LOCUS       NM_001199016            1702 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 9 (Slc7a9), transcript variant 3,
            mRNA.
ACCESSION   NM_001199016
VERSION     NM_001199016.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Mayayo-Vallverdu,C., Lopez de Heredia,M., Prat,E., Gonzalez,L.,
            Espino Guarch,M., Vilches,C., Munoz,L., Asensi,M.A., Serra,C.,
            Llebaria,A., Casado,M., Artuch,R., Garrabou,G., Garcia-Roves,P.M.,
            Pallardo,F.V. and Nunes,V.
  TITLE     The antioxidant l-Ergothioneine prevents cystine lithiasis in the
            Slc7a9-/- mouse model of cystinuria
  JOURNAL   Redox Biol 64, 102801 (2023)
   PUBMED   37418888
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Sasaki,H., Sasaki,T., Hiura,K., Watanabe,M. and Sasaki,N.
  TITLE     A mouse model of type B cystinuria due to spontaneous mutation in
            FVB/NJcl mice
  JOURNAL   Urolithiasis 50 (6), 679-684 (2022)
   PUBMED   35988091
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Lopez de Heredia,M., Munoz,L., Carru,C., Sotgia,S., Zinellu,A.,
            Serra,C., Llebaria,A., Kato,Y. and Nunes,V.
  TITLE     S-Methyl-L-Ergothioneine to L-Ergothioneine Ratio in Urine Is a
            Marker of Cystine Lithiasis in a Cystinuria Mouse Model
  JOURNAL   Antioxidants (Basel) 10 (9), 1424 (2021)
   PUBMED   34573056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Wu,K.C., Reisman,S.A. and Klaassen,C.D.
  TITLE     Tissue distribution, hormonal regulation, ontogeny, diurnal
            expression, and induction of mouse cystine transporters Slc3a1 and
            Slc7a9
  JOURNAL   Free Radic Res 54 (7), 525-534 (2020)
   PUBMED   32873097
  REMARK    GeneRIF: Tissue distribution, hormonal regulation, ontogeny,
            diurnal expression, and induction of mouse cystine transporters
            Slc3a1 and Slc7a9.
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Di Giacopo,A., Rubio-Aliaga,I., Cantone,A., Artunc,F., Rexhepaj,R.,
            Frey-Wagner,I., Font-Llitjos,M., Gehring,N., Stange,G.,
            Jaenecke,I., Mohebbi,N., Closs,E.I., Palacin,M., Nunes,V.,
            Daniel,H., Lang,F., Capasso,G. and Wagner,C.A.
  TITLE     Differential cystine and dibasic amino acid handling after loss of
            function of the amino acid transporter b0,+AT (Slc7a9) in mice
  JOURNAL   Am J Physiol Renal Physiol 305 (12), F1645-F1655 (2013)
   PUBMED   24107421
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Broer,A., Klingel,K., Kowalczuk,S., Rasko,J.E., Cavanaugh,J. and
            Broer,S.
  TITLE     Molecular cloning of mouse amino acid transport system B0, a
            neutral amino acid transporter related to Hartnup disorder
  JOURNAL   J Biol Chem 279 (23), 24467-24476 (2004)
   PUBMED   15044460
  REMARK    GeneRIF: mouse amino acid transport system B0 is a neutral amino
            acid transporter related to Hartnup disorder
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Feliubadalo,L., Arbones,M.L., Manas,S., Chillaron,J., Visa,J.,
            Rodes,M., Rousaud,F., Zorzano,A., Palacin,M. and Nunes,V.
  TITLE     Slc7a9-deficient mice develop cystinuria non-I and cystine
            urolithiasis
  JOURNAL   Hum Mol Genet 12 (17), 2097-2108 (2003)
   PUBMED   12915471
  REMARK    GeneRIF: Slc7a9-deficient mice develop cystinuria non-I and cystine
            urolithiasis
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
  REMARK    GeneRIF: a decreasing expression gradient of heterodimeric
            rBAT-b(0,+)AT along the proximal tubule is responsible for
            virtually all apical cystine reabsorption
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Rajan,D.P., Huang,W., Kekuda,R., George,R.L., Wang,J., Conway,S.J.,
            Devoe,L.D., Leibach,F.H., Prasad,P.D. and Ganapathy,V.
  TITLE     Differential influence of the 4F2 heavy chain and the protein
            related to b(0,+) amino acid transport on substrate affinity of the
            heteromeric b(0,+) amino acid transporter
  JOURNAL   J Biol Chem 275 (19), 14331-14335 (2000)
   PUBMED   10799513
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Pfeiffer,R., Loffing,J., Rossier,G., Bauch,C., Meier,C.,
            Eggermann,T., Loffing-Cueni,D., Kuhn,L.C. and Verrey,F.
  TITLE     Luminal heterodimeric amino acid transporter defective in
            cystinuria
  JOURNAL   Mol Biol Cell 10 (12), 4135-4147 (1999)
   PUBMED   10588648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142541.1 and BE136295.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142541.1, SRR5189685.164020.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1613              AK142541.1         2-1614
            1614-1702           BE136295.1         3-91                c
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     gene            1..1702
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 9"
                     /db_xref="GeneID:30962"
                     /db_xref="MGI:MGI:1353656"
     exon            1..49
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            50..186
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1563
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /note="glycoprotein-associated amino acid transporter
                     b0,+AT1; b(0,+)AT; solute carrier family 7 member 9; b<o>,
                     +AT; b<o>, + amino acid transporter"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_001185945.1"
                     /db_xref="CCDS:CCDS21150.1"
                     /db_xref="GeneID:30962"
                     /db_xref="MGI:MGI:1353656"
                     /translation="MEETSLRRRREDEKSTHSTELKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGILATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYSGCKPPAVVVKLLAAAAIL
                     FITTVNALSVRLGSYVQNVFTAAKMVIVAIIIISGLVFLAQGNVKNFQNSFEGTQTSV
                     GAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALIFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPLFIPIIVILVSLFLILAPIISEPAWEYLYCVLFILSGLIF
                     YFLFVYYKFGWAQRISRPVTKHLQMLMEVVPPEKDPE"
     exon            187..334
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..577
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..703
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..803
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..848
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..972
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1076
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1173
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1323
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1498
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1702
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /note="hexamer: AATGAA"
     polyA_site      1669
                     /gene="Slc7a9"
                     /gene_synonym="CSNU3"
                     /note="major polyA site"
ORIGIN      
        1 acaattgcgg gctgggtggt ggtcagctga gagagtatca ccgactcagc tgactcaaga
       61 gactctcctc tcagcccctg gagctaccag cgggcaacca tggaggagac aagcctgagg
      121 agacggagag aggatgagaa atccacccac agtactgaac tcaagaccac aagtctccag
      181 aaagaggtgg gtcttctcag tggcatctgt atcattgtgg gcaccatcat cggctccggg
      241 atcttcatct cccccaagtc tgtgctggcc aacacagaat ccgtggggcc ctgtctcatc
      301 atatgggccg cctgtggaat cctggctaca ctgggcgccc tgtgctttgc agagcttggc
      361 acaatgatta ccaagtcagg gggtgagtac ccctatctga tggaggcctt tggccccatc
      421 cctgcctacc tcttctcctg gaccagcctg atcgtcatga agccctcatc cttcgccatc
      481 atctgcctca gcttttcaga gtatgtgtgt gcagcctttt actcaggttg caagcctcct
      541 gctgtggtag tgaaactcct ggctgctgct gccatcttgt ttatcacgac agtgaatgcg
      601 ctaagcgtgc ggcttggcag ctatgtccag aatgtcttca cggcagccaa gatggtgatc
      661 gtggccatca tcatcatcag cggactggtc ttcctggccc aaggaaatgt aaagaacttt
      721 cagaattctt ttgagggtac acagacctct gtgggtgcca tcagtctggc attttacaat
      781 ggactctggg cctacgatgg ttggaaccaa ctcaactata tcactgaaga gcttagaaac
      841 ccttacagaa acctgcccat ggccattgtc attgggattc ctctggtgac cgtatgctac
      901 atcctcatga atattgccta cttcacagtg atgaccccaa cggagctctt gcagtcccag
      961 gctgtggctg tgaccttcgg agaccgcgtt ctctatccag catcttgggt agtcccactt
     1021 tttgtggcat tttcaaccat cggtgctgct aatggtacct gctttacagc cggcaggctc
     1081 atctatgtgg caggccggga aggccacatg cttaaagtgc tctcctacat cagtgtcaag
     1141 cgcctcacgc cagcccctgc cctcatattt tatggtataa tagccatcat ttacatcatc
     1201 cctggggaca tcaactcctt agtcaattat ttcagttttg ctgcatggct gttttatggt
     1261 atgacaatcc taggactcgt tgtgatgcga ttcacaagga aagatctaga gaggcccatc
     1321 aaggtgcccc tcttcatccc tatcattgtg attctcgtat ctcttttctt gatcctggct
     1381 ccaatcatca gtgagccggc ctgggagtat ctctactgtg tgttgttcat actgagtgga
     1441 cttatatttt acttcctttt tgtctactac aagttcggat gggcccagag aatctccagg
     1501 ccggtcacaa agcacctgca gatgctcatg gaagtcgtcc caccagaaaa ggacccagag
     1561 taaaaggtcc atcactcgta gcccaaagct gtgatcaatt tatttttgta agcaattatt
     1621 tgtggttatt tcttcctggt gtttttctta atgaaaacat gtattcagat atttgtttaa
     1681 tactattatt tttagctatc cc
//
