LOCUS       NM_010020               3456 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            dopamine), member 3 (Slc6a3), mRNA.
ACCESSION   NM_010020
VERSION     NM_010020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Batten,S.R., Hartle,A.E., Barbosa,L.S., Hadj-Amar,B., Bang,D.,
            Melville,N., Twomey,T., White,J.P., Torres,A., Celaya,X.,
            McClure,S.M., Brewer,G.A., Lohrenz,T., Kishida,K.T., Bina,R.W.,
            Witcher,M.R., Vannucci,M., Casas,B., Chiu,P., Montague,P.R. and
            Howe,W.M.
  TITLE     Emotional words evoke region- and valence-specific patterns of
            concurrent neuromodulator release in human thalamus and cortex
  JOURNAL   Cell Rep 44 (1), 115162 (2025)
   PUBMED   39786997
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Wei,A., Zhao,A., Zheng,C., Dong,N., Cheng,X., Duan,X., Zhong,S.,
            Liu,X., Jian,J., Qin,Y., Yang,Y., Gu,Y., Wang,B., Gooya,N., Huo,J.,
            Yao,J., Li,W., Huang,K., Liu,H., Mao,F., Wang,R., Shao,M., Wang,B.,
            Zhang,Y., Chen,Y., Song,Q., Huang,R., Qu,Q., Zhang,C., Kang,X.,
            Xu,H. and Wang,C.
  TITLE     Sexually dimorphic dopaminergic circuits determine sex preference
  JOURNAL   Science 387 (6730), eadq7001 (2025)
   PUBMED   39787240
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Carbonell-Roig,J., Aaltonen,A., Wilson,K., Molinari,M.,
            Cartocci,V., McGuirt,A., Mosharov,E., Kehr,J., Lieberman,O.J.,
            Sulzer,D., Borgkvist,A. and Santini,E.
  TITLE     Dysregulated acetylcholine-mediated dopamine neurotransmission in
            the eIF4E Tg mouse model of autism spectrum disorders
  JOURNAL   Cell Rep 43 (12), 114997 (2024)
   PUBMED   39607825
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Fushiki,A., Ng,D., Lewis,Z.R., Yadav,A., Saraiva,T., Hammond,L.A.,
            Wirblich,C., Tasic,B., Menon,V., da Silva,J.A. and Costa,R.M.
  TITLE     A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor
            Deficits in Parkinson's Disease
  JOURNAL   bioRxiv (2024)
   PUBMED   39763754
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Choi,A., Kim,B., Labriola,E., Wiest,A., Wang,Y., Smith,J., Shin,H.,
            Jin,X., An,I., Hong,J., Antila,H., Thomas,S., Bhattarai,J.P.,
            Beier,K., Ma,M., Weber,F. and Chung,S.
  TITLE     Circuit mechanism underlying fragmented sleep and memory deficits
            in 16p11.2 deletion mouse model of autism
  JOURNAL   iScience 27 (12), 111285 (2024)
   PUBMED   39628570
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Caron,M.G.
  TITLE     Images in neuroscience. Molecular biology, II. A dopamine
            transporter mouse knockout
  JOURNAL   Am J Psychiatry 153 (12), 1515 (1996)
   PUBMED   8942444
REFERENCE   7  (bases 1 to 3456)
  AUTHORS   Giros,B., Jaber,M., Jones,S.R., Wightman,R.M. and Caron,M.G.
  TITLE     Hyperlocomotion and indifference to cocaine and amphetamine in mice
            lacking the dopamine transporter
  JOURNAL   Nature 379 (6566), 606-612 (1996)
   PUBMED   8628395
REFERENCE   8  (bases 1 to 3456)
  AUTHORS   Yokoi,N., Kitada,K., Kuramoto,T., Maihara,T., Andoh,Y., Takami,S.,
            Higaki,J., Miki,T., Ogihara,T., Lathrop,G.M. and Serikawa,T.
  TITLE     Mapping of 20 polymorphic DNA markers in the rat by somatic hybrid
            and linkage analysis
  JOURNAL   Mamm Genome 7 (1), 71-73 (1996)
   PUBMED   8903735
REFERENCE   9  (bases 1 to 3456)
  AUTHORS   Donovan,D.M., Vandenbergh,D.J., Perry,M.P., Bird,G.S.,
            Ingersoll,R., Nanthakumar,E. and Uhl,G.R.
  TITLE     Human and mouse dopamine transporter genes: conservation of
            5'-flanking sequence elements and gene structures
  JOURNAL   Brain Res Mol Brain Res 30 (2), 327-335 (1995)
   PUBMED   7637582
REFERENCE   10 (bases 1 to 3456)
  AUTHORS   Lossie,A.C., Vandenbergh,D.J., Uhl,G.R. and Camper,S.A.
  TITLE     Localization of the dopamine transporter gene, Dat1, on mouse
            chromosome 13
  JOURNAL   Mamm Genome 5 (2), 117-118 (1994)
   PUBMED   8180472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154547.3 and AC158359.2.
            
            On Nov 17, 2006 this sequence version replaced NM_010020.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054119.1, AF109072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC154547.3         38687-38800         c
            115-443             AC154547.3         36746-37074         c
            444-575             AC154547.3         34571-34702         c
            576-807             AC154547.3         30635-30866         c
            808-946             AC154547.3         18367-18505         c
            947-1081            AC154547.3         17263-17397         c
            1082-1185           AC154547.3         14561-14664         c
            1186-1310           AC154547.3         13122-13246         c
            1311-1423           AC154547.3         9164-9276           c
            1424-1552           AC154547.3         7905-8033           c
            1553-1652           AC154547.3         7263-7362           c
            1653-1753           AC154547.3         5579-5679           c
            1754-1921           AC154547.3         3930-4097           c
            1922-1993           AC154547.3         2676-2747           c
            1994-3456           AC158359.2         25242-26704
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.1 cM"
     gene            1..3456
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, dopamine), member 3"
                     /db_xref="GeneID:13162"
                     /db_xref="MGI:MGI:94862"
     exon            1..114
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..443
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2017
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /note="DA transporter; dopamine transporter 1"
                     /codon_start=1
                     /product="sodium-dependent dopamine transporter"
                     /protein_id="NP_034150.1"
                     /db_xref="CCDS:CCDS26632.1"
                     /db_xref="GeneID:13162"
                     /db_xref="MGI:MGI:94862"
                     /translation="MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTN
                     STLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY
                     LLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVII
                     AWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFER
                     GVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVL
                     TALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSY
                     NKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFII
                     YPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLG
                     IVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIK
                     QMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATS
                     SMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV"
     exon            444..575
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..807
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..946
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1081
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1185
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1310
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1423
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1552
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1652
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1753
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1921
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1993
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..3456
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /note="hexamer: AAGAAA"
     polyA_site      3456
                     /gene="Slc6a3"
                     /gene_synonym="DAT; Dat1"
                     /note="major polyA site"
ORIGIN      
        1 taggcggacc gacccggagg cccgataaga gctcaaggct gagacctgcc agagctgtga
       61 agcgcgactg gaggcttaca ggacctcaaa gctgaagtct gacgctggag gcagtcgaag
      121 aagaaggaaa cagacttcct cgggctcccg tctacccatg agtaaaagca aatgctccgt
      181 gggaccaatg tcttctgtgg tggccccggc taaagagccc aatgctgtgg gccccagaga
      241 ggtggagctc atcttggtca aggagcagaa tggagtgcag ctgaccaact ccaccctcat
      301 caacccaccg cagacaccag tggaggttca agagcgggag acctggagca agaaaatcga
      361 tttcctgctc tcagtcatcg gcttcgctgt ggacctggcc aatgtctgga ggtttcccta
      421 cctgtgctac aaaaatggtg gaggtgcctt cctggtgccc tacctgctct tcatggttat
      481 tgccgggatg cccctcttct acatggagct ggctctcggg cagttcaaca gagaaggagc
      541 tgctggtgtc tggaagatct gccctgtcct gaaaggtgtg ggcttcactg tcatcctcat
      601 ctctttctac gtgggcttct tctacaatgt catcattgca tgggcactgc actacttctt
      661 ctcctccttc accatggacc tcccatggat ccactgcaac aacacctgga acagccccaa
      721 ctgctctgat gcacatagca gcaactctag cgatggcctg ggcctcaacg acacctttgg
      781 gaccacaccc gctgctgagt attttgagcg tggtgtgctg cacctccatc agagtcgtgg
      841 cattgatgac ctgggccctc cacggtggca gctcacagcc tgcctggtgc tggtcattgt
      901 tctgctctac ttcagcctgt ggaagggagt aaagacttca gggaaggtgg tgtggatcac
      961 agctaccatg ccctatgtag tcctcacagc cctgctcctg cgtggagtca ccctccctgg
     1021 ggccatggat ggcatcagag catacctcag tgtggacttc taccgtctct gtgaggcatc
     1081 tgtgtggatc gatgccgcca cccaggtgtg cttctccctt ggcgttgggt ttggggtgct
     1141 gattgccttc tccagttaca ataagttcac caataactgc tatagagatg caatcatcac
     1201 cacctccatt aactccctga cgagcttctc ctctggcttc gttgtcttct ccttcctggg
     1261 gtacatggca cagaagcaca atgtgcccat cagggatgtg gccacagatg gacctgggtt
     1321 gatcttcatc atctaccctg aggcaatcgc cacactcccg ctgtcttcag cctgggccgc
     1381 tgtcttcttc ctcatgctgc tcactctggg tatcgacagt gccatggggg gcatggagtc
     1441 tgtgatcact gggcttgtcg atgagttcca gctgctacat cggcatcgag agctcttcac
     1501 tcttggcatt gtcctggcta ctttcctgct gtctctcttc tgtgtcacca acggtggcat
     1561 ctatgtcttc acactgctgg accactttgc agctggcaca tctatcctct ttggagtgct
     1621 cattgaagcc attggggtgg cctggttcta cggtgtccag caattcagtg atgacatcaa
     1681 gcagatgact gggcagcgac ccaacctgta ctggcggcta tgctggaagc tggtcagccc
     1741 ctgcttcctt ctgtatgtgg tcgtggtcag cattgtgacc ttcagacccc cacactatgg
     1801 agcctacatc ttcccagact gggccaatgc cctgggctgg atcattgcca catcctccat
     1861 ggccatggtg cccatttatg ccacctataa gttctgcagc ctgccagggt ccttccgaga
     1921 gaaactggcc tatgccatca cacctgagaa agaccgccag ctagtggaca gaggggaggt
     1981 gcgccaattc acgctgcgcc attggctgtt ggtgtaaagt ggaaggagac agctgccagc
     2041 tgggccatct cacaacagcg gggacaggga gatcacaaag gaaaccaaca cgtcaagaaa
     2101 ggagggccac ttccacagtc cccttttgcc atatggaaaa ataatccaag catgggcttc
     2161 aatctttgac tgttcacacc caatccatgc cacaaagaag cctctgtctg tgtgtgactg
     2221 taaaaacaca cacctctata cagtgaagtc aaccatgtcc ctgtccctaa tgggtgggga
     2281 aacccctagc tggtatcctg tcctgcaagg ctgactcccc catctgtggt cactctggga
     2341 gaacaggtca tactgttccc tgcattctag gagagggact ttggtacctg tatatacact
     2401 gtgccagaat cctgtgctca cggtagttgc ctagataatt tcttttgctt aaatttacag
     2461 tgtcaagtat cctatttttt gctgttggta gaaaagacag ttaatacatg ccaagtcctt
     2521 tcctggtgct tggctccgag cagacaccat gaccttagca tcctgttcac atattacaca
     2581 cacgcagggt ctgttctgag ccacggagga caagggactt ggtgcaggtg accagaggtt
     2641 agggtttttt tttttccctt tattgctgag ataaaattca tgaattcagg ttgggagaca
     2701 agccctactc ctggcccctg gaaggcctgg tcagcttgca gccactttag tatggacttg
     2761 tagaccacag agaaagtgta cttctcctag ccagtgtgtc cctgcctcct ggacacctgc
     2821 tcttcacaga gtctcaatgc aacctgaaga tcatattctt ggcctggagc cctgcctggt
     2881 tttcggggaa agacacccac ttcttgggtt tgatttccga ctggctcctg tcatacccat
     2941 ggacattatc catgttataa atggcttttt aaaaccatat ttatgtgtga atcaaaatta
     3001 ttctcaaagt gtaaggttag tttgttcaaa tccatttgct gaagagtagt tagcataaga
     3061 agaaggtatg ccaaaaatac cttctcctgg agagctggct ttaacctctg aagtgaaaag
     3121 tggaagtcat gattttcctt gagctcataa ctgtgaactt tggcctagcc tgtgtcccat
     3181 agaaatggca ccatgtgtct gtctgagagc caaccttagg tattctctgc aagtagacag
     3241 tggcacgaag atcttgaatg tgctaccagg gtggaaatgc aggcctgttg gctctgcaga
     3301 ctgtagcgtg gctgagaaga atcaggttta ccatctcctc tcagagctga gtggctccat
     3361 gtataaatcc aggtgttgtc agcatctgtt atttatgtct atagccagta ccttgttgtg
     3421 ggtccttata aacaataaaa gaaatatatg ttggaa
//
