LOCUS       NM_001381903            2361 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            betaine/GABA), member 12 (Slc6a12), transcript variant 3, mRNA.
ACCESSION   NM_001381903 XM_006505534
VERSION     NM_001381903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Ding,X., Chang,Y., Wang,S., Yan,D., Yao,J. and Zhu,G.
  TITLE     Transcriptomic Analysis of the Effect of GAT-2 Deficiency on
            Differentiation of Mice Naive T Cells Into Th1 Cells In Vitro
  JOURNAL   Front Immunol 12, 667136 (2021)
   PUBMED   34149704
  REMARK    GeneRIF: Transcriptomic Analysis of the Effect of GAT-2 Deficiency
            on Differentiation of Mice Naive T Cells Into Th1 Cells In Vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Lie,M.E.K., Kickinger,S., Skovgaard-Petersen,J., Ecker,G.F.,
            Clausen,R.P., Schousboe,A., White,H.S. and Wellendorph,P.
  TITLE     Pharmacological Characterization of a Betaine/GABA Transporter 1
            (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile
            and Anti-seizure Effects
  JOURNAL   Neurochem Res 45 (7), 1551-1565 (2020)
   PUBMED   32248400
  REMARK    GeneRIF: Pharmacological Characterization of a Betaine/GABA
            Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic
            Inhibition Profile and Anti-seizure Effects.
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Liu,Z., Li,Q., Shen,R., Ci,L., Wan,Z., Shi,J., Huang,Q., Yang,X.,
            Zhang,M., Yang,H., Sun,R., Wang,Z., Huang,F., Lu,T. and Fei,J.
  TITLE     Betaine/GABA transporter-1 (BGT-1) deficiency in mouse prevents
            acute liver failure in vivo and hepatocytes apoptosis in vitro
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (3), 165634 (2020)
   PUBMED   31830527
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Ren,W., Liao,Y., Ding,X., Jiang,Y., Yan,J., Xia,Y., Tan,B., Lin,Z.,
            Duan,J., Jia,X., Yang,G., Deng,J., Zhu,C., Hardwidge,P.R., Li,J.,
            Zhu,G. and Yin,Y.
  TITLE     Slc6a13 deficiency promotes Th17 responses during intestinal
            bacterial infection
  JOURNAL   Mucosal Immunol 12 (2), 531-544 (2019)
   PUBMED   30523310
  REMARK    GeneRIF: GAT-2 deficiency promotes Th17 cell responses through
            activation of GABA-mTOR signaling
REFERENCE   6  (bases 1 to 2361)
  AUTHORS   Kwakowsky,A., Schwirtlich,M., Kooy,F., Abraham,I., Mate,Z.,
            Katarova,Z. and Szabo,G.
  TITLE     GABA neurotransmitter signaling in the developing mouse lens:
            dynamic regulation of components and functionality
  JOURNAL   Dev Dyn 237 (12), 3830-3841 (2008)
   PUBMED   18985723
REFERENCE   7  (bases 1 to 2361)
  AUTHORS   Hoglund,P.J., Adzic,D., Scicluna,S.J., Lindblom,J. and
            Fredriksson,R.
  TITLE     The repertoire of solute carriers of family 6: identification of
            new human and rodent genes
  JOURNAL   Biochem Biophys Res Commun 336 (1), 175-189 (2005)
   PUBMED   16125675
REFERENCE   8  (bases 1 to 2361)
  AUTHORS   Evans,J.E., Frostholm,A. and Rotter,A.
  TITLE     Embryonic and postnatal expression of four gamma-aminobutyric acid
            transporter mRNAs in the mouse brain and leptomeninges
  JOURNAL   J Comp Neurol 376 (3), 431-446 (1996)
   PUBMED   8956109
REFERENCE   9  (bases 1 to 2361)
  AUTHORS   Liu,Q.R., Lopez-Corcuera,B., Mandiyan,S., Nelson,H. and Nelson,N.
  TITLE     Molecular characterization of four pharmacologically distinct
            gamma-aminobutyric acid transporters in mouse brain [corrected]
  JOURNAL   J Biol Chem 268 (3), 2106-2112 (1993)
   PUBMED   8420981
  REMARK    Erratum:[J Biol Chem 1993 Apr 25;268(12):9156]
REFERENCE   10 (bases 1 to 2361)
  AUTHORS   Lopez-Corcuera,B., Liu,Q.R., Mandiyan,S., Nelson,H. and Nelson,N.
  TITLE     Expression of a mouse brain cDNA encoding novel gamma-aminobutyric
            acid transporter
  JOURNAL   J Biol Chem 267 (25), 17491-17493 (1992)
   PUBMED   1517200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153982.8.
            
            On Apr 20, 2020 this sequence version replaced XM_006505534.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.123513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC153982.8         103669-103711
            44-99               AC153982.8         104145-104200
            100-329             AC153982.8         108498-108727
            330-464             AC153982.8         113034-113168
            465-605             AC153982.8         114483-114623
            606-693             AC153982.8         115377-115464
            694-826             AC153982.8         116382-116514
            827-961             AC153982.8         118013-118147
            962-1065            AC153982.8         119696-119799
            1066-1190           AC153982.8         120117-120241
            1191-1303           AC153982.8         121529-121641
            1304-1441           AC153982.8         122051-122188
            1442-1544           AC153982.8         122929-123031
            1545-1645           AC153982.8         124324-124424
            1646-1816           AC153982.8         124781-124951
            1817-2361           AC153982.8         126324-126868
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.25 cM"
     gene            1..2361
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, betaine/GABA), member 12"
                     /db_xref="GeneID:14411"
                     /db_xref="MGI:MGI:95628"
     exon            1..43
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            44..99
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            100..329
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..464
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..605
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..693
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..826
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..961
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1065
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1190
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1303
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1441
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1544
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1645
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1816
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2361
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /note="hexamer: AACAAG"
     polyA_site      2361
                     /gene="Slc6a12"
                     /gene_synonym="BGT-1; BGT1; Gabt2; GAT-2; GAT2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtccagc ctgaaagttg gtggctccca tcccactgct ctggtctgga gacgcttact
       61 cattctggag caggagttct agctgggctg agagaccagg gcctccctat ccagtatgga
      121 caggaaggtt gcagtccatg aagatggcta tcctgtggtc tcttgggtcc ctgaggaagg
      181 agagatgatg gaccagaaag gcaaggacca ggtgaaggat cgtggccaat ggaccaacaa
      241 gatggagttt gtgctgtcag tggctggaga gatcattggc ttaggcaacg tctggaggtt
      301 tccctatctc tgctacaaga atggaggtgg agctttcttc atcccctact tcatcttctt
      361 cttcagctgt ggcatcccag tgttcttcct ggaggtggca ctgggccagt atagcagcca
      421 ggggagtgtg actgcttgga ggaagatctg tcccctcctc caaggcattg gcatggcctc
      481 tgtggtcatc gagtcttatt tgaacatcta ctacattatc atccttgcct gggctctctt
      541 ctacctgttc agctccttca cctgggagct tccctggaca acctgcacca actcgtggaa
      601 cacagagcac tgcgtggact ttctgaatca ctcatcggcc agaggagtga gctcttctga
      661 gaactttacc tcgcctgtca tggaattctg ggagagacgg gttttgggta ttacatcggg
      721 catccacgac ctggggtccc tgcgttggga gctggccttg tgcctcctgc ttgcctggat
      781 tatctgctac ttctgcatct ggaagggggt caagtccaca ggcaaggttg tttacttcac
      841 agccactttt ccctacctga tgctgattat tcttctgatc cggggtgtca cccttcctgg
      901 agcctaccag ggcatcgtct tctacctgaa gccagacttg ctccgtctca aggaccccca
      961 ggtgtggatg gatgcgggca cccagatctt cttttccttt gccatctgcc aggggtgcct
     1021 gacagccctg ggcagctaca acaagtacca caacaactgc tacagggact ccatcgccct
     1081 ctgcttcctg aacagtgcta ccagcttcgt ggctgggttt gttgtcttct ccatcttggg
     1141 cttcatgtct caggagcagg gaatacccat ttctgaagtg gctgagtcag gtcctgggct
     1201 ggccttcatt gccttcccca aagctgtcac catgatgcct ttgtcccagc tgtggtcctg
     1261 cctcttcttc atcatgctcc tgtttctagg gctggacagc cagttcgtct gtatggagtg
     1321 cctggtgacc gcttccatgg atatgttccc tcagcagctc cgaaagagtg gccggcggga
     1381 gctgctgatc ctcgctatct ctgttttgtg ctacttgatg gggctccttt tggtcacaga
     1441 gggcgggatg tatatcttcc agctctttga ctactacgcc tccagcggca tatgcctact
     1501 cttcctctcc ttgtttgagg tgatctgcat tggctgggtg tatggggccg accgtttcta
     1561 tgacaacgtg gaagacatga ttggctatcg gccatggccc ttggtgaaga tctcctggct
     1621 cttcctgact cctggccttt gcctggccac tttcttcttc tccttgagca agtatacacc
     1681 tctcaaatac aacaatgtct acatgtatcc ttcttgggga tactccattg gatggctctt
     1741 ggctttctcc tccatggcct gtgtcccact ctttatcatc atcaccttcc tgaagaccca
     1801 gggctccttc aagaagcgtc ttcgaagact catcacacca gaccccagtc tgccccagcc
     1861 agggcggcgc ccaccacagg atggctcctc tgctcaaaac tgttcgtcct ctccagccaa
     1921 acaagaactc attgcctggg agaaggagac tcatttgtag gaagtgccag aggccaggtg
     1981 actccagagc caggaacctg gtcaaggcta gctcctccca ggggtaacct ctgctgcacc
     2041 ctgctgtgac ctctcaggtc tccggacacc cctgccagtc ttctgggagc cactcttctg
     2101 ttcagctgga acagcttgtc acctctcagt cctttccaag tgagctctag gaagctgagt
     2161 ctgccaagtg ttttgaactc aacatcttga ctttctggat taaaaaacta agaaccagac
     2221 aggcaaagtg atattttcaa ggtcacacag cctgtcagag ccctagacct tccttgaact
     2281 tgctgctctc agctgaggcg tgtgagcctc cagcatcacc cctgcagcag ctaacaagcc
     2341 tgcatggatc acctgctgtg a
//
