LOCUS       NM_001358821            3693 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 15 (Slc6a15), transcript variant c, mRNA.
ACCESSION   NM_001358821 XM_006512982
VERSION     NM_001358821.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3693)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3693)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3693)
  AUTHORS   Schraut,K.G., Kalnytska,O., Lamp,D., Jastroch,M., Eder,M.,
            Hausch,F., Gassen,N.C., Moore,S., Nagaraj,N., Lopez,J.P., Chen,A.
            and Schmidt,M.V.
  TITLE     Loss of the psychiatric risk factor SLC6A15 is associated with
            increased metabolic functions in primary hippocampal neurons
  JOURNAL   Eur J Neurosci 53 (2), 390-401 (2021)
   PUBMED   33007132
  REMARK    GeneRIF: Loss of the psychiatric risk factor SLC6A15 is associated
            with increased metabolic functions in primary hippocampal neurons.
REFERENCE   4  (bases 1 to 3693)
  AUTHORS   Zhang,Q., Huang,R., Ye,Y., Guo,X., Lu,J., Zhu,F., Gong,X.,
            Zhang,Q., Yan,J., Luo,L., Zhuang,S., Chen,Y., Zhao,X., Evans,S.M.,
            Jiang,C., Liang,X. and Sun,Y.
  TITLE     Temporal requirements for ISL1 in sympathetic neuron proliferation,
            differentiation, and diversification
  JOURNAL   Cell Death Dis 9 (2), 247 (2018)
   PUBMED   29445148
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3693)
  AUTHORS   Chandra,R., Francis,T.C., Nam,H., Riggs,L.M., Engeln,M.,
            Rudzinskas,S., Konkalmatt,P., Russo,S.J., Turecki,G., Iniguez,S.D.
            and Lobo,M.K.
  TITLE     Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress
            Susceptibility
  JOURNAL   J Neurosci 37 (27), 6527-6538 (2017)
   PUBMED   28576941
  REMARK    GeneRIF: Our study demonstrates a role for reduced Slc6a15, a
            neutral amino acid transporter, in nucleus accumbens (NAc) in
            depression and stress susceptibility. The reduction of Slc6a15
            occurs selectively in the NAc D2-neurons. Genetic reduction of
            Slc6a15 induces susceptibility to a subthreshold stress, while
            genetic overexpression in D2-neurons prevents social avoidance
            after chronic social defeat stress.
REFERENCE   6  (bases 1 to 3693)
  AUTHORS   Hagglund,M.G., Roshanbin,S., Lofqvist,E., Hellsten,S.V.,
            Nilsson,V.C., Todkar,A., Zhu,Y., Stephansson,O., Drgonova,J.,
            Uhl,G.R., Schioth,H.B. and Fredriksson,R.
  TITLE     B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is
            involved in mediating the effect of leucine in the brain
  JOURNAL   PLoS One 8 (3), e58651 (2013)
   PUBMED   23505546
REFERENCE   7  (bases 1 to 3693)
  AUTHORS   Drgonova,J., Liu,Q.R., Hall,F.S., Krieger,R.M. and Uhl,G.R.
  TITLE     Deletion of v7-3 (SLC6A15) transporter allows assessment of its
            roles in synaptosomal proline uptake, leucine uptake and behaviors
  JOURNAL   Brain Res 1183, 10-20 (2007)
   PUBMED   17931606
  REMARK    GeneRIF: Slc6a15 knockout mice demonstrate only modest alterations
            in rotarod performance with aging and lack reproducible alterations
            in other motor, memory, anxiety or olfactory tests
REFERENCE   8  (bases 1 to 3693)
  AUTHORS   Broer,A., Tietze,N., Kowalczuk,S., Chubb,S., Munzinger,M., Bak,L.K.
            and Broer,S.
  TITLE     The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral
            amino acid transporter (B0AT2)
  JOURNAL   Biochem J 393 (Pt 1), 421-430 (2006)
   PUBMED   16185194
  REMARK    GeneRIF: The structure and function of B0AT2 are reported.
REFERENCE   9  (bases 1 to 3693)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   10 (bases 1 to 3693)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN460271.1, CF736974.1, BC076593.1 and AW124505.1.
            
            On Dec 9, 2017 this sequence version replaced XM_006512982.3.
            
            Transcript Variant: This variant (c) represents the longest
            transcript. Variants a, b and c encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.146293.1,
                                           SRR1660813.140026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               CN460271.1         1-108
            109-805             CF736974.1         1-697
            806-3673            BC076593.1         676-3543
            3674-3693           AW124505.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 53.98 cM"
     gene            1..3693
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 15"
                     /db_xref="GeneID:103098"
                     /db_xref="MGI:MGI:2143484"
     exon            1..346
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..791
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             503..2692
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /note="orphan sodium- and chloride-dependent
                     neurotransmitter transporter NTT73; B0AT2 protein; orphan
                     transporter v7-3; solute carrier family 6 member 15"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT2"
                     /protein_id="NP_001345750.1"
                     /db_xref="CCDS:CCDS24156.1"
                     /db_xref="GeneID:103098"
                     /db_xref="MGI:MGI:2143484"
                     /translation="MPKNSKVVKRDLDDDVIESVKDLLSNEDSVEEVSKKSELIVDVQ
                     EEKDTDAEDGSEADDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLP
                     YLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNV
                     IIGWTLFYFSQSFQQPLPWDQCPLVKNASHTYVEPECEQSSATTYYWYREALDITSSI
                     SDSGGLNWKMTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLN
                     GSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA
                     VLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKMGNISWDVIPHH
                     INLSAVTVEDYRLVYDIIQKVKEEEFAVLHLNACQIEDELNKAVQGTGLAFIAFTEAM
                     THFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPIVDTFKVRKEILTVICCLLAFCI
                     GLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFIEDLTDMLGFAPS
                     KYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFS
                     LMVLAILPVPVVFIIRRCNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDASLIHGKIP
                     SEMSSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADMPDMPESDL"
     exon            792..949
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1076
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1258
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1369
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1611
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1804
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1997
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2157
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2320
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..3677
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3654..3659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /note="hexamer: AATAAA"
     polyA_site      3677
                     /gene="Slc6a15"
                     /gene_synonym="v7-3"
                     /note="major polyA site"
ORIGIN      
        1 cacaagcaca tacacacata cacacacgca cgcacacaca cagacatgca catacacaca
       61 ttcacataac acgcacgcac acatacatac atacatacat tcacaggcgc cccaggaacc
      121 acacgccagc atcccgtgca atattccagg cagacacagg cgctcacgag tttctccgtg
      181 ccagcttgca ggacagcgac tcccgaaacc aatcctgccc ttggcaagct gtttctgttc
      241 tccagacagc tcctctgcgg cctcccgcac catctgctgg atccgaccct ttttcgacct
      301 aggaacctgg aagctgtaag aggtgctagc tcaagaagca ccagaggtat atacagagta
      361 ttgggatcag atccaggatc cataatagtt tctcaccttg aatcaaggat ttatatgata
      421 ttcttctcag atttactttg tgttaaataa catttaaaat atatatttgc ctcaagggtg
      481 tctttaagaa gattaatttc caatgcctaa gaatagcaaa gtggtaaaga gagatttgga
      541 tgatgatgtc attgaatctg tcaaagacct cctgtccaac gaagactcag tggaagaggt
      601 ttctaagaag agtgaactaa ttgtcgatgt tcaggaagag aaagatacag atgctgaaga
      661 tggatctgaa gctgatgatg aaaggccagc ctggaacagt aagctgcaat acattctggc
      721 ccaagttgga ttttctgtag gtctggggaa tgtgtggcgg ttcccatacc tctgccaaaa
      781 gaatggtggt ggtgcatatc ttttgccgta tttaatacta cttctggtga taggaattcc
      841 actctttttc ctggaacttt ctgtgggtca aagaattcga agaggcagca ttggggtttg
      901 gaattacata agccctaaat tgggtgggat tggcttcgca agctgtgtag tgtgctattt
      961 tgtggctctc tactacaatg tcatcattgg ctggacatta ttttactttt ctcagtcttt
     1021 tcaacaacct cttccttggg atcaatgccc cctggtgaaa aacgcatctc atacttatgt
     1081 tgagccagaa tgtgaacaaa gttctgccac cacctattac tggtaccggg aagcactgga
     1141 tatcaccagc tccatctctg acagtggagg cttaaactgg aagatgacgg tctgccttct
     1201 ggttgcctgg gtcatggttt gtctggccat gatcaaaggc attcagtcct ctggaaaaat
     1261 catgtatttc agttctctgt tcccctacgt ggtccttata tgtttcctaa taagatctct
     1321 ccttttaaat ggttcaattg atggcatccg acacatgttc actcctaagc tggaaatgat
     1381 gttggagccc aaggtttgga gagaggcagc aactcaggtg ttctttgcat tgggtttggg
     1441 atttggtgga gtcatcgcgt tttcaagtta taacaagaga gacaacaact gccacttcga
     1501 tgctgtccta gtgtctttca tcaacttttt cacttcagtt ctggcaacac tggtggtgtt
     1561 tgcagttctg gggttcaaag ccaatatcgt aaatgaaaaa tgcatttcac aaaactccga
     1621 gatgatcttg aaacttttga aaatgggaaa cattagttgg gatgtcattc cccatcacat
     1681 caacctctca gctgtcactg tggaagatta tcgtttagtt tacgacatca ttcaaaaagt
     1741 gaaggaggag gagtttgctg ttcttcatct caacgcctgt caaattgagg atgagctaaa
     1801 taaagctgtg cagggcactg gcttggcttt cattgccttt acagaggcca tgacacattt
     1861 ccctgcatct cctttctggt cagtgatgtt tttcctcatg ttgataaatc tcggcctcgg
     1921 cagcatgttt ggaacaattg aagggatcat cactcctatt gtggatacct tcaaagtgag
     1981 gaaggaaata ctcactgtta tctgttgcct cctggcattt tgtattggct tgatattcgt
     2041 gcagcgctct ggaaattact tcgtgacaat gtttgacgat tattctgcta cattgcctct
     2101 gctaattgtg gtcatcttgg agaatattgc cgtgagcttt gtttatggca tagataagtt
     2161 tatagaagac ctcacagaca tgttaggatt tgctccaagc aaatattact attatatgtg
     2221 gaaatacatt tctcctctaa tgctactaac gttgctaata gctagcattg tgaatatggg
     2281 attaagtcct cccggatata atgcatggat caaggagaag gcatcggaag aatttctgag
     2341 ctacccgatg tgggggatgg tcgtctgttt ctctctgatg gtgctggcca tacttcctgt
     2401 cccagtggtg ttcatcattc gtcgctgcaa cctcatagat gatagttctg gtaacttggc
     2461 ctccgtgacc tataagagag gaagagtcct gaaggaacct gtgaacttgg aaggagatga
     2521 cgcaagcctc attcatggaa agataccgag tgaaatgtca tctccaaatt ttggtaaaaa
     2581 tatttatcga aaacaaagtg gttccccaac actggatact gctcccaatg gacgctatgg
     2641 gattgggtat ttgatggcag acatgccaga tatgccagag tctgacttgt agctgaacga
     2701 aagcaggggt tgagtttggt taatttttat cagtgagcat cggttctcct atgagaagca
     2761 ttgggcttca ctatcacacg gtgatctcag gtgtccatgg ctatgatctt taatcccaac
     2821 agttttagac agttcaagaa cagcaatcct cagtttacat ttgctcagaa atgatggcag
     2881 acaaagctta cattgactga ggtcatattt tgccaggatt ttttaaaaaa acaagcactt
     2941 tggcatattt tcaaatattt ctatctctta aaaaaaggtg ttacctcagt ttctaataat
     3001 ttctggattt aatatcattg gcaattttaa aaactccctg gtatatctta caattcataa
     3061 ttttgccttc agcataagtt ccagtattac catgaacagt tgtgtgagcc ggtgcctctc
     3121 agcacattcc catgagtatg ttctgtagat agtctgtact taattttggt agcattgaaa
     3181 ccttcctagg cacttagttg gagaaaactg caaagtattt tcttatatga tagccgcata
     3241 gagcaatagt atcaaagggt aagaaggcac tgatactggg gaaaaggtta ggtccagatg
     3301 tgactttggg ttccatgtgg ttggctgtat aatttgtgta aaataggtgt gtggaaatga
     3361 ttgatgggag tggctccata ctctcaagaa ttatgcagac tgcatctttc ttatgccgtg
     3421 tgcctaaaag tctacttaat atttattgtg gttttgagat cacttatagt atatttatat
     3481 aatatacttg caatgcatag agatgcctac caggactctt aagtgctgat ttgaaaactt
     3541 gaagcaagat agcattttga tttcatatgt ttctgttttg cttcatttta tgcaaataca
     3601 aattcttttt taagtgattg ttaaaactgt atggcattac attttaacct acaaataaac
     3661 gaagtttaaa gaacggaaaa aaaaaaaaaa aaa
//
