LOCUS       NM_016981               4659 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),
            member 1 (Slc9a1), transcript variant 1, mRNA.
ACCESSION   NM_016981
VERSION     NM_016981.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Ahn,W., Burnett,F.N., Wojnar-Lason,K., Doja,J., Sreekumar,A.,
            Ghoshal,P., Singla,B., Gonsalvez,G., Harris,R.A., Wang,X.,
            Miano,J.M. and Csanyi,G.
  TITLE     Activation of receptor-independent fluid-phase pinocytosis promotes
            foamy monocyte formation in atherosclerotic mice
  JOURNAL   Redox Biol 78, 103423 (2024)
   PUBMED   39615283
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Song,S., Oft,H., Metwally,S., Paruchuri,S., Bielanin,J.,
            Fiesler,V., Sneiderman,C., Kohanbash,G. and Sun,D.
  TITLE     Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial
            subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk
  JOURNAL   J Neuroinflammation 21 (1), 69 (2024)
   PUBMED   38509618
  REMARK    GeneRIF: Deletion of Slc9a1 in Cx3cr1[+] cells stimulated
            microglial subcluster CREB1 signaling and microglia-oligodendrocyte
            crosstalk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4659)
  AUTHORS   Ahn,W., Burnett,F.N., Pandey,A., Ghoshal,P., Singla,B., Simon,A.B.,
            Derella,C.C., A Addo,S., Harris,R.A., Lucas,R. and Csanyi,G.
  TITLE     SARS-CoV-2 Spike Protein Stimulates Macropinocytosis in Murine and
            Human Macrophages via PKC-NADPH Oxidase Signaling
  JOURNAL   Antioxidants (Basel) 13 (2), 175 (2024)
   PUBMED   38397773
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4659)
  AUTHORS   Yun,C.H., Tse,C.M., Nath,S.K., Levine,S.A., Brant,S.R. and
            Donowitz,M.
  TITLE     Mammalian Na+/H+ exchanger gene family: structure and function
            studies
  JOURNAL   Am J Physiol 269 (1 Pt 1), G1-G11 (1995)
   PUBMED   7631785
  REMARK    Review article
REFERENCE   7  (bases 1 to 4659)
  AUTHORS   Dyck,J.R., Silva,N.L. and Fliegel,L.
  TITLE     Activation of the Na+/H+ exchanger gene by the transcription factor
            AP-2
  JOURNAL   J Biol Chem 270 (3), 1375-1381 (1995)
   PUBMED   7836405
REFERENCE   8  (bases 1 to 4659)
  AUTHORS   McClive,P.J. and Morahan,G.
  TITLE     Assignment of the mouse homologues of 6 loci from HSA1p to
            chromosomes 3 and 4
  JOURNAL   Genomics 23 (1), 243-246 (1994)
   PUBMED   7829080
REFERENCE   9  (bases 1 to 4659)
  AUTHORS   McClive,P.J., Huang,D. and Morahan,G.
  TITLE     C57BL/6 and C57BL/10 inbred mouse strains differ at multiple loci
            on chromosome 4
  JOURNAL   Immunogenetics 39 (4), 286-288 (1994)
   PUBMED   7907077
REFERENCE   10 (bases 1 to 4659)
  AUTHORS   Dudley,C.R., Giuffra,L.A., Tippett,P., Kidd,K.K. and Reeders,S.T.
  TITLE     The Na+/H+ antiporter: a 'melt' polymorphism allows regional
            mapping to the short arm of chromosome 1
  JOURNAL   Hum Genet 86 (1), 79-83 (1990)
   PUBMED   1979310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671882.6, AK165501.1, AK150135.1, BU056477.1 and CO041694.1.
            
            On Dec 1, 2017 this sequence version replaced NM_016981.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154857.1, AK150135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL671882.6         124993-125029
            38-2457             AK165501.1         1-2420
            2458-4643           AK150135.1         2424-4609
            4644-4646           BU056477.1         475-477
            4647-4659           CO041694.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..4659
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /note="solute carrier family 9 (sodium/hydrogen
                     exchanger), member 1"
                     /db_xref="GeneID:20544"
                     /db_xref="MGI:MGI:102462"
     exon            1..1173
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     CDS             810..3272
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Na+/H+ antiporter; sodium/hydrogen exchanger 1; solute
                     carrier family 9, member 1; NHE-1; Na(+)/H(+) exchanger 1;
                     slow-wave epilepsy; Na+/H+, amiloride sensitive"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 1 isoform 1"
                     /protein_id="NP_058677.1"
                     /db_xref="CCDS:CCDS38903.1"
                     /db_xref="GeneID:20544"
                     /db_xref="MGI:MGI:102462"
                     /translation="MMLRWSGVWGFHPPRIFPSLLVVVALVGLLPVLRSHGLQHSPTA
                     STIRGSEPPRERSIGDVTTAPSEPLHRPDDHNLTNLIIEHGGKPSRKAFPVLDIDYPH
                     VRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFL
                     QSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLV
                     GGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVV
                     LYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIE
                     PLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSS
                     VSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTP
                     KDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVD
                     LLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCL
                     IAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKAVTSDRIL
                     PALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQ
                     KITNYLTVPAHKLDSPTLSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEE
                     LKGKVLGLNRGPRVTPEEEEEDEDGIIMIRSKEPSSPGTDDVFTPGSSDSPSSQRIQR
                     CLSDPGPHPEPGEGEPFIPKGQ"
     exon            1174..1634
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1885
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2103
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2306
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2396
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2467
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2641
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2756
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2858
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2931
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..4647
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4620..4625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /note="hexamer: AATAAA"
     polyA_site      4647
                     /gene="Slc9a1"
                     /gene_synonym="Apnh; mir-5122; Mir5122; Nhe1; swe"
                     /note="major polyA site"
ORIGIN      
        1 tggtgcctat aaatggctgc gctgtgctca gcgaggcatc agtccgctac cgcgggaccc
       61 ggggctgtgt caggtctgga agtggagctg gagctgaccg aaggagctgc cgctgggccg
      121 gggtggaaca cagctctgca ccggggtctt aaggaggggt gtgttgctgc tggctcactg
      181 cgagccgcct ccagcctgcg ccgaggcacc ttcccgccag gccgtctgcc tctgtcttcc
      241 gcctccctcc atttccccgg aatctcagcc cggcgcggct ggaccctggc tctcctgtgg
      301 gtgggaaagc cccagccttt ttcctgctat actcctttat cccaggctgg ccttccagcc
      361 ttctctcgcc tttccctgcg gagtgggtct cacccttttc cgtctttagc ccaggctcct
      421 tacccctccc ctttagccga gttccagcac cctggtgatt ttccttagcc aaaggtccta
      481 tccttcttcc tcctttccct tgcccgtggt ccagcctatc cggcccttcc cctctcttca
      541 ggacgcagtt tccccgattt ccttctctca gcctgaagtt ctagatcctt tcggtttcct
      601 ccttagtccc tccaaggtac ttaacccctt tttgcagttt ggactttgag attgtgaatc
      661 tctagaaaac gaaaatactt ctctaaaaca tgaacttttc ctagagattg ccccagtctc
      721 accccatctg caggactcct tgctacctat gtcccaggtc ttacacgcac ttcgctaagg
      781 gctgaggcct cctaggctgg gggatcagta tgatgcttcg gtggtccggc gtctggggat
      841 ttcatccacc tcggatcttc ccctccttgc tggtggtggt tgccttggtg ggactgctac
      901 ctgttctcag gagccacggc ctccagcaca gccctactgc cagcaccatc agaggttctg
      961 aaccaccccg ggaacgctca attggggatg tcaccacggc accatcagag cctctccatc
     1021 gcccagatga ccacaatttg accaacttaa tcattgaaca tggcggtaag ccatctcgga
     1081 aggccttccc agtcctggac attgactacc ctcacgtgcg cacacccttt gagatctccc
     1141 tctggattct cctggcctgc ctcatgaaga taggtttcca tgtgatcccc accatctcaa
     1201 gcatcgtccc ggagagctgc ctgctgatcg tagtggggct gctggtgggg ggcctgatca
     1261 agggcgtcgg agagacgccc cccttcctgc aatcagacgt cttcttcctc ttcctgctgc
     1321 cacccatcat cctggatgca ggctacttcc tgcctctgcg gcagttcacg gagaacctgg
     1381 gcaccatcct gatctttgct gtggtgggca cactgtggaa tgcgttcttc ctgggtggcc
     1441 tcctgtacgc cgtgtgcctg gtgggcggcg agcagatcaa caacattggc ctgctggaca
     1501 ccctgctctt tggcagcatc atctctgccg tggaccctgt ggctgtgctg gccgtcttcg
     1561 aggagatcca catcaacgaa ctgctacaca tccttgtctt cggggagtcc ctgctcaacg
     1621 atgccgtcac tgtggtcctc tatcacctct ttgaggaatt tgccagctat gactctgtgg
     1681 gcatctcgga catcttcctc ggcttcctga gcttcttcgt ggtggccctc ggtggggtgt
     1741 ttgtgggcgt ggtctacggg gtaatcgcag ctttcacctc ccgatttacc tctcacatcc
     1801 gggtcatcga gccgctcttc gtcttcctct acagctacat ggcttacctg tcagctgagc
     1861 tcttccacct gtccggaatc atggccctca tcgcctcagg agtagtgatg cgcccctatg
     1921 tggaggccaa catctcccac aaatcccaca ccaccatcaa gtacttcctg aagatgtgga
     1981 gcagcgtcag tgagaccctc atcttcatct tcctcggcgt ctccactgtg gccggctccc
     2041 accagtggaa ctggaccttc gtcatcagca ccctgctctt ctgcctcatc gcccgggtgc
     2101 tgggtgtcct ggtcctgacc tggttcatca acaagttccg cattgtcaag ctgaccccca
     2161 aggaccagtt catcattgcc tatgggggcc tgcgaggggc catcgccttc tcgctgggct
     2221 acctcctgga caagaagcac ttccccatgt gtgacctgtt cctcaccgcc atcatcaccg
     2281 tcatcttttt caccgtcttt gtgcagggca tgaccattcg gcccctggtc gacctgttgg
     2341 ccgtgaagaa aaagcaagaa acaaagcgct ccatcaacga ggagatccac acacagttcc
     2401 tggaccacct tctgacaggc atcgaggaca tctgtggtca ttatggccac catcactgga
     2461 aggacaagct caaccgtttt aataagaagt atgtgaagaa gtgcctgata gcaggagagc
     2521 gctccaaaga gccccagctc attgccttct accacaagat ggagatgaag caggccattg
     2581 agctggtgga gagcggaggc atgggcaaga tcccatctgc tgtctccact gtctctatgc
     2641 agaacatcca ccccaaggct gtgacttcag accgcatctt gccagcactg tccaaggaca
     2701 aggaggaaga gatccgcaaa atcttgagga gcaatctgca gaaaacccgg caacggctgc
     2761 ggtcctataa cagacacacg ctggtggccg acccctacga ggaagcctgg aaccagatgc
     2821 tgctccggag gcagaaggcc cggcagctgg agcagaagat caccaactac ctgacagtac
     2881 cggcccacaa gctggactcg cccaccctgt ctcgggcccg cataggctca gacccactgg
     2941 cctatgaacc caaggcagac ctgcctgtca tcaccattga cccggcctcc ccacagtccc
     3001 ctgagtctgt ggacctggtg aacgaggagt tgaagggcaa ggtcctaggg ctaaaccggg
     3061 gtcccagggt gactccggag gaggaggagg aagatgagga cggcatcatc atgattcgga
     3121 gcaaggagcc ctcatcccca ggcaccgacg acgtcttcac ccctggatca agtgacagcc
     3181 ccagctccca gagaatacaa cgctgcctca gtgacccagg cccccaccct gagcctgggg
     3241 agggagagcc tttcatcccc aaaggacagt agagccaggc tagtgggtgt cccacagact
     3301 ctcccacgag agtgggggct gggcgctcct cttgtctcct gacctggatt ggctctgccc
     3361 ccttcctccg catggcagct gggcccacag cccccactgc agcacggctt gcccctgcct
     3421 cctgggaagg gtcctctcct acagaactgc cttcccaatc catccatttg gcggacggct
     3481 gggctgctga ggcaggcccc gccccatctc tagatccagg ctctcccata gtggaaccag
     3541 ggctcctcaa ggccctcctt ccctccagcc cctcctcatc cagaccaact ctccatcctt
     3601 gatcatcatt tctaaccaaa gagccactgg ctccactgtg gtcccagcag gaaaggaggg
     3661 agctgagcct tccgtggccg tgactgggcc cctgtatcag aggacagcag gcctgtggct
     3721 gggaaacaga cccgtgaccc atagcagagc tgcccacggc agcgccacgg ttctcccgct
     3781 agcctcggtg ctctggccac cacccgagct gtccttactc agagctgcgg gctgagggcg
     3841 tctctgagct tctctgctgg gcgctggggc acattcgaca gtgacatgat tggggtgatg
     3901 aggaccactg ggccttagtg gggcttacac gggagggact gtccgaggcg ctggaaagtg
     3961 tcctctactt acacttggct tatttgcacc tcactgtaag tatgattctg tttgcacaga
     4021 ggcactcttg ttttcagacc ctttgagtcc cccatgccag tcagagctct gccctttccc
     4081 cctcgtcctt cctcgtgtct aacaccgtcc cttaaatgga acctctgctg ctgggggccc
     4141 ttgcccacag caccgattct gatgtggccc aacctgtcat gactcaagct caccagcagg
     4201 gggcctcctg gtacctcctt tgctcttggg cctgctttta cttctgttgg ccagttctac
     4261 caccacccct tatctggacc actctctttc ctgcattctg tagagtagaa agtactggac
     4321 cccctagagg cctttgctca caggcacaca ctccctaccg ccaccatggc tggggccaag
     4381 cccatgggta tctgcccaac ccctgggcac tccctcccca ggatcgtgca ataatagtca
     4441 gagggtccct cccaggggat ggggccatgg gtgcatggcc cagctgtctc ctctccatgc
     4501 aagtgctgtt ttgggcagga gttgccaggc agggtgacat cgacaaccat gtacaaagcc
     4561 accgcagctg ctgccgctct gccgcctgta caaaggaaac tgaacctttt tcatattcta
     4621 ataaatcaat gtgagttttt gataagaaaa aaaaaaaaa
//
