LOCUS       NP_001035782             615 aa            linear   ROD 01-JUN-2024
DEFINITION  sodium-dependent neutral amino acid transporter B(0)AT3 isoform 1
            [Mus musculus].
ACCESSION   NP_001035782
VERSION     NP_001035782.1
DBSOURCE    REFSEQ: accession NM_001040692.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 615)
  AUTHORS   Kaminski,M.M., Tosic,J., Kresbach,C., Engel,H., Klockenbusch,J.,
            Muller,A.L., Pichler,R., Grahammer,F., Kretz,O., Huber,T.B.,
            Walz,G., Arnold,S.J. and Lienkamp,S.S.
  TITLE     Direct reprogramming of fibroblasts into renal tubular epithelial
            cells by defined transcription factors
  JOURNAL   Nat Cell Biol 18 (12), 1269-1280 (2016)
   PUBMED   27820600
REFERENCE   2  (residues 1 to 615)
  AUTHORS   Fairweather,S.J., Broer,A., Subramanian,N., Tumer,E., Cheng,Q.,
            Schmoll,D., O'Mara,M.L. and Broer,S.
  TITLE     Molecular basis for the interaction of the mammalian amino acid
            transporters B0AT1 and B0AT3 with their ancillary protein
            collectrin
  JOURNAL   J Biol Chem 290 (40), 24308-24325 (2015)
   PUBMED   26240152
  REMARK    GeneRIF: analysis of the interaction of amino acid transporters
            B0AT1 and B0AT3 with their ancillary protein collectrin
REFERENCE   3  (residues 1 to 615)
  AUTHORS   McClelland,K.S., Bell,K., Larney,C., Harley,V.R., Sinclair,A.H.,
            Oshlack,A., Koopman,P. and Bowles,J.
  TITLE     Purification and Transcriptomic Analysis of Mouse Fetal Leydig
            Cells Reveals Candidate Genes for Specification of Gonadal
            Steroidogenic Cells
  JOURNAL   Biol Reprod 92 (6), 145 (2015)
   PUBMED   25855264
REFERENCE   4  (residues 1 to 615)
  AUTHORS   Vanslambrouck,J.M., Broer,A., Thavyogarajah,T., Holst,J.,
            Bailey,C.G., Broer,S. and Rasko,J.E.
  TITLE     Renal imino acid and glycine transport system ontogeny and
            involvement in developmental iminoglycinuria
  JOURNAL   Biochem J 428 (3), 397-407 (2010)
   PUBMED   20377526
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 615)
  AUTHORS   Danilczyk,U., Sarao,R., Remy,C., Benabbas,C., Stange,G.,
            Richter,A., Arya,S., Pospisilik,J.A., Singer,D., Camargo,S.M.,
            Makrides,V., Ramadan,T., Verrey,F., Wagner,C.A. and Penninger,J.M.
  TITLE     Essential role for collectrin in renal amino acid transport
  JOURNAL   Nature 444 (7122), 1088-1091 (2006)
   PUBMED   17167413
REFERENCE   6  (residues 1 to 615)
  AUTHORS   Romeo,E., Dave,M.H., Bacic,D., Ristic,Z., Camargo,S.M., Loffing,J.,
            Wagner,C.A. and Verrey,F.
  TITLE     Luminal kidney and intestine SLC6 amino acid transporters of
            B0AT-cluster and their tissue distribution in Mus musculus
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F376-F383 (2006)
   PUBMED   16174864
REFERENCE   7  (residues 1 to 615)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   8  (residues 1 to 615)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (residues 1 to 615)
  AUTHORS   Quan,H., Athirakul,K., Wetsel,W.C., Torres,G.E., Stevens,R.,
            Chen,Y.T., Coffman,T.M. and Caron,M.G.
  TITLE     Hypertension and impaired glycine handling in mice lacking the
            orphan transporter XT2
  JOURNAL   Mol Cell Biol 24 (10), 4166-4173 (2004)
   PUBMED   15121838
  REMARK    GeneRIF: The XT2 orphan transporter is involved in glycine
            reabsorption, and the absence of this transporter is sufficient to
            cause hypertension.
REFERENCE   10 (residues 1 to 615)
  AUTHORS   Nash,S.R., Giros,B., Kingsmore,S.F., Kim,K.M., el-Mestikawy,S.,
            Dong,Q., Fumagalli,F., Seldin,M.F. and Caron,M.G.
  TITLE     Cloning, gene structure and genomic localization of an orphan
            transporter from mouse kidney with six alternatively-spliced
            isoforms
  JOURNAL   Recept Channels 6 (2), 113-128 (1998)
   PUBMED   9932288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158359.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.13 cM"
     Protein         1..615
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT3 isoform 1"
                     /note="X transporter protein 2; sodium-dependent neutral
                     amino acid transporter B(0)AT3; system B 0 neutral amino
                     acid transporter AT3; sodium and chloride dependent
                     transporter Xtrp2; b(0)AT3; solute carrier family 6 member
                     18; sodium- and chloride-dependent transporter XTRP2"
                     /calculated_mol_wt=69098
     Region          16..591
                     /region_name="SLC6sbd_B0AT3"
                     /note="glycine transporter, B0AT3; solute-binding domain;
                     cd11517"
                     /db_xref="CDD:212086"
     Site            27..47
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            order(32,35,412,415..416)
                     /site_type="other"
                     /note="Na binding site 2 [ion binding]"
                     /db_xref="CDD:212086"
     Site            order(33..34,36..39,114,262..263,268,270,416,419..420)
                     /site_type="other"
                     /note="putative substrate binding site 1 [chemical
                     binding]"
                     /db_xref="CDD:212086"
     Site            order(34,39,263,295)
                     /site_type="other"
                     /note="Na binding site 1 [ion binding]"
                     /db_xref="CDD:212086"
     Site            order(41..42,113,117,120,381,385)
                     /site_type="other"
                     /note="putative substrate binding site 2 [chemical
                     binding]"
                     /db_xref="CDD:212086"
     Site            53..73
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            106..126
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            143
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (O88576.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (O88576.1)"
     Site            178..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            207..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            289..309
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O88576.1)"
     Site            398..418
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            442..462
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            473..493
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            521..541
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     Site            571..591
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88576.1)"
     CDS             1..615
                     /gene="Slc6a18"
                     /gene_synonym="B0AT3; D630001K16Rik; Xt2; Xtrp2"
                     /coded_by="NM_001040692.3:95..1942"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36727.1"
                     /db_xref="GeneID:22598"
                     /db_xref="MGI:MGI:1336892"
ORIGIN      
        1 maqasgmdpl vdiederpkw dnklqyllsc igfavglgni wrfpylcqth gggaflipyf
       61 ialvfegipl fyielaigqr lrrgsigvwk tispylggvg lgcfsvsflv slyyntvllw
      121 vlwfflnsfq hplpwstcpl dlnrtgfvqe cqssgtvsyf wyrqtlnits disntgtiqw
      181 klflclvacw stvylcvirg iestgkviyf talfpylvlt iflirgltlp gategliylf
      241 tpnmktlqnp rvwldaatqi ffslslafgg hiafasynpp rnncekdavi ialvnsmtsl
      301 yasiaifsvm gfkasndygr cldrnilsli nefdlpelsi srdeypsvlm ylnatqtarv
      361 aqlplktchl edfldksasg pglafivfte avlhmpgasv wsvlffgmlf tlglssmfgn
      421 megvitplld mgilpkgipk evmtgvicfa cflsaicftl qsggywleif dsfaaslnli
      481 ifafmevvgv ihiygmkrfc ddiewmtgrr pglywqvtwr vvspmllfgi flsyivlliq
      541 tppsykawnp qyehfpsree kfypgwvqvt cvllsflpsl wvpgvalaql lsqykqrwka
      601 thlesglklq esrgc
//
