LOCUS       NM_028746               2134 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 7, (cationic amino acid
            transporter, y+ system) member 13 (Slc7a13), mRNA.
ACCESSION   NM_028746
VERSION     NM_028746.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Nagamori,S., Wiriyasermkul,P., Guarch,M.E., Okuyama,H.,
            Nakagomi,S., Tadagaki,K., Nishinaka,Y., Bodoy,S., Takafuji,K.,
            Okuda,S., Kurokawa,J., Ohgaki,R., Nunes,V., Palacin,M. and Kanai,Y.
  TITLE     Novel cystine transporter in renal proximal tubule identified as a
            missing partner of cystinuria-related plasma membrane protein
            rBAT/SLC3A1
  JOURNAL   Proc Natl Acad Sci U S A 113 (3), 775-780 (2016)
   PUBMED   26739563
  REMARK    GeneRIF: a membrane protein AGT1/SLC7A13 is the second partner of
            rBAT.
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Matsuo,H., Kanai,Y., Kim,J.Y., Chairoungdua,A., Kim,D.K.,
            Inatomi,J., Shigeta,Y., Ishimine,H., Chaekuntode,S., Tachampa,K.,
            Choi,H.W., Babu,E., Fukuda,J. and Endou,H.
  TITLE     Identification of a novel Na+-independent acidic amino acid
            transporter with structural similarity to the member of a
            heterodimeric amino acid transporter family associated with unknown
            heavy chains
  JOURNAL   J Biol Chem 277 (23), 21017-21026 (2002)
   PUBMED   11907033
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Blondeau,J.P.
  TITLE     Homologues of amino acid permeases: cloning and tissue expression
            of XAT1 and XAT2
  JOURNAL   Gene 286 (2), 241-248 (2002)
   PUBMED   11943479
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143768.1 and CK346971.1.
            
            On May 9, 2009 this sequence version replaced NM_028746.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128901.1, AB072352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1837              AK143768.1         3-1839
            1838-2134           CK346971.1         1-297               c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.63 cM"
     gene            1..2134
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /note="solute carrier family 7, (cationic amino acid
                     transporter, y+ system) member 13"
                     /db_xref="GeneID:74087"
                     /db_xref="MGI:MGI:1921337"
     exon            1..766
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1512
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /note="aspartate/glutamate transporter 1; X-amino acid
                     transporter 2; sodium-independent aspartate/glutamate
                     transporter 1"
                     /codon_start=1
                     /product="solute carrier family 7 member 13"
                     /protein_id="NP_083022.1"
                     /db_xref="CCDS:CCDS17993.1"
                     /db_xref="GeneID:74087"
                     /db_xref="MGI:MGI:1921337"
                     /translation="MAMDSKKEIRLKRELGYFWGTNFLIINIIGAGIFVSPKGVLQHS
                     SMNVGVSLCVWAVCAVLTLTSALCSAEIGITFPYSGAHYYFLKRCFGPLVAFLRLWTS
                     LFLGPGLIASQALLLAEYGVQPFYPSCSAPILPRKCLALAMLWIVGILNSRGVKELSW
                     LQTVSSVLKVGILGVISLSGLFLLVRGKKENVQRLQNAFDAEFPEVSQLIEAIFQGYF
                     AFSGGGCFTCIAGELKKPSKTIPRCIFTGLPLVTVVYLLANISYLTVLTPQEMLSSDA
                     VALTWTDRVIPQFTWTVPFAISASLFINLVINVLETSRVLYIASENGQLPLLFCALNV
                     HSSPFIAVLLIISMASILIVLTNLIDLINYLYFVVSIWTALSIIGILKLRYQEPNLHR
                     PYKVFLPFTFIALGITLSLVLIPLVKSPKLHYIYVFLFLLSGLVFYVPLIHFKVKFVW
                     FQKLTCYLQLLFNICIPDVSDDHIHEES"
     exon            767..898
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1260
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..2134
                     /gene="Slc7a13"
                     /gene_synonym="0610009O04Rik; AGT-1; AGT1; XAT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatttcaaa gcatccacaa acctataggc agaaacattc acagagtaca attttgtgaa
       61 tgtaaacttc tctcaatggc aatggattca aagaaggaaa tccgtcttaa gagagaactt
      121 ggatatttct gggggacaaa ctttttaatt attaatataa ttggtgcagg aatatttgtg
      181 tcccccaagg gagtgctcca gcactcttcc atgaatgttg gagtctcctt gtgtgtttgg
      241 gctgtctgtg cagtgctgac cttgaccagt gctctctgct ctgcagagat cgggataacc
      301 ttcccataca gtggggctca ctattatttt ttaaagcgat gcttcggccc tctcgtggca
      361 ttcctgaggc tttggactag cttgtttctc ggcccaggct taattgctag ccaagctctg
      421 ctactggctg agtatggcgt tcagcctttt tatcccagct gctctgcccc gattctacca
      481 agaaaatgtc tggccctggc gatgctgtgg attgtgggaa ttctgaattc tcgtggtgta
      541 aaagagctgt catggcttca gacagtgagc tcagtgctga aggtgggcat actcggtgtc
      601 atttccctca gcggcctgtt cttgctggtg agagggaaga aggagaatgt acaaaggctt
      661 cagaatgcgt ttgatgccga gttcccagag gtctctcagt taatagaagc tattttccaa
      721 ggatactttg cgttttctgg cgggggatgc tttacatgta tagcagggga gctgaagaaa
      781 cccagtaaaa caattcctag atgcatcttt acaggactgc ctctggtaac tgtcgtgtac
      841 ttactggcta atatttccta cctgacagtt ctgacacccc aggaaatgct ctcttcagat
      901 gctgttgctc ttacatggac agacagggtc attccccaat tcacatggac tgttcctttt
      961 gctatttctg cttcactgtt tatcaacctt gtgattaatg tacttgagac atcaagagtg
     1021 ttatatattg caagtgagaa tggccagctg cctttgttgt tttgtgccct gaatgtccat
     1081 tcctctccct ttatagctgt gctactaatt atcagtatgg catccatttt aattgtctta
     1141 acaaacctaa ttgatctgat aaactatctc tattttgttg tttccatttg gactgcctta
     1201 tcaataatag gaatcttgaa actgaggtac caagagccca atctacacag accatataag
     1261 gtgtttttac cgttcacatt catagcgttg ggcatcaccc tgagcttggt tttgatcccg
     1321 cttgtcaagt ctccaaagtt gcattatatc tatgtgttcc tcttccttct cagtgggctg
     1381 gtgttttacg tgccattgat acactttaaa gtgaagttcg tttggtttca gaagttgact
     1441 tgctatctgc agttactgtt taatatttgc atccctgatg tgtctgatga ccacatacat
     1501 gaagaaagtt gaggaagaat agcctttgta gccatactgt gttccagata aaggttaagt
     1561 gtaagctaaa atagtaatga tggcaatgct ataaactgaa atggtatata gaaaagtacc
     1621 caggaaattc ctagttttta aaatatcaaa ggaaatggct gggtagatga ctgtgctgtt
     1681 aagggcacca gatgtccttc caggggactg aagttcaatt cacaggcccc acttagaagt
     1741 tcataactat ctgtaattct agtcacagag gatccaatat cctctactgg attctaccag
     1801 cactgcatgc atctggagta gagacataca tgtaggcacc catgcacatt tacaagaaga
     1861 aagaaagaga gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagggaga
     1921 gggagagagg aaggaaggaa ggaaataagg aaagaaggaa ggaggaaaga aagacagtaa
     1981 agaaagtatt tcacataact aaactgtttt tattaaaaat aaaatttcta gcttgtatag
     2041 cttcatgtag taagaatatc tttctcattc ttctgtttat ctcatcgatt ttctactgaa
     2101 tgtattctta taataaaagt tactgatgga aatt
//
