LOCUS       NM_201353               3350 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            L-proline), member 7 (Slc6a7), transcript variant 1, mRNA.
ACCESSION   NM_201353 XM_140385
VERSION     NM_201353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Schulz,D., Morschel,J., Schuster,S., Eulenburg,V. and Gomeza,J.
  TITLE     Inactivation of the Mouse L-Proline Transporter PROT Alters
            Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required
            to Respond to Environmental Changes
  JOURNAL   Front Mol Neurosci 11, 279 (2018)
   PUBMED   30177871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Leone,D.P., Panagiotakos,G., Heavner,W.E., Joshi,P., Zhao,Y.,
            Westphal,H. and McConnell,S.K.
  TITLE     Compensatory Actions of Ldb Adaptor Proteins During Corticospinal
            Motor Neuron Differentiation
  JOURNAL   Cereb Cortex 27 (2), 1686-1699 (2017)
   PUBMED   26830346
REFERENCE   4  (bases 1 to 3350)
  AUTHORS   Amaniti,E.M., Fu,C., Lewis,S., Saisana,M., Magnani,D., Mason,J.O.
            and Theil,T.
  TITLE     Expansion of the piriform cortex contributes to corticothalamic
            pathfinding defects in Gli3 conditional mutants
  JOURNAL   Cereb Cortex 25 (2), 460-471 (2015)
   PUBMED   24014668
REFERENCE   5  (bases 1 to 3350)
  AUTHORS   Chou,S.J., Perez-Garcia,C.G., Kroll,T.T. and O'Leary,D.D.
  TITLE     Lhx2 specifies regional fate in Emx1 lineage of telencephalic
            progenitors generating cerebral cortex
  JOURNAL   Nat Neurosci 12 (11), 1381-1389 (2009)
   PUBMED   19820705
REFERENCE   6  (bases 1 to 3350)
  AUTHORS   Anas,M.K., Lee,M.B., Zhou,C., Hammer,M.A., Slow,S., Karmouch,J.,
            Liu,X.J., Broer,S., Lever,M. and Baltz,J.M.
  TITLE     SIT1 is a betaine/proline transporter that is activated in mouse
            eggs after fertilization and functions until the 2-cell stage
  JOURNAL   Development 135 (24), 4123-4130 (2008)
   PUBMED   19029042
  REMARK    GeneRIF: We assessed two candidates for the betaine/proline
            transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7).
            mRNA from both genes was present in eggs and 1-cell embryos.
REFERENCE   7  (bases 1 to 3350)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124431.4.
            
            On Mar 21, 2023 this sequence version replaced NM_201353.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057070.1, AK141581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC124431.4         130835-131064       c
            231-414             AC124431.4         126280-126463       c
            415-546             AC124431.4         124574-124705       c
            547-781             AC124431.4         124233-124467       c
            782-920             AC124431.4         122570-122708       c
            921-1055            AC124431.4         121247-121381       c
            1056-1159           AC124431.4         120345-120448       c
            1160-1284           AC124431.4         120099-120223       c
            1285-1397           AC124431.4         119184-119296       c
            1398-1529           AC124431.4         118981-119112       c
            1530-1629           AC124431.4         118428-118527       c
            1630-1730           AC124431.4         118150-118250       c
            1731-1898           AC124431.4         117280-117447       c
            1899-3350           AC124431.4         112238-113689       c
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..3350
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, L-proline), member 7"
                     /db_xref="GeneID:240332"
                     /db_xref="MGI:MGI:2147363"
     exon            1..230
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2111
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium-dependent proline transporter; solute carrier
                     family 6 member 7"
                     /codon_start=1
                     /product="sodium-dependent proline transporter isoform 1"
                     /protein_id="NP_958741.1"
                     /db_xref="CCDS:CCDS29278.1"
                     /db_xref="GeneID:240332"
                     /db_xref="MGI:MGI:2147363"
                     /translation="MKKLQEAHLRKPITPDLLMTPSDQGDVDLDVDFAADRGNWTGKL
                     DFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSS
                     LGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNW
                     WNTELCLEHRGPKSGNGVLPLNLSSTVSPSEEYWSRYVLHIQGSQGIGRPGEIRWNLC
                     LCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLT
                     PQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITS
                     ILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFML
                     LTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWL
                     VLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPA
                     TLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLW
                     ERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEV
                     DREIAEEEEESMM"
     exon            231..414
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            415..546
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            547..781
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            782..920
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1055
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1159
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1284
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1397
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1529
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1629
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1730
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1898
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..3350
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /note="hexamer: AATAAA"
     polyA_site      3350
                     /gene="Slc6a7"
                     /gene_synonym="PROT"
                     /note="major polyA site"
ORIGIN      
        1 agcctagggc gctgcgcagg gagaggcagg gcgttcgtag caccccacgc ccgcagcggc
       61 ctcacggcag cgcctgcgcc ctcccgagcc cgtgcgcggg agccgtgggg gcaaaggcgc
      121 agaggtagga ccagtgctcg gcgcccgctt ggctggctct ctgcgctctt gcaagctgcc
      181 cgcgccggct ctccaagatg aagaagctcc aagaagctca cctccgcaag cccatcaccc
      241 cagacctgct gatgactccc agtgaccagg gcgatgtgga cctggatgta gacttcgcag
      301 cagacagggg caactggacg ggcaagctgg acttcctgct gtcctgcatc ggctactgcg
      361 tgggcttggg aaatgtctgg cgctttccct accgagccta caccaatgga ggcggagcct
      421 tcctcgtgcc ctacttcctc atgctggcca tctgtggaat ccccctcttc tttcttgagc
      481 tctccctggg ccagttctcc agcctgggac ccctggctgt ctggaaaatc agccctctct
      541 ttaaaggtgc aggtgcggcc atgctgctca ttgtaggcct ggtggccatt tactacaaca
      601 tgattatcgc ctacgtcctc ttctacctct tcgcctccct caccagcaat ttgccctggg
      661 agcactgtgg caactggtgg aacacggagc tttgcctgga gcacagaggc cccaagagtg
      721 gtaatggggt gctgcctctt aacctcagca gcaccgtcag ccccagtgag gagtactgga
      781 gccgctatgt cctgcacata cagggcagcc agggcatcgg ccgaccgggg gagattcgct
      841 ggaacctctg cctctgcctg ctgctggcct gggtcatcgt gttcctctgt atcttgaagg
      901 gggtgaagtc ctcgggcaag gtggtgtatt tcacggccac ctttccctac ctcatcctcc
      961 tcatgctgct ggttcgagga gtgacccttc ccggggcctg gaagggcatc cagttctatc
     1021 tcacccccca gttccaccac ctgttatctt caaaggtgtg gattgaagct gctcttcaga
     1081 tcttttattc tctaggagtg ggctttgggg gtctcctcac ctttgcttcc tacaacacat
     1141 tccatcagaa catctacaga gacaccttca ttgtcactct gggcaatgcc atcactagca
     1201 tcctggctgg ctttgctatc ttctcggtgc tgggctacat gtctcaggag ctgggtgtgc
     1261 ccgtggacca agtggccaaa gcaggccctg gcctggcctt tgttgtctac ccacaggcca
     1321 tgaccatgtt gcctctgtca cctttctggt ccttcctctt cttcttcatg cttctgacgc
     1381 ttggcctgga tagccagttt gcctttctag aaaccatagt gactgcagtg actgatgagt
     1441 tcccatacta cctgcggccc aagaaggcag tgttctcagg actcatctgt gtggccatgt
     1501 acctgatggg actgattctc accactgatg ggggtatgta ctggctggtc cttttggatg
     1561 actacagcgc cagcttcgga ctcatggtgg tggtgatcac cacgtgcctc gctgtcaccc
     1621 gggtatatgg catccagcgg ttctgccgag atatccacat gatgctaggc ttcaagccag
     1681 gcctctactt cagggcctgc tggctgtttc tgtctccagc tacactcttg gccttgctgg
     1741 tgtacagcat cgtcaagtac cagccctcag aatatggcag ctatcgcttc cccgcctggg
     1801 ccgagctgct aggcatcctg atgggtctgc tctcttgcct catgatccca gctggtatgc
     1861 tggtagctgt gcttcgagag gagggctcgc tctgggagag acttcagcaa gccagtcggc
     1921 ctgctatgga ctggggccca tctctggaag agaaccggac gggaatgtat gtggccacac
     1981 tggctgggag ccagtcacca aagccactga tggtacacat gcgcaaatac gggggcatca
     2041 ccagcttcga gaacacggcc attgaggtgg accgtgagat cgcagaggag gaggaggagt
     2101 ctatgatgtg aggccagaga ccaccaaata ggagggctgg tcggggcctc acagtccctt
     2161 ccgtggcctg caggggattc tgacaggcaa tgggaggttg ccgtggcaac gacagtcccc
     2221 agcataagtc cctcttagtg gcctctacat ctcctggaac ctctatctag atggacatac
     2281 atacactagg taactcattc aaagctgaaa tgatccagct cagcccttgg tttgtgaggg
     2341 atgtgttgaa gccagggaga gaaggtctgg accaaagtca catgcccaag aggacctgtt
     2401 cccaagcctc cagccagcca actccctttc tctttggggg gagcaagcac catgtttgat
     2461 atcattgttc agacattttg acaagataca tttccataca agccaacttt aaacccccgg
     2521 ggtcagggta gtggaacgct ggagagtccc aaggtcctgg atagagagag ccagggagtg
     2581 aattgggcag aaaagtctct gtgggttcct atgttaaggc cagtttttcc agaagaggtg
     2641 ggagctttgg gggctgagag agatgaaaga ttgcagaaca tgcaggaggg aaggcttatg
     2701 ggtcagagct gccgctgggc caggaggagg cccaatctgc cagagcagag accaggagtg
     2761 gctggagatg ctgatgctcc caggttataa gagggaatga ggactattag cagggagggg
     2821 gagccagaaa ggcagggtgg ggggacttgc atggcactgt atagcatttt aggtctgttt
     2881 gggggtggat tagggacagg tatagaggtg ggaggactgt ggaggacagg agagaggtac
     2941 taatggctgg agttagatgc ttgggtggga gtgggtagag cccacccttc accgtttgga
     3001 taccatcctt gggctggcag gcgtcctgaa gagctcccac catggggata ggaatgagaa
     3061 atgagagttt tctcccttgc cgctgtggct tccaataaca atggctaccg agactctgag
     3121 gtggtccaca cgtcggacat cctgatgctg cagggcacct gacagggggc agcctctgtc
     3181 ctgggtccct gcgagatgct gttcaggtgt ggcccacgca ctgcattccc caggagagca
     3241 gggcacgttt catgcagcat atgacctaag agtgacctct ctcctggcct ctccccagcc
     3301 catttgtgtt cttctggtag gttgtcaata aatcccaaat ggcatcgtca
//
