LOCUS       NM_017394               1967 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus solute carrier family 7 (cationic amino acid
            transporter, y+ system), member 10 (Slc7a10), mRNA.
ACCESSION   NM_017394
VERSION     NM_017394.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Jersin,R.A., Sri Priyanka Tallapragada,D., Skartveit,L.,
            Bjune,M.S., Muniandy,M., Lee-Odegard,S., Heinonen,S., Alvarez,M.,
            Birkeland,K.I., Andre Drevon,C., Pajukanta,P., McCann,A.,
            Pietilainen,K.H., Claussnitzer,M., Mellgren,G. and Dankel,S.N.
  TITLE     Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association
            With Insulin Resistance and Altered BCAA Metabolism
  JOURNAL   J Clin Endocrinol Metab 108 (9), 2217-2229 (2023)
   PUBMED   36916878
  REMARK    GeneRIF: Impaired Adipocyte SLC7A10 Promotes Lipid Storage in
            Association With Insulin Resistance and Altered BCAA Metabolism.
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Nakahara,K., Okuda,H., Isonishi,A., Kawabe,Y., Tanaka,T.,
            Tatsumi,K. and Wanaka,A.
  TITLE     Amino acid transporter Asc-1 (SLC7A10) expression is altered in
            basal ganglia in experimental Parkinsonism and L-dopa-induced
            dyskinesia model mice
  JOURNAL   J Chem Neuroanat 127, 102191 (2023)
   PUBMED   36403747
  REMARK    GeneRIF: Amino acid transporter Asc-1 (SLC7A10) expression is
            altered in basal ganglia in experimental Parkinsonism and
            L-dopa-induced dyskinesia model mice.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Suwandhi,L., Altun,I., Karlina,R., Miok,V., Wiedemann,T.,
            Fischer,D., Walzthoeni,T., Lindner,C., Bottcher,A., Heinzmann,S.S.,
            Israel,A., Khalil,A.E.M.M., Braun,A., Pramme-Steinwachs,I.,
            Burtscher,I., Schmitt-Kopplin,P., Heinig,M., Elsner,M., Lickert,H.,
            Theis,F.J. and Ussar,S.
  TITLE     Asc-1 regulates white versus beige adipocyte fate in a subcutaneous
            stromal cell population
  JOURNAL   Nat Commun 12 (1), 1588 (2021)
   PUBMED   33707431
  REMARK    GeneRIF: Asc-1 regulates white versus beige adipocyte fate in a
            subcutaneous stromal cell population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Jersin,R.A., Tallapragada,D.S.P., Madsen,A., Skartveit,L.,
            Fjaere,E., McCann,A., Lawrence-Archer,L., Willems,A., Bjune,J.I.,
            Bjune,M.S., Vage,V., Nielsen,H.J., Thorsen,H.L., Nedrebo,B.G.,
            Busch,C., Steen,V.M., Bluher,M., Jacobson,P., Svensson,P.A.,
            Ferno,J., Ryden,M., Arner,P., Nygard,O., Claussnitzer,M.,
            Ellingsen,S., Madsen,L., Sagen,J.V., Mellgren,G. and Dankel,S.N.
  TITLE     Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte
            Lipid Storage, Obesity, and Insulin Resistance
  JOURNAL   Diabetes 70 (3), 680-695 (2021)
   PUBMED   33408126
  REMARK    GeneRIF: Role of the Neutral Amino Acid Transporter SLC7A10 in
            Adipocyte Lipid Storage, Obesity, and Insulin Resistance.
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Neame,S., Safory,H., Radzishevsky,I., Touitou,A., Marchesani,F.,
            Marchetti,M., Kellner,S., Berlin,S., Foltyn,V.N., Engelender,S.,
            Billard,J.M. and Wolosker,H.
  TITLE     The NMDA receptor activation by d-serine and glycine is controlled
            by an astrocytic Phgdh-dependent serine shuttle
  JOURNAL   Proc Natl Acad Sci U S A 116 (41), 20736-20742 (2019)
   PUBMED   31548413
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Xie,X., Dumas,T., Tang,L., Brennan,T., Reeder,T., Thomas,W.,
            Klein,R.D., Flores,J., O'Hara,B.F., Heller,H.C. and Franken,P.
  TITLE     Lack of the alanine-serine-cysteine transporter 1 causes tremors,
            seizures, and early postnatal death in mice
  JOURNAL   Brain Res 1052 (2), 212-221 (2005)
   PUBMED   16026768
  REMARK    GeneRIF: Lack of the alanine-serine-cysteine transporter 1 causes
            tremors, seizures, and early postnatal death in mice.
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Rehli,M., Poltorak,A., Schwarzfischer,L., Krause,S.W., Andreesen,R.
            and Beutler,B.
  TITLE     PU.1 and interferon consensus sequence-binding protein regulate the
            myeloid expression of the human Toll-like receptor 4 gene
  JOURNAL   J Biol Chem 275 (13), 9773-9781 (2000)
   PUBMED   10734131
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Fukasawa,Y., Segawa,H., Kim,J.Y., Chairoungdua,A., Kim,D.K.,
            Matsuo,H., Cha,S.H., Endou,H. and Kanai,Y.
  TITLE     Identification and characterization of a Na(+)-independent neutral
            amino acid transporter that associates with the 4F2 heavy chain and
            exhibits substrate selectivity for small neutral D- and L-amino
            acids
  JOURNAL   J Biol Chem 275 (13), 9690-9698 (2000)
   PUBMED   10734121
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Matsuo,H., Chairoungdua,A., Kim,D.K., Cha,S.H., Fukuda,J., Endou,H.
            and Kanai,Y.
  TITLE     Mouse Asc-1 (asc-type amino acid transporter 1) maps to chromosome
            7, region B1-B5
  JOURNAL   Chromosome Res 8 (5), 456 (2000)
   PUBMED   10997788
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150683.3 and BC054765.1.
            
            On May 1, 2009 this sequence version replaced NM_017394.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054765.1, AK031867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC150683.3         117133-117190
            59-1967             BC054765.1         2-1910
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.13 cM"
     gene            1..1967
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 10"
                     /db_xref="GeneID:53896"
                     /db_xref="MGI:MGI:1858261"
     exon            1..266
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            267..471
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            472..623
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            624..749
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            750..903
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1027
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1131
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1228
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1378
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1556
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1950
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1; D7Bwg0847e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccgggct gcgagggccg cgagcgcacc gacagacgaa ccgaccgacg gaggactggc
       61 tgcgggccgg acagacgggg tagcgcaggg aactgggatg aggcgggaca gcgacatggc
      121 aagccacata caacagccag gcgggcacgg gaaccccggc cctgcgccct cgccttcccc
      181 gggccctggt cccggcccgg gcgcctcgga gcgggtggca ctcaagaaag agatcgggct
      241 ggtgagcgct tgcaccatca tcatcgggaa catcattggc tcaggcatct tcatctcacc
      301 caagggtgtc ctggaacact cgggctccgt gggtttggcc ctcttcgtct gggtcctggg
      361 tgggggcgtg acagctctgg gctctctctg ctatgcagag ctgggtgtcg ccatccccaa
      421 gtctggtggg gactacgcct atgtcactga gatcttcggg ggcctggctg gattcctact
      481 gctctggagt gctgtcctca tcatgtaccc caccagcctg gctgtcatct ccatgacctt
      541 ctccaactat gtgcttcagc ctgtctttcc caactgtatc cccccagcca cagcctctcg
      601 agtactctcc atggcctgcc tgatgctcct gacgtgggtg aacagctcca gcgtacgctg
      661 ggccacgcgc atccaggtta tcttcactgg tgggaagctg ctggcgctgt ctctcatcat
      721 cactgttggc tttgtccaga tcttccaagg acactttgaa gagctgagac ccaccaatgc
      781 cttcgccttc tggatgacac cgtctgtggg tcacctggcc ctggctttcc tccaaggttc
      841 ttttgccttc agtggctgga acttcctcaa ctatgtcacg gaggagctgg ttgacccacg
      901 caagaaccta cctcgtgcca tcttcatttc catcccactg gtcacctttg tgtacacatt
      961 caccaatgtc gcctacttca ctgccatgtc cccccaggag ttgctgtcct ccaacgccgt
     1021 ggcggtgacc ttcggcgaga agctgctggg ctacttttcg tgggtcatgc ccgtctctgt
     1081 ggccctctct acttttggag ggatcaatgg ctacctgttc acctcatcca ggctatgctt
     1141 ctctggagcc cgagagggac acttacccag cttcctggcc atgattcatg tcagacgctg
     1201 caccccaatc cctgccctcc ttgtctgttg cggggccaca gcggtcatca tgctcgtggg
     1261 tgacacatac acactcatca actatgtgtc cttcatcaac tacctctgct acggagtcac
     1321 tatcctgggc ctgcttgtgc tgcgctggag acggccggca ctccacaggc ccattaaggt
     1381 gaacctcctc gttcctgttg tgtacttggt gttctgggca ttcctactgg tcttcagctt
     1441 catctcggag cccatggtct gtggggtcgg catcatcatt atcctcactg gggttcccat
     1501 cttcttcctg ggagtgttct ggagaagcaa accaaagtgt gtacacagat tcacagagtc
     1561 catgacacgc tggggccagg agctgtgttt cgtggtttac ccccagggct ccctagagga
     1621 ggaggaaaat ggccccatgg gccagccctc cccattgccc atcacggaca agcccttgaa
     1681 gacacaatga gaccttgtag agactggaac agccgattct gtttacatgt tgtttattga
     1741 gaagggggtt gtgttttgtt ttgttttcaa aaattttttt tctgcaaaaa aagagagaga
     1801 gagagagaga gagagagaga aagagagacc caacccttag aggcctattg taagggactg
     1861 gccactgggg tcgggcttcc tgccttagca atgccctgct agcttctcca gaaatgcctg
     1921 taaataaaca gggctggttg ttgctgtgtg aaaaaaaaaa aaaaaaa
//
