LOCUS       NM_020049               3433 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter
            transporter), member 14 (Slc6a14), mRNA.
ACCESSION   NM_020049
VERSION     NM_020049.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Schniers,B.K., Wachtel,M.S., Sharma,M., Korac,K., Rajasekaran,D.,
            Yang,S., Sniegowski,T., Ganapathy,V. and Bhutia,Y.D.
  TITLE     Deletion of Slc6a14 reduces cancer growth and metastatic spread and
            improves survival in KPC mouse model of spontaneous pancreatic
            cancer
  JOURNAL   Biochem J 479 (5), 719-730 (2022)
   PUBMED   35212370
  REMARK    GeneRIF: Deletion of Slc6a14 reduces cancer growth and metastatic
            spread and improves survival in KPC mouse model of spontaneous
            pancreatic cancer.
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Sivaprakasam,S., Sikder,M.O.F., Ramalingam,L., Kaur,G.,
            Dufour,J.M., Moustaid-Moussa,N., Wachtel,M.S. and Ganapathy,V.
  TITLE     SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic
            syndrome but only under conditions of a high-fat diet
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (5), 166087 (2021)
   PUBMED   33513428
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Sivaprakasam,S., Ramachandran,S., Sikder,M.O.F., Bhutia,Y.D.,
            Wachtel,M.W. and Ganapathy,V.
  TITLE     alpha-Methyl-l-tryptophan as a weight-loss agent in multiple models
            of obesity in mice
  JOURNAL   Biochem J 478 (7), 1347-1358 (2021)
   PUBMED   33720280
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Sikder,M.O.F., Sivaprakasam,S., Brown,T.P., Thangaraju,M.,
            Bhutia,Y.D. and Ganapathy,V.
  TITLE     SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a
            tumor promoter in colon and is a target for Wnt signaling
  JOURNAL   Biochem J 477 (8), 1409-1425 (2020)
   PUBMED   32219372
  REMARK    GeneRIF: SLC6A14, a Na+/Cl--coupled amino acid transporter,
            functions as a tumor promoter in colon and is a target for Wnt
            signaling.
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Ugawa,S., Sunouchi,Y., Ueda,T., Takahashi,E., Saishin,Y. and
            Shimada,S.
  TITLE     Characterization of a mouse colonic system B(0+) amino acid
            transporter related to amino acid absorption in colon
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (2), G365-G370 (2001)
   PUBMED   11447016
REFERENCE   8  (bases 1 to 3433)
  AUTHORS   Nakanishi,T., Hatanaka,T., Huang,W., Prasad,P.D., Leibach,F.H.,
            Ganapathy,M.E. and Ganapathy,V.
  TITLE     Na+- and Cl--coupled active transport of carnitine by the amino
            acid transporter ATB(0,+) from mouse colon expressed in HRPE cells
            and Xenopus oocytes
  JOURNAL   J Physiol 532 (Pt 2), 297-304 (2001)
   PUBMED   11306651
REFERENCE   9  (bases 1 to 3433)
  AUTHORS   Hatanaka,T., Nakanishi,T., Huang,W., Leibach,F.H., Prasad,P.D.,
            Ganapathy,V. and Ganapathy,M.E.
  TITLE     Na+ - and Cl- -coupled active transport of nitric oxide synthase
            inhibitors via amino acid transport system B(0,+)
  JOURNAL   J Clin Invest 107 (8), 1035-1043 (2001)
   PUBMED   11306607
REFERENCE   10 (bases 1 to 3433)
  AUTHORS   Sloan,J.L. and Mager,S.
  TITLE     Cloning and functional expression of a human Na(+) and
            Cl(-)-dependent neutral and cationic amino acid transporter B(0+)
  JOURNAL   J Biol Chem 274 (34), 23740-23745 (1999)
   PUBMED   10446133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807250.9 and BC129908.1.
            
            On Jul 18, 2009 this sequence version replaced NM_020049.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF320226.1, BC129909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AL807250.9         12041-12249
            210-2673            BC129908.1         1-2464
            2674-3433           AL807250.9         38740-39499
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.78 cM"
     gene            1..3433
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter), member 14"
                     /db_xref="GeneID:56774"
                     /db_xref="MGI:MGI:1890216"
     exon            1..296
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..2165
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /note="amino acid transporter ATB0+; solute carrier family
                     6 member 14; colonic system B0+ amino acid transporter
                     CATB0+"
                     /codon_start=1
                     /product="sodium- and chloride-dependent neutral and basic
                     amino acid transporter B(0+)"
                     /protein_id="NP_064433.3"
                     /db_xref="CCDS:CCDS30051.1"
                     /db_xref="GeneID:56774"
                     /db_xref="MGI:MGI:1890216"
                     /translation="MDRLKCPNFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSD
                     YLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASL
                     GPVSVWRILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANCSSWA
                     DENCSRTPIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQLPSEQYWDKVT
                     LQRSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILL
                     IRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNK
                     FNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYP
                     EALAQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGC
                     CLILFLLGLLCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEM
                     MIGAKRWIFWLWWRACWFVITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMI
                     IFCIIWIPIMAIIKIVQAEGNILQRIISCCRPASNWGPYLEKHRGERYRDMAEPAKET
                     DHEIPTISGSTKPE"
     exon            297..462
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            463..594
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            595..756
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            757..892
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1025
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1166
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1395
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1521
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1640
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1740
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1850
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2018
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..3433
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3401..3406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /note="hexamer: AATAAA"
     polyA_site      3433
                     /gene="Slc6a14"
                     /gene_synonym="1110007A17Rik; 9030613J17Rik; ATB0plus;
                     CATB0plus"
                     /note="major polyA site"
ORIGIN      
        1 aaggaattgc tacattcagg attacctggg ggaaaaacca gaggcttgct ttggtccctt
       61 ccggtaattg aaaggactgg ccgtcagcga gggggaggag agagcttccc tccataaatg
      121 gtcccacccc tgggcaaggt ggctcacttt ggcaggtagc aaccggggag tgtgcacctg
      181 ccaccagtca agctcagcca gactgtgaga agaggagagg cgaggcacac caagggatcc
      241 agtgaaccat ggacagattg aagtgcccga acttcttcaa gtgcagacag aaggagaaag
      301 tgacagcttc atccgagaac ttccatgttg gtgaaaatga tgaaaatcag gaacgtggta
      361 actggtccaa aaagtcagat tatcttcttt ccatggttgg ctatgcagtg ggattgggca
      421 atgtgtggag attcccatat ctgacctaca ccaatggcgg aggtgctttc ttgataccct
      481 atgcaatcat gctagcattg gctggtctgc ctttgttctt tctggaatgt tcactgggac
      541 aatttgctag cttaggtcca gtttcagttt ggaggatttt gccactgttt caaggtgtgg
      601 gaatcacgat ggtcctgata tccgtttttg tggcaatcta ttataatgtc ataattgcct
      661 acagccttta ctacttgttt gcttcttttc aaagtgtatt gccgtgggca aattgttctt
      721 cttgggcaga cgaaaactgt agcagaacac caatagtaac tggctgtaat gtgagcatag
      781 gggcaggaga gatgtttatg aatataagct gggtaaatac caacaatctc acctgcttga
      841 atggtagtga agtttttcgg ccaggacaac ttcccagtga acagtattgg gataaagtga
      901 cacttcagag gtcaagtgga atggatgaaa ctggagttgt tgtgtggtat ttagcacttt
      961 gccttcttct ggcttggctc atagttggag cagcactgtt taaaggaatc aaatcctctg
     1021 gcaaggtggt atattttaca gctcttttcc catatgtggt ccttctcatt ctgttaatac
     1081 gaggtgcaac tttggagggt gcatcaaaag gcatttcata ttacattgga gcacagtcaa
     1141 attttacaaa actaagagaa gctgaggtct ggaaggatgc tgccactcag atattttatt
     1201 ccctttctgt ggcttggggt ggcctagtgg ctctgtcatc ttacaacaag ttcaacaaca
     1261 actgttactc tgatgccatt atagtttgct tgacaaactg cctcactagt gtgtttgctg
     1321 gatttgctat attttctatt ctgggacaca tggctcatat atctggaaaa gaagtctctc
     1381 aagttgtaaa atcaggattt gacttggcat tcattgccta tcctgaagct ctagctcaac
     1441 tcccagctgg tccattctgg tccatattat ttttcttcat gcttttaaca ttgggccttg
     1501 attctcagtt tgcttctatt gaaacaatta caacaacatt tcaagatttg tttcccaaag
     1561 caatgaaacg catgagggtt cctataactt tgggatgctg cttgattttg tttctccttg
     1621 gcctcctctg tgtgactcag gctggaattt actgggttca tttgattgat cacttctgtg
     1681 ctggatgggg aattttaatt gctgctatct tggaaattgc aggaatcatc tggatttatg
     1741 gaggaaatag attcattgaa gatatagaaa tgatgattgg agcaaaaaga tggatattct
     1801 ggctttggtg gagagcttgc tggtttgtca tcactcctat tctgttgtct gcaattctag
     1861 tctggtcact ggtgaaattt cacagacctg attatgctga tattccatat cctgactggg
     1921 gagttgctct tggctggtgt atgatcattt tctgcattat ttggatacca attatggcta
     1981 tcataaaaat agttcaggca gaaggaaaca tacttcagcg tatcataagc tgctgtagac
     2041 cagcttcgaa ctggggtcca tacctggaaa aacatcgtgg ggagagatac agagacatgg
     2101 ctgaacctgc aaaggagact gaccacgaaa tacctactat tagtggcagt acaaaaccag
     2161 aatgagatgt cacctttgaa aatatctaat tgttatataa tgtgattttg tagagtaagg
     2221 gagattttta atttatttgt atgttaatca attagggaaa tgtacatgtc atgctcagta
     2281 catgattgta agtacttttt tcacttaatc aagaatgaaa tattaaaatg tgaatctatc
     2341 agtgtttagt aatgtgtttc tctttaagat tagctatttg ttagtacata tacccagttc
     2401 tgttttgcaa tgacattttg taaatattac tgtaattgtt ttgttttgtt ttgtttttag
     2461 tgtactgaag gtctcctgtg agatgattac ttacgaagta atcatacttt gtactttgtg
     2521 attttaaaca cactgcttct gtagtctaaa tatgtacttt tctctttcat agaataggga
     2581 aataagtcag tgaagttaaa agctagtgtt acacagttaa agtcctcact taccttacat
     2641 atgtcacaaa ttggcctggg gtgattgctc agtgacaaga taaatggcta tcacagagga
     2701 tgtaggttca attctcagca ccaaggttac taataccatc tttaactcta gttccatgaa
     2761 acccgatgtc ctcttctgac ctctatgata ctgcatgctc atggtgcaca tacacacagg
     2821 cagaaaacac ccatacccat aaaataaaat gaataaacat ctttatccaa agaagttcca
     2881 caaatatgta ggaaaatgac tgtatgtgat atgaggattg ttgtttaata tctgtgatcc
     2941 aaatatgtct aaacatgtta tcaatttatt atgtatcatg ttttctatgt aagctttgca
     3001 gttgtactct ttagttagag tgaaatgata caaaaatgag gaacaggtat ccagacagtg
     3061 ataaacctag gaaatgaaat attgaaattt tgaatacttc ttacctttca gaatatcttt
     3121 attcattaag ttgtatttgg aataaaacca cgacacgttt aatttttatt gtgtttcagg
     3181 aaaaacaagt agttcattac gttctctgga ttctagattc aattgcaagt agaatttgta
     3241 tgaaattgtt actgataaca tgactttaaa tttggcattt tttgataatg atatatatct
     3301 aatagataaa tagcaataat cttctctttt atagatttgt ttttgcctaa gtgtaacaaa
     3361 gtattcatat atgaattgat gctaattgtt aattgtcacc aataaaaatt ttatatcctg
     3421 ttttcctcac aaa
//
