LOCUS       NM_001167920            4943 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus solute carrier family 8 (sodium/calcium exchanger),
            member 3 (Slc8a3), transcript variant 1, mRNA.
ACCESSION   NM_001167920
VERSION     NM_001167920.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Sheikh,I.A., Midura-Kiela,M.T., Herchuelz,A., Sokolow,S.,
            Kiela,P.R. and Ghishan,F.K.
  TITLE     The Na+/Ca2+ exchanger NCX3 mediates Ca2+ entry into matrix
            vesicles to facilitate initial steps of mineralization in
            osteoblasts
  JOURNAL   J Extracell Vesicles 13 (6), e12450 (2024)
   PUBMED   38859730
  REMARK    GeneRIF: The Na[+]/Ca[2+] exchanger NCX3 mediates Ca[2+] entry into
            matrix vesicles to facilitate initial steps of mineralization in
            osteoblasts.
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Trendafilova,T., Adhikari,K., Schmid,A.B., Patel,R., Polgar,E.,
            Chisholm,K.I., Middleton,S.J., Boyle,K., Dickie,A.C.,
            Semizoglou,E., Perez-Sanchez,J., Bell,A.M.,
            Ramirez-Aristeguieta,L.M., Khoury,S., Ivanov,A., Wildner,H.,
            Ferris,E., Chacon-Duque,J.C., Sokolow,S., Saad Boghdady,M.A.,
            Herchuelz,A., Faux,P., Poletti,G., Gallo,C., Rothhammer,F.,
            Bedoya,G., Zeilhofer,H.U., Diatchenko,L., McMahon,S.B., Todd,A.J.,
            Dickenson,A.H., Ruiz-Linares,A. and Bennett,D.L.
  TITLE     Sodium-calcium exchanger-3 regulates pain 'wind-up': From human
            psychophysics to spinal mechanisms
  JOURNAL   Neuron 110 (16), 2571-2587 (2022)
   PUBMED   35705078
  REMARK    GeneRIF: Sodium-calcium exchanger-3 regulates pain ''wind-up'':
            From human psychophysics to spinal mechanisms.
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Afewerky,H.K., Li,H., Zhang,T., Li,X., Mahaman,Y.A.R., Duan,L.,
            Qin,P., Zheng,J., Pei,L. and Lu,Y.
  TITLE     Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.)
            Dunal therapeutic intervention ameliorates cognition in the 5xFAD
            mouse model of Alzheimer's disease
  JOURNAL   Sci Rep 12 (1), 1537 (2022)
   PUBMED   35087161
  REMARK    GeneRIF: Sodium-calcium exchanger isoform-3 targeted Withania
            somnifera (L.) Dunal therapeutic intervention ameliorates cognition
            in the 5xFAD mouse model of Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Di Martino,R., Sisalli,M.J., Sirabella,R., Della Notte,S.,
            Borzacchiello,D., Feliciello,A., Annunziato,L. and Scorziello,A.
  TITLE     Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to
            Neuroinflammation in Striatum of A53t-alpha-Synuclein Transgenic
            Old Mice
  JOURNAL   Int J Mol Sci 22 (15), 8177 (2021)
   PUBMED   34360942
  REMARK    GeneRIF: Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads
            to Neuroinflammation in Striatum of A53t-alpha-Synuclein Transgenic
            Old Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   Pyrski,M., Koo,J.H., Polumuri,S.K., Ruknudin,A.M., Margolis,J.W.,
            Schulze,D.H. and Margolis,F.L.
  TITLE     Sodium/calcium exchanger expression in the mouse and rat olfactory
            systems
  JOURNAL   J Comp Neurol 501 (6), 944-958 (2007)
   PUBMED   17311327
REFERENCE   7  (bases 1 to 4943)
  AUTHORS   Sokolow,S., Manto,M., Gailly,P., Molgo,J., Vandebrouck,C.,
            Vanderwinden,J.M., Herchuelz,A. and Schurmans,S.
  TITLE     Impaired neuromuscular transmission and skeletal muscle fiber
            necrosis in mice lacking Na/Ca exchanger 3
  JOURNAL   J Clin Invest 113 (2), 265-273 (2004)
   PUBMED   14722618
  REMARK    GeneRIF: NCX3 plays an important role in vivo in the control of
            Ca(2+) concentrations in the skeletal muscle fibers and at the
            neuromuscular junction
REFERENCE   8  (bases 1 to 4943)
  AUTHORS   Wakimoto,K., Fujimura,H., Iwamoto,T., Oka,T., Kobayashi,K.,
            Kita,S., Kudoh,S., Kuro-o,M., Nabeshima,Yi., Shigekawa,M., Imai,Y.
            and Komuro,I.
  TITLE     Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and
            swollen mitochondria in cardiomyocytes
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 135 (1), 9-15 (2003)
   PUBMED   12781968
REFERENCE   9  (bases 1 to 4943)
  AUTHORS   Yamaji,R., Fujita,K., Takahashi,S., Yoneda,H., Nagao,K., Masuda,W.,
            Naito,M., Tsuruo,T., Miyatake,K., Inui,H. and Nakano,Y.
  TITLE     Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in
            mouse brain capillary endothelial cells: involvement of Na+/Ca2+
            exchanger
  JOURNAL   Biochim Biophys Acta 1593 (2-3), 269-276 (2003)
   PUBMED   12581871
REFERENCE   10 (bases 1 to 4943)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044636.1, BC080862.1 and AK139260.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139260.1, BC052435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-621               AK044636.1         2-622
            622-4657            BC080862.1         110-4145
            4658-4943           AK139260.1         4645-4930
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.44 cM"
     gene            1..4943
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="solute carrier family 8 (sodium/calcium exchanger),
                     member 3"
                     /db_xref="GeneID:110893"
                     /db_xref="MGI:MGI:107976"
     exon            1..540
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..2385
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..3367
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Na(+)/Ca(2+)-exchange protein 3; solute carrier
                     family 8 member 3; sodium/calcium exchanger 3"
                     /codon_start=1
                     /product="sodium/calcium exchanger 3 isoform 1 precursor"
                     /protein_id="NP_001161392.1"
                     /db_xref="CCDS:CCDS49103.1"
                     /db_xref="GeneID:110893"
                     /db_xref="MGI:MGI:107976"
                     /translation="MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAGDSGDVPSAGQN
                     NESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASI
                     EVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
                     IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLY
                     MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIE
                     TEGDHPKGIEMDGKMMNSHFLDGNFTPLEGKEVDESRREMIRILKDLKQKHPEKDLDQ
                     LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPE
                     DFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTE
                     GTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLAEGMLPAILNSLPL
                     PRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF
                     RTVEGTAKGGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWM
                     ERGISEVTDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTN
                     LALVVGTHSWRDQFMEAITVSAGGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACV
                     PPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDT
                     FASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLA
                     FSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEA
                     YCYIKGF"
     exon            2386..2489
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2614
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2714
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2990
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..4943
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4822..4827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="hexamer: AATAAA"
     polyA_site      4839
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
     regulatory      4903..4908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="hexamer: AATAAA"
     polyA_site      4926
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
ORIGIN      
        1 agaaaccagc ccctacgctc gtcccctctg agcgcggcga ggccgagacg tctccggtgg
       61 tgacagtggg caaggctgag ccgcgcgctc ccagcccggg gaaagcccgg gcgtcgcggc
      121 agccagcccc cgccggggtc cctccgagcc gccagggcgc gccgcgctgc tctccgtccc
      181 acccctccca tagggatccc caggcgaccg cggccgggac tccgggcctt gcttgggcca
      241 ctcgggcagt ctctgctcct tggctggacg ccgccgaggg tctgtacaac gctccctgcg
      301 ccctggcccc agcgatcctg ctccagatgc gctgcctggt agccccctga cagctgctag
      361 cccacagctc cgggcggcag ccgcggcgga ctgccatgcc ctggacgccg ctgcagccgg
      421 cccgcagccc gcgggggcga tgagccgctg cggcccgtga ggagctgggc ggcgcgggca
      481 tcgtgcacct tcctagcccg cctcacttgc ccatcgagct ctggaggctg aggggaatcg
      541 gtcacaggcc tgtcaggagg accattggtg ctgtggtgga gccagaacct aagtcttgtg
      601 tatggcgtgg ttacggctgc agcctctcac ctctgccttc ctccattttg ggctggttac
      661 ttttgtgctc ttcctgaatt gtcttcgagc agaggctggt gactcggggg atgtgcccag
      721 tgcagggcag aacaatgagt cctgttcggg gtcatcagac tgcaaggagg gtgtcatttt
      781 gccaatctgg tatccagaga acccttccct tggggacaag attgccaggg tcattgtcta
      841 ttttgtggcc ctgatataca tgtttcttgg ggtgtctatc attgctgacc gattcatggc
      901 atctattgaa gtcattactt cccaagagag ggaagtgacc atcaagaagc ccaatggaga
      961 gaccagcaca actacaattc gggtatggaa tgaaactgtc tccaatctga ccctgatggc
     1021 cctgggctct tctgctccag agattctcct gtctttaatt gaggtgtgtg gtcacgggtt
     1081 cattgctggt gatctgggac catctaccat cgttggcagt gcagccttca acatgttcat
     1141 catcattggc atctgtgtct atgtgatccc agatggggag actcgaaaga tcaagcacct
     1201 gcgagtcttc ttcgtcacgg ctgcttggag catcttcgcc tacatttggc tctatatgat
     1261 cctggcagtc ttctctcctg gtgtggtcca ggtttgggaa ggcctcctta ctctcttctt
     1321 ctttcccgtg tgtgtcctgc tggcttgggt ggcagataag cgactgctct tctacaaata
     1381 catgcacaaa aaataccgca cagataaaca ccgaggaatt atcattgaga cagagggtga
     1441 ccaccctaag ggcattgaga tggatgggaa aatgatgaat tctcactttc tagatgggaa
     1501 ctttacacct ttggaaggaa aggaggtaga tgaatctcgc agggaaatga tccggattct
     1561 aaaggatctg aaacaaaaac acccagaaaa ggacctagat cagctggtgg agatggccaa
     1621 ttactatgct ctttcccatc aacagaagag ccgtgctttc taccgcatcc aagccacccg
     1681 gatgatgact ggtgcgggca atatacttaa gaagcatgca gccgagcaag ccaagaagac
     1741 ctccagcatg agcgaggtgc ataccgatga gccggaggac tttgcctcta aggtcttctt
     1801 tgacccatgt tcttatcagt gcctggagaa ctgtggagct gtcctcctga ccgtggtgag
     1861 gaaaggggga gatatatcca agaccatgta cgtggactac aaaacagagg acggctccgc
     1921 caatgcaggg gcagactatg agttcacaga gggcactgtg gttctgaagc caggagagac
     1981 ccagaaggag ttctctgtgg gcatcattga tgatgacatt tttgaggagg atgaacactt
     2041 ctttgtgagg ctgagcaatg tccgtgtaga agaggagcag ctggcggagg ggatgctccc
     2101 agcaatactc aatagtcttc ctttgcctcg ggctgtcctg gcctcccctt gtgtggccac
     2161 agtaaccatc ttggatgatg accatgcagg aattttcact tttgaatgtg ataccattca
     2221 tgtcagtgaa agtattggtg ttatggaagt caaggttttg aggacatcag gtgccagggg
     2281 cacagtcatc gtccctttta ggacagtaga agggacagcc aagggtggtg gcgaggactt
     2341 tgaagatgca tatggggagc tggagttcaa gaatgatgaa acagtgaaaa ccataagggt
     2401 taaaatagta gatgaggagg agtacgagag gcaagagaat ttcttcattg cccttggtga
     2461 accgaaatgg atggaacgtg gaatatcaga agtgacagac aggaagctga ctgtggagga
     2521 agaggaagcc aagagaatag cagagatggg aaagccagta ttgggtgaac accccaaact
     2581 agaggtcatc attgaagagt cctatgagtt caagagtaca gtggataagc tgatcaagaa
     2641 gacaaacctg gcattggttg tggggaccca ttcctggagg gaccagttca tggaagccat
     2701 cactgttagt gcaggagggg atgaggatga agacgaatct ggagaggaga ggctgccatc
     2761 ctgctttgac tacgtcatgc acttcctgac ggtcttctgg aaggtgctct ttgcctgtgt
     2821 gccccccaca gagtactgcc acggctgggc ctgcttcgtg gtctccatcc tcattattgg
     2881 catgctcacc gccatcatcg gggacctggc ctctcacttc ggctgcacca tcgggctcaa
     2941 ggattcggtc acagctgttg tttttgtggc attcggcacc tctgtgccag atacatttgc
     3001 cagcaaagcc gctgccctgc aggacgtgta tgcagatgct tccattggca acgtcacagg
     3061 cagtaatgcc gtcaatgtct tcctgggtat tggtttggcc tggtccgtgg ccgccatcta
     3121 ctgggccatg cagggacagg agttccatgt gtccgctggc actctggcct tctcggtcac
     3181 tcttttcacc atctttgcat ttgtctgcct cagtgtgctc ttgtatcgtc ggcggcccca
     3241 tctgggcggg gagctcggag gtcctcgtgg ctgcaagctt gccacgacat ggctctttgt
     3301 gagcctatgg ctcctctaca tactatttgc cacgctggag gcctactgct acatcaaggg
     3361 gttctgaacc gccggaacaa gaccgccaca gggcagacct gggacttctc ctgagagaag
     3421 gacgcatcct caccaacctt cccaggttac tcatccctgg agcagacaca tcgggacccg
     3481 agccccagga acttcacctg accttggccc tggcactgca cagaaagggc aaaacttaac
     3541 caatccaata aactggagaa ggcatccact gtccaaagta tttaattaaa aacaaaccaa
     3601 caacagcaaa aaatccacct ctccccatcc tgccactcac agccctgagc gtccccttct
     3661 atcccaccac ccaactattc ctttgactct agttccccac aaggggcagg atctgccctg
     3721 tctccagcaa gatgcatcaa gactccctca ctcagctgtc agggtatgag aaggagccat
     3781 ctggacaatg gctgccttgg gatgctctct tcacctggtc gtcattgtag tcattttcat
     3841 tctcctacca ggttattgtc ttgtcttctc ttcctgaagt tagtgacaaa ggaccctgaa
     3901 ggaattccaa atctgagtga cagacaccct cccactctca tcaggccgct gccatctctt
     3961 ggctccaact cagggcatag gaggagcttc attcttcgtg cattgacatc aaagccaaac
     4021 cacagaggaa tcaccttctt ctcagtggaa gccattctac gtctctgtgc tgcacctgtg
     4081 tgtgtgtgtg ccctcccaca aagagacttc agagcagaga taagagtgtt ccaggctgac
     4141 caagggcacc cggggacaca cggggaacac ctctccaatg tttctgagtt tgtgtctgag
     4201 gtgggggaga agagggtctt caactgggga ggtctctaag ggagtgtgtc tctaagggtc
     4261 tcttaaagtg tcagtgattg ggggcatggc agcgtcacca cccctccctg gctgatgtgc
     4321 catactccga gggctgaaga ggtggcttga aatgaatttg gaggcttgta agagaacagg
     4381 ggcttccttc cccctctcct ggccttcagg ccacttttga aagcatgttc attggatggg
     4441 gaccggaatc cttcatttcc cccatgttcc tgcttgtttt taaaccgcat aaagctccct
     4501 cttcccagac tgtggggcat ttcttatgcc ctgcccccaa gggatccaag tcaccacatt
     4561 gccaaagaat ccaggcttct agaaaacaag aactgacacg ctgacacccc acctcccaga
     4621 cctttcccct gtgtgttttg aaaagacctg gctttaaatc acacacacac acacacacac
     4681 acacacacac acacacacac acactacaaa actgcccacg ggtcttgagg ctttctgcat
     4741 tgacataaat acattttcta agagagaaag acaaaattaa aacgacacct gtttaatttt
     4801 aaacagattt tttaaaaaga aaataaaaaa taaaacaatg ctcgtgtcct aagctgtgtt
     4861 gacagttgcc ggtggaaatg ttgggttggt tcaaaaaaaa ataataaaaa taaaataaaa
     4921 ggtctactta tatgtctcta cac
//
