LOCUS       NM_001379499            2047 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 7 (Slc7a7), transcript variant 6,
            mRNA.
ACCESSION   NM_001379499 XM_006518754
VERSION     NM_001379499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Stroup,B.M., Li,X., Ho,S., Zhouyao,H., Chen,Y., Ani,S., Dawson,B.,
            Jin,Z., Marom,R., Jiang,M.M., Lorenzo,I., Rosen,D., Lanza,D.,
            Aceves,N., Koh,S., Seavitt,J.R., Heaney,J.D., Lee,B. and
            Burrage,L.C.
  TITLE     Delayed skeletal development and IGF-1 deficiency in a mouse model
            of lysinuric protein intolerance
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37486182
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Guan,N., Kobayashi,H., Ishii,K., Davidoff,O., Sha,F., Ikizler,T.A.,
            Hao,C.M., Chandel,N.S. and Haase,V.H.
  TITLE     Disruption of mitochondrial complex III in cap mesenchyme but not
            in ureteric progenitors results in defective nephrogenesis
            associated with amino acid deficiency
  JOURNAL   Kidney Int 102 (1), 108-120 (2022)
   PUBMED   35341793
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Hagen,C.M., Roth,E., Graf,T.R., Verrey,F., Graf,R., Gupta,A.,
            Pellegrini,G., Poncet,N. and Camargo,S.M.R.
  TITLE     Loss of LAT1 sex-dependently delays recovery after
            caerulein-induced acute pancreatitis
  JOURNAL   World J Gastroenterol 28 (10), 1024-1054 (2022)
   PUBMED   35431492
  REMARK    GeneRIF: Loss of LAT1 sex-dependently delays recovery after
            caerulein-induced acute pancreatitis.
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Stroup,B.M., Marom,R., Li,X., Hsu,C.W., Chang,C.Y., Truong,L.D.,
            Dawson,B., Grafe,I., Chen,Y., Jiang,M.M., Lanza,D., Green,J.R.,
            Sun,Q., Barrish,J.P., Ani,S., Christiansen,A.E., Seavitt,J.R.,
            Dickinson,M.E., Kheradmand,F., Heaney,J.D., Lee,B. and Burrage,L.C.
  TITLE     A global Slc7a7 knockout mouse model demonstrates characteristic
            phenotypes of human lysinuric protein intolerance
  JOURNAL   Hum Mol Genet 29 (13), 2171-2184 (2020)
   PUBMED   32504080
  REMARK    GeneRIF: A global Slc7a7 knockout mouse model demonstrates
            characteristic phenotypes of human lysinuric protein intolerance.
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Sperandeo,M.P., Annunziata,P., Bozzato,A., Piccolo,P., Maiuri,L.,
            D'Armiento,M., Ballabio,A., Corso,G., Andria,G., Borsani,G. and
            Sebastio,G.
  TITLE     Slc7a7 disruption causes fetal growth retardation by downregulating
            Igf1 in the mouse model of lysinuric protein intolerance
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C191-C198 (2007)
   PUBMED   17376816
  REMARK    GeneRIF: The Slc7a7(-/-) mouse displayed intrauterine growth
            restriction, leading to neonatal lethality. After heavy protein
            ingestion, the surviving adult animals presented metabolic
            derangement consistent with lysinuric protein intolerance.
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
REFERENCE   8  (bases 1 to 2047)
  AUTHORS   Moret,C., Dave,M.H., Schulz,N., Jiang,J.X., Verrey,F. and
            Wagner,C.A.
  TITLE     Regulation of renal amino acid transporters during metabolic
            acidosis
  JOURNAL   Am J Physiol Renal Physiol 292 (2), F555-F566 (2007)
   PUBMED   17003226
  REMARK    GeneRIF: selective regulation of SNAT3 and y(+)LAT1 expression may
            serve a major role in the renal adaptation to acid secretion and
            thus for systemic acid-base balance.
REFERENCE   9  (bases 1 to 2047)
  AUTHORS   Takabe,W., Kanai,Y., Chairoungdua,A., Shibata,N., Toi,S.,
            Kobayashi,M., Kodama,T. and Noguchi,N.
  TITLE     Lysophosphatidylcholine enhances cytokine production of endothelial
            cells via induction of L-type amino acid transporter 1 and cell
            surface antigen 4F2
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (9), 1640-1645 (2004)
   PUBMED   15178563
  REMARK    GeneRIF: Increased LAT1 expression can be induced by lipid
            oxidation products relevant to inflammatory responses in
            atherogenesis. LAT1 mediates lysophosphatidylcholine-enhanced
            cytokine production by endothelial cells.
            Erratum:[Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2425]
REFERENCE   10 (bases 1 to 2047)
  AUTHORS   Pfeiffer,R., Rossier,G., Spindler,B., Meier,C., Kuhn,L. and
            Verrey,F.
  TITLE     Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and
            members of the glycoprotein-associated amino acid transporter
            family
  JOURNAL   EMBO J 18 (1), 49-57 (1999)
   PUBMED   9878049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC206013.3.
            
            On Apr 6, 2020 this sequence version replaced XM_006518754.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.673021.1,
                                           SRR5189685.108008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC206013.3         140005-140130       c
            127-672             AC206013.3         138430-138975       c
            673-798             AC206013.3         108923-109048       c
            799-943             AC206013.3         107693-107837       c
            944-1067            AC206013.3         104475-104598       c
            1068-1171           AC206013.3         104141-104244       c
            1172-1268           AC206013.3         103769-103865       c
            1269-1418           AC206013.3         102867-103016       c
            1419-1602           AC206013.3         100020-100203       c
            1603-2047           AC206013.3         99369-99813         c
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.76 cM"
     gene            1..2047
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 7"
                     /db_xref="GeneID:20540"
                     /db_xref="MGI:MGI:1337120"
     exon            1..126
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..672
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1703
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /note="y+LAT1; y+LAT-1; solute carrier family 7 member 7;
                     y(+)L-type amino acid transporter 1"
                     /codon_start=1
                     /product="Y+L amino acid transporter 1"
                     /protein_id="NP_001366428.1"
                     /db_xref="GeneID:20540"
                     /db_xref="MGI:MGI:1337120"
                     /translation="MVNSTKYEVAAQHEADDGSALGDGASPVAEQVKLKKEISLLNGV
                     CLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSG
                     ASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGR
                     LLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATANFENS
                     FEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYL
                     LTNVAYYSVLDIKEILASDAVAVTFADQIFGVFNWIIPVAVAFSCFGGLNASIVAASR
                     LLFVGSREGHLPDAICMVHVERFTPVPSLLFNGVLSLVYLCVEDIFQLINYYSFSYWF
                     FVGLSIVGQLYLRWKDPDRPRPLKLSLFFPIIFCLCTIFLVAVPLYSDTINSLIGIGI
                     ALSGLPFYFFIIRVPEHKRPLFLRRIVASITRYLQILCMSVAAEMDLEDGELSKQDPK
                     SK"
     exon            673..798
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..943
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1067
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1171
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1268
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1418
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1602
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..2047
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /note="hexamer: AATAAA"
     polyA_site      2047
                     /gene="Slc7a7"
                     /gene_synonym="my+lat1"
                     /note="major polyA site"
ORIGIN      
        1 ccctcttact gctggaggaa ggaggagctg tcagatctct gttcttggag ggtgtgtgtg
       61 cctctttgtc tcagagactg cggctggcca ttgctgtggg aacctcctta tatccagagc
      121 cagggaaggg caatgcgagc aagctggtga aggtcttcct tctcttcgcc atggtcaaca
      181 gcaccaagta tgaagtggct gctcagcacg aggccgacga tggctctgct ctcggggatg
      241 gggccagccc agtggcggag caggtcaaac tgaagaagga gatctccctg cttaatggcg
      301 tgtgtctcat agtggggaac atgatcggct ccggcatctt tgtctcccct aagggtgtgc
      361 tcatgtacag tgcctctttt ggcctctcac tggtcatctg ggctgtcggg ggcattttct
      421 ccgtctttgg ggccctttgt tacgctgaac tgggtaccac cattaagaaa tccggggcca
      481 gctatgctta tatcctggag gccttcgggg gattccttgc gttcatccgc ctctggactt
      541 ctctgctcat cattgaaccc accagccagg ccgtcattgc catcaccttt gccaactaca
      601 tggtgcagcc cctcttcccg agctgtggcg ctccctatgc cgccggccgc ctgctggccg
      661 ctgcctgcat ctgtctctta accttcatta actgtgccta tgtcaagtgg ggaaccctgg
      721 tccaagatat tttcacctat gctaaggtgt tggcgctgat tgcagtcatc attgcaggca
      781 ttgttagact tggccaggga gccacagcta actttgagaa ctcctttgag ggctcatcct
      841 ttgcaatggg tgacattgct ctggcactct actcagccct gttctcctac tcgggctggg
      901 acacccttaa ctatgtcacc gaagagatca ggaaccccga gaggaacttg cccctctcca
      961 ttggcatttc catgccaatc gtcaccatca tctacctctt gaccaatgtg gcctattaca
     1021 gtgtgctaga cataaaggaa atcctggcca gtgacgctgt tgccgtgacc tttgcagatc
     1081 aaatttttgg agtattcaat tggataattc cagtagcggt tgcattctct tgctttggtg
     1141 ggctcaacgc ctccatcgtg gctgcttcca ggcttttatt tgtgggctcg agagaaggcc
     1201 acctccctga cgccatctgt atggttcatg ttgaacggtt cacaccagtg ccttctctac
     1261 tcttcaatgg tgtgttgtcc ctggtctacc tgtgcgtgga ggacatcttc cagctcatta
     1321 actactatag cttcagctac tggttctttg tgggcctttc tattgtgggt cagctttatc
     1381 tacgctggaa ggaccccgac cggcctcgcc ctctcaagct cagccttttc ttccccatca
     1441 tcttctgcct ctgcaccatc ttcctggtgg ctgttccact ttacagcgac accatcaact
     1501 ccctcatcgg cattggcatt gcactctcag gcctgccctt ctacttcttc atcatcagag
     1561 tgccagagca caaacgacca ctgttcctcc gcaggattgt agcctctatc acacggtacc
     1621 tccagatcct ctgtatgtca gttgctgcag aaatggactt ggaagatgga gagttgtcca
     1681 aacaagatcc caagtctaaa tagagcaagg gattctgagg tgtggacaga acgggtgttt
     1741 cgtatctccc attggccaga accctggagg cacggtccag gagcccaagc ttggcagctt
     1801 caactctgaa cttgcttttg agggatgaag agtaatttat ttgttttgct acatgtttca
     1861 gacttcataa atggatgatg cagactgtgg caggaagtag gccattttgg ggcagtcctg
     1921 gcagcacctg ggtgtggcca cccactcctc tttcctttac aagggccaac aatgctccaa
     1981 acttgtctcc ttcagaggaa cacaaaactg tcacagatgc aaaacaataa aaaagttatg
     2041 ttcctaa
//
