LOCUS       NM_148946               4726 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus solute carrier family 8 (sodium/calcium exchanger),
            member 2 (Slc8a2), transcript variant 1, mRNA.
ACCESSION   NM_148946 XM_982013 XM_982048 XM_982087 XM_982130 XM_982167
            XM_982202 XM_982243
VERSION     NM_148946.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4726)
  AUTHORS   Ballarini,E., Malacrida,A., Rodriguez-Menendez,V., Pozzi,E.,
            Canta,A., Chiorazzi,A., Monza,L., Semperboni,S., Meregalli,C.,
            Carozzi,V.A., Hashemi,M., Nicolini,G., Scuteri,A., Housley,S.N.,
            Cavaletti,G. and Alberti,P.
  TITLE     Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced
            Peripheral Neurotoxicity and Axonal Damage?
  JOURNAL   Int J Mol Sci 23 (17), 10063 (2022)
   PUBMED   36077454
  REMARK    GeneRIF: Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin
            Induced Peripheral Neurotoxicity and Axonal Damage?
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4726)
  AUTHORS   Kon,N., Wang,H.T., Kato,Y.S., Uemoto,K., Kawamoto,N., Kawasaki,K.,
            Enoki,R., Kurosawa,G., Nakane,T., Sugiyama,Y., Tagashira,H.,
            Endo,M., Iwasaki,H., Iwamoto,T., Kume,K. and Fukada,Y.
  TITLE     Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for
            temperature-compensated circadian rhythms
  JOURNAL   Sci Adv 7 (18) (2021)
   PUBMED   33931447
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4726)
  AUTHORS   Moriguchi,S., Kita,S., Inagaki,R., Yabuki,Y., Sasaki,Y.,
            Ishikawa,S., Sakagami,H., Iwamoto,T. and Fukunaga,K.
  TITLE     Aberrant Amygdala-Dependent Cued Fear Memory in Na+/Ca2+ Exchanger
            1 Heterozygous Mice
  JOURNAL   Mol Neurobiol 56 (6), 4381-4394 (2019)
   PUBMED   30324228
REFERENCE   4  (bases 1 to 4726)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   5  (bases 1 to 4726)
  AUTHORS   Moriguchi,S., Kita,S., Fukaya,M., Osanai,M., Inagaki,R., Sasaki,Y.,
            Izumi,H., Horie,K., Takeda,J., Saito,T., Sakagami,H., Saido,T.C.,
            Iwamoto,T. and Fukunaga,K.
  TITLE     Reduced expression of Na+/Ca2+ exchangers is associated with
            cognitive deficits seen in Alzheimer's disease model mice
  JOURNAL   Neuropharmacology 131, 291-303 (2018)
   PUBMED   29274751
  REMARK    GeneRIF: NCX2 and NCX3 protein and mRNA levels are relatively
            reduced in hippocampal CA1 of APP23 and APP-KI mice. Likewise,
            NCX2(+/-) or NCX3(+/-) mice exhibited impaired hippocampal LTP and
            memory-related behaviors. Moreover, relative to controls,
            calcium/calmodulin-dependent protein kinase II (CaMKII)
            autophosphorylation significantly decreased in NCX2(+/-) mouse
            hippocampus but increased in hippocampus of NCX3(+/-) mice.
REFERENCE   6  (bases 1 to 4726)
  AUTHORS   Wakimoto,K., Fujimura,H., Iwamoto,T., Oka,T., Kobayashi,K.,
            Kita,S., Kudoh,S., Kuro-o,M., Nabeshima,Yi., Shigekawa,M., Imai,Y.
            and Komuro,I.
  TITLE     Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and
            swollen mitochondria in cardiomyocytes
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 135 (1), 9-15 (2003)
   PUBMED   12781968
REFERENCE   7  (bases 1 to 4726)
  AUTHORS   Yamaji,R., Fujita,K., Takahashi,S., Yoneda,H., Nagao,K., Masuda,W.,
            Naito,M., Tsuruo,T., Miyatake,K., Inui,H. and Nakano,Y.
  TITLE     Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in
            mouse brain capillary endothelial cells: involvement of Na+/Ca2+
            exchanger
  JOURNAL   Biochim Biophys Acta 1593 (2-3), 269-276 (2003)
   PUBMED   12581871
REFERENCE   8  (bases 1 to 4726)
  AUTHORS   Ivandic,B.T., Utz,H.F., Kaczmarek,P.M., Aherrahrou,Z., Axtner,S.B.,
            Klepsch,C., Lusis,A.J. and Katus,H.A.
  TITLE     New Dyscalc loci for myocardial cell necrosis and calcification
            (dystrophic cardiac calcinosis) in mice
  JOURNAL   Physiol Genomics 6 (3), 137-144 (2001)
   PUBMED   11526197
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4726)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   10 (bases 1 to 4726)
  AUTHORS   Li,Z., Matsuoka,S., Hryshko,L.V., Nicoll,D.A., Bersohn,M.M.,
            Burke,E.P., Lifton,R.P. and Philipson,K.D.
  TITLE     Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+
            exchanger
  JOURNAL   J Biol Chem 269 (26), 17434-17439 (1994)
   PUBMED   8021246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY731737.1 and BC058704.1.
            
            On Dec 1, 2016 this sequence version replaced NM_148946.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058704.1, AK035163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               BY731737.1         1-474
            475-4726            BC058704.1         1-4252
FEATURES             Location/Qualifiers
     source          1..4726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.75 cM"
     gene            1..4726
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="solute carrier family 8 (sodium/calcium exchanger),
                     member 2"
                     /db_xref="GeneID:110891"
                     /db_xref="MGI:MGI:107996"
     exon            1..596
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1287
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             613..3378
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Na(+)/Ca(2+)-exchange protein 2; solute carrier
                     family 8 member 2; sodium/calcium exchanger 2"
                     /codon_start=1
                     /product="sodium/calcium exchanger 2 isoform 1 precursor"
                     /protein_id="NP_683748.1"
                     /db_xref="CCDS:CCDS20845.1"
                     /db_xref="GeneID:110891"
                     /db_xref="MGI:MGI:107996"
                     /translation="MAPLALMGVVLLLGVPHCLGEATPTPSLPPPTANDSDASPEGCQ
                     GSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMVYMFLGVSIIADRFMASIEVITS
                     KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL
                     GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAV
                     FSPGVVQVWEALLTLIFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDP
                     PKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQL
                     MGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGATDGAPDDEDDG
                     ASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGT
                     LVFKPGETQKDLRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVA
                     PLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTA
                     RGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISAL
                     LLNQGNGDKKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNL
                     ALVIGTHSWREQFIEAVTVSAGDEEEDEDGPREERLPSCFDYVMHFLTVFWKVLFACV
                     PPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDT
                     FASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLA
                     FSVTLFTVFAFVCIAVLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEA
                     YCHIRGF"
     exon            1288..1952
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2375
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2479
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2497
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2622
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2722
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..3001
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..4709
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="hexamer: CATAAA"
     polyA_site      4709
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="major polyA site"
ORIGIN      
        1 ataaacccta ccctctcctg gctcctcttt tcctccagcg actatatccc tcctcctggt
       61 ggtcctttcc ccagctcccc tgtgcccact ctctctcctc cttcaactcc tccctcttcc
      121 aggctgtccc tgtcctccaa cccacaacta ccctgttccc acacaccacc ctgcctaaat
      181 ttcctctctc ccacctcctg gtggtccttt ccccagctca cttgtcccac cccctcccgt
      241 cagcggcaac tccctccttc agcctagact ctcttaacgg ctgattcccc cgccccagtt
      301 cctctgtccc cgcccccttc ccccggcctc ctcccaagct gtattcccct acctctccag
      361 tctagccccc tctccggggc tgctctctca actcccccct tttctctgtc cccgccccct
      421 cccctgggct ccgccctcct cccggcccct tcccggttcc cctcctcgca tcccctctcc
      481 tccctcctcc ctgctctccc tcagtccccg gctcctctcc ctctttctcc cttttctcct
      541 cgggcggagg cgcccaccgc gggggcccag cggggaccgg cccggccgca aggcaggacc
      601 tcaccacccc caatggctcc cttggctttg atgggggttg ttctccttct gggggtaccc
      661 cactgcttgg gggaagccac tccgacccct tccctaccgc ctcccacagc taatgacagc
      721 gatgccagcc cagaaggctg ccaaggttcc taccgctgcc aaccaggtgt gctgctgcct
      781 gtgtgggaac ccgaggaccc atcgctgggc gacaaggttg cacgggccgt ggtgtacttt
      841 gtggccatgg tctacatgtt cctgggtgtg tctatcattg ccgatcgatt tatggcatcc
      901 attgaggtca tcacatccaa ggagaaagag atcaccatca ccaaggcaaa tggggagacc
      961 agcgtgggca cggtgcgcat ctggaacgag acggtgtcca accttacact catggccctg
     1021 ggctcctcag cgcctgagat tctgttgact gtcatcgagg tctgtggcca caacttccag
     1081 gccggtgagc taggcccagg caccatcgtg ggcagtgccg ccttcaacat gtttgtggtc
     1141 attgctgttt gtgtgtatgt catcccggct ggcgagagcc gtaagatcaa gcacctgagg
     1201 gtcttctttg tcacagcctc ctggagcatc tttgcctatg tctggcttta tctcattcta
     1261 gcagttttct ccccaggtgt agtccaggtg tgggaggcac tgctcacact gatcttcttc
     1321 ccggtgtgtg tggtgtttgc ctggatggcg gacaagcgac tgctcttcta caagtacgtg
     1381 tacaagcgct accgcaccga ccctcgcagt ggaatcatca tcggggcaga gggagaccca
     1441 cccaagagca tcgagctgga cggcacattc gtgggcactg aggtccctgg cgagctgggc
     1501 gcattgggca caggtcctgc tgaggcgcgt gaactagatg ccagccggcg tgaggtcatc
     1561 cagatcctta aggacttgaa gcagaagcac ccggataagg acctggagca gctgatgggc
     1621 atcgccaagt actatgcact gctgcaccag cagaagagcc gcgccttcta ccgcatccag
     1681 gccacgcggc tgatgacagg tgcgggcaat gtgctgcgca gacatgctgc ggatgctgcc
     1741 cgcaggccgg gagccaccga tggtgccccc gatgatgagg acgatggtgc cagtcgcatc
     1801 ttctttgagc ccagcctcta tcactgcctg gaaaactgcg ggtcagtgct gctgtccgtg
     1861 gcttgccagg gcggtgaggg caacagcacc ttctacgtgg actaccgtac cgaggacggt
     1921 tctgcaaagg caggctccga ttatgagtac agcgagggca cgctggtgtt caagcccggg
     1981 gagacgcaga aggacctgcg catcgggatc atcgacgacg acatcttcga ggaggatgag
     2041 cacttcttcg tgaggctgct gaacctgcgt gtgggcgatg ctcagggcat gttcgagccc
     2101 gacggcggtg ggcggcccaa ggggcggctg gtggcgccgc tgctggccac tgtcaccatc
     2161 ctggacgacg accacgcggg catcttctcc ttccaggacc gcctgctgca tgtgagcgag
     2221 tgcatgggca ctgtggatgt gcgcgtggtt cgcagctcgg gcgcccgtgg cactgtacgc
     2281 ctcccctacc gcacagtgga cggcacggcc cgtggcggtg gtgtacatta cgaggatgct
     2341 tgtggagagc tggagttcgg cgatgatgag accatgaaaa ctcttcaggt caagatagtg
     2401 gatgatgaag agtatgagaa gaaggacaac ttcttcattg agctgggcca gccccagtgg
     2461 cttaagcgag gcatctcagc tctgctactc aaccaaggga atggagacaa gaagataact
     2521 gcagagcagg aggaggccca gaggatagca gagatgggca agccagttct tggggagaac
     2581 aatcgcctcg aggtcatcat cgaggagtct tatgacttta agaacacggt ggataaactc
     2641 ataaagaaaa cgaacctggc cttggtgatt gggactcact catggaggga gcagtttata
     2701 gaggcagtta ccgtaagcgc aggggacgag gaggaggatg aggatggacc tcgtgaggag
     2761 cggctgccgt cctgctttga ctacgtgatg cacttcctga cggtattctg gaaagttcta
     2821 ttcgcctgcg ttccacccac ggagtactgc aatggctggg cctgctttgg tgtctgcatc
     2881 ctggtcattg gtgtgctcac tgccctcatc ggagacctgg cctcacactt tgggtgcacc
     2941 gtgggcctca aggactcagt caacgccgtg gtcttcgtag ccctgggcac ctccatccct
     3001 gacacgttcg ccagcaaggt ggccgcgctg caggaccagt gtgccgacgc gtccatcggt
     3061 aacgtgaccg gctccaatgc ggtgaacgtg ttcctgggcc tgggtgtggc ctggtcggtg
     3121 gcagcggtat actgggcggt gcagggtcgc cccttcgagg tgcgtgcagg cacgctggcc
     3181 ttctcggtca cgctgttcac cgtcttcgcc ttcgtgtgca tcgcagtgct gttgtaccgg
     3241 cgccggccgc agattggcgg cgagctgggc ggcccgcggg gacccaagct ggccaccacc
     3301 gctctcttcc tgggcctctg gttcctctac attctcttct ccagcctgga ggcttactgc
     3361 cacatccggg gcttctaggg ccctagccac cgccctgagg gtggggactt ggtggcattt
     3421 gctcttggac ccaccagtct ctctacccag actcagcctg ggcgctccct aggctcttcc
     3481 tcctcagcct tcttcctggg atcagcctcc ctttccccct ggaatcccat cctttgccct
     3541 cccttctcag ctgcatcccc ttcagcccat cctttgtgag gtaaacccga gtcccctggc
     3601 cagacactac ttctcggtct ttctgggcac cgagcctgat tctgtcttct cgtgtccctc
     3661 cctcaagcca cgaacttcca cctgtgcgcc caggtcttag aacatctccc taggtacctc
     3721 agagggaggc tgtgccatcc caggacgcca tccatctctg cccttaacca ccccaaccct
     3781 cagggagctc ccttgcagtc cccagggaaa ggaatagggg tttgtgcggg gagcagggag
     3841 aaaggcacgc accttccctg atttatccac tcagaggctt ggagatggag gagggacgtt
     3901 tggagtatct gtcccccagg cttagccaga ggaggcacat cttgaaccca ctacttctga
     3961 cattccagcg ccctactcac cctccactac ctctgagagc ctagccacgc cttggaggga
     4021 ggagcctgtg tgtgtatata gtgtgtttgg ggagggggga cacgggaggg tgcatgtctt
     4081 ggggaaaggg gcgttgacag actttccctt ctgagagggc agcaggactc actcagcctg
     4141 agaaccagct tagtggatga gactgagact caaagggagc ccacctgacc tcccctgaca
     4201 gtattctaga agggttaacg aaagtactct agtctagaag gtttattttg ctctcagtgc
     4261 cagccaatct gggcaggacc ctcgaagagg agaccgaggg tcccagagga ccaatgctac
     4321 aagccagcaa atgctgccac atctctgcct gttggggggc gggggtggag gggagggtgg
     4381 gaggggggct gggtgggcat ttttaacttt gcaggccata catctgttgg taggccacct
     4441 gcattttctt actgttgatg tctcctgccc caaaaaagac atccttgggg aacggggagt
     4501 gctgcccact ccttgcgacc ttaggtgacc ctgccaccct cacagccttc tgctttccct
     4561 aagttattat ttttgcattt tcttgtccat ttgtgcatca gacccattac ccacggccct
     4621 tctcacccct tgctcatcag catcacttga tgtcccttct ctgtggtttc tgtaaaaaac
     4681 tgccataaaa ctttgaaatt ctgcctgaaa aaaaaaaaaa aaaaaa
//
