LOCUS       NM_178798               3761 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 6 (Slc7a6), transcript variant 1,
            mRNA.
ACCESSION   NM_178798
VERSION     NM_178798.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3761)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   2  (bases 1 to 3761)
  AUTHORS   Hinz,K.M., Meyer,K., Kinne,A., Schulein,R., Kohrle,J. and Krause,G.
  TITLE     Structural insights into thyroid hormone transport mechanisms of
            the L-type amino acid transporter 2
  JOURNAL   Mol Endocrinol 29 (6), 933-942 (2015)
   PUBMED   25945809
  REMARK    GeneRIF: these data help to elucidate the molecular mechanisms and
            role of Lat2 in thyroid hormone transport.
REFERENCE   3  (bases 1 to 3761)
  AUTHORS   Corbett,H.E., Dube,C.D., Slow,S., Lever,M., Trasler,J.M. and
            Baltz,J.M.
  TITLE     Uptake of betaine into mouse cumulus-oocyte complexes via the
            SLC7A6 isoform of y+L transporter
  JOURNAL   Biol Reprod 90 (4), 81 (2014)
   PUBMED   24599290
  REMARK    GeneRIF: Both transcripts and protein of one y+L isoform, SLC7A6
            (y+LAT2), are present in cumulus oocyte complexes, with little or
            no expression in isolated germinal vesicle (GV)-stage oocytes, MII
            eggs, or one-cell embryos.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3761)
  AUTHORS   Sekine,Y., Nishibori,Y., Akimoto,Y., Kudo,A., Ito,N., Fukuhara,D.,
            Kurayama,R., Higashihara,E., Babu,E., Kanai,Y., Asanuma,K.,
            Nagata,M., Majumdar,A., Tryggvason,K. and Yan,K.
  TITLE     Amino acid transporter LAT3 is required for podocyte development
            and function
  JOURNAL   J Am Soc Nephrol 20 (7), 1586-1596 (2009)
   PUBMED   19443642
  REMARK    GeneRIF: LAT3 may play a crucial role in the development and
            maintenance of podocyte structure and function by regulating
            protein synthesis and the actin cytoskeleton.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855052.1, AK053899.1, CF725752.1, AI118666.1 and BB398929.1.
            
            On Oct 26, 2017 this sequence version replaced NM_178798.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049478.1, AK165979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BB855052.1         1-14
            15-3062             AK053899.1         3-3050
            3063-3474           CF725752.1         217-628
            3475-3745           AI118666.1         80-350
            3746-3761           BB398929.1         256-271
FEATURES             Location/Qualifiers
     source          1..3761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.1 cM"
     gene            1..3761
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 6"
                     /db_xref="GeneID:330836"
                     /db_xref="MGI:MGI:2142598"
     exon            1..101
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            102..660
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1685
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="isoform 1 is encoded by transcript variant 1; y+L
                     amino acid transporter 2; y(+)L-type amino acid
                     transporter 2; solute carriersolute carrier family 7
                     (cationic amino acid transporter, y+ system), member 6"
                     /codon_start=1
                     /product="Y+L amino acid transporter 2 isoform 1"
                     /protein_id="NP_848913.1"
                     /db_xref="CCDS:CCDS22631.1"
                     /db_xref="GeneID:330836"
                     /db_xref="MGI:MGI:2142598"
                     /translation="MEAQELGSPTPTYHLLPKANQHTVKEDAGSPSQGSPETMQLKKE
                     ISLLNGVSLVVGNMIGSGIFVSPKGVLKYTASYGLSLIVWAIGGLFSVVGALCYAELG
                     TTITKSGASYAYILEAFGGFIAFIRLWVSLLIVEPTSQAIIAITFANYIIKPSFPTCD
                     PPYVACRLLAAACVCLLTFVNCAYVKWGTRVQDTFTYAKVLALIAIIIMGLVKLCQGH
                     TEHFQDAFKGSSWNVGDLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMP
                     IVTLIYILTNVAYYTVLNIQDVHKSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNA
                     SIFASSRLFFVGSREGHLPNLLSMIHIERFTPVPALLFNCTMTLIYLVVKDVFLLINY
                     FSFSYWFFVGLSVVGQLYLRWKEPDWPRPLKLSLFFPIVFCVCSLFLVAVPLFSDTIN
                     SLIGIGIALSGVPVYFLGVYLPESRRPLFIRNVLATVTRVTQKLCFCVLTELDVTEEK
                     NVERKTD"
     exon            661..786
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..931
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1055
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1159
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1256
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1406
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1590
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..3761
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3038..3043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="hexamer: AATAAA"
     polyA_site      3070
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="major polyA site"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="Slc7a6"
                     /gene_synonym="LAT-2; LAT3; y+LAT-2"
                     /note="major polyA site"
ORIGIN      
        1 gacgtggcgt gggcggggct tgagcggccg ccggggcgac ggcgcgaccg agcatcctgg
       61 aagctccggg ccacgaggag gtagctggcg aggccgagga ggccatacta agcacaggtg
      121 tacaggaacc atttaccatg gaagcacagg agcttgggag ccccacaccc acctaccatc
      181 ttctccccaa agccaaccag cacactgtaa aagaagatgc cggctcacca tctcaagggt
      241 ctccagaaac gatgcagctg aagaaggaga tctccttgct gaacggggtc agcctggtgg
      301 tgggcaacat gattggctca gggatctttg tctcaccgaa gggtgtcctc aagtacactg
      361 cttcctatgg gttgtcactt atagtgtggg ccattggtgg gctcttctct gtcgtgggtg
      421 ccctttgcta tgcagaactg gggaccacca tcaccaaatc aggggctagc tatgcttata
      481 ttctagaggc cttcgggggc ttcattgcct ttatccgtct gtgggtctca cttctaattg
      541 ttgagcccac cagtcaggcc atcatcgcca tcacctttgc caactatatc atcaagccct
      601 ccttccccac ctgtgatcct ccatatgtgg cctgccgtct cctcgctgct gcctgcgtat
      661 gtctgctgac atttgtgaac tgtgcctacg tcaagtgggg cacacgagta caagacacat
      721 tcacgtatgc caaggtcctg gcactcattg ccatcattat catgggcctt gttaaactgt
      781 gtcagggaca cactgagcac tttcaggacg cctttaaagg ttcctcgtgg aatgtgggag
      841 acctctctct tgccctgtac tctgccctct tctcttactc aggttgggac acccttaatt
      901 ttgtaacaga agaaatcaaa aacccagaaa ggaatttgcc cttggccatt gggatttcta
      961 tgccaattgt gacactcatc tacatcctga ccaacgtggc ctattacaca gtgctgaaca
     1021 ttcaggatgt ccataagagt gacgctgtgg ctgtgacatt tgctgaccag acattcggca
     1081 tgttcagttg gaccatcccc attgctgttg ctctgtcctg cttcgggggc ctaaatgcat
     1141 ccatctttgc ttcatcaagg ttgtttttcg tgggctctcg tgagggccac ctcccgaacc
     1201 ttctgtccat gatccatatt gagcgcttta cacccgtgcc tgcgttactg ttcaattgca
     1261 ccatgacact tatctacctc gtggtgaagg acgtcttcct gctcatcaac tacttcagct
     1321 tcagctactg gttcttcgtg ggcttgtctg ttgttggaca gctctacctt cgctggaaag
     1381 agcctgactg gcctcgacct ctcaagctga gcctcttttt tcccatcgtg ttctgcgtct
     1441 gctccttgtt tctggtggcc gtacccctct tcagtgacac catcaattcc ctcattggca
     1501 ttgggattgc cctctctggg gtccctgtct acttcttggg tgtatacctg ccagagtccc
     1561 ggagaccact ctttattagg aatgtgctgg ctactgtcac cagagtcacc cagaagcttt
     1621 gcttttgcgt cttgactgag ctagatgtaa ctgaagagaa aaatgttgag aggaaaactg
     1681 actagaagcc agagatgaca ttccctgaag cccaaaaggc tgtggtcgca gccaccaaag
     1741 accagttccc taaaccttct gaattaaagg agcctcttgg cccacattct gtaagggggc
     1801 tcagggccaa tgctctctca ttggtaagct atgggaagat accaattagg ccagcctgaa
     1861 gatggggact tcagtgggag gggaggttgg gcagggcatt gatttagttt tacttctgat
     1921 gagtagatgc agccctgaag gaatattaga ctgacagctc tggctcttga ttcacagctc
     1981 tttgtagttt aaaccaggag tctacagtgg ggctccttca tgggaagttt tcctctgacc
     2041 ctctgaccaa gtccagctac ttgattttta gaggtctgaa atgctaccat ttcttcctat
     2101 ggctcaaaat tcttccttga ggagagcgtt gtgttcccct ttttgtttgt tgggtggcat
     2161 gaacagcaag gtgctgtgta actgacatgg gatcaatgtg tgcctccttc ctgaattcca
     2221 caagaggaac aacactccct ccctccccgg aacttcaggc tcaagcagac agtgagctta
     2281 atgggaagca gactgttgag gatctaggca tgaaagtcct ctaactcgtg gatccgaatg
     2341 ttgctgtgtc tttgggatct tattgtgtat agagtgtccc tctccttgag gaggggctgc
     2401 ctgtctgact ttgcttaggt cacattagca gtatggtcag gattctcagg caaggaggtg
     2461 agcttctggc ttttcaagga attcgactgg gccacttgat tgtgcccttc ctagctgaat
     2521 ccatggtgct gtggagccct tgaaacaagg gctgagagaa aaacctcact actccagctg
     2581 agtggagcgt ctctactacc tggacaagcc acaactgtca ccaaatttca actcctgtat
     2641 gtcattattt attgatattt aatccaggat accagttgta acaaaccatt agtgatcatt
     2701 tctctatagg atgcaataag tgaattgtgt ttttatctta gctggcctgg ttgcacacat
     2761 ctgtaatctg aacttggtat ggtgaggcat aaggagtttg aatttgaggc taatttaggc
     2821 tacataattt ccaggtagcc actctggaaa gatcagacaa gatcttgtct cacaatatac
     2881 ctgttatact ttaatataca gataagtcac atgttattat catctggctc agatccagca
     2941 aggacagatg agcaacttca tgagtcataa tactgctatt ttgaaggaca atcctttgtt
     3001 ttattaagac tgtagatctt tgttctactt gacataaaat aaatctttgg atttttggta
     3061 tgaactgcaa gaggcctgga atgttctaca taaggtgtta tgcaaaattc aggtagataa
     3121 cctgatttat cagttgtcac tggactcctg gattcaagtc aaatagtttg ttatctttaa
     3181 gagcctgtgc aagattggct atgtatggac tcacaaaagc ccactctgct ggaagtggtc
     3241 actaattttc tgaaagcacc aagctttgtt tacatgcttg ggtcatggga cagtataccc
     3301 gcttgccttc tcttgtccaa gggctgggca ggtgagattg aagtctcaga aaatgcttgg
     3361 tacttgtgca tctgtcttct ccctatgaag atcgatgaag actgtgggag aaaacagctt
     3421 ccaccccagc ctcgctcctg gtaaacggta gaaactaatt ctggtgatcg gactaggctg
     3481 ccagttaaag ccaaagcaat aggcgtgaat ctctgtgagc agtgtgtcta cacaagattg
     3541 tagaactctt ttgatgccct tagacattgc caccttggac acagaagaac ctgctatgct
     3601 gtcttggcat ccttcaagga catttcaagt tttagaattt gtgaacaata cagatagtaa
     3661 ctatgtggca gtctcccagt accaaactgg ctctagactc acaggagtaa ccttagatat
     3721 atgcttgctc aataaagact taggggagtc taatcacagt t
//
