LOCUS       NM_139142               1894 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 20A (Slc6a20a), mRNA.
ACCESSION   NM_139142
VERSION     NM_139142.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1894)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1894)
  AUTHORS   Wu,Y., Yang,D. and Chen,G.Y.
  TITLE     Targeted disruption of Rab1a causes early embryonic lethality
  JOURNAL   Int J Mol Med 49 (4) (2022)
   PUBMED   35137917
REFERENCE   3  (bases 1 to 1894)
  AUTHORS   Kim,J., Roh,J.D., Kim,S., Kang,H., Bae,M. and Kim,E.
  TITLE     Slc6a20a Heterozygous and Homozygous Mutant Mice Display
            Differential Behavioral and Transcriptomic Changes
  JOURNAL   Front Mol Neurosci 15, 857820 (2022)
   PUBMED   35321029
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1894)
  AUTHORS   Bae,M., Roh,J.D., Kim,Y., Kim,S.S., Han,H.M., Yang,E., Kang,H.,
            Lee,S., Kim,J.Y., Kang,R., Jung,H., Yoo,T., Kim,H., Kim,D., Oh,H.,
            Han,S., Kim,D., Han,J., Bae,Y.C., Kim,H., Ahn,S., Chan,A.M.,
            Lee,D., Kim,J.W. and Kim,E.
  TITLE     SLC6A20 transporter: a novel regulator of brain glycine homeostasis
            and NMDAR function
  JOURNAL   EMBO Mol Med 13 (2), e12632 (2021)
   PUBMED   33428810
  REMARK    Erratum:[EMBO Mol Med. 2024 Oct;16(10):2653. doi:
            10.1038/s44321-024-00125-y.. PMID: 39242973]
REFERENCE   5  (bases 1 to 1894)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1894)
  AUTHORS   Anas,M.K., Lee,M.B., Zhou,C., Hammer,M.A., Slow,S., Karmouch,J.,
            Liu,X.J., Broer,S., Lever,M. and Baltz,J.M.
  TITLE     SIT1 is a betaine/proline transporter that is activated in mouse
            eggs after fertilization and functions until the 2-cell stage
  JOURNAL   Development 135 (24), 4123-4130 (2008)
   PUBMED   19029042
  REMARK    GeneRIF: We assessed two candidates for the betaine/proline
            transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7).
            mRNA from both genes was present in eggs and 1-cell embryos.
REFERENCE   7  (bases 1 to 1894)
  AUTHORS   Romeo,E., Dave,M.H., Bacic,D., Ristic,Z., Camargo,S.M., Loffing,J.,
            Wagner,C.A. and Verrey,F.
  TITLE     Luminal kidney and intestine SLC6 amino acid transporters of
            B0AT-cluster and their tissue distribution in Mus musculus
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F376-F383 (2006)
   PUBMED   16174864
REFERENCE   8  (bases 1 to 1894)
  AUTHORS   Kowalczuk,S., Broer,A., Munzinger,M., Tietze,N., Klingel,K. and
            Broer,S.
  TITLE     Molecular cloning of the mouse IMINO system: an Na+- and
            Cl--dependent proline transporter
  JOURNAL   Biochem J 386 (Pt 3), 417-422 (2005)
   PUBMED   15689184
  REMARK    GeneRIF: molecular cloning of two mouse homologues corresponding to
            the single human SLC6A20 gene: these have been named XT3 and XT3s1
            [Xt3s1]
REFERENCE   9  (bases 1 to 1894)
  AUTHORS   Takanaga,H., Mackenzie,B., Suzuki,Y. and Hediger,M.A.
  TITLE     Identification of mammalian proline transporter SIT1 (SLC6A20) with
            characteristics of classical system imino
  JOURNAL   J Biol Chem 280 (10), 8974-8984 (2005)
   PUBMED   15632147
REFERENCE   10 (bases 1 to 1894)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC118933.2.
            
            On Jun 10, 2007 this sequence version replaced NM_139142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC118933.2, AJ428067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.26 cM"
     gene            1..1894
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 20A"
                     /db_xref="GeneID:102680"
                     /db_xref="MGI:MGI:2143217"
     exon            1..147
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1805
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /note="IMINO-B; solute carrier family 6 member 20A; X
                     transporter protein 3 similar 1"
                     /codon_start=1
                     /product="sodium- and chloride-dependent transporter
                     XTRP3A"
                     /protein_id="NP_631881.1"
                     /db_xref="CCDS:CCDS40817.1"
                     /db_xref="GeneID:102680"
                     /db_xref="MGI:MGI:2143217"
                     /translation="MEKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFL
                     VPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYY
                     NVINAWGFWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSI
                     QENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLH
                     GATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHA
                     IIVSIINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLE
                     EVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWS
                     VLYFFMLLMLGIGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTM
                     EAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVM
                     WAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASS
                     TMCIPLVALGTFIRNRLKRGGSAPVA"
     exon            148..288
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..380
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..608
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..719
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..961
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1124
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1329
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1489
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1655
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1894
                     /gene="Slc6a20a"
                     /gene_synonym="A730081N20Rik; Xt3s1; Xtrp3s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacgggga gcagcgagct cgggacatgg agaaggcacg gcctcagtgg ggccatccgc
       61 tgcagttcgt gttcgcctgc atctcctacg ccgtgggttt gggcaacgtg tggcgcttcc
      121 cttacctgtg ccagatgtac ggcggaggga gtttcctggt cccctacatc atcatgctca
      181 ttgtggaggg gatgccactc ctgtacctgg agctggccgt gggacagcgc atgcggcagg
      241 gcagcattgg tgcctggagg accatcagcc cctacctcag tggtgtcggt gttgccagtg
      301 ttgtggtctc cttcttcctc tccatgtact acaatgtcat caatgcctgg ggcttctggt
      361 acctcttcca ctccttccag gatcccctgc cgtggtctgt ctgcccactg aacagcaacc
      421 acacaggcta cgatgaggag tgtgagaagg cttcgtcgac acagtacttc tggtacagga
      481 aaacactcaa catctcaccg tccatccagg agaatggagg agtgcagtgg gagccagcgc
      541 tgtgcctcac cctggcctgg ctgatggtct atctgtgcat cctgagaggc accgaatcta
      601 ctggcaaggt ggtctacttc accgcatcga tgccttactg tgttcttatt atctacttgg
      661 tccgtggcct tacactccat ggagccacca atggcctgat gtacatgttc acacctaaga
      721 tggaacagct agccaacccc aaggcctgga tcaatgcagc cacgcagatc ttcttctcac
      781 tgggcttggg ttttggcagc ctgatcgctt ttgccagcta caatgaaccc tccaacaact
      841 gccagaagca tgccattatt gtgtccatca tcaacagctc cacctccata tttgccagca
      901 ttgtcacctt ctccatctat ggcttcaagg ccaccttcaa ctatgaaaac tgcttaaaca
      961 aggtgattct gctgctgacc aattcttttg accttgaaga tggctttctg acagtcagca
     1021 acctggagga ggtgaagaac tacctggcat ctacttaccc aaacaagtac agtgaagtgt
     1081 tcccacacat tagaaactgc agcttggaat cagagctgga cacggctgtc cagggcacag
     1141 gcctggcctt catcgtctac actgaggcca ttaaaaacat ggaagtttcc cagctctggt
     1201 cagtgctcta cttcttcatg ctgctgatgc tgggtatcgg aagcatgctt ggaaacacag
     1261 cggccatcct cacccctctg actgacagca aggtcatctc cagctacctg cccaaggagg
     1321 ccatttcagg tttggtatgc ctcatcaact gtgctgttgg catggtgttc accatggagg
     1381 ctgggaacta ctggtttgac atattcaatg actatgcggc caccctgtct ctgctgctca
     1441 ttgtgctggt agagaccata gctgtgtgct atgtgtatgg gctgaagaga tttgaaagtg
     1501 accttcgggc catgactggc cgcaccctca gctggtactg gaaggtcatg tgggcgtttg
     1561 tgagtccact gctcatcgtc ggcctcttta tcttctacct gagtgactac atcctcacgg
     1621 gaacactgca gtaccaagcc tgggatgcta ctcaggggca gttggtgacc aaggattacc
     1681 ccccacatgc gctagctgtc atcggtttgc tggtggcttc atctaccatg tgcatccccc
     1741 tggtggccct ggggactttc atcaggaatc gcctcaagag gggaggctct gccccagtgg
     1801 cctaagaatg gacctcccag agaccggaag tcagccactc tgtttcacag tcactgcctg
     1861 ctggtgggaa cttcttggct ggagtgctgg tctg
//
