LOCUS       NM_001301840            2277 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 3 (Slc7a3), transcript variant 2,
            mRNA.
ACCESSION   NM_001301840 XM_006527752
VERSION     NM_001301840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Yan,Y., Chen,C., Li,Z., Zhang,J., Park,N. and Qu,C.K.
  TITLE     Extracellular arginine is required but the arginine transporter
            CAT3 (Slc7a3) is dispensable for mouse normal and malignant
            hematopoiesis
  JOURNAL   Sci Rep 12 (1), 21832 (2022)
   PUBMED   36528691
  REMARK    GeneRIF: Extracellular arginine is required but the arginine
            transporter CAT3 (Slc7a3) is dispensable for mouse normal and
            malignant hematopoiesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Lowman,X.H., Hanse,E.A., Yang,Y., Ishak Gabra,M.B., Tran,T.Q.,
            Li,H. and Kong,M.
  TITLE     p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by
            Upregulating Slc7a3 to Increase Arginine Uptake
  JOURNAL   Cell Rep 26 (11), 3051-3060 (2019)
   PUBMED   30865893
  REMARK    GeneRIF: Slc7a3 expression is significantly induced by p53 upon
            glutamine deprivation.
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Magarin,M., Pohl,T., Lill,A., Schulz,H., Blaschke,F., Heuser,A.,
            Thierfelder,L., Donath,S. and Drenckhahn,J.D.
  TITLE     Embryonic cardiomyocytes can orchestrate various cell protective
            mechanisms to survive mitochondrial stress
  JOURNAL   J Mol Cell Cardiol 97, 1-14 (2016)
   PUBMED   27106802
REFERENCE   6  (bases 1 to 2277)
  AUTHORS   Raefski,A.S., Carone,B.R., Kaur,A., Krueger,W. and O'Neill,M.J.
  TITLE     Wnt pathway anomalies in developing amygdalae of Turner
            syndrome-like mice
  JOURNAL   J Mol Neurosci 32 (2), 111-119 (2007)
   PUBMED   17873295
REFERENCE   7  (bases 1 to 2277)
  AUTHORS   Bae,S.Y., Xu,Q., Hutchinson,D. and Colton,C.A.
  TITLE     Y+ and y+ L arginine transporters in neuronal cells expressing
            tyrosine hydroxylase
  JOURNAL   Biochim Biophys Acta 1745 (1), 65-73 (2005)
   PUBMED   16085056
  REMARK    GeneRIF: In a neuronal cell model, y+,L and y+ transport systems
            are the predominant form of arginine uptake mechanisms and the
            transport of arginine is altered by membrane potential and redox
            factors.
REFERENCE   8  (bases 1 to 2277)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2277)
  AUTHORS   Nicholson,B., Sawamura,T., Masaki,T. and MacLeod,C.L.
  TITLE     Increased Cat3-mediated cationic amino acid transport functionally
            compensates in Cat1 knockout cell lines
  JOURNAL   J Biol Chem 273 (24), 14663-14666 (1998)
   PUBMED   9614060
REFERENCE   10 (bases 1 to 2277)
  AUTHORS   Ito,K. and Groudine,M.
  TITLE     A new member of the cationic amino acid transporter family is
            preferentially expressed in adult mouse brain
  JOURNAL   J Biol Chem 272 (42), 26780-26786 (1997)
   PUBMED   9334265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK141558.1 and AK077593.1.
            
            On Sep 19, 2014 this sequence version replaced XM_006527752.1.
            
            Summary: The protein encoded by this gene is a member of the system
            y+ cationic amino acid transporter family. Proteins of this family
            allow uptake of arginine from extracellular media. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077593.1, AK165931.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AK141558.1         3-136
            135-2265            AK077593.1         106-2236
            2266-2277           AK141558.1         2709-2720
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.72 cM"
     gene            1..2277
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 3"
                     /db_xref="GeneID:11989"
                     /db_xref="MGI:MGI:1100521"
     exon            1..134
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            135..538
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2025
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /note="amino acid transporter, cationic 3; solute carrier
                     family 7 member 3; cationic amino acid transporter y+"
                     /codon_start=1
                     /product="cationic amino acid transporter 3"
                     /protein_id="NP_001288769.1"
                     /db_xref="CCDS:CCDS30309.1"
                     /db_xref="GeneID:11989"
                     /db_xref="MGI:MGI:1100521"
                     /translation="MLWQALRRFGQKLVRRRVLELGMGETRLARCLSTLDLVALGVGS
                     TLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPGSGSAYLYSY
                     VTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISRTLKGTILLKMPHVL
                     AEYPDFFALALVLLLTGLLVLGASKSALVTKVFTGMNLLVLSFVIISGFIKGELRNWK
                     LTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFYAFVGFDCIATTGEE
                     AQNPQRSIPMGIVISMFICFLAYFGVSSALTLMMPYYKLHPESPLPEAFSYVGWEPAR
                     YLVAIGSLCALSTSLLGSMFPMPRVMYSMAEDGLLFRVLAKVHSVTHIPIVATLVSGV
                     IAAFMAFLFELTDLVDLMSIGTLLAHSLVSICVLILRYQPDQEMKSVEEEMELQEETL
                     EAEKLTVQALFCPVNSIPTLLSGRVVYVCSSLLAVLLTVLCLVLTWWTTPLRSGDPVW
                     VTVVVLILGLILAISGVIWRQPQNRTPLHFKVPAVPLLPLVSIFVNVYLMMQMTAGTW
                     ARFGIWMLIGFAIYFGYGIQHSMKEVKNHQTLPKTRAQTIDLDLTTSCVHSI"
     exon            539..697
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..875
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..988
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1211
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1351
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1454
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1618
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1785
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1894
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2277
                     /gene="Slc7a3"
                     /gene_synonym="Atrc3; CAT-3; CAT3; SLC7A1; SLC7A2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatataagg ggcgcttggc ttgcaaggac cctgagctgc ggcattgaag cacacccaac
       61 ccaactcgac tgaagtcagc ctcactgaac cggatctgag aatcttctct ctctgggctt
      121 gccagggctc tccgaaccta gctagcatcc tcttcaattc caactagaat gctgtggcag
      181 gcacttcgaa gatttggtca aaagctggtg cggagacgtg tgttggagct gggtatgggt
      241 gagacccgcc ttgccagatg cctgagcacc ctcgacttag tggctctggg tgtgggcagc
      301 acattaggtg caggtgtgta tgtcctggct ggagaggtgg ccaaagataa agcaggacca
      361 tccattgtga tctgcttttt ggtggctgct ctgtcctctg tgttggctgg actgtgttat
      421 gctgaatttg gtgcccgggt ccccggctct ggttctgcat atctctacag ttatgtcacc
      481 gtaggtgaac tctgggcctt caccaccggc tggaatctca ttctctccta cgtcattggt
      541 acagccagtg tggcccgggc ttggagctct gcttttgaca acctgattgg aaaccacatc
      601 tctcggactc tgaaggggac catcttgctg aagatgcctc atgttcttgc agaatatcca
      661 gatttctttg ccttggccct tgtgttgctg ctcactggat tgctggtttt aggggcaagt
      721 aaatcagccc tggttaccaa agtgttcaca gggatgaacc ttttggttct cagctttgtc
      781 atcatctctg gcttcattaa gggagaactg agaaactgga agctcacgaa agaggactat
      841 tgcttgacca tgagtgaatc caacggcact tgtagcttgg actctatggg ctctggaggt
      901 ttcatgcctt ttggcttgga agggattctc cgtggcgctg ctacctgttt ctatgccttc
      961 gttggttttg actgtattgc aaccaccgga gaagaggctc agaatcccca gcgctccatc
     1021 cccatgggta ttgtgatctc gatgttcatc tgctttttgg cttactttgg tgtgtcttca
     1081 gcacttaccc tcatgatgcc ttactacaag cttcatcctg agagccctct gcctgaagca
     1141 ttttcctatg ttggctggga gcctgcccgc tacttggtgg ctattggctc cctctgtgca
     1201 ctttctacta gccttttggg ctctatgttt cctatgcctc gggtgatgta ttcaatggca
     1261 gaagatggcc tcctgttccg tgtccttgct aaggttcaca gtgtcacaca tatacccatt
     1321 gtggccacct tggtatctgg tgttattgca gcattcatgg cattcctctt tgaactcact
     1381 gacctcgtgg acctcatgtc aatcgggact ctgcttgctc actccctggt gtccatttgt
     1441 gttctcatcc tcagatatca gcctgatcag gaaatgaaga gtgttgaaga ggaaatggaa
     1501 ttgcaagagg agacacttga agcagagaag ctgactgtcc aggctctatt ttgtcctgtc
     1561 aactccatcc ccacactcct ttctggccga gttgtctatg tttgctcctc actgcttgcc
     1621 gtactactaa ctgttctttg cctggtgctg acctggtgga caactccact tcgttctgga
     1681 gacccagtgt gggtcacagt ggttgtgctg atcctggggc tcattcttgc aatttctggg
     1741 gtcatctgga gacagccaca gaaccgcact ccccttcact ttaaggtgcc tgctgttcct
     1801 ctactcccac tggtgagcat ctttgtgaat gtttacctga tgatgcaaat gacagctggc
     1861 acttgggccc gatttgggat ctggatgctg attggatttg ctatctactt tggctatggg
     1921 atccaacaca gtatgaaaga agttaagaat catcaaactc tacccaaaac aagggcccaa
     1981 actatagacc ttgatctcac aacttcctgt gttcacagca tttgacctaa ccatacctaa
     2041 ttgttgtctt gttctcctat acaataatgg agagtactct tgaccccacg aagagctggg
     2101 cctctcatgt ggtgttagtg acggatatga aataatgctc tgtatttctt gtgaaatgat
     2161 ggctatgtct ttgctgtttc tcatttgttt ttaacttgta tactttgaaa tagtctctgt
     2221 agttgtttcc tggctttgaa aaaaatgtta ttaaaggaaa attgtaaaaa aaaaacc
//
