LOCUS       NM_011406              18609 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus solute carrier family 8 (sodium/calcium exchanger),
            member 1 (Slc8a1), transcript variant A, mRNA.
ACCESSION   NM_011406
VERSION     NM_011406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 18609)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18609)
  AUTHORS   Scranton,K., John,S., Angelini,M., Steccanella,F., Umar,S.,
            Zhang,R., Goldhaber,J.I., Olcese,R. and Ottolia,M.
  TITLE     Cardiac function is regulated by the sodium-dependent inhibition of
            the sodium-calcium exchanger NCX1
  JOURNAL   Nat Commun 15 (1), 3831 (2024)
   PUBMED   38714663
  REMARK    GeneRIF: Cardiac function is regulated by the sodium-dependent
            inhibition of the sodium-calcium exchanger NCX1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 18609)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   4  (bases 1 to 18609)
  AUTHORS   Wu,N., Li,F., Yang,W., Du,W.W., Awan,F.M., Zhang,C., Lyu,J.,
            Misir,S., Zeng,K., Eshaghi,E. and Yang,B.B.
  TITLE     Silencing mouse circular RNA circSlc8a1 by circular antisense
            cA-circSlc8a1 induces cardiac hepatopathy
  JOURNAL   Mol Ther 31 (6), 1688-1704 (2023)
   PUBMED   36245125
  REMARK    GeneRIF: Silencing mouse circular RNA circSlc8a1 by circular
            antisense cA-circSlc8a1 induces cardiac hepatopathy.
REFERENCE   5  (bases 1 to 18609)
  AUTHORS   Yang,Y., Wang,X., Tan,Y., Xu,Y., Guo,X., Wu,Y., Wang,W., Jing,R.,
            Zhu,F., Ye,D., Zhang,Q., Lu,C., Kang,J. and Wang,G.
  TITLE     LncCMRR Plays an Important Role in Cardiac Differentiation by
            Regulating the Purb/Flk1 Axis
  JOURNAL   Stem Cells 41 (1), 11-25 (2023)
   PUBMED   36318802
REFERENCE   6  (bases 1 to 18609)
  AUTHORS   Kim,I., Koh,G.Y. and Lee,C.O.
  TITLE     Identification of alternatively spliced Na(+)-Ca2+ exchanger
            isoforms expressed in the heart
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 119 (1), 157-161 (1998)
   PUBMED   9530817
REFERENCE   7  (bases 1 to 18609)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   8  (bases 1 to 18609)
  AUTHORS   Kim,I. and Lee,C.O.
  TITLE     Cloning of the mouse cardiac Na(+)-Ca2+ exchanger and functional
            expression in Xenopus oocytes
  JOURNAL   Ann N Y Acad Sci 779, 126-128 (1996)
   PUBMED   8659820
REFERENCE   9  (bases 1 to 18609)
  AUTHORS   Komuro,I., Wenninger,K.E., Philipson,K.D. and Izumo,S.
  TITLE     Molecular cloning and characterization of the human cardiac
            Na+/Ca2+ exchanger cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4769-4773 (1992)
   PUBMED   1374913
REFERENCE   10 (bases 1 to 18609)
  AUTHORS   Nicoll,D.A., Longoni,S. and Philipson,K.D.
  TITLE     Molecular cloning and functional expression of the cardiac
            sarcolemmal Na(+)-Ca2+ exchanger
  JOURNAL   Science 250 (4980), 562-565 (1990)
   PUBMED   1700476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB660129.1, U70033.1, BC079673.1 and AC122399.4.
            
            On Nov 14, 2013 this sequence version replaced NM_011406.2.
            
            Transcript Variant: This variant (A) encodes the longest isoform
            (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70033.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BB660129.1         1-49
            50-1444             U70033.1           40-1434
            1445-1909           BC079673.1         1336-1800
            1910-2248           U70033.1           1900-2238
            2249-4161           BC079673.1         2104-4016
            4162-18609          AC122399.4         41342-55789         c
FEATURES             Location/Qualifiers
     source          1..18609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 51.29 cM"
     gene            1..18609
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="solute carrier family 8 (sodium/calcium exchanger),
                     member 1"
                     /db_xref="GeneID:20541"
                     /db_xref="MGI:MGI:107956"
     exon            1..79
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..1909
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3023
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="isoform A precursor is encoded by transcript
                     variant A; sodium/calcium exchanger 1; Na/Ca exchanger;
                     Na(+)/Ca(2+)-exchange protein 1; solute carrier family 8
                     member 1"
                     /codon_start=1
                     /product="sodium/calcium exchanger 1 isoform A precursor"
                     /protein_id="NP_035536.2"
                     /db_xref="CCDS:CCDS37706.1"
                     /db_xref="GeneID:20541"
                     /db_xref="MGI:MGI:107956"
                     /translation="MLRLSLPPNVSMGFRLVALVALLFSHVDHITADTEAETGGNETT
                     ECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV
                     ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA
                     GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYII
                     LSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHE
                     GDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKH
                     PEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHE
                     VNMEMAENDPVSKIFFEQGTYQCLENCGTVALTIMRRGGDLSTTVFVDFRTEDGTANA
                     GSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSDVSEDGILE
                     SNHASSIACLGSPSTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGN
                     VIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIG
                     EPRLVEMSEKKALLLNELGGFTLTGKEMYGQPIFRKVHARDHPIPSTVITISEEYDDK
                     QPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNS
                     WREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGW
                     ACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQ
                     DQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIF
                     AFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF"
     exon            1910..2016
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2037
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2055
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2070
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2139
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2270
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2370
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2646
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..18609
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6095..6100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="hexamer: AATAAA"
     polyA_site      6113
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="major polyA site"
     regulatory      18089..18094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="hexamer: AACAAA"
     polyA_site      18115
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="major polyA site"
     regulatory      18196..18201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="hexamer: AATACA"
     polyA_site      18220
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
     regulatory      18591..18596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
                     /note="hexamer: TATAAA"
     polyA_site      18609
                     /gene="Slc8a1"
                     /gene_synonym="D930008O12Rik; Ncx1"
ORIGIN      
        1 tttctggtct atctggagca gccttcagag ctggtcggtt tctcatccag cccatgcaga
       61 cagagacggc ttgacagagg ttggagcagt tggaagtctt attgtacaac atgcttcgat
      121 taagtctccc acccaatgtt tcaatgggat ttcgtctggt agctctggtg gctctcttgt
      181 tttcccatgt tgaccatata actgcagata cagaggcaga aacaggagga aatgaaacca
      241 ctgaatgtac tggctcatat tactgtaaga aaggggtgat cttgcccatt tgggaacccc
      301 aagacccatc ttttggggac aaaattgcta gagcaactgt gtattttgtg gccatggtct
      361 acatgttcct tggagtttct attattgcag accggtttat gtcctctata gaggtcatca
      421 cctctcaaga gaaagaaata acgataaaga aaccgaatgg agagaccacc aagacgacgg
      481 tgagaatctg gaacgagact gtgtcgaacc tgaccttgat ggccctggga tcttctgctc
      541 ctgagattct cctgtcagtc attgaagtgt gcggccataa cttcaccgca ggggacctgg
      601 gtcccagcac catcgtggga agtgctgcct ttaacatgtt catcataatc gcactctgtg
      661 tttacgtggt ccctgatgga gagacaagga agatcaagca tctgcgtgtg ttctttgtga
      721 cagcagcctg gagcatcttt gcctatacct ggctttatat aatcttgtct gtcagctctc
      781 ctggagttgt ggaggtctgg gaaggcttgc ttactttctt cttctttccc atctgcgttg
      841 tgttcgcgtg ggtagcagac aggcggcttc tcttttacaa gtatgtctac aagcggtaca
      901 gggccggcaa gcagaggggg atgatcattg aacatgaagg agacagacca gcttccaaaa
      961 ctgaaatcga aatggatggg aaagtggtca actctcatgt tgacaatttc ttagatgggg
     1021 ctctggtttt ggaagttgat gagagggacc aagatgatga ggaagccagg cgtgagatgg
     1081 caaggattct gaaggaactt aagcagaagc atcctgagaa agaaattgag caattaatag
     1141 aattagccaa ctaccaggtc ctaagtcaac agcagaaaag ccgagcattt tacaggattc
     1201 aagctactcg cctgatgacc ggagctggca acatcttgaa gaggcacgca gctgatcaag
     1261 caaggaaggc tgtcagtatg catgaagtca acatggaaat ggctgaaaac gacccagtca
     1321 gtaagatctt ctttgagcaa ggaacatacc agtgtctaga gaactgtggt actgtggccc
     1381 tcaccattat gcgcagaggg ggcgacttga gcaccactgt gtttgttgac ttcaggacag
     1441 aagacggcac agccaatgct gggtctgatt atgaattcac ggaagggact gtgatcttca
     1501 aaccagggga gacccagaag gaaatcagag ttggcatcat tgatgatgat atctttgaag
     1561 aagatgaaaa cttccttgtg catcttagca atgtcagagt ctcttcagat gtttcagaag
     1621 atggcatact agaatccaat cacgcttctt caattgcttg tcttgggtca cccagcactg
     1681 ccaccataac catttttgat gatgaccatg caggcatctt tacatttgag gaacccgtga
     1741 ctcacgtgag cgagagcatt ggcatcatgg aggtgaaggt tttgagaacc tctggagctc
     1801 gaggaaatgt tatcattccc tacaaaacta ttgaaggcac agcccgaggt ggaggggaag
     1861 actttgagga cacctgtgga gagctcgaat tccagaacga tgaaatagtc aaaacaatat
     1921 cagtcaaggt aatcgatgac gaggagtatg agaaaaacaa gaccttcttc attgagattg
     1981 gagagccccg tctggtggag atgagtgaga agaaagccct gttgttgaat gagcttggtg
     2041 gcttcacatt aacaggaaaa gagatgtatg gccaacctat cttcaggaag gtccatgcta
     2101 gagatcatcc gattccctct actgtaatca ccatctcaga ggaatatgat gacaagcagc
     2161 cactgaccag caaagaagag gaggagaggc gcattgcgga aatggggcgc cccatcctag
     2221 gcgagcacac caagctggag gtgatcatcg aagagtctta cgaattcaag agcactgtgg
     2281 acaaactcat taagaagacg aacctggccc ttgtggtggg gaccaacagc tggagagagc
     2341 agtttatcga agccatcact gtcagcgctg gggaagatga cgatgatgat gaatgtgggg
     2401 aggagaagct gccctcctgt tttgattacg tgatgcactt tctcacagtg ttctggaagg
     2461 ttctgtttgc cttcgtccca cctacagaat actggaatgg ctgggcctgc ttcattgtct
     2521 ccatcctcat gatcggccta ctgaccgcct tcattggaga cctggcttcc cactttggct
     2581 gcaccattgg tctgaaagat tccgtgactg ccgttgtgtt tgttgctctt ggaacctcgg
     2641 tgccagacac atttgccagc aaagtagcag ctacccagga ccagtatgca gatgcgtcta
     2701 taggcaatgt cactggaagc aatgctgtga atgtcttcct gggaatcggc gtggcctggt
     2761 ccattgctgc catctaccat gcggccaacg gggaacagtt caaagtgtcc cccggcacgc
     2821 tagctttctc tgtcactctc ttcactattt ttgctttcat caacgtgggg gtgctgctgt
     2881 atcggcggag gccagaaata ggaggtgagc tgggagggcc ccggactgcc aagctcctca
     2941 catcttccct gtttgtgctc ctgtggctct tgtacatttt cttctcctcc ctggaagcct
     3001 actgccacat aaagggcttc taaaggaaca atcagatata gtaaatttat atatatatat
     3061 gtatacatat atatatacat aaaaattatg tataatgaac agaggaaact gacatttgtc
     3121 atgttcactt aaactgctga tggaatccag cttcaagaac atccgtacta ggccggaagt
     3181 cagaaaccat catctcccat tcccgggcat catcaagttg aacaaggcat ggaggcaggg
     3241 tcatcttgca gctcgtccta gaagagctat actctctccg agttcttaaa tggttaaggc
     3301 ttctatttgt tttcttgttt tattttgttt tgttttgttt tgttttgttt ccagtggtgg
     3361 ggggagaggg agggatgtgg gtggctgatg tttggctttc ggttttggtt ttggttttgc
     3421 tttgttttgt ttggagggcc aagatcttct ccttatagaa agtagtgatc cacccaaagg
     3481 ggagtggatt ttggatgaat attagaatca ttaagattcg ctcctcacct cctccgaaca
     3541 ctttaaacat tacttggatt aaggaaggag ctgggcgtgg aagaagaaaa aaaccacatc
     3601 ttcactacat taccaaattg tatgcttatc tccggaatgt gaacagtggt gaactgcctc
     3661 cagagagaag catgggagct gaaaaggagc caggaaaagc aatggttcta gacatagttt
     3721 aaggatacgg tgtctggcac tcttgttcaa caggtacagg gataatgtgc ctagattccc
     3781 aggaactcat agaacccttc atcccttatt tctagctctg aactgtgatt agcaagaccc
     3841 ttactccttc cagcccagcc tgttccccgg gttttccatc ccagacctcc tcctgccctc
     3901 cacccagccc ctgcaaggag gaaaattaac cccaccccca aagccctacc atttcagtca
     3961 tcacgtgtgt ccaggtccca tgttgctctt gcctgggatt ttccatccgt tttattttca
     4021 gtggcatcca tggcttgcac aatcctgttc cagtcatgac tgaacatttg cccctccttc
     4081 atgtgcctgt tagggactgt tgtcgtgatc cccattacac agtgcatgga cgaaaaacaa
     4141 ataaaacaaa gcgtatctgt atatagtaga gtatagcaaa tactgtcctc ccattcagcg
     4201 atgttgattg gacattgaag acataagtga gttttctttt cacctgagtt gttccttttg
     4261 agttgtgatt gagtttggat attaataggg ataaaagaag aaaatggctt attgttcatg
     4321 aatcttgcac gctcattact aagaagcaat aattgtcgtg tgaaaagata ttaaagttga
     4381 gaggatagca ggcaaactac aaagatgtct atgaaataat agccatgtag agcacatcag
     4441 aggtctctaa gaatcaccca ttaattcagg tagactgaga agaaaggctg ggagaccagt
     4501 ggatactttg gatgtgcctg gatttttaca gccaccattt ccacaccacc cctcccccaa
     4561 catatttatt gcacatctgc tctgtctggc acagatgata gatagtgcta gttgatttta
     4621 ttaatggaga aggctgtttt gagccctgtt ttgttcacct ttcagttcag atagcaactc
     4681 ctgagtggaa gtctgagtga ccagtgggac tttagaggtc cactgggtat gactaagagg
     4741 acgttactca aagagactgg gagtaaccat tgcaaggaat gactctttcc attcaaaata
     4801 ccaaagagca gagataaacc caacattcca aaagctgtga ttctactgat gggaaatggg
     4861 acggcttggc ccatctctca gacacttctc tgagcctttc tggccctctg cgttgactcc
     4921 agatacttaa gagataaatg tagctgagaa ctcctttccc tccttccact cagtgatcat
     4981 aaccattcat tgtttaacca acatgtagtg actgagtgaa tagaaacttg ttgcccgttc
     5041 agtaggccag gtaatactac aacctgggag cagaacagtg accaagacag cccaaattcc
     5101 tgctcccaag gggaatgtag tgagtgggat tcctcctcag agagtgagag ttgacactga
     5161 gacagttttg atcttggaag agaaaaggaa ttatgacttt taacctaggc acattaaaat
     5221 tgcacaacaa aggcagttga ccaaatgctc atgttttgtt tttcctaaaa gaatgtaatt
     5281 tttagctctg gaaaagtact ctttatagcc ttggccaact cgcaggtatt tttatcttcc
     5341 taatttaggc caagcaggac actatggtgg tgaccaatat cactgagaag agctaattag
     5401 ccggtgttta gtctctgtgg caatggtacc tttccatcac aacactccac aggccaccaa
     5461 cagtggtgac agtggggact cctcagggga gccctctaag ccatcctgtt ttgatttttt
     5521 ttttaatctt aattttagat tttaaaagtg gaaagctagc ctagacatac ccagtaaatc
     5581 tagtcaaagg atatatgtgg ttaaaaacct tagaaagatt ttgcactggt ttttgtttag
     5641 ttctgttttt ttgttttgtt tttaagccat cttcggaatg tcaataattc tgtagtgaat
     5701 ttcacagaga acttcccaag aacgtcttgc tgttggtcag tttcaagttc aagctttttg
     5761 gtgtgtttgc cttttcagtc ttcatgctgt agggaaaatc tgatctggat cttcagggtt
     5821 cttaattatt atgtgtaaat gatttcattt gatttgtttg attattttta ttttgtgtgt
     5881 attgtgcacg gctttagggg gacaggcaca ctcggtgctg ttcctgacaa ttggtacaca
     5941 ttattgacac agaaaacaaa aacaaaaatc aataaagttt ctaactgttt gtgatttcat
     6001 caccagtggc acagcatgtt ctgtactgtg gaatgtcccc tctcctcact gtcacctact
     6061 tcattttcag ttgtttgttt tcatgctctg aagaaataaa gaccaaaaag gtatccttgt
     6121 gcaatctata tccttatcca tgggaaagga gacagccaca atccaaaccc atacacatgt
     6181 cagcccttag ctcatgctgt gcttaaatgg cccacgagca gcacgtggag tcggaatgtt
     6241 tgtctgttgt gtgatgctgt gataagcatt gggtgtacct tcttttcacc atttttccac
     6301 cttttaattt aactctatct tcttgcttcc tgaacccaag cacatgaact cacaggctat
     6361 tacttgttaa acaactttca tcacacagcg catcatagta aatcatgcca cccattgcac
     6421 tggttttttt ttcgaagtat agttacttcc caagggacaa acaaattgtt cacttagtat
     6481 catatattgt atttcttctt attcctagaa caacttcttt atgttgataa cttctgattc
     6541 tatgaattgt ataagtcact gattttcata tctcatgcaa tcaaaagtac acagaaagag
     6601 gtgacaccag acatagaata agaattgtgg ggaggaatgc cctcttgctc tggtagaatc
     6661 tggacactgg gtacatgcaa atcactcttg gttcatctga gcatcttaaa gtttcccata
     6721 ggccctttca tcacagcatc atgttggcat gtgtggcaca ctttcaaggg aaaaaaaatg
     6781 agggacaact caaacactct tcttgaatca aagaattgac atgtgtcctg aatattgatc
     6841 tttaatttca tataaaattg gcaggctgaa tttgcttctt gaataagaac caaactgagt
     6901 attatagtga ggatccttga ccacttagta gacctcagca aaattcttga ctgattgatt
     6961 ctcaagtgat aggagcaaac attaatttgt tgatggattc tgattcgatc cgtccaacca
     7021 tgaagatttc agagaacctt ccttgctata gtataatata tatagtttgt gaaattttgg
     7081 ttgtcattgt ctttcaaata ttagattaac atacaattat actgttcaga acaagcctgc
     7141 agagatggat aggtggcttg caactgatga gggacccctt cgcaggaagt gatctcaaag
     7201 caaatagaaa cgtgttgttt ctactgtcat ttgtaaccag gcatcctcca ctagaaactc
     7261 tatgctcaca cattcctggt tttaatctaa aaaaataaat aaataaagtg agaggatcta
     7321 gcttgctcat acatctgaga gctttataga aaagatgaga gaattttctc tgggagatga
     7381 tgaaactcct cttttctaaa gcagatcagc ttcattaaga cttctttcag tttttctgag
     7441 ttcaaaatgt ggaatctctc ttgattttga ttttcctttt ctgatgtttg gcaactataa
     7501 ccataacaag ccctagttgt actttcatga ctttaggaac attgagccat ttcaccattg
     7561 acaatataca atccattcta acttacaagt agcatccaac agtccttaca ataatcatgt
     7621 ctgttggcca agacattcta agcatgtgac tattggttga ggaattagtg tcatgacaca
     7681 tagaagaaac ctgcaaaatc acatttatta tactggggat atgtgttctt gtggatagat
     7741 ttggaatgtg tgcttgtgcc tccctacaga ttttgtttta taactgatta gggatttagc
     7801 tattcttttc aaacactatt attgttgtaa ctattattgt caaacattct agcgtatttc
     7861 aaaggtttgg gttgaatact gctgatggta ctttatctcc agggataccc tgggaaagaa
     7921 acacatgtga aatagttagg tgtttcattt ttaatattta accatgggta acaatctccc
     7981 aaagcagaga atgtccttcc tgcagaaggg caaagcactg aggcgtagaa ctcccaagag
     8041 agacagaatg tgctttcact ttccagtccg caggaaatgg taagtaccca gcttgctgtt
     8101 cgcagcctgc caaggtgtcc aaagagatgc actcagagaa cctctggatt ttcagtgtca
     8161 tcgaagggtc tctgatttca ttgcctcaag gggcatttaa ggagatgggt ttgtaaatca
     8221 ctatttttga tatactcact ctgaggaaag accatcactt cttagtgtgt cctttccttt
     8281 ccctgtggcc caaccttgtc attcttttca ttggctaccc ttggtccatc cagtagactt
     8341 cgtgatgtgc ctggtattgc ctctcagcaa taggggaaag ctcactctgt aaggaattgc
     8401 ttgggaattt ttcttgtaga agcaaacttg tcatagaaaa atcaaatatg ttgacattgc
     8461 agagacatta gagacccttg tgttatcgct acaaatagag acagacttta gaatagtgtc
     8521 atctccacaa atgcctgagg tatatgctac cctagagttt tgtgccacct tatggatttt
     8581 atctctcttg aggtcatatt tatcttgtcc ccgtgtccaa tctctagcct gttccatcaa
     8641 tatgtgtagg tacagagcgg aaaagaaaaa aaaaatatat atatatcccc aagccccata
     8701 agggtgtctc taaagctgtc atatgtaaaa cagaataatg catatgactc tactagatac
     8761 tgtgtttcgg gtatggaatg gataggaaaa ttcacattag tgaccaaata aaccaagaaa
     8821 gaaattagca aacttcagag ttgctggatc agttttgata gttaattcac aaagccagat
     8881 cctagtagtc agtgtggtac ataatttcag gtatgctcag ccaaatctaa aactgtattg
     8941 gaggaagcga aagctggttt attgggatgg ttgatggttg catagccctc tctgctggga
     9001 ctccttgcaa gtgagcttgt aatttacaga actttttctt ggactccctt gaagacacat
     9061 aatagaggag ctcaaatctg caaggagatc ttttctaaaa gtgtgattct tgatttgtaa
     9121 tgctccagcc tctattatca agaacataat cctgagtttt ctttccaagt gggaggatta
     9181 ctcttattat taatgtatta aattaaacca aatatgtaac tgcttcacaa aatattttac
     9241 ctaagaaata aactagatgg tataaatatc catgataaaa accataccat cttaatagtt
     9301 gcttttgtga aaaaattata ctctttgtga atctttctct acatttctaa atccacttta
     9361 gcaaacatta tacttgaaaa atatcccaaa gaaaaatctt gggagctttt tatactgtat
     9421 tgcaataata cagagagaag aaagttgtat ggttatgata atgatgtgaa tgagaattat
     9481 ctacactgtt gacaagatta tatttttaaa ggaaatagtt tggcacaaag aaaatgtgtt
     9541 aagtgggatt tcatcatgta ttgcccttgt ttatgaaagt ttctgaaagt cattaccttt
     9601 aacaaagatg cccattttcc tgagacaact gtataattta atctcattct caggtttgac
     9661 atgaaaatca aagctgggca tatatagttt tggcttggac aaccaaagaa aaatgtgttt
     9721 tggcatactt tccacgccat tgaattattt taaagaatac attaggtctg tgcagatgtc
     9781 tcataaaata ctttttaaaa tttccttcca ctcttaaaag taaattttaa attactcaac
     9841 ttgataactt aatacttttc catttcaaag gacaactcca tttttatatt gttactaata
     9901 ttttaggact aatttataat ttgaatcaat acataggagg gggtattaga ctggagtcta
     9961 gtcccataac cacatggtgc agacagatct atcagtgact aagtggtttt agatgaacca
    10021 gccttagaca atatagcaat gtgaatacgg tttttagtct ttttttctgt caaaggtttg
    10081 cattttaagc agtgtaataa caactttaga aaagttggat taccagttgc aagattcttt
    10141 ttcttggaat tatttcattg tttcaacgta cttgttctcc tctaccttat ttctcccata
    10201 ccatagggat atgtatatta aaaacaaaaa tacattttac atgttgaata acctaaattg
    10261 tattctgcat agtacccaaa aattcatgtc aagttaattt tctctcataa atgaaacaaa
    10321 gtacagagaa ggagtcttat tcttcaggta aatgtacaca gttgtttgag aattgtttgg
    10381 aaaactggca tccttcccaa aatagaagca aatatcttaa agaaagaaat tcatgactat
    10441 tccttttgtt tgcttaacaa gtgttttaga caggaagtca ttagggttaa tttgattcct
    10501 tctgctgcct ttgattgtga gcgttgagaa cagttctggg gggtgggggg aaataagctg
    10561 gtcaaggtca acttctggaa gttaatagaa tgagattttg tattttccct tgagagatgg
    10621 taccaagcag gcaagcaacc atgtacctac cagttaacat tttctagaaa tgtagtttgg
    10681 catgttggga gaaaaggagg gagggagtcc tcacccaatc tgtcggctga tatctcatca
    10741 cccaacactc agcctgtgga tctttcacga gttctagtta aggtcagaca ttcccaaaag
    10801 agccagtctc catcttgcct atgtgttgat tgtcttgtct ctgacatttc ttctccaaaa
    10861 tcctactaac aagcaaacta gcctggccag ccagttgcct atgatacttc tcagtgctct
    10921 cagaaggagg gatgtagttg aacaggtgca aagcctttgg aattcattta taattgctat
    10981 cattggattc tcagaatcgt ttgtctttga agtttctgtc ccaagctctg agaacagggt
    11041 ttctgctgtc atcagcatct tataggaact ttgacaatcc aatggttgca tcattagtaa
    11101 aatgaaaata aaattgcttt attactactc aggattcact catcggtgtt cagagcttcc
    11161 actaaccaac atcgcaggat tgacaaagga tcagaaataa gccagagagg cataaaattg
    11221 cctcatcatt attgaagttc tttctactga ctactactac tactactaac tactaactac
    11281 taactactac taattactaa gtaactgcta ttaactactg accttcatcc aggatcactc
    11341 actgactttc cattctgttc agactttaag tcaagccagt agaaaagttt caaaatcaga
    11401 attttataaa cttcaagcat ttattttatt aaaatgttct gttaattatc ataaagtaat
    11461 gatgacttaa gaaacctaac actggcccta gatttaataa gattccaatt acagtcttct
    11521 aattaaatta acctttcatt ttggtctaag gatattttat taatgtgaga ctctttaatg
    11581 gggtcattct gaaactgatc aaagaacttc cctttaagaa tggttgtctt aacttctcat
    11641 tctctatttc accatcaaga tgaatggatt caggctcaat gagcacatca caatcttcta
    11701 tgagccaatc tctatgtgag gcagatacct ggtttgttag ctaacatttc acgttgtgga
    11761 attggcatca tttacctcat cactactact aactactaac taactgccac taactactaa
    11821 cactgaatgt tctggacttg gaggcactgg ctggtctctg agctaaaact tcagagccct
    11881 catcaactga cagcacctag agaaggggac cacagcttct ctctttgagc acacagtgct
    11941 ctctccattt gaatgtctag ttgtcatcag agaggagact caaaggcttt ctcttttgga
    12001 agggtagatc ttttggcttc agaagatcat ggatcttcag attgctctgg atttaaatct
    12061 tcacattgct atatgagaga tgatacatac cttcatgtct tttggggttt tttgttttgt
    12121 tttgttttgt tttgttttgt tttttgtttt tctgaaacac accgagcccc catgatgggg
    12181 cttcttattt ccttctgctt gtaggcatga gctgaagaag ctgcatgtgg ccaagcagtt
    12241 gttcctcgtc atatttcatt atcagaacaa atgtcaaagc aatcaagcca catgcatgcg
    12301 ggaggaacta aaaatttatt tttttaaaag taatcacttg tacaccactg agggtgggac
    12361 tcttttccct gaagagagag agtagaaaat ttcccccaga tgaaaagcat tcaaaagata
    12421 gaaaggattt caactcaatg accttgttaa ggccacaact attcttcttc caaggatgac
    12481 ctttcaaatt cacttttgtt ttctcatttc ttaagcttac catcagatag gagaaagaga
    12541 ttgtcagtac tgttttctac tcaactatat gaaatataaa caagctatac agtggccagc
    12601 ccctccccac acccagttta tttaaagtta caggtattgt aaaggagaac ggaagcagga
    12661 agccaattgc tacagactca attgtctttt aaagagcctc cttgttatag agaaatgact
    12721 atcccaaaag atgtcacaaa aatacttctt aaatcgtacc tggagcaaat accagaatgg
    12781 ccttggccaa aatgcttcat tactgatctg aaattgcaca taaaacacag aacagacaca
    12841 ctttttcaca aggaaaggaa gataaaaacc agacaaacaa acaaaaaaac aaaaaaacag
    12901 aaacaaataa acaaagaaaa aacaaacgga gctccgctta tgaaaacaaa gaatatttct
    12961 gtggcatgaa tgtaaccttt cgctcgaaag aatcccaatt ggaatgtctt aagaaatgac
    13021 aaaactattt caacatagtg ggaagaatgc atccagctct gttagtcctg agccacagag
    13081 ccaaatttgt gagaggcaaa aggggaagca aacatcactg gcatgtcgca acagataaag
    13141 cggctttgtg agagaaatca tttaaacaga taatattttt cttatgctat aacaattcta
    13201 tggttgattc tcgtggacaa aaacaaaaac aaaactcttt cttttctcat gatttatttc
    13261 catctagagc tggctatgga gctgcagtag aagcatctaa ttttgacact gcaatgattt
    13321 ctttgtgtcg aatctgatcg ctcattcaga tttccttagg aaatagtaaa ttggaaccaa
    13381 aaaattgggt tttgtcttct ttaaaaacaa ataggtaccg taagcatttt ctgctgacga
    13441 ctgccttaag cattcttagt tgtgctgtca atcaaaggca ggtctttgct tgaagacttg
    13501 agaacttgat ttttttcctg agcaagctca gccttcttcc catgcaggca acatcccatc
    13561 cacataaatt catgtcattc ctcctcaact ccctgccaca gccccagcct gacccacctc
    13621 ttaagctaac ccacctcttc cagccaagca aattacaacc tttaacgatg tgtgctcaca
    13681 gcttgtccac ctgaataccc cagaaagtct ctgaaaacct cccctctctt cagccttttc
    13741 cagaagccct tgggattcaa aaacatcaac aactcatttg tttgtgctca gccaagaaac
    13801 tgtgaacaaa ttgagtcacc gtgttaatta ccctgaggtg ataaggtgac tgtcacagaa
    13861 gtggctggca gaagagaatt gcaaggctat tactaaaata atgttctatg aagaaagagt
    13921 gtacagtctt ctagaaacgg attttcaggg tgccatgctt aataacatag aaaattatat
    13981 aggaaggcca aacataaaac atggtttaga attatattat atggacacga ttattatata
    14041 tgctgacatg tccttaactt tctaaaccta ggaaccatct ataattaaac taataccaat
    14101 agaatctagt tcttcctact ttatgagttt ctaaggagaa aattcaatat tgatcttccc
    14161 atcccacatg gaaaggcttt gctggaggaa tgcaattagg gtgacatggg taactatata
    14221 tagtgttgtt ttagaataag caacttcagt gattctttag tctgtggcca agcagcatca
    14281 gtaatgagta ggaaagctgt gaaatatgca aattatctgc tctcctctga gaaaccccca
    14341 gccctctata aatcagagat gccaggagta ggctcctcac tgtgggtttt aacaatctct
    14401 ttgggttgtt ttagttcatg ctgcaattca aaaccattga tccagtcagc ggtttgcatg
    14461 gcttcttaga atgatcagtg tcaccccata tttaactctc ctctctccag aatgaagctt
    14521 ataggattaa atggaagctg gcctgtcagt accatagact aatacatgtg ggtttagaag
    14581 ttcagattta gaattccatt tgaaggaaaa ctaacctcac atctggtttg ttgttgttgt
    14641 tgttgtgttg ttgtgttgtt tttgtggttt tgttttaatg ggacttcaag aagattctct
    14701 tccttgagtc tttctagatc ttttaaaata taactgttca tgtactttac ctgaccatcc
    14761 cagggaccag aaaacagtct aggaaacctt tctcactgtt gaataattag ctctggctgt
    14821 tatccttaat ggccaacaat tctgcagcag tcctgagtcc tgctgaatga gtttcttctg
    14881 gaggagtggg tgtgtatgga gaggcagtga ctgctggtca gtttgggaaa ctggttcaaa
    14941 gtaaacaaca gtgcttataa agtttgggaa catcaagtgg catagtggtc actctaggtc
    15001 tcctaggatc aaccttcaag gctctcttgg tggcactggg gcaaagccag agtggtgaat
    15061 attcaggtca cttatttgat aagaacacct tagaagacag gttaagatag ggagttatct
    15121 gagaatgtat gcccatgtgt ctgtctgtcc tctggatgct aacctgacat cctgaagtac
    15181 ttaaaatatc aacctgtgtt tgtccttcct ttcaatcatg aaaagcagtt caagaatctg
    15241 tgtgcttctg ttggtggtgg tcaaagcttg ggcgctgctt gtccatttgc tccggctggg
    15301 ggtgccttcc catcgatacc ttccctcttg tcctactcct gttaaacaca cctgaccact
    15361 tgcagctcca gcccaagcac agcccattta tctcactcct cctcatcacc cgcaactcca
    15421 cgtacatatt cttttactca aaatcagagc ccttctgaga gatcatatca gcatagcagg
    15481 ccattgcagt gatgggatgt aatatttgca gcagaaaggc ttacgtcagg ttccatgcaa
    15541 ttgactcaaa tccatcacta agattccaag ccttaatatc ctctctgacc tttgaaatgt
    15601 caccttggaa gcgtccatgg gggaaactgc caatgtaagc ttgctgtcca tctctcctcg
    15661 gtccacagtc catgcactgt gctatttgct ccggtcatga agccttgaaa taagcctgga
    15721 tttgaattgc aaagagcaga taaacaggtc cataataaac gacccttact atgtagcata
    15781 acaaaaagcc ctggacacta gaaagtgaca gatgatggtt ttaataccat aaacaaattt
    15841 tcctgtcagt aatctgtagt gatagaaaca ggttagtgat acaacacatc tctttctcaa
    15901 aagccataat caccattgtt gaaacaaaca actgttattc taacggaact tcctggggtt
    15961 cctttgggaa ttttgtatgt gtacaatgct catatcaagg aagacattca tggctttcta
    16021 gacaagagcc agacgccccc ccccccacac acacacaaaa gaaagatggc tgttgtatat
    16081 atgcacaaaa cacagctcgt tccatgaggc agacaagatg agaaaggtta gaaaggttag
    16141 aaacaaatcc acaattgtca catgcttctg gtggctcctg gtggcaaata ttccctacta
    16201 acccagtagg tgacttaagg gtaaactgaa ttcatcctga accattgcaa tgggcaatcc
    16261 ctatagaaaa ggccatcaca tccttgtgcc taaaaccttc tttacaaaag aaatgagcac
    16321 aacacacaca cacacacaca cacacacaca cacacacaca cacacaccca accccttgct
    16381 tcgcagggct aaaaagtaaa gaacagaact tgtacaggag ttgtgctcag agtgtaaggg
    16441 atctatcacg agggagcttc aaagacaaag aggtgggaaa gacagacaaa attggacacg
    16501 atcatagtac aggtgatata agcagtcctc agtcctccag ctcagcctgg agactgctcg
    16561 tgtgtctaag actgtatgtt caataacgtc atcatacttg gaatgccttg agcagtagtt
    16621 tggtcatgat ctacatggaa gattaactga gtctttcagt ttcgaatctc tcaggccaac
    16681 caacataatc tatggctatt ttcagtgtga aacacatgca aacatgtgca tggactatgt
    16741 ttgtgattct gtggagaaac aaaatgttta acaatcagag actttccagt gtttccgagt
    16801 tttgcaggaa gcaaaagtca gcatggccat gattgctaac ggtactagag ttacaatcat
    16861 cagaagtgct gttggaactg ctgtgtaaga caccctctgt agcaccagtg tatcaatact
    16921 atttgaattg aactgtcgat ctgtgctcct taaatatttt tttttctatc tgtggtggtc
    16981 tactgttatc ctgcaatagt gatcatgtga ccaggaaagg aagtagcctc attgaaatgt
    17041 tagaagtaga ggaagttatt tatggtcttc tgccaaagaa aagtgtttaa tgatctgtaa
    17101 aatgtagatt aacttcttat attatgaatg tgattgtaag aaatgctcac ttcatcatct
    17161 atcctttgaa aatgaatctt gtgtttctaa tgatcaaggg aaatattttt agctgatgta
    17221 atacacagaa gtgttagaaa aagaaagcta gatccgaatt tgaaaactca gtggcacagc
    17281 ctttccctca aattcttgca tcatgctaag accttaaaca caccaacatt aataacagct
    17341 ccaatcacat agagaaaagg cgtcgaaaca tttctgttca tgaacgttga gtcgacggaa
    17401 attactgtct aatttcctcg cccatctgcc acatacgtgt ggactcaaag gtctaccaat
    17461 gttgcacaga aagttaacag gctgtgtacg ccaatttcat ctgtgcagtg agcaagaact
    17521 agccattaaa ctatatattt aaacgttttg taaataaact tttgattact acagttttgt
    17581 tcaaactgct gtcttttaaa ataattagac ttgatttgaa tttttttaaa taatctgtta
    17641 tattagatgt tgcgttattg actgtgattc aatgtacact cagccatatt cctgtgggaa
    17701 atatcagtcc tattgacttt cttggcatga gccagaagct cttagtttct ctaaggactc
    17761 ttaagtataa agacaaaaaa aaaatcaaaa tgaaatgcta gtgaaataag aaacctattg
    17821 tacaaaatgt atttttaaaa atcttaagat tcatgtgatt tacactgcct gttaatctag
    17881 tctctctgtg aaataaccac agcatatttg ttaagatgga aacaccaaat atttacgatc
    17941 tttgtatagc accttgttat aatatgtgac ttcaaatggt aaacatgtct attgtgacca
    18001 tgtgagccca cagaagaata agttcctgct gttatgtaaa atccagctct cagaattcag
    18061 attccctgca gctgctgtac caccaataaa caaaaattaa ttgtgaaaaa aataattttt
    18121 aagtttatga tcactgtgca ttttgttaat gaattcagag aattttattt ttaccagaaa
    18181 ttctctcagc cagtaaatac aactgctgat ttcaaccata ctatcatttc tgtggtttct
    18241 ctattcttga tacaactacc aaaaaattgg aagcttggtg caaagtatat cctaacaaag
    18301 atacaatcaa tgacttttcc tgcatgctgc ctgagataat attgtaattt gagatgtctt
    18361 atcaaaaaat tatctcatag cccaaactgt aaccggcaat atttcttatg tgtataactg
    18421 atggtatgtc aatacctaaa gcaatgtctg tcgtacatgt atgttatatg tactgtttaa
    18481 tcatgttaaa ctgtaatctg tgagactgtc attgcctgaa ctagtcgact gtgtaacaaa
    18541 tcgttgtgtt ctctgttttc ctaacctcac cgtgtttcct aacactgaaa tataaatgtt
    18601 tgtaaatta
//
