LOCUS       NM_001146013            2549 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            glycine), member 5 (Slc6a5), transcript variant a, mRNA.
ACCESSION   NM_001146013
VERSION     NM_001146013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Lecoin L, Dempsey B, Garancher A, Bourane S, Ruffault PL,
            Morin-Surun MP, Rocques N, Goulding M, Eychene A, Pouponnot C,
            Fortin G and Champagnat J.
  TITLE     Mafa-dependent GABAergic activity promotes mouse neonatal apneas
  JOURNAL   Nat Commun 13 (1), 3284 (2022)
   PUBMED   35672398
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Locatelli F, Soda T, Montagna I, Tritto S, Botta L, Prestori F and
            D'Angelo E.
  TITLE     Calcium Channel-Dependent Induction of Long-Term Synaptic
            Plasticity at Excitatory Golgi Cell Synapses of Cerebellum
  JOURNAL   J Neurosci 41 (15), 3307-3319 (2021)
   PUBMED   33500277
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Turecek J and Regehr WG.
  TITLE     Cerebellar and vestibular nuclear synapses in the inferior olive
            have distinct release kinetics and neurotransmitters
  JOURNAL   Elife 9, e61672 (2020)
   PUBMED   33259288
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Mona B, Villarreal J, Savage TK, Kollipara RK, Boisvert BE and
            Johnson JE.
  TITLE     Positive autofeedback regulation of Ptf1a transcription generates
            the levels of PTF1A required to generate itch circuit neurons
  JOURNAL   Genes Dev 34 (9-10), 621-636 (2020)
   PUBMED   32241803
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Willett RT, Bayin NS, Lee AS, Krishnamurthy A, Wojcinski A, Lao Z,
            Stephen D, Rosello-Diez A, Dauber-Decker KL, Orvis GD, Wu Z,
            Tessier-Lavigne M and Joyner AL.
  TITLE     Cerebellar nuclei excitatory neurons regulate developmental scaling
            of presynaptic Purkinje cell number and organ growth
  JOURNAL   Elife 8, e50617 (2019)
   PUBMED   31742552
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Gomeza J, Ohno K, Hulsmann S, Armsen W, Eulenburg V, Richter DW,
            Laube B and Betz H.
  TITLE     Deletion of the mouse glycine transporter 2 results in a
            hyperekplexia phenotype and postnatal lethality
  JOURNAL   Neuron 40 (4), 797-806 (2003)
   PUBMED   14622583
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Jursky F and Nelson N.
  TITLE     Developmental expression of the glycine transporters GLYT1 and
            GLYT2 in mouse brain
  JOURNAL   J Neurochem 67 (1), 336-344 (1996)
   PUBMED   8667011
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Malandro MS and Kilberg MS.
  TITLE     Molecular biology of mammalian amino acid transporters
  JOURNAL   Annu Rev Biochem 65, 305-336 (1996)
   PUBMED   8811182
  REMARK    Review article
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Adams RH, Sato K, Shimada S, Tohyama M, Puschel AW and Betz H.
  TITLE     Gene structure and glial expression of the glycine transporter
            GlyT1 in embryonic and adult rodents
  JOURNAL   J Neurosci 15 (3 Pt 2), 2524-2532 (1995)
   PUBMED   7891186
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Jursky F and Nelson N.
  TITLE     Localization of glycine neurotransmitter transporter (GLYT2)
            reveals correlation with the distribution of glycine receptor
  JOURNAL   J Neurochem 64 (3), 1026-1033 (1995)
   PUBMED   7861131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC157997.1 and BC138126.1.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_001146013.2.
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157997.1, AY147186.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               BC157997.1         1-629
            630-2549            BC138126.1         551-2470
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..2549
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, glycine), member 5"
                     /db_xref="GeneID:104245"
                     /db_xref="MGI:MGI:105090"
     exon            1..83
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2480
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /note="isoform a is encoded by transcript variant a;
                     sodium- and chloride-dependent glycine transporter 2;
                     glyT-2; solute carrier family 6 member 5"
                     /codon_start=1
                     /product="sodium- and chloride-dependent glycine
                     transporter 2 isoform a"
                     /protein_id="NP_001139485.1"
                     /db_xref="GeneID:104245"
                     /db_xref="MGI:MGI:105090"
                     /translation="MDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAP
                     TATVQPPRVPRSASTGAQTFQSADARACEAQQSGVGFCNLSSPRAQATSAALRDLSEG
                     HSAQANPPSGPAGAGNALHCKIPALRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQST
                     VVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWR
                     FPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGI
                     AMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCV
                     IGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKISAGIEYPG
                     EIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGA
                     GIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVT
                     CTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWA
                     IIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMIT
                     QGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVC
                     WAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMY
                     LAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQ
                     C"
     exon            84..626
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            627..765
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            766..897
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1071
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1213
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1346
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1481
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1585
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1710
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1823
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1955
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2055
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2156
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2324
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2549
                     /gene="Slc6a5"
                     /gene_synonym="Glyt2; prestin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcgcctc ttgttccagg gccaaaccta gatcagtaga ggattttact ctacggttca
       61 atctgttgtc cgcatcagac atggattgca gtgctcccaa ggaaatgaat aaacagccag
      121 ccaacatctt ggaggcagcg gtgccaggcc accgggatag tcctcgtgca cctaggacca
      181 gccctgaaca ggatcttcct gctgaggccc ccacggccac tgtccagccg ccacgtgtgc
      241 ccaggtcggc ttccaccggc gcccaaactt tccagtctgc ggatgcgaga gcctgcgagg
      301 cccagcagtc cggagtaggg ttttgtaatc tcagcagccc ccgggcacaa gcgacctccg
      361 cggccctccg ggacttaagc gaagggcaca gcgcacaggc caatccccct tccgggcccg
      421 ccggggctgg caacgctctg cactgcaaga ttccagctct gcgtggcccg gaggaggacg
      481 cgaacgtgag tgtgggcaag ggcacgctgg agcacaacaa taccccagcc gtgggctggg
      541 tgaatatgag ccagagcaca gtagtgttgg gaaccgatgg catcgcgtcg gtgctcccgg
      601 gcagcgtggc caccactacc ataccggagg acgagcaagg ggatgagaat aaggcccgag
      661 ggaactggtc cagcaaactg gacttcatcc tgtccatggt ggggtacgca gtggggctgg
      721 gcaatgtttg gaggtttccc tacctggcct tccagaacgg gggaggcgcg ttcctcatcc
      781 cttacttgat gatgctggca ctggctggct tacccatctt cttcctagag gtgtccctgg
      841 gccagtttgc cagccagggt cctgtgtctg tgtggaaggc catcccagct ctgcagggtt
      901 gtggcattgc gatgctcatc atctctgtcc tcatagccat atactacaac gtcatcatct
      961 gctacacgct cttctacctg tttgcctcct tcgtgtctgt gctgccctgg gggtcctgca
     1021 acaacccgtg gaacacacca gaatgcaaag ataaaaccaa acttttacta gattcctgtg
     1081 ttatcggtga ccatcccaag atacagatca agaactctac tttctgcatg actgcctatc
     1141 cgaacttgac aatggttaac ttcaccagcc agaccaataa gacatttgtc agcgggagtg
     1201 aagagtactt caagtatttt gtgctgaaga tttctgcagg gattgaatat ccgggtgaga
     1261 tccggtggcc cttggccttc tgccttttct tggcttgggt gattgtgtac gcatcactgg
     1321 cgaaaggaat taagtcatca ggaaaagtag tctacttcac agccacattc ccttatgtcg
     1381 tcctggtcat cctccttatt cgaggagtca ccctgcctgg agctggagcc ggcatctggt
     1441 acttcatcac acctaagtgg gaaaaactca cggatgccac ggtatggaag gatgcggcca
     1501 ctcagatttt cttctccctg tctgcggcct ggggagggct catcactctt tcttcttaca
     1561 acaaattcca caacaactgc tacagggata cgttaattgt aacctgcact aacagtgcca
     1621 ctagcatctt tgctgggttt gtcatcttct ctgtcatcgg cttcatggcc aacgagcgca
     1681 aagtcaacat tgagaatgtg gccgaccaag ggcctggcat tgcatttgtg gtttaccctg
     1741 aggccttaac taggctgcct ctctctccat tctgggccat catctttttt ctgatgcttc
     1801 tcacgcttgg actcgacacc atgtttgcca ccattgagac catcgtgacc tccatctcgg
     1861 atgagtttcc caagtacctg cgcacacaca agcctgtgtt caccctgggc tgctgcatct
     1921 gcttcttcat tatgggcttc cctatgatca cacagggtgg aatctacatg tttcagcttg
     1981 tggacaccta cgctgcctcc tatgcccttg tcatcattgc catatttgag cttgttggca
     2041 tctcctatgt gtatggcttg cagagattct gtgaagacat cgagatgatg attggattca
     2101 agcccaacat tttctggaaa gtctgctggg cattcgtcac accgaccatt ttgactttta
     2161 tcctttgctt cagcttctac cagtgggagc ccatgaccta tggctcttac cgctacccta
     2221 actggtccat ggtgcttgga tggctgatgc tcgcctgctc cgttatctgg atcccgatta
     2281 tgttcgtgat aaaaatgtat ctggctcccg ggagatttat tgagaggctg aagttggtat
     2341 gctcgccaca gcccgactgg ggcccattct tagctcagca ccgcggggaa cgctacaaga
     2401 atatgatcga ccccttggga acttcgtcgc tgggactcaa gctgcccgtg aaggatttgg
     2461 aactgggcac tcagtgctag tccagtcgtg tggatggtcc ggtattactc ccgggcttcc
     2521 tctctgcctc cccttcacac tttccccag
//
