LOCUS       NM_001293689            6335 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 17 (Slc6a17), transcript variant 1, mRNA.
ACCESSION   NM_001293689 XM_006501405
VERSION     NM_001293689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6335)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 6335)
  AUTHORS   Jia,X., Zhu,J., Bian,X., Liu,S., Yu,S., Liang,W., Jiang,L., Mao,R.,
            Zhang,W. and Rao,Y.
  TITLE     Importance of glutamine in synaptic vesicles revealed by functional
            studies of SLC6A17 and its mutations pathogenic for intellectual
            disability
  JOURNAL   Elife 12, 86972 (2023)
   PUBMED   37440432
  REMARK    GeneRIF: Importance of glutamine in synaptic vesicles revealed by
            functional studies of SLC6A17 and its mutations pathogenic for
            intellectual disability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6335)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6335)
  AUTHORS   Iqbal,Z., Willemsen,M.H., Papon,M.A., Musante,L., Benevento,M.,
            Hu,H., Venselaar,H., Wissink-Lindhout,W.M., Vulto-van
            Silfhout,A.T., Vissers,L.E., de Brouwer,A.P., Marouillat,S.,
            Wienker,T.F., Ropers,H.H., Kahrizi,K., Nadif Kasri,N.,
            Najmabadi,H., Laumonnier,F., Kleefstra,T. and van Bokhoven,H.
  TITLE     Homozygous SLC6A17 mutations cause autosomal-recessive intellectual
            disability with progressive tremor, speech impairment, and
            behavioral problems
  JOURNAL   Am J Hum Genet 96 (3), 386-396 (2015)
   PUBMED   25704603
REFERENCE   5  (bases 1 to 6335)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY155578.1, AK083807.1 and AC124727.4.
            
            On Jun 13, 2014 this sequence version replaced XM_006501405.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083807.1, ERR3363658.1580839.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AY155578.1         2-102
            102-313             AK083807.1         3-214
            314-314             AC124727.4         139350-139350       c
            315-3518            AK083807.1         216-3419
            3519-4061           AK083807.1         3421-3963
            4062-4115           AK083807.1         3965-4018
            4116-4707           AK083807.1         4020-4611
            4708-6335           AY155578.1         4700-6327
FEATURES             Location/Qualifiers
     source          1..6335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..6335
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 17"
                     /db_xref="GeneID:229706"
                     /db_xref="MGI:MGI:2442535"
     exon            1..413
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..786
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..2684
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orphan sodium- and chloride-dependent neurotransmitter
                     transporter NTT4; sodium-dependent neutral amino acid
                     transporter SLC6A17"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     SLC6A17 isoform 1"
                     /protein_id="NP_001280618.1"
                     /db_xref="CCDS:CCDS79998.1"
                     /db_xref="GeneID:229706"
                     /db_xref="MGI:MGI:2442535"
                     /translation="MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGET
                     GGKQKVAEEELDTEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPY
                     LVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVI
                     IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSIS
                     ESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRG
                     AVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAA
                     LVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHV
                     NFSHLTTKDYSEMYSVIMTVKEKQFPALGLDPCLLEDELDKSVQGTGLAFIAFTEAMT
                     HFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVG
                     LLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFQPYR
                     FYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITL
                     IAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPS
                     EAPSPMPTHRSYLGPGSTSPLDNSNNPNGRYGSGYLLASTPESEL"
     exon            787..944
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1071
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1253
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1364
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1606
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1799
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1992
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2152
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2315
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..6317
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6296..6301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /note="hexamer: AATAAA"
     polyA_site      6317
                     /gene="Slc6a17"
                     /gene_synonym="D130012J15Rik; Ntt4"
                     /note="major polyA site"
ORIGIN      
        1 agggtggcct ttcggaaagc gagggaacag cgcgcgccgc gctccgccca gctccgttcc
       61 gctccgcaga gccgacgcgg accgggcacg gggacgacgg cactcggccg gggccttcgc
      121 agccacgcgc tccctccgcg gcgggatctg agccccgggg cggctcccta gagccccgag
      181 cgagcggagg gcgggagcag ggttgggact cacggcgacg gagggagcga caagccagct
      241 gagtcgcgtg cgccggcgcg cgcagctcca ggtcccccag ccccagctgg ggcctgtcgc
      301 tgcctgactc cccttgccct cgggaaggac ggtgcaccca cgacccgtcc gggaccacgg
      361 ccactcggcg gaaatccagg ggccgagtcc gcgcgacggc ccacgcggga caggcttttg
      421 gatgagaaaa agctgacagg aaccgagccc caccttctct gtgtgctggg gaacagggct
      481 acacggcccc agtggcaccc atgccgaaga acagcaaggt gacccagcgc gaacacagca
      541 atgagcatgt caccgagtca gtggctgact tgctggctct ggaggagcct gtggactaca
      601 agcagagtgt actgaacgtg gccggcgaga caggtggcaa gcagaaggtg gcggaggagg
      661 agctggacac agaggaccgg ccagcctgga atagcaagct gcagtacatc ctggcccaga
      721 ttggcttctc tgtgggcctg ggcaacatct ggaggttccc ctacctgtgc cagaaaaatg
      781 gaggaggtgc ctatctggtg ccctatctgg tgctgcttat catcattggc atccccctct
      841 tctttctgga gctggctgtg ggccagagga tccgccgtgg cagcattggt gtgtggcact
      901 atgtgtgccc ccgcctgggg ggcatcggct tttccagctg tattgtctgc ctcttcgttg
      961 ggctgtacta caatgtgatc attgggtgga gcgtcttcta tttcttcaag tctttccagt
     1021 acccactgcc ctggagtgaa tgtcctgtca tcaggaatgg gactgtagca gtggtggagc
     1081 ctgagtgtga gaagagctca gctactacct acttttggta ccgagaggcc ttggacatct
     1141 ccaactcgat ttcagagagt gggggcctca actggaagat gacactctgc ctccttgtgg
     1201 cctggagcat cgtgggcatg gctgtcgtca agggcatcca gtcctctgga aaggtaatgt
     1261 atttcagctc cctcttccct tatgtggtgt tggcctgctt cctggtccgg gggctgctgc
     1321 ttcgaggggc agtggatggc atcctgcaca tgttcactcc taagctggac aagatgctgg
     1381 acccccaggt gtggcgggag gcagccacac aggtcttctt cgccctgggg ctgggctttg
     1441 gaggcgtcat cgccttttcc agctacaaca aacaggacaa taactgccac ttcgatgctg
     1501 ccctggtgtc cttcatcaac ttcttcacct cggtgttggc caccctcgtg gtgtttgctg
     1561 tgctgggctt caaagccaac atcatgaatg agaagtgtgt ggtcgagaat gctgagaaaa
     1621 ttctagggta cctcaactcc aatgtcttga gccgggacct catcccacct cacgtcaact
     1681 tctcacacct gactaccaag gactactcag agatgtacag cgtcatcatg actgttaagg
     1741 agaagcagtt cccagccctg ggcctggatc cctgcctctt ggaggatgag ctggacaagt
     1801 ctgtgcaggg cacaggcctg gccttcatcg ccttcactga ggccatgaca catttcccgg
     1861 cctccccgtt ctggtccgtc atgttcttct tgatgctcat caacctgggc ctgggcagca
     1921 tgatcgggac catggcagga atcaccacac ccatcatcga caccttcaag gtgcccaagg
     1981 agatgttcac agttggctgc tgtgtctttg cattcttcgt ggggctgttg ttcgtccagc
     2041 gctccggaaa ctactttgtc accatgtttg atgactattc ggccaccctg ccactcaccg
     2101 tcatcgtcat ccttgagaac atcgctgtgg cctggattta tggaaccaag aagtttatgc
     2161 aggagctgac agagatgctg ggcttccagc cgtatcgatt ctatttctac atgtggaagt
     2221 ttgtgtctcc actgtgcatg gctgtgctca ccacagccag catcatccag ctgggggtgt
     2281 cgcccccagg ctacagtgcc tggatcaaag aggaggctgc tgagcgctac ttgtacttcc
     2341 ccaactgggc catggcactg ctgatcaccc tcattgccgt ggccaccctg cccatccctg
     2401 tggtgttcat cctgcggcac ttccacttgc tctccgacgg gtccaacacc ctctctgtgt
     2461 cctacaagaa gggccgcatg atgaaggaca tctccaatct ggaggagaac gatgagacgc
     2521 gcttcatcct cagcaaggtg cccagtgagg cgccctcccc catgcccacc caccgctcct
     2581 atctggggcc tggcagcaca tcacccttgg ataacagcaa caatcccaac ggacgctatg
     2641 gaagcggcta cctcttggcc agcacccctg agtcagagct gtgaccacag ctccaccctg
     2701 cctgcctccc ctcaataccc aacctgccca cttgtctggg cctggtctct tcctccatgg
     2761 tggccaccag acccaggcca gtccaaggag agaggatctg tcctgccttg ttccccaccc
     2821 aagtcccagc agactcccta cctatgagca ggggactggg gacaattcag tccctattcc
     2881 aggcccccaa cccgtgtaac ttttttgaga actcttgcca agttgcagtc atgtaaccac
     2941 aaaatcccag tatgggggga cttcaagtgg acactttagg agtcacctcc ccctctccct
     3001 gtaaaaccta tcacttgtag ttcttgggtc tcagggaggg tccatttgtg ctgctggtca
     3061 cggtgggtgg tggtggacag gggctttagg gctgagggtg caggatgtag gcgttagccc
     3121 agcctgccaa aagactcatc gtcctgtcca gccctgccag gctcctcctg agctaagata
     3181 gggttaggga tgcgtgtatc aggtctcagg ctttgctttg ccagaaggta tatggagtct
     3241 cttcaattct gtcttttgag aaaggtggag acctctcagg cttaagcatg aatgctgcca
     3301 tcgaatgaaa tgaatccaca gccagctcgt ggagccttta aatgtcccta tttacaggtc
     3361 ctgccggaga gcacagtgat ggggtcactt taactagggc ttagccattt ctcaatctcc
     3421 tctatccaac ctggagccac gggtggtggt ctttgcctct gtcccagaaa gaagagggca
     3481 cagtgcataa tgggtgaggt ttccagagca caatttgcag gctcccagca caatctagat
     3541 ggtttggagc acaagagaaa caagcgcacc tcacctggag ccccatcttc tccttagtgg
     3601 cagcttctcc cctggattga gggttcctgg aggtcagagg tgtgtcacca ggagcccttg
     3661 tttctaagga aagacaggta aactcactgc cctctctggc tgccactcac tctccttgtt
     3721 gtacaagcac agccgctggt gtgcacatca tgcggagaca ccttgggaac ctttccctaa
     3781 cttcccccag cctgttcagg ggagtggcac aggcagttct gggcagcgga aagcctctgg
     3841 tcttaggctc caagggagat acaatctatg gcactgtccc tgaccacctt tcaaggctcc
     3901 tctgggagga aggctgcctc agagcggcct gtgaggattc ggaagctgac ctgagactca
     3961 gagtatctct ctgcagtatc accttagaga gatgggtgta tggacttata tggttggccg
     4021 gttgggatgg acagatggat gggtgcatgg atggggtcac cttagctagg gtttagtcat
     4081 ttctcaatct tctccttcca acctggagcc aggggtggtg gtcttacata caacatccat
     4141 gcacacacac acacacacac acacacacac acacacacac acacacacac actgtttcta
     4201 tctttgaaag ttctggtcag caggaacaga cctgggcacc tgacagaggt tcctgggtca
     4261 ttgttgtggc ctaaatttcc ctcagtcctg agagggacga cagcctaggc ccagatgtcc
     4321 accacttgct cctaaagcct cctggatacc tccctcccta gcctgagagg tcccccaccc
     4381 tcagcctgcc atctcttatt cctcagttcc acacaccttc tctcacttct agccttcttg
     4441 gtcccacctg tcatagtatt taaggtgaga gggaaatgag ctttggggtc ccaccatcgg
     4501 ccccctcacc tgacaacacc ccctagctgg ccccgtgcct agtcctgagc agaattagaa
     4561 aacaggaaag ccaggcccta gcagagactc cactctctct cctcctctcc acatgctatt
     4621 tctattgtac attcaatctg tacatgtggg tgtagatgct gtgaaatgac aaacccaata
     4681 ttatactgtg gctggtggac tattttcatc ctcagtgccg tacagatcta ttttcattgt
     4741 atatttgata tatttttaat tttgtagcgt ggctgggcca ggccccagcc tgtgagcctg
     4801 cagtgagtgg gggatggggg gtgggggcgg ggggctgggt ggagctgagc tagggctgtt
     4861 tgcttatgcc ttgtgggctc tgtagtgtgt gttgtagcct tttgctgtaa gccagaatct
     4921 gtcctggcta catctttgct tctgtgagtt ggacatagga cccagagctc tatggttgtg
     4981 tgtatgtgtg tgtgtgtctg tgtgtgtgtg tgtgtgttac attcgtaggt gtgagtgcat
     5041 aaggtgctga tctgtgacac ccccacccac ccagtgttca tcaccttctg aagaccccgt
     5101 gtcttcctct cagctctatg ggtgagacct caggacaggc acctctaaga agcaccagct
     5161 gtggggaaag gcacgtgttt ccttcaggtg actcattgtc atttcacctt tggtgggaag
     5221 gagggccttg ggtgggggtg gaaagccctc agatttattt tccagtcaac cttctgttgt
     5281 tcacactgga gtcacgatgt cttaggcaga cagtaccggg cttcttagga ggaaggcatc
     5341 tctctgccct tcggtcctgc ccttgtcctt gaaaaagtct ggagtactca gaaagcaaca
     5401 gccgcttctc agacctccgc tggctcctcc ggagagatga ggtgggctca cctgaccact
     5461 gaagaccagc ctcagcttcc gtggaagagc tggaagtgag ggctgggtct ccaagtcttg
     5521 gcgcagggtc cctagtgctg gttggcgctg ctcatacggt gcctaccagg agacaagggg
     5581 tttccggggc tgagtcattc gagttggggc agtgcagagg tacacctaag agttcctgtt
     5641 ctgacagctc tcagctccag tcaccagctt cttgctcagg gagccctcag ccctcttcat
     5701 ggggacagcg aggagcctga ggcctaggtt gggtggtggg ggagacgtga ggtgcagagg
     5761 aattatagat agggttggct tctgccatca agcaatacat cgtcaggagc tggctgctgc
     5821 tttttaagtg ccaggagacg tcctccagag gccgtgctcg tgtgtgagcc ctgaggctat
     5881 gagccaatcc ccgtgcagat ctgcagtatt cccaggcagg gactgctctt cttcccttcc
     5941 ttaccactac attacccttc cctcaactag agtatgccca ctgtgaaaag agaagtgaga
     6001 tcacgcaggc tgtaatacac ctgactctgt acacctctga gtccctcttc ttaggtctga
     6061 actatgggga gctaggggag gagggccccg ggtcatttct catgagaagt cctgctttgt
     6121 acagacctaa acacatacca ggcagtcact tccggtcctg acacacgttc agaacagttt
     6181 aagttcatgt gtcctggagt ggccagtgct ctgagtcagg atcacttggc ccaggagagg
     6241 gcatgaggca ttgtcacccc agggccccca cttcatctcc cccaccctgc tgtacaataa
     6301 agtgtctgtt cttagcaaaa aaaaaaaaaa aaaaa
//
