LOCUS       NM_011731               3257 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 20B (Slc6a20b), transcript variant 1, mRNA.
ACCESSION   NM_011731
VERSION     NM_011731.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Kim,J., Roh,J.D., Kim,S., Kang,H., Bae,M. and Kim,E.
  TITLE     Slc6a20a Heterozygous and Homozygous Mutant Mice Display
            Differential Behavioral and Transcriptomic Changes
  JOURNAL   Front Mol Neurosci 15, 857820 (2022)
   PUBMED   35321029
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Broer,A., Balkrishna,S., Kottra,G., Davis,S., Oakley,A. and
            Broer,S.
  TITLE     Sodium translocation by the iminoglycinuria associated imino
            transporter (SLC6A20)
  JOURNAL   Mol Membr Biol 26 (5), 333-346 (2009)
   PUBMED   19657969
  REMARK    GeneRIF: Using homology modeling we identified two highly conserved
            Na(+)-binding sites and a putative Cl(-)-binding site of SLC6A20.
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Kowalczuk,S., Broer,A., Munzinger,M., Tietze,N., Klingel,K. and
            Broer,S.
  TITLE     Molecular cloning of the mouse IMINO system: an Na+- and
            Cl--dependent proline transporter
  JOURNAL   Biochem J 386 (Pt 3), 417-422 (2005)
   PUBMED   15689184
  REMARK    GeneRIF: molecular cloning of two mouse homologues corresponding to
            the single human SLC6A20 gene: these have been named XT3 and XT3s1
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Takanaga,H., Mackenzie,B., Suzuki,Y. and Hediger,M.A.
  TITLE     Identification of mammalian proline transporter SIT1 (SLC6A20) with
            characteristics of classical system imino
  JOURNAL   J Biol Chem 280 (10), 8974-8984 (2005)
   PUBMED   15632147
  REMARK    GeneRIF: Up-regulated in the kidneys of 3-day-old mice, accounting
            for the maturation of proline reabsorption in the mouse.
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Kiss,H., Kedra,D., Kiss,C., Kost-Alimova,M., Yang,Y., Klein,G.,
            Imreh,S. and Dumanski,J.P.
  TITLE     The LZTFL1 gene is a part of a transcriptional map covering 250 kb
            within the common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Genomics 73 (1), 10-19 (2001)
   PUBMED   11352561
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Nash,S.R., Giros,B., Kingsmore,S.F., Kim,K.M., el-Mestikawy,S.,
            Dong,Q., Fumagalli,F., Seldin,M.F. and Caron,M.G.
  TITLE     Cloning, gene structure and genomic localization of an orphan
            transporter from mouse kidney with six alternatively-spliced
            isoforms
  JOURNAL   Recept Channels 6 (2), 113-128 (1998)
   PUBMED   9932288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144038.1 and AC132852.12.
            
            On Jan 18, 2019 this sequence version replaced NM_011731.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144038.1, AK164706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2422              AK144038.1         29-2450
            2423-3257           AC132852.12        86092-86926
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.19 cM"
     gene            1..3257
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 20B"
                     /db_xref="GeneID:22599"
                     /db_xref="MGI:MGI:1336891"
     exon            1..429
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2087
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="isoform 1 is encoded by transcript variant 1; X
                     transporter protein 3; solute carrier family 6
                     (neurotransmitter transporter), member 20; solute carrier
                     family 6, member 20B; sodium- and chloride-dependent
                     transporter XTRP3B; IMINO-K"
                     /codon_start=1
                     /product="sodium- and chloride-dependent transporter
                     XTRP3B isoform 1"
                     /protein_id="NP_035861.2"
                     /db_xref="CCDS:CCDS23661.1"
                     /db_xref="GeneID:22599"
                     /db_xref="MGI:MGI:1336891"
                     /translation="MESPSAHAVSLPEDEELQPWGGAGGPGQHPGRPRSTECAHPGVV
                     EKVRPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLL
                     YLELAVGQRMRQGSIGAWRTISPYLSGVGIASLVVSFLASVYFNVINTWALWYLFHSF
                     QDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLT
                     LAWLMVYLCILRGTESTGKVVYFTTSLPYFVLIIYLVRGLTLHGATNGLAYMFTPKIE
                     QLANPKAWINAATQIFFSLGLGCGGLIAFASYNEPSNDCQKHALIVSVINSTTAIFSS
                     IVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYS
                     EVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLTLGMGSM
                     VGTGTAILTPLTDSKIISSYLPKEAISGLVCLLNCAIGMVFTMEAGNYWFDLFNDYTA
                     TLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIF
                     YLSDYILTGTLQYQAWDATQGHVVTKDYPTYALAVIGLLVASSTMCIPLVALGTFVTR
                     HFKIREQFSAA"
     exon            430..570
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..662
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..890
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1001
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1243
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1406
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1611
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1771
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1937
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..3257
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="major polyA site"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="hexamer: AATAGA"
     polyA_site      2527
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="major polyA site"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="hexamer: ATTAAA"
     polyA_site      3257
                     /gene="Slc6a20b"
                     /gene_synonym="Sit1; Slc6a20; XT3; Xtrp3"
                     /note="major polyA site"
ORIGIN      
        1 acctgtgagg ttgaggcagc gagggaagca ctggtcaaga agggaaccaa cacagaattg
       61 gggtcgaaag ctgattccag agtcctggaa agaaacagta gaaaacacag gggtttgggg
      121 gtggggcgcg gaagagggca caggtgttgc tcattctaca gtgagagttg tctcagaaga
      181 tggaatcacc ttcagcacat gcggtctccc tgccagagga tgaggagctc cagccctggg
      241 gaggcgctgg aggacctggt cagcacccag gaagaccgag gtcaacagag tgtgcccacc
      301 ctggggttgt ggagaaggtg cggccaaagt gggacaaccc cctgcagttc ctacttgtct
      361 gtatctccta tgctgtgggc ctgggcaatg tatggcgctt cccctacctg tgccagatgt
      421 atggcggagg gagtttcctg gtcccctaca tcatcatgct cattgtggag gggatgccac
      481 tcctgtacct ggagctggcc gtgggacagc gcatgcggca gggcagcatt ggtgcctgga
      541 ggaccatcag cccctacctc agtggtgtcg gcattgctag cttggtggtc tcgtttttgg
      601 cctctgtgta cttcaatgtc atcaacacct gggctctttg gtacctcttc cactccttcc
      661 aggatcccct gccgtggtct gtctgcccac tgaatagtaa tcacacaggc tacgatgagg
      721 agtgtgagaa ggcttcgtcg acacagtact tctggtacag gaaaacactc aacatctcac
      781 cgtccatcca ggagaatgga ggagtgcagt gggagccagc gctgtgcctc accctggcct
      841 ggctgatggt ctatctgtgc atcctgagag gcaccgaatc tactggcaag gtggtctatt
      901 tcaccacgtc actgccttac tttgtgctca tcatctacct ggtccggggc ctcacactcc
      961 atggagccac caatggcctg gcatacatgt tcacacctaa gattgagcag ctagccaacc
     1021 ccaaggcctg gatcaatgca gccacgcaga tcttcttctc actgggctta gggtgtggtg
     1081 gcctgattgc ttttgccagc tacaacgaac cctccaacga ctgccagaag catgccctca
     1141 ttgtgtctgt catcaatagt actactgcca tattttccag tattgtcacc ttctccatct
     1201 atggcttcaa ggccaccttc aactatgaaa actgcttaaa caaggtgatt ctgctgctga
     1261 ccaattcttt tgaccttgaa gatggctttc tgacagtcag caacctggag gaggtgaaga
     1321 actacctggc atctacttac ccaaacaagt acagtgaagt gttcccacac attagaaact
     1381 gcagcttgga atcagagctg gacacggctg tccagggcac aggcctggcc ttcatcgtct
     1441 acactgaggc cattaaaaac atggaagttt cccagctctg gtcagtgctc tacttcttca
     1501 tgttgctaac actgggtatg ggaagcatgg tggggacagg aacggccatc ctcacccctc
     1561 tgactgacag caagatcatc tccagctacc tgcccaagga ggccatttca ggtttggtat
     1621 gcctcctcaa ctgtgccatt ggcatggtgt tcaccatgga ggctgggaac tactggtttg
     1681 acctattcaa tgactataca gccacgctgt ctctgctgct cattgtgctg gtagagacca
     1741 tagctgtgtg ctatgtgtat gggctaaaga gatttgaaag tgaccttcgg gccatgactg
     1801 gccgcaccct cagctggtac tggaaggtca tgtgggcgtt tgtgagtcca ctgctcatcg
     1861 tcggcctctt tatcttctac ctgagtgact acatcctcac gggaacgctg cagtaccaag
     1921 cctgggatgc tactcagggc cacgtggtga ctaaggatta tcctacatac gcactagctg
     1981 tcattgggct tctggtagcc tcctccacca tgtgcatccc tctggtagcc ctggggactt
     2041 ttgtcacacg ccacttcaag atcagagaac agttttctgc agcctgagaa ctggaggtcc
     2101 cacagacttc ctgtcagtca ctgtttcaca gccactccct atatatccag cagtgggagg
     2161 tctacagctg ctttttaaag ccacaagtat tttctgcttc ctgaatctgc aaggaaaatt
     2221 aaattctctg tattaaattg taggctgaca gaaacctaac tctgaccata aatgctgagg
     2281 cttttaccct tttgtttttg ttttcaagac agggtttctc tgtgtagccc tggctgtcct
     2341 ggaactcact ctgtagatca gactgacgtt gaactcagat ctacgtgcat cccaagtgct
     2401 gggaataaag gtgtgcacca ccacttccca acagctttta ttcctcctct tccatgacgt
     2461 atacttttgt tgttaaaatt tataccattt gtattatata gctcataata gatataattt
     2521 ttgatcattt tgatctttag ctctcattct ttacacacca ctactacagt catgatatgc
     2581 tagaccacaa atttacctct aacattgctt tttttggttg aggtagagtc ttggtatata
     2641 tggacctcag gttggtctgg acctatgcat tccaggttag gctagaatct gtgatcttct
     2701 agccatagcc tccccatact agcacaacag gtcatgtgcc accaggccag gtatatacgt
     2761 tttagaacat taattatcct tttgtttttg tttaaaccat tcctttgcag agggggtggg
     2821 taaatgggga gggagcagcc gatgccagcc tgggttcaaa cactctctta cttcacccat
     2881 ccagtatttc ttgaagcata ttgtattctt gactgacagg tttctttctt ttagtagtct
     2941 gaatgtacag ataaatccat tttttacaat ctaatggata ttcctttata tgtgactaga
     3001 ctcttgctaa tagagaaggg gaaaatgagc tgtagaccaa acaatacaaa atagagatgt
     3061 gggggaaaaa cctggagtgc tatatgcaac acaaaactgt taggattttt tttaactaaa
     3121 tctgatttta ctattaagaa caactgtgtg ggatgacgta gtaatgccct ggtatactac
     3181 acatttatta cgtaacttct tataactatg ttgtgaacct caaatacaat acattttatt
     3241 aaaaattaag tgtggaa
//
