LOCUS       NM_080852               1730 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 12 (Slc7a12), mRNA.
ACCESSION   NM_080852
VERSION     NM_080852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Haller,M., Mo,Q., Imamoto,A. and Lamb,D.J.
  TITLE     Murine model indicates 22q11.2 signaling adaptor CRKL is a
            dosage-sensitive regulator of genitourinary development
  JOURNAL   Proc Natl Acad Sci U S A 114 (19), 4981-4986 (2017)
   PUBMED   28439006
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Blondeau,J.P.
  TITLE     Homologues of amino acid permeases: cloning and tissue expression
            of XAT1 and XAT2
  JOURNAL   Gene 286 (2), 241-248 (2002)
   PUBMED   11943479
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Chairoungdua,A., Kanai,Y., Matsuo,H., Inatomi,J., Kim,D.K. and
            Endou,H.
  TITLE     Identification and characterization of a novel member of the
            heterodimeric amino acid transporter family presumed to be
            associated with an unknown heavy chain
  JOURNAL   J Biol Chem 276 (52), 49390-49399 (2001)
   PUBMED   11591708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163676.4 and AC131593.16.
            
            On Aug 15, 2018 this sequence version replaced NM_080852.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055005.1, AJ417663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               AC163676.4         218444-219204
            762-893             AC131593.16        129616-129747
            894-1255            AC131593.16        131439-131800
            1256-1730           AC131593.16        137735-138209
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.05 cM"
     gene            1..1730
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 12"
                     /db_xref="GeneID:140918"
                     /db_xref="MGI:MGI:2156159"
     exon            1..761
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1498
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /note="Asc-2,asc-type amino acid transporter 2; X-amino
                     acid transporter 1"
                     /codon_start=1
                     /product="solute carrier family 7 member 12"
                     /protein_id="NP_543128.1"
                     /db_xref="CCDS:CCDS17246.1"
                     /db_xref="GeneID:140918"
                     /db_xref="MGI:MGI:2156159"
                     /translation="MQLLRALGVFHVSMILFSATLGTGIFVTPKAVLKYSSLNIPVSL
                     SIWAGCGLLSIMSALCNAEIATTYPLSGASYYFLKRTLGSSVAFLSLWIKLFAHFLGI
                     GAQCLLIATSVIQCFYSGCPAPELPTKCLALAILWSFGIVSARGIKTVAWFNTVSSFI
                     KLSVLCLISLTVLLVNGKKENVSRFENALDAELPNASQIADAILQVSYSYLGSSVLIV
                     IAGEIKRPTETIPKTLIYGISIVTVLYLLTNISYLAVLTSQEIIFSDSVGVTWMNRVF
                     PSIQWISSFLISAFLLGSVSCGIVSASRVFYSASQEGEFPSIYSMLNDHHSPAVADIQ
                     IVILSSVAIISSSIIYLVKYVSLGSFCINLLQMIGLLKIRYQNPDIPRPYKVWLPFIF
                     GSIALSLFLIFTPVIQSPSIEHVYQVVFLFCGFLCYWLQANLNGHATCFDTITCYCQL
                     LFNISPSEDPEEQKN"
     exon            762..893
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1255
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1730
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1730
                     /gene="Slc7a12"
                     /gene_synonym="Asc-2; XAT-1; XAT1"
                     /note="major polyA site"
ORIGIN      
        1 gcaacaccct gtttgacagg gtttttcaca aactgacaga aaagcaccat aaagaaaaac
       61 tgtatttttc agtatttgaa agagcaaaaa aggcataacc atgcaactct tgagagcact
      121 aggagtcttc catgtaagca tgatcttatt tagtgccacc ctggggacag ggatttttgt
      181 gactcctaaa gcagtattaa aatactcctc actaaatatc cctgtctcct taagtatttg
      241 ggcaggctgc ggcctgctga gcatcatgag tgcgctctgt aatgcagaga tagcaaccac
      301 ctaccctttg agtggagcat cttattattt cctcaagaga actcttggat cctctgttgc
      361 ttttctcagt ctctggatta aactttttgc tcactttcta ggcattggtg ctcagtgctt
      421 gctaatagct acttctgtaa tccagtgttt ctattctggg tgcccagctc cagagctacc
      481 aacgaaatgt ctggctttgg ctattttgtg gtcatttgga attgtcagtg ctcgagggat
      541 aaaaacagtg gcttggttta atactgtcag cagtttcatc aagttgagtg tcctttgtct
      601 catttctcta actgtgctgt tagtgaatgg caaaaaggag aatgtgtcca ggtttgagaa
      661 tgctttggat gctgaacttc ctaatgcctc acagatcgca gatgccattc tccaagtgtc
      721 ctactcatat ctaggatcat cagtcctcat cgtcatagca ggagaaataa aacggccaac
      781 tgaaacaatt ccaaaaacac taatttatgg tatatccatt gtgactgtgt tatacttact
      841 gactaatata tcatacttgg cagttttgac atcccaggaa atcatctttt cagattctgt
      901 tggtgtcaca tggatgaaca gagtctttcc ttccatacaa tggataagtt cattcttgat
      961 ctcagctttc ctacttggct ccgtttcttg tggaatagtt tctgcatcaa gagtattcta
     1021 ctctgcaagt caagagggag aatttccttc tatctactca atgcttaatg atcatcactc
     1081 accagctgta gctgacatcc agattgttat tttatcttct gttgcaataa tatcttcaag
     1141 tatcatctat ttagtgaaat atgttagtct aggatcattt tgtataaatt tgctgcaaat
     1201 gatcgggttg cttaagataa ggtaccagaa ccctgatata ccaagacctt ataaggtgtg
     1261 gctgccattt atatttggat ctatagcttt atcacttttc ctcattttca caccagtgat
     1321 tcagtctcct agtatagagc atgtctatca agttgtgttt cttttttgtg ggtttctgtg
     1381 ttattggctt caagctaacc ttaatggaca tgctacttgt tttgacacaa tcacttgcta
     1441 ctgccaatta cttttcaata tctccccatc tgaagatcca gaagaacaga aaaattaatt
     1501 ccttctccaa atcctgacta aagaagtata tttgaaaaga aagaagcaaa actattttta
     1561 aatgagcaaa attttattgc aattttattt ttagatatat atgctttaac atgcttgctc
     1621 acattattcc cacccaaaaa aaaaatgttg caaattttca attccacctc ataaacatct
     1681 ttattctatg aataattagt agaaataaga ttaaaggtaa aaaacacaaa
//
