LOCUS       NM_144852               3231 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 4 (Slc7a4), transcript variant 2,
            mRNA.
ACCESSION   NM_144852
VERSION     NM_144852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Racedo,S.E., McDonald-McGinn,D.M., Chung,J.H., Goldmuntz,E.,
            Zackai,E., Emanuel,B.S., Zhou,B., Funke,B. and Morrow,B.E.
  TITLE     Mouse and human CRKL is dosage sensitive for cardiac outflow tract
            formation
  JOURNAL   Am J Hum Genet 96 (2), 235-244 (2015)
   PUBMED   25658046
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   O'Shaughnessy,P.J., Abel,M., Charlton,H.M., Hu,B., Johnston,H. and
            Baker,P.J.
  TITLE     Altered expression of genes involved in regulation of vitamin A
            metabolism, solute transportation, and cytoskeletal function in the
            androgen-insensitive tfm mouse testis
  JOURNAL   Endocrinology 148 (6), 2914-2924 (2007)
   PUBMED   17332066
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043772.1.
            
            On Apr 6, 2007 this sequence version replaced NM_144852.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (2) with a shorter N-terminus, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043772.1, SRR1660815.99681.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3231              AK043772.1         2-3232
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.89 cM"
     gene            1..3231
                     /gene="Slc7a4"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 4"
                     /db_xref="GeneID:224022"
                     /db_xref="MGI:MGI:2146512"
     exon            1..32
                     /gene="Slc7a4"
                     /inference="alignment:Splign:2.1.0"
     exon            33..1046
                     /gene="Slc7a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1972
                     /gene="Slc7a4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cationic amino acid transporter 4; CAT4; CAT-4; solute
                     carrier family 7 member 4"
                     /codon_start=1
                     /product="cationic amino acid transporter 4 isoform 2"
                     /protein_id="NP_659101.2"
                     /db_xref="CCDS:CCDS28008.1"
                     /db_xref="GeneID:224022"
                     /db_xref="MGI:MGI:2146512"
                     /translation="MARGLPSTACLARFCQKLNRLKPLEESSMETSLRRCLSTLDLTL
                     LGVGGMVGSGLYVLTGTVAKDMAGPAVLLSFLVAAVASLLAALCYAEFGARVPRTGSA
                     YLFTYVSMGEIWAFLIGWNVLLEYLIGGAAVARAWSGYLDAIFNHSIRNFTESHLGVW
                     QVPFLAHYPDFLAAGILLVASAFVSCGARVSSWLNHTFSAISLIVILFIIVLGFILAR
                     PHNWSAEEGGFAPFGFSGILAGTATCFYAFVGFDVIAASSEEAKNPRWAVPMAIAISL
                     SLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYSWAGFIVAVGSICAMNTVLL
                     SNLFSLPRIVYAMAADGLFFQVFARVHPRTQVPVVGILVFGVLMALLALLLDLEALVQ
                     FLSIGTLLAYTFVATSIIVLRFQKASPPSSPCLASPGPTAKKYDSFSDHIQLVGAEQT
                     SMSEPGQLRPALKPFLGFLDGCSPGTAVAWALGILVASAISLACVLVFGNSDLHLPQW
                     GYVLLLVISGAVFLSSLLVLGAHQQQKKQDTFQIPLVPLTPALSILLNTCLMLKLSYL
                     TWLRFIFWLLVGLVVYFGYGIWHSKENQREPLELTTAHYVVFPSGSLEETVQAVQPSS
                     QSPVRESGCTE"
     exon            1047..1687
                     /gene="Slc7a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1796
                     /gene="Slc7a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..3231
                     /gene="Slc7a4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2724
                     /gene="Slc7a4"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcacg gtggcagcga cggcgacagc aggttccaga aactggttca gtactccgtc
       61 tgccatggcc cggggactgc ccagtactgc ctgtttggca cgcttctgcc agaaactgaa
      121 ccgtctgaag ccactggaag agtctagcat ggagacatca ctgcggcgct gcctgtccac
      181 actggacttg actctactgg gtgtgggtgg catggtggga tctgggctct atgtgctcac
      241 aggcacagtg gccaaggaca tggctggccc cgctgtgctc ttgtcctttt tggtggccgc
      301 tgtagcctcc ctgctggcgg ccctatgcta tgcagagttt ggagcccgtg tgccccgtac
      361 tggctcagca tacctattca cgtacgtgtc catgggggag atatgggcat tcctcatagg
      421 ctggaatgtg cttctagaat acctcattgg aggtgccgct gtagcccgtg cctggagtgg
      481 ctatttggat gccatcttta accacagcat tcgcaacttc acggagtctc acctgggcgt
      541 ctggcaggtg cccttcctag ctcactatcc agattttctg gccgctggca ttttactcgt
      601 ggcttctgcc tttgtctcct gcggagcccg agtctcctcc tggcttaatc acacgttctc
      661 agccatcagt ctgattgtga tcctcttcat cattgtcctg ggtttcatcc tggcccgtcc
      721 tcacaactgg agtgcagaag aaggtggttt cgcacccttc ggcttctctg gcatcctggc
      781 tggcacagcc acctgtttct atgccttcgt gggatttgat gttattgctg cctccagtga
      841 ggaggccaaa aacccacggt gggcggtgcc catggccatc gccatctccc tcagcctggc
      901 agctggtgcc tatattctgg tctccactgt gttaaccctc atggtacctt ggcacagcct
      961 agaccctgac tcggcgcttg ctgatgcttt ctacaggcgg ggttacagct gggctggctt
     1021 cattgtggca gttggctcta tctgtgccat gaacaccgtc ctgctcagca acctcttctc
     1081 cctgccgcgc attgtctacg ccatggctgc cgatgggctc ttcttccagg tgtttgcccg
     1141 tgtacacccc cggacacagg tgcctgtggt aggaatcctg gtgtttgggg tcctcatggc
     1201 cctcctggca ctgctgctgg accttgaggc actggtccag ttcctatcca tcggcaccct
     1261 gctggcctat acctttgtag ccaccagcat cattgtgctg cgtttccaaa aagcttctcc
     1321 acccagctcc ccttgcctag ccagccctgg ccccacagct aagaaatatg actccttttc
     1381 ggaccatata cagctagtgg gtgctgagca gacctcaatg tctgagcctg ggcagctgcg
     1441 gccagccctg aagcccttcc tgggcttcct ggatggatgc agccctggaa ccgccgtggc
     1501 ctgggcgctt ggcatcttgg tagcctcggc tatctctctg gcgtgtgtgc tggtcttcgg
     1561 gaactcagac ctgcacctcc cacagtgggg ctatgtcttg ctgctggtca tcagtggtgc
     1621 tgtctttctg tccagcctcc tggtcctggg ggctcatcag cagcaaaaga agcaagacac
     1681 tttccagatc cctttggtgc ccctgactcc agccctgagc atccttctca acacttgcct
     1741 catgctgaag ctgagctacc tgacctggct acgctttatc ttctggctgc tggtcggact
     1801 tgtcgtgtat tttggctatg gcatctggca cagcaaggag aaccagaggg agccattgga
     1861 gctgactaca gcacactacg tggtattccc cagcggtagc ctggaggaaa ctgtgcaagc
     1921 tgtgcagccc tctagtcaat caccagtccg ggagtcaggt tgtactgagt agctggccac
     1981 ggaggcttgc tcatggaggt ctccatcccc aacatccaga ggccagaaga attggcagct
     2041 gcctacttaa ggaagcttgg gtttgaagcc tgcccagact gggctgggag tgttctcaga
     2101 gtctcaacac aggaacggag tcttcggcta tcatggacta ggctgaggct agtgctggtg
     2161 tggactcgtt gcccactgtc ttcctgttta tgattaactc tggatacctg ggcaggtggg
     2221 gcagagtggg cagggaagtg gcttcagccc ctgagaccca gaataataac taatcagcta
     2281 gtgttgtgac cagctgtcat gtacactgtg gtattcttca tagctctgag ttctcacctg
     2341 cctggagaac caagcagttg ttcctagtcc acagcagaga cacagaaggc ctgtcaaaga
     2401 ctttctgagg aggaaagttc catgcatgat gtgaagaggg ttatatgaca agacaggaac
     2461 agatttctga catgttctca gcagcgtgtg catgtgcatg cgtgtgtgca cacatgtatg
     2521 ttcatatgtg agtgtgtgag tacgtgtgtg gtgtgcgcac acgcatatgc acatgtggta
     2581 cttgaggtgg gagccagggc cttgagattg ttagacaagc attccactac tgacatatac
     2641 acccccctcc cccagatccc tgacatgttc tctagcaggg aatatctatc acaatctgga
     2701 tttaaaatgg gtaactcaaa aagacattgg atgtcaggat cttttgattt tcctgggctt
     2761 ccaggaaaca tgtgcccaag gtctgcttag ggccactgaa atgcactgaa caagcaatgc
     2821 ccccaagaca ctctccccag cacattcttg cacgctcagg gcagccaccc ttgcagtaca
     2881 cactatgtac agagtgaatt gactgatgtt tccaaattca ggctcctggc cacagctctt
     2941 attgcctccg tatcccctgg aaatgttttc agatggatcc cttgggttct ctgctaccta
     3001 gtaatctcca gggcaacagt gtccctggaa ggtgggcttg gattagtgca tgagtgatac
     3061 acttgggtat gcacaggtac ttggacttgc agccactact tctagcctac ggctacagtt
     3121 cagagaagga gaaagcccta ggtctactct gaacctcctg ctggggttcc catggctgga
     3181 ccatctccct ttccttgttt ctccctttaa ggactacaca ggactactac t
//
