LOCUS       NM_001033289            3493 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 2 (Slc9a2), mRNA.
ACCESSION   NM_001033289 XM_129721
VERSION     NM_001033289.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3493)
  AUTHORS   Nikolovska,K., Cao,L., Hensel,I., Di Stefano,G., Seidler,A.E.,
            Zhou,K., Qian,J., Singh,A.K., Riederer,B. and Seidler,U.
  TITLE     Sodium/hydrogen-exchanger-2 modulates colonocyte lineage
            differentiation
  JOURNAL   Acta Physiol (Oxf) 234 (3), e13774 (2022)
   PUBMED   34985202
  REMARK    GeneRIF: Sodium/hydrogen-exchanger-2 modulates colonocyte lineage
            differentiation.
REFERENCE   2  (bases 1 to 3493)
  AUTHORS   Engevik,K.A., Hanyu,H., Matthis,A.L., Zhang,T., Frey,M.R.,
            Oshima,Y., Aihara,E. and Montrose,M.H.
  TITLE     Trefoil factor 2 activation of CXCR4 requires calcium mobilization
            to drive epithelial repair in gastric organoids
  JOURNAL   J Physiol 597 (10), 2673-2690 (2019)
   PUBMED   30912855
REFERENCE   3  (bases 1 to 3493)
  AUTHORS   Hadsell,D.L., Hadsell,L.A., Rijnkels,M., Carcamo-Bahena,Y., Wei,J.,
            Williamson,P. and Grusak,M.A.
  TITLE     In silico mapping of quantitative trait loci (QTL) regulating the
            milk ionome in mice identifies a milk iron locus on chromosome 1
  JOURNAL   Mamm Genome 29 (9-10), 632-655 (2018)
   PUBMED   30073618
  REMARK    GeneRIF: Expression of solute carrier family 40 (iron-regulated
            transporter) member 1 (Slc40a1) within the mammary gland can
            mediate the effect of milk mineral concentration quantitative trait
            loci 9 (Mmcq9) on milk iron concentration.
REFERENCE   4  (bases 1 to 3493)
  AUTHORS   Dho,S.H., Manson,S.R., Jung,S.H., Lim,J.C. and Weintraub,S.J.
  TITLE     Bcl-xL deamidation is regulated by multiple ion transporters and is
            intramolecularly catalyzed
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (7), 995-1001 (2018)
   PUBMED   29694915
REFERENCE   5  (bases 1 to 3493)
  AUTHORS   Shawki,A., Engevik,M.A., Kim,R.S., Knight,P.B., Baik,R.A.,
            Anthony,S.R., Worrell,R.T., Shull,G.E. and Mackenzie,B.
  TITLE     Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron
            absorption in the mouse
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 311 (3), G423-G430 (2016)
   PUBMED   27390324
REFERENCE   6  (bases 1 to 3493)
  AUTHORS   Barr,K.J., Garrill,A., Jones,D.H., Orlowski,J. and Kidder,G.M.
  TITLE     Contributions of Na+/H+ exchanger isoforms to preimplantation
            development of the mouse
  JOURNAL   Mol Reprod Dev 50 (2), 146-153 (1998)
   PUBMED   9590530
REFERENCE   7  (bases 1 to 3493)
  AUTHORS   Schultheis,P.J., Clarke,L.L., Meneton,P., Harline,M., Boivin,G.P.,
            Stemmermann,G., Duffy,J.J., Doetschman,T., Miller,M.L. and
            Shull,G.E.
  TITLE     Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene
            causes reduced viability of gastric parietal cells and loss of net
            acid secretion
  JOURNAL   J Clin Invest 101 (6), 1243-1253 (1998)
   PUBMED   9502765
REFERENCE   8  (bases 1 to 3493)
  AUTHORS   Helou,K., Das,A.T., Lamers,W.H., Hoovers,J.M., Szpirer,C.,
            Szpirer,J., Klinga-Levan,K. and Levan,G.
  TITLE     FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1)
            in rat, and the chromosomal localization of GLUL in human and Cps1
            in mouse
  JOURNAL   Mamm Genome 8 (5), 362-364 (1997)
   PUBMED   9107685
REFERENCE   9  (bases 1 to 3493)
  AUTHORS   Pathak,B.G., Shull,G.E., Jenkins,N.A. and Copeland,N.G.
  TITLE     Mouse chromosomal location of four Na/H exchanger isoform genes
  JOURNAL   Genomics 31 (2), 261-263 (1996)
   PUBMED   8824815
REFERENCE   10 (bases 1 to 3493)
  AUTHORS   Szpirer,C., Szpirer,J., Riviere,M., Levan,G. and Orlowski,J.
  TITLE     Chromosomal assignment of four genes encoding Na/H exchanger
            isoforms in human and rat
  JOURNAL   Mamm Genome 5 (3), 153-159 (1994)
   PUBMED   8199403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC103685.1.
            
            On Sep 18, 2005 this sequence version replaced NM_001033289.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103685.1, AK077026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.66 cM"
     gene            1..3493
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 2"
                     /db_xref="GeneID:226999"
                     /db_xref="MGI:MGI:105075"
     exon            1..454
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2607
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /note="Na(+)/H(+) exchanger 2; sodium/hydrogen exchanger;
                     solute carrier family 9 member 2; sodium/hydrogen
                     exchanger 2"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 2 precursor"
                     /protein_id="NP_001028461.2"
                     /db_xref="CCDS:CCDS14914.1"
                     /db_xref="GeneID:226999"
                     /db_xref="MGI:MGI:105075"
                     /translation="MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRAR
                     GASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLY
                     HKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPT
                     RPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAV
                     DPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGI
                     ANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGI
                     MAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNW
                     AFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLL
                     PATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFF
                     DHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAI
                     EMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHN
                     LTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQ
                     KKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGS
                     VRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRR
                     ASEPGNRKGRLGNEKP"
     exon            455..918
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1169
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1387
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1590
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1680
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1751
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1913
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2010
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2142
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2233
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..3493
                     /gene="Slc9a2"
                     /gene_synonym="2210416H12Rik; 4932415O19Rik; NHE-2; NHE2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccaccga actggttggc gacagggccc cgaccccgtg gaggcggtgg tgtggtactc
       61 tcgcagtccc gttgagttag tagtgctgtc cctcccgcga tgctctgagg gaacccagat
      121 cctacaccag cgtcctctgc tgcgctcata gctgccgacc ccatgggccc ccggggcacc
      181 gcgcacagcg tgcgggcgcc actgtcttgg ctgctgctgc tgctgctgtc tctgcaggtg
      241 gcagtgccgg cgggcgcgct ggccgagacc ctgctggacg cacccagggc caggggtgcc
      301 agctccaacc cgccaagtcc tgccagtgtg gtggccccgg gaacgacgcc gttcgaggaa
      361 agtcggttgc ccgtgttcac cctggattac ccccacgtgc aaatcccttt cgagatcact
      421 ttgtggatcc tactggcctc cttggccaag attggttttc atctctatca caagttgccc
      481 acaatcgtgc cggagagctg ccttctcata atggtcgggc ttctactggg tgggattatc
      541 ttcggtgttg atgagaagtc tcccccggca atgaagacag atgtgttttt cctatacctc
      601 ctgccaccca tcgttctgga tgctggctac ttcatgccaa ctcgcccctt ctttgagaac
      661 ttcggcacca ttttctggta tgctgtggta ggcacactgt ggaattccat tggcattggg
      721 gtgtctttgt ttggcatctg ccagattgag gcgtttggcc tcagtgacat caccctgctc
      781 cagaacctgc tcttcggcag cctgatttca gctgtggacc ccgtggctgt gcttgctgtc
      841 tttgagaaca ttcacgtcaa tgaacagctc tatatcctgg tttttggcga gtctctgctc
      901 aacgatgcag tcacagtggt cctgtacaac ttgttcaagt ccttctgcca gatgaaaacc
      961 atccagaccg tagacgtgtt tgctggcatc gctaacttct tcgtcgtggg tattggcggg
     1021 gtgctgattg gcatcctcct gggattcata gcagcgttta ccacccgttt cacacacaac
     1081 atccgggtca ttgagccact ctttgtcttc ttgtacagct acttgtccta catcactgct
     1141 gaaatgttcc acctttcagg catcatggcg atcacagcgt gtgccatgac aatgaataag
     1201 tacgtggaag agaacgtgtc tcagaagtcc tacacaacca tcaagtactt catgaagatg
     1261 ctgagcagcg tgagcgagac cctgatcttc atcttcatgg gcgtgtccac tgttgggaag
     1321 aaccacgagt ggaactgggc tttcgtctgc tttaccctgg ccttctgcct gatctggcga
     1381 gcactgggcg tctttgtcct gactcaggtg attaactggt tccggaccat cccgctaacc
     1441 ttcaaggacc agttcatcat tgcctacgga gggctccgtg gcgccatctg ctttgcactg
     1501 gtgtttctcc tccctgctac tgtgtttccc cgaaagaagc tgttcatcac ggctgctatt
     1561 gtcgttatat tcttcactgt cttcatcctg ggtataacca tccggccact ggtggaattt
     1621 cttgatgtta agagatccaa taagaagcag caagctgtca gtgaagagat ccactgtcgg
     1681 ttttttgatc atgtgaagac tgggattgaa gatgtgtgtg gacactgggg tcacaacttc
     1741 tggagagaca agtttaagaa gtttgatgac aaataccttc ggaagcttct gattcgggaa
     1801 aaccaaccca agtccagtat tgtgtcctta tataaaaagc ttgagataaa gcatgccatt
     1861 gaaatggcag agacagggat gataagcact gtcccctcat ttgcatctct caatgactgc
     1921 cgtgaagaga aaataaggaa gctcacgcca ggcgaaatgg atgaaattag agagatatta
     1981 tcacggaatc tctatcaaat ccgtcagcgg accttgtcct ataacagaca caacctgacg
     2041 gcagacacaa gcgagaggca agccaaggag atcctgattc gcaggcggca cagtcttcgg
     2101 gaaagtctca ggaaagacaa cagctcaaac cgcgagcgca gggcttccac ttcaacctcc
     2161 cgatatttat ccttacctaa gaacacaaag cttccagaga agctgcagaa gaagaagaag
     2221 gtttcaaatg cagatggaaa tagcagcgac tcggacccag atgttggaac cactgtgctc
     2281 aatttgcagc ccaggaccag gcgcttcttg ccagatcagt tctcaaagaa agcctcccag
     2341 gcctacaaaa tggaatggaa gaacgaggtg gatgtgggtt ctgtgcgagt gccccccagc
     2401 gtctctccag cgccccgcag taaagacggg ggcacccaaa caccggggtt gctgaggcag
     2461 cccctgctct ccaaagacca acggtttggc cggggtaggg aagacagttt gactgaagac
     2521 gttccaccca agcccccacc aaggttggtg cgacgagcgt cagaacccgg gaacaggaaa
     2581 ggccgccttg gcaatgaaaa gccatgataa gaagccaaag ccgacttggg gtgaatgggc
     2641 tagcatggct gtgacttgtt actcaaacct gatctaccat ttaaaatcct ctacctagag
     2701 gcattctttg ggaagtagag tcaagccact gattcccagg aggagcgctg cttatctatc
     2761 ccaagaagag gaagtcccac aaaatgactt ttgtgacttt tggctagtaa atgtattctt
     2821 tcaaggcctg aaagaaaaaa aaagtgtgcc tttactgaac ttgaatgaca gaacttgaaa
     2881 attttaacgc gcctttgttg gtgaaaattt taatatatta caaatatgcc tcagatttat
     2941 ttatgaaaaa aatgtgttta tctgtagtga ttttttttaa gggaatgaca ccaaaagtgt
     3001 cgagaatatt tttccaaggg ggtgagggtc aactcctaga ggtgggtcct aagttccaga
     3061 tcctaccatt tccatgctga gctgaaggac tcagtgaaga agaacattgt ccctagaaga
     3121 ggctttgact gacagtaata gggcacaggt tggaatgggt aggcacatga aatggtgtga
     3181 ctctcagagt gtgggtggga agtccctgta caactttaaa acaatgaggt tcaggctgct
     3241 cttggtccat ttctgtgttt ttcctggctt tggagtaaca tgcactctcc acctgccacc
     3301 tcaccacacc cccctttttg tctaggtaca gacagattca ctcgggcaaa aatcagccca
     3361 tagtgtttaa agacttggtg gcagcttctg agaagtccta ccagtgagga cctcttgtgg
     3421 ccattgtgga catggcagcc actagagacc gcttgggttt tatgttgtgt ggggctggga
     3481 ggaaagggag gtg
//
