LOCUS       NM_028878               3948 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 19 (Slc6a19), transcript variant 1, mRNA.
ACCESSION   NM_028878 XM_127449
VERSION     NM_028878.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3948)
  AUTHORS   Veniaminova,N.A., Jia,Y.Y., Hartigan,A.M., Huyge,T.J., Tsai,S.Y.,
            Grachtchouk,M., Nakagawa,S., Dlugosz,A.A., Atwood,S.X. and
            Wong,S.Y.
  TITLE     Distinct mechanisms for sebaceous gland self-renewal and
            regeneration provide durability in response to injury
  JOURNAL   Cell Rep 42 (9), 113121 (2023)
   PUBMED   37715952
REFERENCE   2  (bases 1 to 3948)
  AUTHORS   Cuny,H., Bozon,K., Kirk,R.B., Sheng,D.Z., Broer,S. and
            Dunwoodie,S.L.
  TITLE     Maternal heterozygosity of Slc6a19 causes metabolic perturbation
            and congenital NAD deficiency disorder in mice
  JOURNAL   Dis Model Mech 16 (5) (2023)
   PUBMED   36374036
  REMARK    GeneRIF: Maternal heterozygosity of Slc6a19 causes metabolic
            perturbation and congenital NAD deficiency disorder in mice.
REFERENCE   3  (bases 1 to 3948)
  AUTHORS   Treleaven,T., Zada,M., Nagarajah,R., Bailey,C.G., Rasko,J.E.J.,
            Morris,M.B. and Day,M.L.
  TITLE     Stage-Specific L-Proline Uptake by Amino Acid Transporter
            Slc6a19/B0AT1 Is Required for Optimal Preimplantation Embryo
            Development in Mice
  JOURNAL   Cells 12 (1), 18 (2022)
   PUBMED   36611813
  REMARK    GeneRIF: Stage-Specific L-Proline Uptake by Amino Acid Transporter
            Slc6a19/B[0]AT1 Is Required for Optimal Preimplantation Embryo
            Development in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3948)
  AUTHORS   Yu,Y., Zhang,B., Ji,P., Zuo,Z., Huang,Y., Wang,N., Liu,C., Liu,S.J.
            and Zhao,F.
  TITLE     Changes to gut amino acid transporters and microbiome associated
            with increased E/I ratio in Chd8+/- mouse model of ASD-like
            behavior
  JOURNAL   Nat Commun 13 (1), 1151 (2022)
   PUBMED   35241668
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3948)
  AUTHORS   Yap,Y.W., Rusu,P.M., Chan,A.Y., Fam,B.C., Jungmann,A.,
            Solon-Biet,S.M., Barlow,C.K., Creek,D.J., Huang,C.,
            Schittenhelm,R.B., Morgan,B., Schmoll,D., Kiens,B., Piper,M.D.W.,
            Heikenwalder,M., Simpson,S.J., Broer,S., Andrikopoulos,S.,
            Muller,O.J. and Rose,A.J.
  TITLE     Restriction of essential amino acids dictates the systemic
            metabolic response to dietary protein dilution
  JOURNAL   Nat Commun 11 (1), 2894 (2020)
   PUBMED   32518324
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3948)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   7  (bases 1 to 3948)
  AUTHORS   Bohmer,C., Broer,A., Munzinger,M., Kowalczuk,S., Rasko,J.E.,
            Lang,F. and Broer,S.
  TITLE     Characterization of mouse amino acid transporter B0AT1 (slc6a19)
  JOURNAL   Biochem J 389 (Pt 3), 745-751 (2005)
   PUBMED   15804236
  REMARK    GeneRIF: The mechanism of the mouse (m)B0AT1 (slc6a19) transporter
            was studied in detail using two electrode voltage-clamp techniques
            and tracer studies in the Xenopus oocyte expression system.
REFERENCE   8  (bases 1 to 3948)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 3948)
  AUTHORS   Kleta,R., Romeo,E., Ristic,Z., Ohura,T., Stuart,C.,
            Arcos-Burgos,M., Dave,M.H., Wagner,C.A., Camargo,S.R., Inoue,S.,
            Matsuura,N., Helip-Wooley,A., Bockenhauer,D., Warth,R.,
            Bernardini,I., Visser,G., Eggermann,T., Lee,P., Chairoungdua,A.,
            Jutabha,P., Babu,E., Nilwarangkoon,S., Anzai,N., Kanai,Y.,
            Verrey,F., Gahl,W.A. and Koizumi,A.
  TITLE     Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
  JOURNAL   Nat Genet 36 (9), 999-1002 (2004)
   PUBMED   15286787
  REMARK    GeneRIF: We isolated the human homolog of B(0)AT1, called SLC6A19,
            and determined its size and molecular organization. We then
            identified mutations in SLC6A19 in members of the original family
            in whom Hartnup disorder was discovered
REFERENCE   10 (bases 1 to 3948)
  AUTHORS   Broer,A., Klingel,K., Kowalczuk,S., Rasko,J.E., Cavanaugh,J. and
            Broer,S.
  TITLE     Molecular cloning of mouse amino acid transport system B0, a
            neutral amino acid transporter related to Hartnup disorder
  JOURNAL   J Biol Chem 279 (23), 24467-24476 (2004)
   PUBMED   15044460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158359.2, BY148246.1, AK028784.1, AK014544.1, AK162399.1 and
            BP760806.1.
            
            On Jan 8, 2018 this sequence version replaced NM_028878.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028784.1, AK014544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC158359.2         148758-148812       c
            56-85               BY148246.1         3-32
            86-2492             AK028784.1         2-2408
            2493-2524           AK014544.1         2409-2440
            2525-3310           AK162399.1         2185-2970
            3311-3311           AC158359.2         128402-128402       c
            3312-3934           AK162399.1         2972-3594
            3935-3948           BP760806.1         33-46               c
FEATURES             Location/Qualifiers
     source          1..3948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.14 cM"
     gene            1..3948
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 19"
                     /db_xref="GeneID:74338"
                     /db_xref="MGI:MGI:1921588"
     exon            1..349
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2052
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium-dependent neutral amino acid transporter B(0)AT1;
                     solute carrier family 6 member 19; system B(0) neutral
                     amino acid transporter AT1"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT1 isoform 1"
                     /protein_id="NP_083154.1"
                     /db_xref="CCDS:CCDS26634.1"
                     /db_xref="GeneID:74338"
                     /db_xref="MGI:MGI:1921588"
                     /translation="MVRLVLPNPGLEERIPSLDELEVIEKEEAGSRPKWDNKAQYMLT
                     CVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLYLEFAIGQRLRKGSMG
                     VWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSECPLNQNQT
                     GYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCIIRGIET
                     TGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVF
                     YSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVYAATVVYSIIGFRATERFD
                     DCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQTCDINSFLSEG
                     VEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITP
                     KKWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSFAGSIPLLIIAFCEMFAVVYV
                     YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPN
                     YEEFPKSQKIPYPNWVYAVVVTVAGVPCLSIPCFAIYKFIRNCCQKSDDHHGLVNTLS
                     TASVNGDLKN"
     exon            350..490
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..628
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..810
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..921
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1034
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1163
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1320
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1525
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1685
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1848
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..3936
                     /gene="Slc6a19"
                     /gene_synonym="4632401C08Rik; B<0>AT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgctgacg cctcctttcg gcccaggtgc ttgggttgag gtgccaaagg ttctctataa
       61 agagccggag ctcctggaca caaccacttg ccctttggct gccgagctgc ccgagtgtgc
      121 caggcccggc ccagcccagc gaccaccatg gtgaggcttg tgctgcccaa ccctggccta
      181 gaggagcgga ttccatctct ggatgagtta gaggtcattg aaaaggaaga ggccggctcc
      241 aggcccaaat gggacaacaa ggcccagtac atgctcacct gtgtgggctt ttgtgtgggg
      301 ctgggcaacg tgtggcgctt cccctaccta tgccagagcc atggaggagg ggccttcatg
      361 atcccattcc tcatccttct ggtgttcgag ggaattcctt tgctgtacct ggagtttgcc
      421 atcggtcaga ggctacgcaa gggcagcatg ggtgtgtgga gctccatcca ccctgctctg
      481 aagggtatag gcatcgcctc catgttcgtg tccttcatgg tgggcctgta ctacaacacc
      541 atcatcgcct gggtcatgtg gtacttcttc aactcctttc aggaacctct gccatggagt
      601 gaatgtccac tcaaccagaa ccagacaggc tatgtggaag agtgtgccaa gagctcttcc
      661 gtggactact tctggtaccg agagactctt aatatctcca cttccatcag tgactcaggc
      721 tccatccagt ggtggatcct gctctgcctg acatgtgcct ggagtgtgct gtatgtgtgt
      781 attatccgtg gcatcgagac cactgggaag gctgtgtaca tcacctccac cctgccctat
      841 gttgtactga ccatctttct catccgtggc ttgactctga agggtgccac caacggcatt
      901 gtcttccttt tcacacccaa tatcacagag ctgagcaacc ccaacacgtg gctggatgca
      961 ggtgctcagg tcttctactc cttctcactg gccttcgggg gcctcatctc cttctccagc
     1021 tacaactctg tgcacaataa ttgtgagatg gattctgtga tcgtgtctgt catcaatggc
     1081 ttcacatctg tgtatgcggc caccgtggtc tactccatca ttggcttccg agccactgag
     1141 cgctttgatg actgtgtcaa cacgaacatc ctgaccctca tcaatgggtt cgacctgccg
     1201 gagggcaatg tgacttcaga gaactttgag gcctaccaac agtggtgcaa tgccactaat
     1261 ccccaggcct atgcacaact gaagtttcag acctgtgaca ttaacagctt cctttctgag
     1321 ggtgtggagg gcacaggcct ggccttcatt gtcttcacgg aagccatcac gaagatgcca
     1381 gtgtccccac tgtggtcggt gctctttttt ataatgctct tctgcctggg actctcctcc
     1441 atgtttggga acatggaggg tgtggtcgta ccccttcagg acctcaatat cacccctaag
     1501 aagtggccca aagaattgtt gacaggcctc atctgcttgg ggacatatct catcgccttc
     1561 attttcacac tgaattcggg ccagtactgg ctctctctcc tggacagctt tgctggctcc
     1621 attcctctgc taatcatcgc cttttgtgag atgtttgccg tcgtctacgt gtatggagtt
     1681 gacaggttca acaaggacat cgagttcatg atcggccata agcccaacat cttctggcaa
     1741 gtcacgtgga gagtggtcag tccactgatc atgctggtca tcttcctctt cttttttgtg
     1801 attgaggtca acaaaacgct catgtatagc atctgggacc ctaactatga ggagttcccg
     1861 aaatctcaga agattccata ccccaactgg gtgtatgcag ttgtggtcac tgtggctgga
     1921 gtaccctgcc tctccatccc ctgctttgcc atctacaagt tcatcagaaa ttgttgtcag
     1981 aagtctgatg accaccatgg gctggtcaat acactgtcca cagcctctgt gaatggggac
     2041 cttaagaact gaatgggcct agtctgcata aggcagaaga tggtgtgtgg aggaagcaag
     2101 atgcaggacc catgggggga agtaggctgt aatatgtgtg aatgtgtgag tacagataca
     2161 tgtattcatg tcacacagat gtgtatacaa gtgttacaca aacatgtggg acacatagac
     2221 atgcttatgt gtatatacca gttttacaca tgtgtatata tagatcacat ctaccacatg
     2281 taaacgtaag tgtatatgca tgtaattgtg agttaatgta catatgatgt gcatatgttt
     2341 gtgtatatat tctgaagagg gcatatttat gcacacatgt atatatgcac acatgtgtta
     2401 tctagatgta tatatatatg ctcacatgtt aacacatatc tgtgtacaca tgtgtataca
     2461 tatattcatg aatggaatct atgatatgta tgaacatgca cactcataaa cttattatat
     2521 atgtatgtct gtatgtatgt gtgtatcttc tcaagtgaat tttgtgttgt atgtgtatgt
     2581 gcatgcactt gttcatttat gtttgttcat tgcaaatagg tatgtgtaca tgcctatgcc
     2641 atctttgtac acattgcaca catgtgaaaa tatttttaca tgctcttgat ggaagtgcct
     2701 accactatgg cctagtggtc ctccgcttgc tctcactata gggcatggac tacagcctgg
     2761 gtacagacag cttaggacct acctttccct gcagagagcc aaaagtgatt atgtggaggg
     2821 cccagtctgg tctccttccc tctgagtgga aggtaggagg tgagtatgtg ctgcaggcct
     2881 ggctcctggt aatgctgtca ctacccaggc atccctctgc cccttgctgt gagggctgga
     2941 ccgaggttct tctgctctgt aagaagcaca ggaagctggt ggactgacaa ggctgagaag
     3001 acttgtctca gtcagacctg atacaccctc acttcctgca tgcctgctta atcattagtc
     3061 actgagctgg ctgctcagcc aagctgacct tcccttctct tctgaatcag gggccactct
     3121 gtacacttat gaagagggaa tgagtctgta aatctttagc caaatgttgg aaaaggaggg
     3181 ttacagggta actcagctgt ggccactgct gttgagaaca ctccaaggaa aatgggcacc
     3241 ccagtgactg aagcctagaa gtctttggtc ctgtggcagt cagtgaagcc agggagggct
     3301 atgtctgctc ctccctacaa caggctggtt attcctgggt tcacatctac ccatctactt
     3361 gggacttggg gtttctgtta aaagctgatg tcctattttc atgggaaagc ccaaattaag
     3421 ttgaatttga ctttctgaaa atcctcacag aaaagggtaa gaaactgtgg tgggccccga
     3481 taccagtcat gtgccttcta tttggtgaca ccagccacat ctcacccacc agaaagctga
     3541 ggctcctact gctgaatcac ggagccctct tacacccttc tctacacacc gattccctga
     3601 gtactatcac cttaagaacc atacagaggc ataagatggg ggttggccct gggagaatat
     3661 gaagagtctc acactagtaa tttcaggggg ttcctcctct gggcctctga agcctcagct
     3721 ggaaaaatac tgctggtatt tatagccata aatatatgcc ctgttatgta cataatggag
     3781 attcctttct ggtcctgtgt ggtcttgctg gaggccaacc aaattctctg atttctctgg
     3841 ttcatgcctt atggactcat gtctccattg ggacagaaat ccaggttggt tgttgagtct
     3901 aaaatgtatc tttctcaata aagtactcct atttaaaaaa aaaaaaaa
//
