LOCUS       NM_010484               2747 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            serotonin), member 4 (Slc6a4), mRNA.
ACCESSION   NM_010484
VERSION     NM_010484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Kuznetsova,M., Wilson,C., Cheng,L., Pang,T., Li,S., Roberts,B.R.,
            Lago,L.C., Tran,H., Hill,A.F., Hannan,A.J. and Renoir,T.
  TITLE     Serotonergic-dependent effects of exercise and elevated stress
            hormone on small non-coding RNA transcriptomics and proteomics in a
            mouse model of affective disorders
  JOURNAL   Neuropharmacology 265, 110240 (2025)
   PUBMED   39613253
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Batten,S.R., Hartle,A.E., Barbosa,L.S., Hadj-Amar,B., Bang,D.,
            Melville,N., Twomey,T., White,J.P., Torres,A., Celaya,X.,
            McClure,S.M., Brewer,G.A., Lohrenz,T., Kishida,K.T., Bina,R.W.,
            Witcher,M.R., Vannucci,M., Casas,B., Chiu,P., Montague,P.R. and
            Howe,W.M.
  TITLE     Emotional words evoke region- and valence-specific patterns of
            concurrent neuromodulator release in human thalamus and cortex
  JOURNAL   Cell Rep 44 (1), 115162 (2025)
   PUBMED   39786997
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Anthony,D.C., Probert,F., Gorlova,A., Hebert,J., Radford-Smith,D.,
            Nefedova,Z., Umriukhin,A., Nedorubov,A., Cespuglio,R., Shulgin,B.,
            Lyundup,A., Lesch,K.P. and Strekalova,T.
  TITLE     Impact of Serotonin Transporter Absence on Brain Insulin Receptor
            Expression, Plasma Metabolome Changes, and ADHD-like Behavior in
            Mice fed a Western Diet
  JOURNAL   Biomolecules 14 (8), 884 (2024)
   PUBMED   39199273
  REMARK    GeneRIF: Impact of Serotonin Transporter Absence on Brain Insulin
            Receptor Expression, Plasma Metabolome Changes, and ADHD-like
            Behavior in Mice fed a Western Diet.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Henderson,F., Dumas,S., Gangarossa,G., Bernard,V., Pujol,M.,
            Poirel,O., Pietrancosta,N., El Mestikawy,S., Daumas,S. and Fabre,V.
  TITLE     Regulation of stress-induced sleep perturbations by dorsal raphe
            VGLUT3 neurons in male mice
  JOURNAL   Cell Rep 43 (7), 114411 (2024)
   PUBMED   38944834
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Arraes,G.C., Barreto,F.S., Vasconcelos,G.S., Lima,C.N.C., da
            Silva,F.E.R., Ribeiro,W.L.C., de Sousa,F.C.F., Furtado,C.L.M. and
            Macedo,D.S.
  TITLE     Long-term Environmental Enrichment Normalizes Schizophrenia-like
            Abnormalities and Promotes Hippocampal Slc6a4 Promoter
            Demethylation in Mice Submitted to a Two-hit Model
  JOURNAL   Neuroscience 551, 205-216 (2024)
   PUBMED   38843988
  REMARK    GeneRIF: Long-term Environmental Enrichment Normalizes
            Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4
            Promoter Demethylation in Mice Submitted to a Two-hit Model.
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Choi,D.S., Ward,S.J., Messaddeq,N., Launay,J.M. and Maroteaux,L.
  TITLE     5-HT2B receptor-mediated serotonin morphogenetic functions in mouse
            cranial neural crest and myocardiac cells
  JOURNAL   Development 124 (9), 1745-1755 (1997)
   PUBMED   9165122
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Bengel,D., Heils,A., Petri,S., Seemann,M., Glatz,K., Andrews,A.,
            Murphy,D.L. and Lesch,K.P.
  TITLE     Gene structure and 5'-flanking regulatory region of the murine
            serotonin transporter
  JOURNAL   Brain Res Mol Brain Res 44 (2), 286-292 (1997)
   PUBMED   9073170
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Chang,A.S., Chang,S.M., Starnes,D.M., Schroeter,S., Bauman,A.L. and
            Blakely,R.D.
  TITLE     Cloning and expression of the mouse serotonin transporter
  JOURNAL   Brain Res Mol Brain Res 43 (1-2), 185-192 (1996)
   PUBMED   9037532
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Ovalle,S., Casanova,E., Garate,C., Alonso-Llamazares,A.,
            Chinchetru,M.A. and Calvo,P.
  TITLE     Immunodetection of serotonin transporter from mouse brain
  JOURNAL   Neuroreport 6 (17), 2353-2356 (1995)
   PUBMED   8747152
REFERENCE   10 (bases 1 to 2747)
  AUTHORS   Gregor,P., Patel,A., Shimada,S., Lin,C.L., Rochelle,J.M.,
            Kitayama,S., Seldin,M.F. and Uhl,G.R.
  TITLE     Murine serotonin transporter: sequence and localization to
            chromosome 11
  JOURNAL   Mamm Genome 4 (5), 283-284 (1993)
   PUBMED   8507984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603842.9.
            
            On Aug 9, 2008 this sequence version replaced NM_010484.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL603842.9         102656-102734       c
            80-531              AL603842.9         90548-90999         c
            532-666             AL603842.9         88276-88410         c
            667-886             AL603842.9         87913-88132         c
            887-1025            AL603842.9         86120-86258         c
            1026-1160           AL603842.9         84568-84702         c
            1161-1264           AL603842.9         84244-84347         c
            1265-1392           AL603842.9         82964-83091         c
            1393-1505           AL603842.9         82094-82206         c
            1506-1637           AL603842.9         81358-81489         c
            1638-1737           AL603842.9         79841-79940         c
            1738-1838           AL603842.9         78056-78156         c
            1839-2006           AL603842.9         74080-74247         c
            2007-2747           AL603842.9         68988-69728         c
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.18 cM"
     gene            1..2747
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, serotonin), member 4"
                     /db_xref="GeneID:15567"
                     /db_xref="MGI:MGI:96285"
     exon            1..79
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            80..531
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2081
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /note="solute carrier family 6 member 4; 5HTT; 5HT
                     transporter; 5-hydroxytryptamine (serotonin) transporter;
                     Sodium-dependent serotonin transporter (5HT transporter)
                     (5HTT)"
                     /codon_start=1
                     /product="sodium-dependent serotonin transporter"
                     /protein_id="NP_034614.2"
                     /db_xref="CCDS:CCDS25074.1"
                     /db_xref="GeneID:15567"
                     /db_xref="MGI:MGI:96285"
                     /translation="METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQIS
                     NGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNI
                     WRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKG
                     IGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNI
                     TWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKT
                     SGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIF
                     FSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNE
                     DVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAV
                     LDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIE
                     AVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLF
                     QYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPGTLKERIIKSITPETPTEIPCGD
                     IRMNAV"
     exon            532..666
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            667..886
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1025
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1160
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1264
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1392
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1505
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1637
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1737
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1838
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2006
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2747
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2726..2731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
     polyA_site      2744
                     /gene="Slc6a4"
                     /gene_synonym="5-HTT; Htt; Sert"
ORIGIN      
        1 agcggccgcg ccggtgcctc gagggcgcga gggtcgagcc gcctccgcag cccgggaccc
       61 gccgccgcgc ctcccgcaga gctctcagtc ttgtctccat aacactgaga ggagattcaa
      121 aaccaagaac caagagctag tcagggtcct tggcagatgg gcatccgcac cactgactga
      181 ccagcagcat ggagaccaca cctttgaatt ctcagaaagt gctgtcagag tgtaaggaca
      241 aagaggactg ccaagaaaat ggtgttctgc agaagggtgt ccccacacca gcagacaagg
      301 cagggcctgg acaaatatcc aatgggtact ccgcagttcc cagtacaagc gctggggatg
      361 aagcgccaca ctctacgcca gctgccacca ccaccctggt ggctgagatt caccaagggg
      421 aacgggagac ctggggcaag aagatggatt tcctcctgtc tgtcattggc tatgccgtgg
      481 acctgggcaa catctggcgt tttccctaca tatgctacca gaatggtgga ggggccttcc
      541 tcctccctta caccatcatg gccatctttg gggggatccc actcttctac atggagctcg
      601 ccctgggcca gtaccaccga aatgggtgca tttctatatg gaagaagatc tgcccgattt
      661 tcaaaggcat tggctatgcc atctgcatca ttgcctttta tatcgcctcc tactataaca
      721 ccatcatagc ctgggcgctc tactacctca tctcctcctt cacggaccag ctgccctgga
      781 ccagctgcaa gaactcttgg aacactggca actgcaccaa ctacttcgcc caggacaaca
      841 tcacctggac actccattcc acgtcacctg ctgaggagtt ttacttgcgc catgtcctgc
      901 agatccatca gtcaaaggga ctccaggacc tggggaccat cagctggcag ctggctctct
      961 gcatcatgct catcttcacc attatctact tcagcatctg gaaaggagtc aaaacgtctg
     1021 gcaaggtggt gtgggtgaca gccaccttcc cttacattgt cctttctgtc ctgctggtga
     1081 ggggagccac ccttcctgga gcctggagag gggttgtctt ttacttgaaa cccaactggc
     1141 agaaactctt ggagacaggg gtgtgggttg atgctgcggc tcagatcttt ttctctcttg
     1201 gcccggggtt tggggttctc ctggcgtttg ctagctacaa caagttcaac aacaactgtt
     1261 accaagatgc cctggtgacc agtgtggtga actgcatgac gagcttcgtc tctggctttg
     1321 tcatcttcac ggtgcttggc tacatggctg agatgaggaa cgaagacgtg tccgaggtgg
     1381 ccaaagacgc gggccccagc ctccttttca tcacatatgc ggaggcaata gctaacatgc
     1441 cagcatccac attctttgcc atcatcttct tcctcatgtt aatcacgctg ggtttggata
     1501 gtacgttcgc aggcctggaa ggtgtgatca cagctgtgtt ggatgagttt cctcacatct
     1561 gggccaagcg cagggaatgg tttgtgctca tcgtggtcat cacttgcatc ttgggatccc
     1621 tgctcacact gacatcagga ggggcgtatg tggtgaccct gctggaggag tacgccacgg
     1681 ggccagcagt gctcaccgtg gctctcatcg aggccgtcgt cgtgtcttgg ttctatggaa
     1741 tcactcagtt ctgcagcgac gtgaaggaaa tgctgggctt cagccccgga tggttttgga
     1801 ggatctgctg ggtggccatc agccctctgt ttctcctgtt catcatttgc agttttttga
     1861 tgagtccacc ccaactccgg cttttccaat acaattatcc ccactggagt atcatcttgg
     1921 gctactgcat aggaacatcg tctgtcatct gcatccctat atacatcatt tatcggctga
     1981 tcagcactcc agggacactt aaggagcgca ttattaaaag tatcactcct gaaacaccaa
     2041 cggaaattcc gtgtggggac atccgcatga atgctgtgta acacactgag ggagaggaca
     2101 tggcctccca gcccccgact cctcatctct gaaaagcccc accttgactc ctcccctcta
     2161 agccaagctg atgatgtaag gtctttctcc atggagtcac agtcctaaag actatggtgc
     2221 ccagactctt gtgggttcca accacttctt tccatgaact ctcttggact tactgccaca
     2281 ttagctggtg acacggctga gctgacttgg atatgtgagg agaggaagga ggggatgaac
     2341 gccacccagt catcagctag cttcaggttt agattaggtc tgtgaacgtc tgtatcatgt
     2401 tctgggtatg atcatattgc cctgcatctg tttgcttcta aagccttcag tgttcatgaa
     2461 tacataaacc acctaagaga aaacagggat gtcttgctag ccatatatat tttctcagta
     2521 gcatagaact ctgtagccgg aatctactag aaccctgtaa cccacgtgct gctgtgaggt
     2581 taagaaagga agacgtaaag acgctacact gaaaactgat atatatgtgt gagctcttgt
     2641 gtctgtccat tgttgtctgt gtcccctcaa ttccaacact ccgggcccat tacaaactat
     2701 ataaatggcc tctaattttt cttacattaa acagattcta cctactc
//
