LOCUS       NM_009209               6073 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            noradrenalin), member 2 (Slc6a2), mRNA.
ACCESSION   NM_009209
VERSION     NM_009209.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6073)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6073)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6073)
  AUTHORS   Zhu,F., Liu,L., Li,J., Liu,B., Wang,Q., Jiao,R., Xu,Y., Wang,L.,
            Sun,S., Sun,X., Younus,M., Wang,C., Hokfelt,T., Zhang,B., Gu,H.,
            Xu,Z.D. and Zhou,Z.
  TITLE     Cocaine increases quantal norepinephrine secretion through
            NET-dependent PKC activation in locus coeruleus neurons
  JOURNAL   Cell Rep 40 (7), 111199 (2022)
   PUBMED   35977516
REFERENCE   4  (bases 1 to 6073)
  AUTHORS   Zhang,C., Vincelette,L.K., Reimann,F. and Liberles,S.D.
  TITLE     A brainstem circuit for nausea suppression
  JOURNAL   Cell Rep 39 (11), 110953 (2022)
   PUBMED   35705049
REFERENCE   5  (bases 1 to 6073)
  AUTHORS   Harris,S.S., Green,S.M., Kumar,M. and Urs,N.M.
  TITLE     A role for cortical dopamine in the paradoxical calming effects of
            psychostimulants
  JOURNAL   Sci Rep 12 (1), 3129 (2022)
   PUBMED   35210489
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6073)
  AUTHORS   Xu,F., Gainetdinov,R.R., Wetsel,W.C., Jones,S.R., Bohn,L.M.,
            Miller,G.W., Wang,Y.M. and Caron,M.G.
  TITLE     Mice lacking the norepinephrine transporter are supersensitive to
            psychostimulants
  JOURNAL   Nat Neurosci 3 (5), 465-471 (2000)
   PUBMED   10769386
REFERENCE   7  (bases 1 to 6073)
  AUTHORS   Wang,Y.M., Xu,F., Gainetdinov,R.R. and Caron,M.G.
  TITLE     Genetic approaches to studying norepinephrine function: knockout of
            the mouse norepinephrine transporter gene
  JOURNAL   Biol Psychiatry 46 (9), 1124-1130 (1999)
   PUBMED   10560019
  REMARK    Review article
REFERENCE   8  (bases 1 to 6073)
  AUTHORS   Fritz,J.D., Jayanthi,L.D., Thoreson,M.A. and Blakely,R.D.
  TITLE     Cloning and chromosomal mapping of the murine norepinephrine
            transporter
  JOURNAL   J Neurochem 70 (6), 2241-2251 (1998)
   PUBMED   9603188
REFERENCE   9  (bases 1 to 6073)
  AUTHORS   Markel,P.D., Bennett,B., Beeson,M., Gordon,L. and Johnson,T.E.
  TITLE     Confirmation of quantitative trait loci for ethanol sensitivity in
            long-sleep and short-sleep mice
  JOURNAL   Genome Res 7 (2), 92-99 (1997)
   PUBMED   9049627
REFERENCE   10 (bases 1 to 6073)
  AUTHORS   Ramachandran,B., Houben,K., Rozenberg,Y.Y., Haigh,J.R.,
            Varpetian,A. and Howard,B.D.
  TITLE     Differential expression of transporters for norepinephrine and
            glutamate in wild type, variant, and WNT1-expressing PC12 cells
  JOURNAL   J Biol Chem 268 (32), 23891-23897 (1993)
   PUBMED   8226929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD551617.1, AJ439987.1, AC140217.3, AK078616.1 and AY188506.1.
            
            On Jan 16, 2008 this sequence version replaced NM_009209.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY188506.1, AY525777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               CD551617.1         1-183
            184-2031            AJ439987.1         1-1848
            2032-3017           AC140217.3         43970-44955         c
            3018-4822           AK078616.1         2-1806
            4823-6073           AY188506.1         4637-5887
FEATURES             Location/Qualifiers
     source          1..6073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     gene            1..6073
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, noradrenalin), member 2"
                     /db_xref="GeneID:20538"
                     /db_xref="MGI:MGI:1270850"
     exon            1..475
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2055
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /note="solute carrier family 6 member 2; NE transporter;
                     norepinephrine transporter"
                     /codon_start=1
                     /product="sodium-dependent noradrenaline transporter"
                     /protein_id="NP_033235.3"
                     /db_xref="CCDS:CCDS22525.1"
                     /db_xref="GeneID:20538"
                     /db_xref="MGI:MGI:1270850"
                     /translation="MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQC
                     LLASQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFL
                     IIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSL
                     YYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGV
                     LHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFV
                     LLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNK
                     FDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYP
                     EAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVT
                     ISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQM
                     MGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALSSM
                     ILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI"
     exon            476..607
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            608..845
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            846..984
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1119
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1223
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1348
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1461
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1590
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1690
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1791
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1959
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2031
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..6073
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6047..6052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /note="hexamer: AATAAA"
     polyA_site      6073
                     /gene="Slc6a2"
                     /gene_synonym="NE-T; NET; Slc6a5"
                     /note="major polyA site"
ORIGIN      
        1 aaaaattccc aactcaggcg ctccttttct tggaagctgg gagtccgctc agccctaaga
       61 tcctgacgtc tgggctcccc tgggtggtct cagtttgtgc aaacgggcgg caagccttgt
      121 tgactgcttt ttctcctttc atacaagcag aactttggtg tgtccccaga acctccgaag
      181 tccctctctc cagccgcacc catgcttctg gcgcgaatga atccgcaggt gcagccggag
      241 ctcggcgggg cggacccgct gcctgagcag cccctgaggc cctgcaaaac cgccgatcta
      301 ctagtggtga aggaacgcaa cggagtccag tgcctcttgg cgtcccagga cagcgacgct
      361 cagccccggg agacttgggg caagaagatt gatttcctgc tgtccgtggt gggcttcgct
      421 gtggacctgg ccaacgtgtg gcggttccct tatctctgct acaagaatgg tggtggtgcc
      481 ttcctgattc catacacgct gttcctcatc attgctggga tgcctctgtt ttacatggag
      541 ctggctctgg ggcaatacaa ccgggagggg gcagccacag tgtggaagat ctgccctttc
      601 ttcaaaggag tgggctatgc tgtgatcctc attgccctct atgtcggctt ttactacaat
      661 gtcatcatcg cctggtcact ctactacctc tttgcatcct tcaccttgaa cctgccctgg
      721 accaactgcg gacactcctg gaacagcccc aactgtacgg accccaaact cctcaacgcc
      781 tcggtgctgg gtgaccatac caaatactcc aaatacaagt tcacaccagc tgcggagttt
      841 tatgaacgcg gagtcctgca cttgcacgag agcagtggga tccatgacat cggcctgcct
      901 caatggcagc tgctgctctg tctgatggtc gtcatcgttg tcttgtattt cagcctctgg
      961 aaaggagtga agacatcagg aaaggttgtc tggatcacag ccaccctgcc ttactttgtc
     1021 ttgtttgtgc tcctggtcca tggcgtcaca ctgcccggtg cctccaatgg catcaatgcc
     1081 tacttgcaca ttgacttcta ccgcctcaag gaggccacgg tatggattga tgctgcaacc
     1141 cagatatttt tttctctggg ggctggattt ggagtcttga ttgcatttgc cagttacaat
     1201 aaatttgaca acaactgtta cagggatgct ctactgacca gcaccatcaa ctgtgttacc
     1261 agttttattt ctggatttgc catcttctcc atccttggtt atatggccca tgaacataag
     1321 gtcaatattg aggatgttgc cactgaagga gctgggcttg tgtttatcct gtatccagaa
     1381 gccatctcta ctctgtcagg atccacgttc tgggccgtcc tgttcttctt gatgctcctg
     1441 gctctggggc tagatagttc aatgggaggc atggaagcag tcatcactgg actggctgat
     1501 gacttccagg tcctgaagcg acaccggaaa ctcttcacgt gtgttgtcac catcagcacc
     1561 ttccttctgg cattgttttg cataacaaag ggagggattt atgtcctcac tctgctggac
     1621 acctttgcag caggcacctc cattctgttt gcggtgctta tggaagctat tggagtttcc
     1681 tggttttatg gtgtggacag gttcagcaat gacatccagc agatgatggg gtttaagcca
     1741 ggcctgtact ggaggctgtg ttggaagttc gtgagccccg ccttcctcct gtttgtggtg
     1801 gtggtcagca tcatcaactt caagccgctt acctatgatg actacaccta tcctccctgg
     1861 gccaactggg tcgggtgggg catcgccctc tcatccatga tcctggtccc tgcctatgtc
     1921 atctacaagt tcctcagcat acgcggctcc ctgtgggaga gagtggccta cggaatcacc
     1981 ccggagaatg agcaccacct ggtggcccag agagacgtga gacagttcca gttgcggcac
     2041 tggctggcta tctgaacctg gcaatgtgga ggaggaggag gaacccatgt gccaacgtcc
     2101 gggtccaggg caccctcttt gcccccattc ggataccgcc ttgggattcc tctcctggaa
     2161 gacaccttcc ccgtcgctcc cgttttctca tttactaatg attccgtgac gctggttttg
     2221 ttcaccttct gttcatctgg cctggaggca agcgagagtg gagaactggt gagcctcaag
     2281 gaagaggctg gaaggaggaa gtgggacgtg aattctggaa ctctggcttg agggcaggtt
     2341 tactgcattt ggagcacacc tcagctgagg tccacagccc gggcagaaac ccctcccgga
     2401 tttgcttgta cttcagatca taaacaaaat cttccattca cccaggctga gaggagattg
     2461 gcttctggtt agatatcaaa agcccaagca aagcctgaca gggtctgtgt gggggccaag
     2521 gtgtgcaggt tacccctctc tttccattta tcctgtcacc gctccagcat ctgagcctct
     2581 gtttgggagt ggggctttat ttgcactgaa aatgcagctg gtagatactc tgagtctggg
     2641 ggcagggcgt taggcagaaa ctcttaccta gctatctagt taatcaaagg ctggttttgg
     2701 tatgttctag aatattactc taacttctga tgtttggaga gcccccaaac catgatttta
     2761 ggggaagaat gtagctgcat caccagtgag ggagttcccc aaagtcagat cctttagaaa
     2821 ggtggtaacc gctagacaaa ttgtgcctgc caaggccacc tgccagtctt gttctgtcag
     2881 acatatgggt agttcccaag accttcctag ggattgagac agggtccctc taaagccaga
     2941 tatgtatgcc catcacaggg atttctgtcc tgggaggcca ggtgggtgtt gtaggacaac
     3001 ttgataggct gccatggttc tttgtggtct tcccctggga acctcagcag acaggggtcc
     3061 tgagcagtag agtccattgg ctctgaaaat ggcctgtttc cttatttact tgacttggca
     3121 ccttggaggg cacgatgggg cttaccacag cccagcccag cccagcctct caagtccagg
     3181 gatggtattc tgactggagg ggacagtcag atggcttcag gaagtttcta agtttcacat
     3241 gtgacacaaa cttgcaacta ctgccctctg gtggttaggt ttggttcatt gagggaaaga
     3301 atggtttggt aaattgatgg catctccttg agctttatgt ttctggtttg agtctcttac
     3361 gccctttctt gaaatctaga atcataggtt gccattgtga tagtaggatt cccttcctag
     3421 gttgtgtgtg tgtgtgcgcg cgcgcatgtc tataagtgca catttgtgtg tgtctgtgta
     3481 tgtgtatata tgtttgttta tatgtgtgtg tatgtctgtg tgtgtccttg tgtatgtgtg
     3541 catgtctatg tgtgtatgtg tgtgttggtg tgcacgtgtg catgtgtgag tgtgtgtgtg
     3601 tgattggagt catgtaggag gcacatggag aaactaggat gttcccatgt cccatggagg
     3661 ctgtaaaaat aggccaggtg aggccagctg gggatgggga gatagtttac tctgaggacc
     3721 accaaaattt cccccgaatc agagtccttg agttattcct tagaggaaat tttgtctttc
     3781 catgtaagaa ggccatgtca gctcaaggca tcccgcattg gcaaatgtct tggagcactg
     3841 gggaagagaa agctcttcca ccccatttca aggtaggtgc aagccaggac cctgctagca
     3901 acaacctcaa cacttctcat gagtagtaat tcctttctag ttgttacctt taaaatattg
     3961 gcacacacct ttactcccag cacttgggag gcagaggcag gtgaatttct gagttcaagg
     4021 ccagcctggt ctacagagtg agttcaagga cagccagggc tacacagaga aaccctgtct
     4081 cgaaaaaacc aaaaccaaat atatattgta ctatttaaac aatccatgct taccctccct
     4141 gcctccaagc tgccccatag aaaggaagac tgcttcctgt ctccccactt ccctggtgag
     4201 aagatgagaa atctcgcttg gtcaacatct catctcccta gggatctggg tggagcctcc
     4261 atcctcatct tgtcgtcaca gtccagagca ccaggggact ccttgtttac ccttctgtgg
     4321 gctgacacca aacagaatgc acagagtcac acttaagggg gaagagtgtt tcttagcaga
     4381 acaaagtgtt gggagggggg cagaaggatg ttactcatct ccccacactg gctccctgag
     4441 aggcattgtc ctcgcctttg atgacaagtc accctttgaa tagtggggcc tgagaagcaa
     4501 gcgtccacct gactgtcttg agagcacatg ctcacaaaac ctgggtgcct tggatcagca
     4561 cagggccacc attttctcgt tgccatctga gtggcctctt cacctgcaga cactgctccc
     4621 tcccaggggt tgaagttgaa aatgtggtgc tagccgaatg agccccagac taaagcaatg
     4681 gtgctgcttt gtggcaaagt tggctcctga gactgggaca aagtgctttg tgtttgtacg
     4741 cccaggtgct ctagtggggg agcggggaga cacccagaaa gctcctggag ggtctcacga
     4801 aggtgctagg aggtcacctg tacccacctt tccacccacg cttgccagat gggggctact
     4861 ctgtcatcat aagtaatgct tgccctctgt gttctgactg atttttttat tttagtagta
     4921 tggctcatcc agggccagca ttctcccaag taccgaatgt gacactcgac gcttttgata
     4981 attaatctga tttttagaga attgttttct atgatatgtg agacctttgt ttaagacttt
     5041 agcattactt agtctctgcc tgccagtctc cattctagag tcaagtgaga caggagagaa
     5101 agtggatact aactcactgc agatatccta cacaacaaag gtcccaaaac tgccttaatt
     5161 cctgcccagg tggaagccag tcccctgctg cacagtcatc cagtctaggt tttctagatt
     5221 tggtaatgta agattgacac gttcttacca aagaaatcat ttctacccca ttaagctcac
     5281 tcacttcatg tgtttatttc ttttgaaaac tatggtgagg aagtgatcag agtcagtgtc
     5341 tggtgtagtg gaagcagctc ggcatttaga gttgattagc agtggctctg cagccaatta
     5401 gctatatctt gagagaggaa ctttatatct ttagattttg ggaggggggc acatctctat
     5461 aaaacagaga tttgatcatg tcatcaaagg acacatccta ttgaaaacat aaaccagaat
     5521 aaagtataat aacatccttg tgctaaagtc acaatgaaga aagcagatca gctcagaagc
     5581 ttccagaagt gaccccataa ctgaccatct attgggctta gaaatagagg tttctgcctg
     5641 cagagctttg atattcctgt aatgtccagt agatcctctt tttcagagtt ttcttttcat
     5701 ctcatgccag aaagccttga tgtttgagaa gaagtcaagt ctagcccagt cgatttgatg
     5761 cttgggtagc attgagaagg cagagggtat cgctctgccc tgtgtttgct ggcctgggca
     5821 cccacagctc tgcccacagg cagggtccct ggccctggtt ggtgaatgtg aagtcagggg
     5881 cacctgtcct tgctctactg tctctacgtc tgtgtaaata ggattgtttc attcacatct
     5941 tctccgtgtc acggaccgtc caagtatcgt gcggatctct gcgtctgctt tggatttatt
     6001 ttgaaagttc tctttgtgga aaaaaaaaca aataaatgta cagtctaata aaggatattt
     6061 cctgtgccgt gta
//
