LOCUS       NM_016972               4064 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 8 (Slc7a8), mRNA.
ACCESSION   NM_016972
VERSION     NM_016972.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4064)
  AUTHORS   Hodge,S.H., Krauss,M.Z., Kaymak,I., King,J.I., Howden,A.J.M.,
            Panic,G., Grencis,R.K., Swann,J.R., Sinclair,L.V. and Hepworth,M.R.
  TITLE     Amino acid availability acts as a metabolic rheostat to determine
            the magnitude of ILC2 responses
  JOURNAL   J Exp Med 220 (3) (2023)
   PUBMED   36571761
REFERENCE   3  (bases 1 to 4064)
  AUTHORS   Venugopalan,V., Rehders,M., Weber,J., Rodermund,L., Al-Hashimi,A.,
            Bargmann,T., Golchert,J., Reinecke,V., Homuth,G., Volker,U.,
            Verrey,F., Kirstein,J., Heuer,H., Schweizer,U., Braun,D.,
            Wirth,E.K. and Brix,K.
  TITLE     Lack of L-type amino acid transporter 2 in murine thyroid tissue
            induces autophagy
  JOURNAL   J Mol Endocrinol 70 (1), e220060 (2022)
   PUBMED   36129170
  REMARK    GeneRIF: Lack of L-type amino acid transporter 2 in murine thyroid
            tissue induces autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4064)
  AUTHORS   Panda,S.K., Kim,D.H., Desai,P., Rodrigues,P.F., Sudan,R.,
            Gilfillan,S., Cella,M., Van Dyken,S.J. and Colonna,M.
  TITLE     SLC7A8 is a key amino acids supplier for the metabolic programs
            that sustain homeostasis and activation of type 2 innate lymphoid
            cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2215528119 (2022)
   PUBMED   36343258
REFERENCE   5  (bases 1 to 4064)
  AUTHORS   Wang,Z., Li,B., Li,S., Lin,W., Wang,Z., Wang,S., Chen,W., Shi,W.,
            Chen,T., Zhou,H., Yinwang,E., Zhang,W., Mou,H., Chai,X., Zhang,J.,
            Lu,Z. and Ye,Z.
  TITLE     Metabolic control of CD47 expression through LAT2-mediated amino
            acid uptake promotes tumor immune evasion
  JOURNAL   Nat Commun 13 (1), 6308 (2022)
   PUBMED   36274066
  REMARK    GeneRIF: Metabolic control of CD47 expression through LAT2-mediated
            amino acid uptake promotes tumor immune evasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4064)
  AUTHORS   Bae,S.Y., Xu,Q., Hutchinson,D. and Colton,C.A.
  TITLE     Y+ and y+ L arginine transporters in neuronal cells expressing
            tyrosine hydroxylase
  JOURNAL   Biochim Biophys Acta 1745 (1), 65-73 (2005)
   PUBMED   16085056
  REMARK    GeneRIF: In a neuronal cell model, y+,L and y+ transport systems
            are the predominant form of arginine uptake mechanisms and the
            transport of arginine is altered by membrane potential and redox
            factors.
REFERENCE   7  (bases 1 to 4064)
  AUTHORS   Bodoy,S., Martin,L., Zorzano,A., Palacin,M., Estevez,R. and
            Bertran,J.
  TITLE     Identification of LAT4, a novel amino acid transporter with system
            L activity
  JOURNAL   J Biol Chem 280 (12), 12002-12011 (2005)
   PUBMED   15659399
REFERENCE   8  (bases 1 to 4064)
  AUTHORS   Broer,A., Wagner,C.A., Lang,F. and Broer,S.
  TITLE     The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates
            arginine efflux in exchange with glutamine
  JOURNAL   Biochem J 349 Pt 3 (Pt 3), 787-795 (2000)
   PUBMED   10903140
REFERENCE   9  (bases 1 to 4064)
  AUTHORS   Rossier,G., Meier,C., Bauch,C., Summa,V., Sordat,B., Verrey,F. and
            Kuhn,L.C.
  TITLE     LAT2, a new basolateral 4F2hc/CD98-associated amino acid
            transporter of kidney and intestine
  JOURNAL   J Biol Chem 274 (49), 34948-34954 (1999)
   PUBMED   10574970
REFERENCE   10 (bases 1 to 4064)
  AUTHORS   Bassi,M.T., Sperandeo,M.P., Incerti,B., Bulfone,A., Pepe,A.,
            Surace,E.M., Gattuso,C., De Grandi,A., Buoninconti,A., Riboni,M.,
            Manzoni,M., Andria,G., Ballabio,A., Borsani,G. and Sebastio,G.
  TITLE     SLC7A8, a gene mapping within the lysinuric protein intolerance
            critical region, encodes a new member of the
            glycoprotein-associated amino acid transporter family
  JOURNAL   Genomics 62 (2), 297-303 (1999)
   PUBMED   10610726
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059004.1.
            
            On Dec 20, 2003 this sequence version replaced NM_016972.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059004.1, SRR1660815.84214.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.91 cM"
     gene            1..4064
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 8"
                     /db_xref="GeneID:50934"
                     /db_xref="MGI:MGI:1355323"
     exon            1..707
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..912
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1064
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1190
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1344
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1468
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1572
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1669
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1819
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1997
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..4034
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4017..4022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /note="hexamer: AATAAA"
     polyA_site      4034
                     /gene="Slc7a8"
                     /gene_synonym="LAT2"
                     /note="major polyA site"
ORIGIN      
        1 cggagctcgg agccgacaag ggcgagaagg aaggggcgac cgcagcaggt ggaaacctga
       61 tccagagccg gcgagcaaga aagtacctga gcacggctcc tcctccgctc cctcagctaa
      121 gaagaactac ttttaccctc atcgtagaag agacttaagg gaaggtggag gcgatctgtt
      181 tcattaggag ggctgcaggg aaatcctgac cagagcaagc cgccgcccgg tacaccgagc
      241 agagcgatcc tgggcttctg aagataaacg ctttccggag aattccagct ggagtcgctg
      301 gtacagttct atttttgtat ttatatatat atatattctt tgccttccat ttaaaaacac
      361 ggcccttgtt tgttaggcag tgacacgtgt gactctcatt tgctgtcact tttagagggt
      421 aggagcgcac tctgttttcg gaaaagggcg ttctaattgg aaactctgtt tttccacata
      481 tctatacgtt tacacgcacg agcgtttaga aaaagactgc tctttttcgc tttgggtggt
      541 cggaacccta cggagaaaga tggaaaaggg agcccgccag cgaaacaaca ccgcgaagaa
      601 ccacccgggt tctgacacca gccctgaggc cgaggctagc tcgggagggg gcggagtagc
      661 cctgaagaaa gagatcggat tggtcagcgc ctgtggtatc attgtaggga acatcattgg
      721 ctccggaatc tttgtctcac cgaaaggtgt gctggaaaac gcgggctctg tgggccttgc
      781 tctcattgtc tggatcgtga caggcatcat cacagccgtg ggagctctct gctatgctga
      841 gctaggcgtc accatcccta agtctggagg tgattactct tatgtgaagg acatcttcgg
      901 aggactggct gggttcctgc ggctgtggat tgctgtgctg gtgatctacc ccaccaacca
      961 agctgtcatc gccctcacct tctccaacta cgtgctgcag ccgctcttcc ctacctgctt
     1021 cccccctgag tccggtctgc gactcctggc tgccatctgt ttgttgctcc tcacatgggt
     1081 caactgctcc agtgtccgat gggccacccg ggttcaagat atcttcacag ctgggaagct
     1141 cctggccctg gctctgatca tcatcatggg tattgtgcag atatgcaaag gagaattctt
     1201 ctggctggag ccaaagaatg catttgagaa tttccaagaa cctgacatcg gcctcgttgc
     1261 tctggcattc ctccagggct cctttgccta tggtggctgg aacttcctta attatgtgac
     1321 tgaggaactt gtggatcctt acaagaacct tcctagagcc atcttcatct ccatcccact
     1381 ggtcacattt gtgtacgtct ttgctaatat tgcatacgtc actgcaatgt ccccccagga
     1441 gctgctagcc tccaatgcag ttgctgtgac ttttggagag aaactcctcg gggtcatggc
     1501 ctggatcatg cccatttctg ttgccctgtc cacgtttggt ggagtcaatg gctccctctt
     1561 cacctcctcc cggctgttct ttgctggagc cagagaaggc caccttccca gtgtgttggc
     1621 catgatccac gtgaagcgct gcactccaat cccagccctg ctcttcacat gcctctccac
     1681 cctgctgatg ctggtcacca gtgacatgta cacactcatc aactatgtgg gcttcatcaa
     1741 ctacctcttc tatggggtaa cggttgcagg acagatagtc cttcgctgga agaagcctga
     1801 cattccccgc cccatcaagg tcagcctgct gtttcccatt atctacctgc tgttctgggc
     1861 cttcctgctg atcttcagcc tgtggtcaga gccagtggtg tgtggcattg gcctggccat
     1921 tatgctgaca ggagttcctg tctacttcct gggtgtctac tggcaacaca aacccaagtg
     1981 tttcaatgac ttcattaagt ccctaaccct agtgagtcag aagatgtgtg tggtcgtgta
     2041 tccccaggag gggaactcgg gggctgagga aacaactgat gacttagagg agcaacacaa
     2101 gcccatcttc aagcctactc ctgtcaagga cccggattcg gaggagcagc cctgaagact
     2161 gccagcctgt aactggccac tcctcccttc atcctttctg ccctgtattc ctgcctaggt
     2221 ccccccaaca cacacacaca cacacacaca cacacacaca cacacacaca cttctgtaag
     2281 gcaggggcca gacctgggtg tccacagtga gacattctaa acaaagaccc tgacctttgt
     2341 acccaaagaa ccaacctgct tccaggaccg aggcccatgg tcaaggtcaa tgcaccaggg
     2401 cctgcacaca ccctaaggtt tggaggagag tggaggtgcc attagtaccc tacagagccc
     2461 ttcctcctgg gcccatgcct gttaggtgcc tctaagaaac ctgggttcac tactatttct
     2521 tctccctaac cctgagccca ggcgaaactt ccattgggga caaaaggtgc agccccagca
     2581 atagctagga agacaactca gattgtcacc gttaagtcag ctggagagac tcagatgtgg
     2641 cttcattctc cagggaacca aaaggcagag ggtacacttc tctttgcctt cttctccact
     2701 ctgtactacc aagactccac tgcccagcct caacccacta cccagagagt tccctttcag
     2761 gaagcctcca ccccactgag ctaaggacca agaaggagga ctgccccacc cccagctcta
     2821 agccaagctt gtggaatata cagggaatgc tcagactgca gaagccaagc cctgccccac
     2881 ccctgccgct gcctcctatc cccttgtggt gccaaagctc cctgaagccg gaaaggcttc
     2941 tatttagtct aatagacatc tctctcttaa gggcaaagtg actctgcccc tccctgtccc
     3001 cctgtgaaag agcagtcacc ctcttatccc agcagctctt cccacccaca gctctgccta
     3061 ccaccctcac ccctttcctc tcctggacca cggctcaagg accaggtatg aaggatctcc
     3121 aagtccttca ggcctgaatt agcatcaaac cagccttaag tcatctccca tccaagaact
     3181 gggcctaaag tgctcccagt ttccaacctc caggacagac ctgatattaa gtccttccct
     3241 ggaaggaagg gtgcttcccc cttcccagca gtgctcagcc ctcaccctgg ggagaccatg
     3301 ttgttggggg gcacggggga gtgaggagaa tgttttccga aggcctgttc ttctcccctc
     3361 ccccaactca aacaacccta ccaccgttct gccatcccac ctgggacaag aggacagaat
     3421 ggcactgact ttggagacct tagaaaaacc ccttccagga gagcttctgg cctgtgctct
     3481 acaggaaggt gacagtgtct gccttctcct ggcagcctcc acacctgctg tgcttaggac
     3541 aggatccttt gatcacaagg cagaacccta accccggtcc atctactcaa actggaatat
     3601 gcagggacct ttccctggcc cctgccagca ggtctcccaa cttcctacct agctcaccct
     3661 acccctaact ggtgagaggc tgagtttggg ctgaattata tgcccttagg aatacagtcc
     3721 aggcaggctg tggggcctct ggggggccag ggaccacccg ctacccctca ttcctctcat
     3781 tccttcagcc tgtacctgcc cctccttgaa ttattgtctc tctctctctc tctttttttt
     3841 taagtggatg ccttactttt tggataacta tttttgaagc tggtatttct atttcttttg
     3901 gattttttaa tgtatggcgg tttgggggca gagctagaac cttaataatc tgtcactgag
     3961 ttcatttagg ttttaaattt tattggtttg ttttatggag tattttcttt tcatgtaata
     4021 aaattttaaa tggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
