LOCUS       NM_001142809            3977 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            creatine), member 8 (Slc6a8), transcript variant 2, mRNA.
ACCESSION   NM_001142809
VERSION     NM_001142809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Kuribayashi,S., Fukuhara,S., Kitakaze,H., Tsujimura,G., Imanaka,T.,
            Ueda,N., Takezawa,K., Ikawa,M. and Nonomura,N.
  TITLE     Intratesticular creatine maintains spermatogenesis by defining
            tight junctions
  JOURNAL   Sci Rep 14 (1), 30692 (2024)
   PUBMED   39730393
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3977)
  AUTHORS   Sawant,H., Selvaraj,R., Manogaran,P. and Borthakur,A.
  TITLE     Intestinal Epithelial Creatine Transporter SLC6A8 Dysregulation in
            Inflammation and in Response to Adherent Invasive E. coli Infection
  JOURNAL   Int J Mol Sci 25 (12), 6537 (2024)
   PUBMED   38928243
  REMARK    GeneRIF: Intestinal Epithelial Creatine Transporter SLC6A8
            Dysregulation in Inflammation and in Response to Adherent Invasive
            E. coli Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3977)
  AUTHORS   Sugimoto,C., Perna,M.K., Regan,S.L., Tepe,E.A., Liou,R.,
            Fritz,A.L., Williams,M.T., Vorhees,C.V. and Skelton,M.R.
  TITLE     A Gad2 specific Slc6a8 deletion recapitulates the contextual and
            cued freezing deficits seen in Slc6a8-/y mice
  JOURNAL   Brain Res 1825, 148690 (2024)
   PUBMED   38030104
  REMARK    GeneRIF: A Gad2 specific Slc6a8 deletion recapitulates the
            contextual and cued freezing deficits seen in Slc6a8[-/y] mice.
REFERENCE   4  (bases 1 to 3977)
  AUTHORS   Mabondzo,A., Harati,R., Broca-Brisson,L., Guyot,A.C., Costa,N.,
            Cacciante,F., Putignano,E., Baroncelli,L., Skelton,M.R., Saab,C.,
            Martini,E., Benech,H., Joudinaud,T., Gaillard,J.C., Armengaud,J.
            and Hamoudi,R.
  TITLE     Dodecyl creatine ester improves cognitive function and identifies
            key protein drivers including KIF1A and PLCB1 in a mouse model of
            creatine transporter deficiency
  JOURNAL   Front Mol Neurosci 16, 1118707 (2023)
   PUBMED   37063368
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3977)
  AUTHORS   Ghirardini,E., Sagona,G., Marquez-Galera,A., Calugi,F.,
            Navarron,C.M., Cacciante,F., Chen,S., Di Vetta,F., Dada,L.,
            Mazziotti,R., Lupori,L., Putignano,E., Baldi,P.,
            Lopez-Atalaya,J.P., Pizzorusso,T. and Baroncelli,L.
  TITLE     Cell-specific vulnerability to metabolic failure: the crucial role
            of parvalbumin expressing neurons in creatine transporter
            deficiency
  JOURNAL   Acta Neuropathol Commun 11 (1), 34 (2023)
   PUBMED   36882863
  REMARK    GeneRIF: Cell-specific vulnerability to metabolic failure: the
            crucial role of parvalbumin expressing neurons in creatine
            transporter deficiency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3977)
  AUTHORS   Acosta,M.L., Kalloniatis,M. and Christie,D.L.
  TITLE     Creatine transporter localization in developing and adult retina:
            importance of creatine to retinal function
  JOURNAL   Am J Physiol Cell Physiol 289 (4), C1015-C1023 (2005)
   PUBMED   15930147
REFERENCE   7  (bases 1 to 3977)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3977)
  AUTHORS   Ohtsuki,S., Tachikawa,M., Takanaga,H., Shimizu,H., Watanabe,M.,
            Hosoya,K. and Terasaki,T.
  TITLE     The blood-brain barrier creatine transporter is a major pathway for
            supplying creatine to the brain
  JOURNAL   J Cereb Blood Flow Metab 22 (11), 1327-1335 (2002)
   PUBMED   12439290
REFERENCE   9  (bases 1 to 3977)
  AUTHORS   Taketo,M.M., Araki,Y., Matsunaga,A., Yokoi,A., Tsuchida,J.,
            Nishina,Y., Nozaki,M., Tanaka,H., Koga,M., Uchida,K., Matsumiya,K.,
            Okuyama,A., Rochelle,J.M., Nishimune,Y., Matsui,M. and Seldin,M.F.
  TITLE     Mapping of eight testis-specific genes to mouse chromosomes
  JOURNAL   Genomics 46 (1), 138-142 (1997)
   PUBMED   9403069
REFERENCE   10 (bases 1 to 3977)
  AUTHORS   Nash,S.R., Giros,B., Kingsmore,S.F., Rochelle,J.M., Suter,S.T.,
            Gregor,P., Seldin,M.F. and Caron,M.G.
  TITLE     Cloning, pharmacological characterization, and genomic localization
            of the human creatine transporter
  JOURNAL   Recept Channels 2 (2), 165-174 (1994)
   PUBMED   7953292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB245363.1, AF459435.1, AB077327.1 and BC029000.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 2.
            The resulting isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077327.1, SRR11927937.5097787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CB245363.1         1-17
            18-665              AF459435.1         1-648
            666-2647            AB077327.1         14-1995
            2648-3977           BC029000.1         1411-2740
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.38 cM"
     gene            1..3977
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, creatine), member 8"
                     /db_xref="GeneID:102857"
                     /db_xref="MGI:MGI:2147834"
     exon            1..918
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..2564
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium- and chloride-dependent creatine transporter 1;
                     solute carrier family 6, member 8; creatine transporter,
                     solute carrier family 6, member 8"
                     /codon_start=1
                     /product="sodium- and chloride-dependent creatine
                     transporter 1 isoform 2"
                     /protein_id="NP_001136281.1"
                     /db_xref="CCDS:CCDS53098.1"
                     /db_xref="GeneID:102857"
                     /db_xref="MGI:MGI:2147834"
                     /translation="MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPG
                     GRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGG
                     IPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLV
                     KSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKV
                     LRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLL
                     VRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFN
                     NNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRA
                     VTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALC
                     CALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIA
                     CMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFAL
                     SSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSE
                     SSKVVVVESVM"
     exon            919..1050
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1300
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1433
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1568
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1672
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1797
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1910
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2048
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2151
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2252
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2423
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..3966
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3942..3947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /note="hexamer: AATAAA"
     polyA_site      3966
                     /gene="Slc6a8"
                     /gene_synonym="Creat; CRT; CRTR; CT1; CTR5"
                     /note="major polyA site"
ORIGIN      
        1 gttcttaagc agcagcgggt cgcgtcggga aagagaggga cagttggagt gccaaggcga
       61 gtctttgagt ccgccgcggc ccggagagcg gctgtagccg ccgccgccgg gaaggagggg
      121 gctagtcgta cccgggacca ccggagccgc cagcgccagg agagccgcaa gcgaacagga
      181 cagccacttg gggctgggcc ggggccgcgg gcctcaggcc ccttgctccg gccgccgctt
      241 gcagacagtg ggcttccgat gccacccgcg acgcgctagg gtgagcctcc ggcagggcga
      301 gcagtcctcg ctgcagccgc caccgccgcc cgagccgcgg gcaggagtct cgggagccgc
      361 cgccgcccgg ccaggctcca ccgccgcccg cgcgctcccg ggcccccgac acacatgaga
      421 ttcttcaggc tcactttcaa gtgcttcgtg gactgcttct gactgcgccg cccccgccgt
      481 cccgcacccc tcccgcccac ccgtcgcccc gtcccccggc ccggccgccc ccgaggcccc
      541 cgggcgggcc cgcgctttcg gggccctctc tccaggtgcc accggagccc cctcgcccgc
      601 ccgccaccct cgaggcgccg cgacccccgg cccggcctca cggccccgct ggggccatgg
      661 cgaaaaagag cgctgaaaac ggtatctata gcgtgtctgg tgacgagaag aagggtcctc
      721 tcatcgtgtc cgggcccgac ggtgccccag ccaagggcga tggccctgcg ggcctggggg
      781 cgcctggcgg ccgccttgca gtgccaccgc gagagacttg gacacgccag atggacttca
      841 tcatgtcgtg cgtgggcttc gccgtgggcc tcggtaacgt gtggcgcttc ccctacctgt
      901 gctacaagaa cggcggaggt gtgttcctta ttccctatgt cctgattgcc ctggttggag
      961 gaatccccat tttcttcctg gaaatctcat tgggccagtt catgaaggcc ggcagcatca
     1021 atgtctggaa catctgtccc ctattcaaag gtctgggcta tgcctccatg gtgattgtct
     1081 tctactgcaa cacttactac atcatggtgc tggcctgggg cttctattac ctggtcaagt
     1141 cctttactac cactttgcca tgggctacat gtggccacac ctggaacact cctgactgtg
     1201 tggagatctt ccgccatgaa gactgtgcca atgccagcct ggccaacctc acatgtgacc
     1261 agcttgctga ccgccggtcc cctgtcatcg agttctggga gaacaaagta ttgaggctct
     1321 ccacggggct ggaggttcca ggagccctca actgggaggt gaccttgtgc ctgctggcct
     1381 gctgggtgct ggtctacttc tgtgtgtgga agggggtcaa gtcaacagga aagatcgtgt
     1441 acttcactgc tacattcccc tacgtggtcc tcgttgtgct gctggtgcga ggggtgctgc
     1501 tgcctggagc cctggatggt atcatctact atctcaagcc tgactggtca aagctagggt
     1561 cccctcaggt atggatagat gctgggaccc agattttctt ctcttatgcc ataggcctgg
     1621 gggccctcac agccctaggc agctacaatc gcttcaacaa caactgctac aaggatgcca
     1681 tcatcctggc actcatcaac agcgggacca gcttctttgc tggctttgtg gtcttctcca
     1741 tcctgggctt catggccaca gagcagggtg tgcatatctc caaggtggca gaatcagggc
     1801 ctggtctagc cttcattgcc tacccacggg ctgtcacact gatgcctgtg gccccactct
     1861 gggctgcctt gttcttcttc atgctgctgc tgctcggtct ggacagccag tttgtaggtg
     1921 tggagggctt cattaccggg ctcctggatc tcctcccggc ctcctactac ttccgtttcc
     1981 aaagggagat ctccgttgct ctctgctgcg ccctctgctt tgtcatcgat ctctccatgg
     2041 tgactgatgg tggaatgtac gtcttccagc tatttgacta ctactcagct agtggcacta
     2101 ccctgctttg gcaagccttt tgggagtgtg tagttgtggc ttgggtttat ggagctgacc
     2161 gcttcatgga tgacattgcc tgtatgattg ggtaccgacc ttgcccctgg atgaaatggt
     2221 gctggtcctt cttcacccca ttggtctgca tgggcatctt catcttcaac attgtgtact
     2281 acgagccact ggtctacaac aacacctacg tgtacccatg gtggggtgaa gctatgggct
     2341 gggcctttgc actctcttct atgctatgtg tacccctcca cctcctgggc tgtctcctca
     2401 gggcaaaagg aaccatggca gagcgatggc agcacctgac ccagcctatc tggggcctcc
     2461 atcacttgga atacagagct caggatgcag atgtcagggg cctgaccacc ctgactcccg
     2521 tgtccgagag cagcaaggtc gtcgtggtgg agagtgtcat gtaacaggca cccccagctc
     2581 acatcaccag ctcatccttt ggtagccata gcagccccaa ctttagcccc cactcatccc
     2641 tccgggggct tgcctttcct tgacagtttg ggggtctgcc tgggggaggg gagggagcac
     2701 catgagtgct aacaaaaata actttttcca tttttaataa aacgccaaaa atatcacaac
     2761 ccaccaaaaa tagatgcctc tcctccccac cccacaacta agctggtatt tgcattgctt
     2821 ccaggcccta cctcctctcc ttctttccag tgcccaggac ccatctccta gccttgccaa
     2881 gcccacctgc ctgcctccca agctctgctc tgtaacatac ctttgcccta gaaacaacag
     2941 tggcagcttg ggtaacagga gaggagggaa aataaggtag gacaggagga gaagagaggg
     3001 acagtggaac caatgtgaat attgcagctg aattagaccc ttcctacccc tattctagaa
     3061 gctagagagc cagtcagcaa tggaactttg tgttcctgcg ccaattgcca ccaatattaa
     3121 ctgtgtgagc ttgggtctga gtgcacaccc ccctctgtgt gtgtgtgtgt gtgtgtgtgt
     3181 gtatgtgtgt gtatgtgtag gtctgtagat ctcttatccc ttagtgaagg tgaataccag
     3241 aagtaaacac agcctctggg caaaggaggc ttatattttg cacattttat aagaaaaact
     3301 tgagagtgag acttctgctt gtatatttct aaaaagcccc caccatctcc acatttccac
     3361 tcctttcctt cacatcctca cctttcttct ctgaccctag ccaaggagtg tgaatttata
     3421 gacttaattt tcataggcaa aacaaaagct tcaggctgtt gagtatatat atgagtctgt
     3481 tgtatggatg ttctgtatgg tctccagcca gagactggag tgggaaagtg ggagcctcaa
     3541 tggtgtcccc acactgctcc tttgcctcta agtctgtggg acggaaggct gtaacactgt
     3601 tccagggaat ctgggtctgc tcacctgaca tgctcagact tgcccacacc cagctccctg
     3661 ggcaggattg cagggatttc ccatggacaa agcccgggaa agggatcctg ggcatggctc
     3721 ccacctccaa gctaaaaggc tgatgtactt tcgacatctc aagtcttccg tgtagcagct
     3781 taaacccaca tctgtgtccc atcaagcctg aaacagccaa gtagccctta gaaaggcttc
     3841 cttcacacag agctggacta agccagagag gtggggctgg gtaagggtgc aagcctttgg
     3901 ggacattctt actgtgctaa aaaagccact gcaaacatag caataaaaac acttcatttt
     3961 ccaaaaaaaa aaaaaaa
//
