctgctggaac ttagctatga aaaccaggct gcctttgcct cctgagtgct
     2881 ggaattaaag atctggctct ttgaaagagc cttatgtgcc ttgaggcttg tgataggttt
     2941 ttagggtaga gcagtagtac ccagggatgg gtgtggcact gctacccctt gtggaggggg
     3001 ctgctatcaa tggcagggtt tgaaagtgtc agaatatggg gagtgagcca gatctgctca
     3061 gtgcatagct gcctaggaag gttcagagac accggctgga actcctccta actctgcagt
     3121 agtgcacagc agaaaatgcc cccatttggt gtggaaggtt aggggtcttt ctttgcactt
     3181 gagcctgagg taccctttcc atggtcaggc acctaatttt gggcaagcca tggaggaaca
     3241 gcaaactcag ggggaaggga atcttggact gagtacaggc ttctggaggt cagtgttgat
     3301 ctggactgag agccactcac actcctgttt tcccacaggt gacacgggct ctggcacatc
     3361 gcttactgga cgcttgtctc gtcagccatc tgctgcttcc cagcagtctt tgctccccgc
     3421 agggctcgcc cacccacgcg ccccaagccc cgccccatct gagcgcacct cgactgtcac
     3481 ttttgcctct ggtgatcccg ggacagagcc agagcaccgg gccccaccca gtgcacatgc
     3541 tcggtcggca gctgcacgcc gggtacacag taggcgctca ttccaaaggc ctcgcccgcg
     3601 ccgacgacca gctctgctaa aactcgcttc tcttccgggc tctatagaac tgccactgca
     3661 cgctctggag caagaagaga cgccactgta attgctgcct ggccaggggc ccagctcaga
     3721 gggtctcctt cagtggcccc tccccaacca gctagtgttc ttagggtcca atgcaccctg
     3781 ggagtcttaa tgcatagcct agccctagga agaatccatc tggtgtcccc aggataccac
     3841 actgcctcct gccatcttct tgccctggtt cagatcctag ggctctgtgg tgctgcctcc
     3901 ccacccctac cctgaggcta gagcccttgt tagtgtttgc cacccttact ctgaggagga
     3961 ggaagatccc tgagcggctt gtggtggact taaatcactg ctggtacaaa agaaggtctc
     4021 aaaaattaag atgtgtagaa gtggcactgc ccagatcaac ctcattctaa ataggtagca
     4081 ggtcctatgc atccccagaa atatacaccc cgaggcccta tctgaccccc ttccaagtta
     4141 gttctccaga ctgccctaga ccttgtgatt aactgcagaa atatttggct cttctagctc
     4201 agactttccc tgcctggccc ctcccagcct ggtccttgcc atcacaaaca aggtgtctgg
     4261 cctgagctat gcctaagttg ggaacactgc agatggccag gcaggctgag ctagggcgct
     4321 agtagtggtt cactagaaac cttggtcaaa attatagcca gctctctggt atcaatcaaa
     4381 ggcagggaag acctggggca tagaggggct ctacatcact caagagtagg ggaatgtagg
     4441 aacccactct ctgggcaatt tgttctgccc ccagatcttc agggactctg ccttagaaca
     4501 ttggccctct gtaggggtaa gaggctgggc catcatccct tatcactttt cctcagaagt
     4561 ccagtattga agagtcacct gagttttgct tccaactcac tggaaacttg gcctgtacca
     4621 cagggtatca cttaagggag atcgagatga gtctaaaggt ggacttaagg acttcctgga
     4681 gacttctgaa acaaagcact caggtttctg ctcaggaaac taaataccat gtctcaggaa
     4741 caaggctgac agtcaccttc agaggagtcc caggaaggtc catcaactta tattaatgct
     4801 gcagttgatt catggatagg aagagagctg agagaagtga atgaaaacaa agcaagttcg
     4861 ctcaacatac tgcattgtgc ttcagagtgc cgttccccaa cggaacctgt cagtatgctg
     4921 ttgactggct agctcagact cggccatcag ggagatgctc agcacctgac ttccacagcc
     4981 ctgaagcatt tgtccatttc tgaagtccag ccaccataca atgctgggat ccggaatttc
     5041 accagattat ttggagctgc catttagagt acctcctagg cacggtgtac ctggctactg
     5101 taccaggggt gttctgcgag gcatctctca gcccctgctc tgcagacaag tttctcatac
     5161 cttcctgtgc caggacactg ccttaacacc tcacctgatc tgctggacat ggggtccaat
     5221 tcccactgca gaattagaag ccaaatgtga tgagacaggc ttcggcaact gtcaccttgc
     5281 accagtaccc agagatacca aagctagcag ctgggtgatc aatctgtgga actctttgac
     5341 actctgtcca tattttagct gtgcacaggc catgtccttt gagcgtgtga accacaccat
     5401 tgggcatagc catatggaat cagagtcttg acaagaaagc ctcattcaca aaaccccact
     5461 tcctgtgctt aaatgacaca gtggccacat ctcatagttg aggaccctct tgttcttgtc
     5521 attgttgtac aatagaatgt aaaatcctat gaatgtattt ccttaggaaa actgttgtaa
     5581 aaggtttttt ttattagaag agaatttcta tttatttaat actgaactca gacctgcttt
     5641 gtggtactac aaagtataca aatttaggaa atttgtattt ccacttctgt attttcttga
     5701 aaataatttt attacagtgt tcaatatact atgtattact aatcttttta tgaaaggaaa
     5761 tttaaaggac ttcatcaaaa ctagaaatat attttgaatg gttaaaattg tgtattaatg
     5821 tgaacatagt catagttgag cttcaattct gatcacagaa tctcgtgcct taaagcggcc
     5881 ctccaatgtg ctgggcagca tttgtacaag gagttcatca gcaaactgca gggactgctt
     5941 gcttatgtct attaaaaaca ctttgaggca
//
