LOCUS       NM_011404               3513 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 5 (Slc7a5), mRNA.
ACCESSION   NM_011404 XM_912386
VERSION     NM_011404.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3513)
  AUTHORS   Yang,B., Wang,Z., Niu,K., Li,T., Tong,T., Li,S., Su,L., Wang,Y.,
            Shen,C., Jin,X., Song,J. and Lu,X.
  TITLE     TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated
            amino acid transport and mTORC1 activation in fibroblasts
  JOURNAL   Cell Commun Signal 22 (1), 444 (2024)
   PUBMED   39304904
  REMARK    GeneRIF: TRIM35 triggers cardiac remodeling by regulating
            SLC7A5-mediated amino acid transport and mTORC1 activation in
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3513)
  AUTHORS   Fan,Y. and Yu,Y.
  TITLE     Cancer-associated fibroblasts-derived exosomal METTL3 promotes the
            proliferation, invasion, stemness and glutaminolysis in non-small
            cell lung cancer cells by eliciting SLC7A5 m6A modification
  JOURNAL   Hum Cell 37 (4), 1120-1131 (2024)
   PUBMED   38625505
  REMARK    GeneRIF: Cancer-associated fibroblasts-derived exosomal METTL3
            promotes the proliferation, invasion, stemness and glutaminolysis
            in non-small cell lung cancer cells by eliciting SLC7A5 m6A
            modification.
REFERENCE   3  (bases 1 to 3513)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   4  (bases 1 to 3513)
  AUTHORS   Bao,L., Fu,L., Su,Y., Chen,Z., Peng,Z., Sun,L., Gonzalez,F.J.,
            Wu,C., Zhang,H., Shi,B. and Shi,Y.B.
  TITLE     Amino acid transporter SLC7A5 regulates cell proliferation and
            secretary cell differentiation and distribution in the mouse
            intestine
  JOURNAL   Int J Biol Sci 20 (6), 2187-2201 (2024)
   PUBMED   38617535
  REMARK    GeneRIF: Amino acid transporter SLC7A5 regulates cell proliferation
            and secretary cell differentiation and distribution in the mouse
            intestine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3513)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3513)
  AUTHORS   Bae,S.Y., Xu,Q., Hutchinson,D. and Colton,C.A.
  TITLE     Y+ and y+ L arginine transporters in neuronal cells expressing
            tyrosine hydroxylase
  JOURNAL   Biochim Biophys Acta 1745 (1), 65-73 (2005)
   PUBMED   16085056
  REMARK    GeneRIF: In a neuronal cell model, y+,L and y+ transport systems
            are the predominant form of arginine uptake mechanisms and the
            transport of arginine is altered by membrane potential and redox
            factors.
REFERENCE   7  (bases 1 to 3513)
  AUTHORS   Bodoy,S., Martin,L., Zorzano,A., Palacin,M., Estevez,R. and
            Bertran,J.
  TITLE     Identification of LAT4, a novel amino acid transporter with system
            L activity
  JOURNAL   J Biol Chem 280 (12), 12002-12011 (2005)
   PUBMED   15659399
REFERENCE   8  (bases 1 to 3513)
  AUTHORS   Kageyama,T., Nakamura,M., Matsuo,A., Yamasaki,Y., Takakura,Y.,
            Hashida,M., Kanai,Y., Naito,M., Tsuruo,T., Minato,N. and
            Shimohama,S.
  TITLE     The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain
            barrier
  JOURNAL   Brain Res 879 (1-2), 115-121 (2000)
   PUBMED   11011012
REFERENCE   9  (bases 1 to 3513)
  AUTHORS   Nakamura,E., Sato,M., Yang,H., Miyagawa,F., Harasaki,M., Tomita,K.,
            Matsuoka,S., Noma,A., Iwai,K. and Minato,N.
  TITLE     4F2 (CD98) heavy chain is associated covalently with an amino acid
            transporter and controls intracellular trafficking and membrane
            topology of 4F2 heterodimer
  JOURNAL   J Biol Chem 274 (5), 3009-3016 (1999)
   PUBMED   9915839
REFERENCE   10 (bases 1 to 3513)
  AUTHORS   Kimura,N., Toyoshima,T., Kojima,T. and Shimane,M.
  TITLE     Entactin-2: a new member of basement membrane protein with high
            homology to entactin/nidogen
  JOURNAL   Exp Cell Res 241 (1), 36-45 (1998)
   PUBMED   9633511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116772.6 and AC121975.3.
            
            On Jul 31, 2009 this sequence version replaced NM_011404.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148134.1, BC026131.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-621               AC116772.6         79937-80557         c
            622-759             AC116772.6         69299-69436         c
            760-865             AC116772.6         61193-61298         c
            866-910             AC116772.6         60368-60412         c
            911-1034            AC116772.6         59729-59852         c
            1035-1069           AC116772.6         59220-59254         c
            1070-1138           AC121975.3         174860-174928       c
            1139-1235           AC121975.3         174489-174585       c
            1236-1385           AC121975.3         173563-173712       c
            1386-1563           AC121975.3         172171-172348       c
            1564-3513           AC121975.3         169726-171675       c
FEATURES             Location/Qualifiers
     source          1..3513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..3513
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 5"
                     /db_xref="GeneID:20539"
                     /db_xref="MGI:MGI:1298205"
     exon            1..621
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1619
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /note="L-type amino acid transporter 1; 4F2 light chain;
                     4F2 LC; solute carrier family 7 member 5"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 1"
                     /protein_id="NP_035534.2"
                     /db_xref="CCDS:CCDS22730.1"
                     /db_xref="GeneID:20539"
                     /db_xref="MGI:MGI:1298205"
                     /translation="MAVAGAKRRAVATPAAAAAEEERQAREKMLEARRGDGADPEGEG
                     VTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGAL
                     CYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKP
                     VFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFI
                     QMGKDMGQGDASNLQQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPY
                     RNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPV
                     FVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSVLSMIHPQLLTPVPSLVFTCIMTLMY
                     AFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLF
                     LIAVSFWKTPMECGIGFAIILSGLPVYFFGVWWKNKPKWILQAIFSVTVLCQKLMQVV
                     PQET"
     exon            622..759
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..865
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..910
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1034
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1138
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1235
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1385
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1563
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..3513
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3509
                     /gene="Slc7a5"
                     /gene_synonym="4F2LC; D0H16S474E; Gm42049; LAT1; TA1"
                     /note="major polyA site"
ORIGIN      
        1 agacgcactt ctcagtacgc ggagagcggc tcggccgcgc gcacgccggg tatccaggcc
       61 gagccgggaa cgccgagagc atggcggtcg cgggcgccaa gaggcgcgcg gttgcgaccc
      121 cggcggcggc ggcggcggag gaggagcggc aggcgcggga gaagatgttg gaggcgcggc
      181 gcggggacgg cgcggacccc gagggcgaag gcgtgaccct gcagcgcaat atcacgctgc
      241 tcaacggtgt ggccatcatc gtgggcacca tcatcggctc tggcatcttc gtgacgccca
      301 ccggcgtgct caaggaagcg gggtcgcccg gactgtcgct cgtggtgtgg gctgtgtgcg
      361 gcgtcttctc catcgtgggc gcactctgct acgcggagct gggcaccacc atctccaagt
      421 caggcggcga ctacgcctac atgctggagg tctacggctc gttgcccgcc ttcctcaagc
      481 tctggatcga gctgctcatc attcggccct cctcgcagta catcgtggcg ctggtcttcg
      541 ccacctactt gctcaagccg gtcttcccca cttgtccggt gcccgaggaa gctgccaagc
      601 tcgtggcctg cctctgcgtg ctgctcctca cagctgtgaa ctgctacagc gtaaaggctg
      661 cgacccgtgt gcaggacgcc tttgcggctg ccaagctgct ggccctggcc ctcatcattt
      721 tgctcggctt catccagatg gggaaggaca tgggacaagg tgatgcgtcc aacctgcagc
      781 agaagttgtc ctttgaaggc accaatctgg acgtggggaa cattgtgttg gctttgtaca
      841 gcggcctctt cgcctacgga ggatggaact atctgaattt tgtcacggag gagatgatca
      901 acccctacag gaacctgccc ctggccatca tcatctcctt gcccattgtc acactggtct
      961 atgtgctgac gaacctggcc tatttcacta ccctctctac caaccagatg ctgacatctg
     1021 aagctgtggc tgtggacttc gggaactacc acttgggtgt catgtcctgg atcattcctg
     1081 tctttgtggg cttgtcttgc ttcggctctg tcaatgggtc tctgttcacg tcctcaagac
     1141 tgttcttcgt gggatccagg gagggccacc tgccttctgt cctctccatg atccacccac
     1201 agctgctgac acctgtgcca tcactggtgt tcacgtgtat catgacgctg atgtacgcct
     1261 tctccagaga tatcttctcc atcatcaact tcttcagctt cttcaactgg ctgtgtgtgg
     1321 ccctggccat catcggtatg atgtggctcc gattcaagaa gcctgagctg gagcgtccca
     1381 tcaaggtgaa tctggccctc ccggtgttct ttatcctggc ctgcctcttc ctcattgccg
     1441 tgtcattctg gaagacaccc atggagtgtg gcattggctt cgccatcatc ctcagcgggc
     1501 tgcctgtcta cttctttggt gtctggtgga agaacaagcc caagtggatt ctgcaggcta
     1561 tcttctctgt gacggtgctc tgccagaagt tgatgcaggt ggtacctcag gagacttagt
     1621 cacgtgtcct gggtgctgcc gcgctgtgcc tgctccagac aactctcctt tggaagatca
     1681 gcggccaggc ctgtcagccc cacagctcca gtgagcacca ccagccgcct aacacaatcc
     1741 actgtccctc aaacgtcagg tgtccacagt ggctgtgaaa gaaaactggt acgatttggt
     1801 cccagaaggt gaccgtccat ggtccatgca gacacagcac ccagtatgag gcgtgctggg
     1861 acctgaggcc tggactttct gactttctgg ggactgccac atccaggctt tctcccctgt
     1921 gatttttgtt ttgttttggt ttttgtagcg tgcatttggg tcaagtttac actagcgaga
     1981 tgattatttt ttaacaaaac agggtagcaa ggagcaggag atgccgtggc cgcacagtcc
     2041 ggccctgtgg gaactgctgg ccacagctct tttcccaagg ctgtcgttca gtagcataga
     2101 gtgcctcaag gggaccgcat cactgtcacc aggtcagaag aactactgag acttgcacat
     2161 cacctgttcc actgtggact tggactgaca gatggacgac acatatgcta gcttggactt
     2221 tagttttctg ggaccctaga gatggaaccc caacctttct catgagacag agctctactg
     2281 tgtgggtcac ttgttaggtt gaaaatgtag agctcagctc tcgccgccct gaagtcctgg
     2341 ctccatatga aagatctctg cagccatgac cctaacagca cctagctgtc cgctgcaggg
     2401 ccttgtgctc tgtgcacaca atgcagcagt gccccggctc tcacacgcac agcactcccc
     2461 gccctgcccc acctctctta gaaccagacc agcaccatgg ctctcccacc cccaccccca
     2521 cccccaagca cctggtctgt ccccattgtt cttgagactg ctagtagcat tctgtcaaag
     2581 tcactactgc tccctccagc cccaccctta gccattgttc agaaaaatag gcaccaagca
     2641 cccctctgct ctctgccacc agtgtggtgt gaccactcca gctccctgag tatgaaagcc
     2701 actggctaca tgtgtgggac catcctgcag ccttcccgtt gtgctctggg tgagacagtt
     2761 gggtccagcc agcacatcac tgaaggagct gatctgctgg agggacttca ggatgtgcgt
     2821 cccctgctgg cctctgccat tgcctcagac catggcctcc ctgaaggggt gtctactgga
     2881 atggctacta tgcagttctt acatagtggt gacttaccac tggccaccct gacctctcct
     2941 ctgtgcttct ggggttccct ttcattgggg tgaggaagca aggtcaaggt cagagtgcct
     3001 cttgaaggtt ctcccagata tgggaactgg ggtctcttcc ctggaaatga gggcagggac
     3061 ccagttccat cctggggtgt gtccccagat acagcctggg ttaaagggca gggattcatg
     3121 gtgctgaccc aggctctctg agaaggccct gtcattcctg tttgtgatgt tctgaggatg
     3181 cccatctgta ggtttttatt ttcaaatcaa gctccgacca ccgccatttt gcccagtgct
     3241 ttctattttg gttttatcct aacatgtcac tgccctgaaa gacaccccta cctggcccct
     3301 ttcaatggtc agtgtctgac ccaccacact gggtccatct gctgtgccac ctgagatagt
     3361 gctgtggtta taatgtcttt tactattgta ttaatggcta gcctgttaca ttagactggg
     3421 gggggggtac agaggtctgc tgttttgtga ggctttttgt ttttttgggg ggttggtttt
     3481 gtttttttta aaagctattg gaattctaag ctg
//
