LOCUS       NM_001040692            4314 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 18 (Slc6a18), transcript variant 1, mRNA.
ACCESSION   NM_001040692
VERSION     NM_001040692.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4314)
  AUTHORS   Kaminski,M.M., Tosic,J., Kresbach,C., Engel,H., Klockenbusch,J.,
            Muller,A.L., Pichler,R., Grahammer,F., Kretz,O., Huber,T.B.,
            Walz,G., Arnold,S.J. and Lienkamp,S.S.
  TITLE     Direct reprogramming of fibroblasts into renal tubular epithelial
            cells by defined transcription factors
  JOURNAL   Nat Cell Biol 18 (12), 1269-1280 (2016)
   PUBMED   27820600
REFERENCE   2  (bases 1 to 4314)
  AUTHORS   Fairweather,S.J., Broer,A., Subramanian,N., Tumer,E., Cheng,Q.,
            Schmoll,D., O'Mara,M.L. and Broer,S.
  TITLE     Molecular basis for the interaction of the mammalian amino acid
            transporters B0AT1 and B0AT3 with their ancillary protein
            collectrin
  JOURNAL   J Biol Chem 290 (40), 24308-24325 (2015)
   PUBMED   26240152
  REMARK    GeneRIF: analysis of the interaction of amino acid transporters
            B0AT1 and B0AT3 with their ancillary protein collectrin
REFERENCE   3  (bases 1 to 4314)
  AUTHORS   McClelland,K.S., Bell,K., Larney,C., Harley,V.R., Sinclair,A.H.,
            Oshlack,A., Koopman,P. and Bowles,J.
  TITLE     Purification and Transcriptomic Analysis of Mouse Fetal Leydig
            Cells Reveals Candidate Genes for Specification of Gonadal
            Steroidogenic Cells
  JOURNAL   Biol Reprod 92 (6), 145 (2015)
   PUBMED   25855264
REFERENCE   4  (bases 1 to 4314)
  AUTHORS   Vanslambrouck,J.M., Broer,A., Thavyogarajah,T., Holst,J.,
            Bailey,C.G., Broer,S. and Rasko,J.E.
  TITLE     Renal imino acid and glycine transport system ontogeny and
            involvement in developmental iminoglycinuria
  JOURNAL   Biochem J 428 (3), 397-407 (2010)
   PUBMED   20377526
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4314)
  AUTHORS   Danilczyk,U., Sarao,R., Remy,C., Benabbas,C., Stange,G.,
            Richter,A., Arya,S., Pospisilik,J.A., Singer,D., Camargo,S.M.,
            Makrides,V., Ramadan,T., Verrey,F., Wagner,C.A. and Penninger,J.M.
  TITLE     Essential role for collectrin in renal amino acid transport
  JOURNAL   Nature 444 (7122), 1088-1091 (2006)
   PUBMED   17167413
REFERENCE   6  (bases 1 to 4314)
  AUTHORS   Romeo,E., Dave,M.H., Bacic,D., Ristic,Z., Camargo,S.M., Loffing,J.,
            Wagner,C.A. and Verrey,F.
  TITLE     Luminal kidney and intestine SLC6 amino acid transporters of
            B0AT-cluster and their tissue distribution in Mus musculus
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F376-F383 (2006)
   PUBMED   16174864
REFERENCE   7  (bases 1 to 4314)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   8  (bases 1 to 4314)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 4314)
  AUTHORS   Quan,H., Athirakul,K., Wetsel,W.C., Torres,G.E., Stevens,R.,
            Chen,Y.T., Coffman,T.M. and Caron,M.G.
  TITLE     Hypertension and impaired glycine handling in mice lacking the
            orphan transporter XT2
  JOURNAL   Mol Cell Biol 24 (10), 4166-4173 (2004)
   PUBMED   15121838
  REMARK    GeneRIF: The XT2 orphan transporter is involved in glycine
            reabsorption, and the absence of this transporter is sufficient to
            cause hypertension.
REFERENCE   10 (bases 1 to 4314)
  AUTHORS   Nash,S.R., Giros,B., Kingsmore,S.F., Kim,K.M., el-Mestikawy,S.,
            Dong,Q., Fumagalli,F., Seldin,M.F. and Caron,M.G.
  TITLE     Cloning, gene structure and genomic localization of an orphan
            transporter from mouse kidney with six alternatively-spliced
            isoforms
  JOURNAL   Recept Channels 6 (2), 113-128 (1998)
   PUBMED   9932288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158359.2.
            
            On Dec 15, 2009 this sequence version replaced NM_001040692.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC158359.2         125805-126055       c
            252-392             AC158359.2         123754-123894       c
            393-530             AC158359.2         123401-123538       c
            531-712             AC158359.2         122468-122649       c
            713-823             AC158359.2         120767-120877       c
            824-936             AC158359.2         119640-119752       c
            937-1065            AC158359.2         117958-118086       c
            1066-1222           AC158359.2         116163-116319       c
            1223-1427           AC158359.2         114887-115091       c
            1428-1587           AC158359.2         114343-114502       c
            1588-1750           AC158359.2         113569-113731       c
            1751-4314           AC158359.2         109782-112345       c
FEATURES             Location/Qualifiers
     source          1..4314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.13 cM"
     gene            1..4314
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 18"
                     /db_xref="GeneID:22598"
                     /db_xref="MGI:MGI:1336892"
     exon            1..251
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1942
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="isoform 1 is encoded by transcript variant 1; X
                     transporter protein 2; sodium-dependent neutral amino acid
                     transporter B(0)AT3; system B 0 neutral amino acid
                     transporter AT3; sodium and chloride dependent transporter
                     Xtrp2; b(0)AT3; solute carrier family 6 member 18; sodium-
                     and chloride-dependent transporter XTRP2"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT3 isoform 1"
                     /protein_id="NP_001035782.1"
                     /db_xref="CCDS:CCDS36727.1"
                     /db_xref="GeneID:22598"
                     /db_xref="MGI:MGI:1336892"
                     /translation="MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFP
                     YLCQTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLG
                     CFSVSFLVSLYYNTVLLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYF
                     WYRQTLNITSDISNTGTIQWKLFLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLV
                     LTIFLIRGLTLPGATEGLIYLFTPNMKTLQNPRVWLDAATQIFFSLSLAFGGHIAFAS
                     YNPPRNNCEKDAVIIALVNSMTSLYASIAIFSVMGFKASNDYGRCLDRNILSLINEFD
                     LPELSISRDEYPSVLMYLNATQTARVAQLPLKTCHLEDFLDKSASGPGLAFIVFTEAV
                     LHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLLDMGILPKGIPKEVMTGVICFA
                     CFLSAICFTLQSGGYWLEIFDSFAASLNLIIFAFMEVVGVIHIYGMKRFCDDIEWMTG
                     RRPGLYWQVTWRVVSPMLLFGIFLSYIVLLIQTPPSYKAWNPQYEHFPSREEKFYPGW
                     VQVTCVLLSFLPSLWVPGVALAQLLSQYKQRWKATHLESGLKLQESRGC"
     exon            252..392
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..530
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..712
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..823
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..936
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1065
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1222
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1427
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1587
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1750
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..4314
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="hexamer: ATTACA"
     polyA_site      2028
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="major polyA site"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="hexamer: AGTAAA"
     polyA_site      3037
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="major polyA site"
     regulatory      4296..4301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /note="hexamer: AATAAG"
     polyA_site      4312
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
ORIGIN      
        1 ttcagcttcc tcagagggcc ttctggacta gtgtgctgca aagtgtccac tgtacaccca
       61 gccttcccag ccctacccaa ggtgactgct catcatggca caggcctcag ggatggaccc
      121 gcttgtggac attgaggatg aaagacccaa gtgggacaac aaactccagt acctcctgag
      181 ctgcatcggt tttgctgtgg ggctggggaa catatggagg ttcccctacc tgtgccagac
      241 ccacggagga ggggccttcc tcatccccta tttcattgcc ctggtctttg agggtatccc
      301 gcttttctac atcgagcttg ccattggcca gcgcctacgg aggggaagca ttggagtgtg
      361 gaagaccatc tccccttacc tcggtggcgt aggcctgggc tgcttctcag tgtccttcct
      421 ggtcagtttg tactacaaca cggttctcct gtgggtctta tggttcttcc tcaactcctt
      481 ccaacacccg ctgccctgga gcacatgtcc gctggatctc aacagaacag gatttgtgca
      541 ggaatgccag agcagtggca ccgtgagcta cttctggtac cggcagactc tgaatatcac
      601 atctgacatc agcaacacag gcactatcca atggaagctg ttcctctgcc tggtggcctg
      661 ctggtcaact gtgtacctgt gtgtcatcag aggcattgag agcacgggga aggtgatcta
      721 ctttacagcc ttattccctt acctggtgct aaccatcttc ctcatcagag gtcttaccct
      781 gcctggagca acagagggcc tgatctacct gtttactccc aatatgaaga ctcttcagaa
      841 tccacgggtg tggttggatg cagccaccca gattttcttc tccctgtccc tggcctttgg
      901 agggcatatt gcttttgcaa gctacaaccc acccaggaac aattgtgaga aggacgccgt
      961 gattattgcc ctggtcaaca gcatgacctc cctgtatgca tccatcgcca tcttctccgt
     1021 catggggttc aaggcatcca atgactatgg aaggtgcctg gacagaaata tcttgagcct
     1081 catcaatgag tttgaccttc cagagcttag catctccagg gatgagtacc catctgtcct
     1141 catgtacctg aatgccactc agactgcgag ggtggcccaa cttcccctga agacctgcca
     1201 tctggaagat tttctggata agagtgcctc gggcccaggc ctggccttca tcgttttcac
     1261 agaagctgtc ctgcacatgc caggtgcttc tgtgtggtct gtgctcttct ttgggatgct
     1321 gtttaccctg ggtctgtcct ccatgtttgg gaacatggag ggtgtcatta caccactatt
     1381 ggacatgggg atcttaccca aaggtatacc caaggaggtc atgactgggg tgatctgctt
     1441 tgcctgtttc ctctcagcca tttgcttcac actgcagtct ggaggctact ggttggagat
     1501 ctttgacagt tttgcagctt ctctgaattt aatcatcttc gccttcatgg aagtggtggg
     1561 agtcattcac atttatggga tgaaacggtt ctgtgatgac attgaatgga tgactgggcg
     1621 gcggcccggc ctctactggc aggtgacatg gagggttgtg agccctatgc tgctgtttgg
     1681 aatcttcctg tcctacattg tccttctgat ccagacaccg cccagttaca aggcctggaa
     1741 cccccaatat gaacattttc cctcaagaga ggagaagttc tacccaggct gggtgcaggt
     1801 cacctgtgtg ctcctgtcct tcctgccctc actgtgggtc cctggagttg ctctggctca
     1861 gttactgtcc cagtacaaac agaggtggaa ggctacgcat ctggaaagtg gtctgaagct
     1921 acaggagagc agaggctgct gaggcggaga actagggtag atcagggttg ggaggaagac
     1981 ctgtgcccac tcagatgcag cctcattaca ctctgtccgc tactgagacc acgtgattat
     2041 tgctttccca gccttctgta tggtggaaga ctcacagatt cagggtagct gcgtgttgcc
     2101 cggtgggagt ccgtgtgatg ccattcctcc aaagctaggt ctcacaggat gcactctgtg
     2161 tggacatggc tttcccctag aatccatgct gagttgggta gccctgagtg tattttgttg
     2221 gcatagtggc aagaccgtgg aacccctttt ctcggagtag cctccacatt actaatttta
     2281 gaaatccaga cctaatgttg atcttcaagg gaaagctgag ctcaggggtg tggggagcct
     2341 gaaaggcagg aaacttcttc ctcccatatc atcctggtgt taccacatct ataaagagag
     2401 agatccacag gtgcagattc cagactatta gaggactggg tttcccatgc ctacaatcat
     2461 tgctgcaagg gagaggtggt cacaggtgag gagggactga ctgtaccctg tttcaccaga
     2521 catattgtca tttttatttt tcaagcttgt caagaaggta caaaatggct cctggacagt
     2581 tagattctac tctcttgcaa gtgataacca gttattcact catatctgtt cacccactgg
     2641 tactcttcac cagtgggggc ctctgcagcc ttgaagtata gccatggctc caaagtcatt
     2701 gcagggttca gagagctgcc ctccaccctg ttctgttttc tgccccttcc atcaagattg
     2761 tgaactaggg tcatctctga aacctgggga cttgggcaag catgttcact tcttgtacca
     2821 accagtggct ttgtgatgct agtaacttcc caggcacagc agaccctggt gcctttgggg
     2881 ggagagggtg gggaggggga gaaggatagt ggtactgtcc acagtgatga cattttaagc
     2941 aaaaaaggct tatgtgtgtg caaatgtgac tcttactgga agccaccctt gtcagggtta
     3001 gcccagaatt caaagtaaac atgaaagtct ctgtttatcc atctgcatat tcactgagca
     3061 atatacacag aatgaacccc aaggtacaca acaaaaagta ctcaagtcta caaagggtta
     3121 aagcccgtac ttggtccagc atcctggact atgacaactg cctatgtcca tccattctgc
     3181 cattgataaa tattcttgat aagcaggaat attagaggca cctatcctta tacaaggtat
     3241 tttatgtcca tatcatgttt caaaattgag ttgtcatagg ggcctattat cagggaaata
     3301 ccttcagtgt tgggcatcat aaaagcaggg tgggctctgc cagcaccttg gaagaatatg
     3361 ccttctgcca ggattgaaat ggaagcatgg gccctagaat ttggagtcct gcttagccat
     3421 agagagcaag ggtttgggtg ctaacctctt cagaatagtc cattctgcac acattcttga
     3481 tacagctatg aaaatatcca ggtagaagga aagatggaca ggaggcatgt ccaatggatg
     3541 gcttacaggt aggcatatca acatatgggc agtccaaaac atcagaggtt ccacctctat
     3601 caaacaggtt gattgtttag agcccctgat gagtgcctgg gatattgggg tggctaccaa
     3661 agcactatcc aggatgaggt gaacaagggg ctctgcagag caaaggtgaa tgaatgacct
     3721 gaaactgcat gaccataact tcatgcaagg tatccctcaa gttgacccta cccttgagaa
     3781 aaccatgggc aaggcccatg cagcaaaaac cagaccacaa aacctgcaac ctgttggaac
     3841 acactacttc tcagggcaac agtgtcaaca tagaaatgaa gctgctatca atagcctgtg
     3901 aactctaaga cgaacacagt gtccatgact aaggttagga ttatacccag agaggtgttc
     3961 atctatactc tagggtgaga ggtagttctg catccaggca atcctgagag cacaagttca
     4021 gacaagtcaa cttactgtat gggaagcaac ccctcttaca tatgggtgga gctggaactc
     4081 attgtgaaag acacccccat gtgactaggg agtgagtctg gtacctcact caggatgata
     4141 gcatttcctt cagatacatc catttgccca agaatttcat aaattcattg tttttaatag
     4201 ctgagtagta ctccattgtg taaatgtacc aaattttctg tatccaatcc tctgttgacg
     4261 gacatctggg ttctttccac cttctggcta ttataaataa ggctgctatg aaca
//
