LOCUS       NM_172890               4066 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus solute carrier family 6 (neurotransmitter transporter,
            GABA), member 11 (Slc6a11), mRNA.
ACCESSION   NM_172890
VERSION     NM_172890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Tong,K., Zhang,J.W., Jing,S.Q., Zhao,X.Y., Han,J., Song,Y.T.,
            Yang,L., Wu,T., Hao,J.R., Sun,N. and Gao,C.
  TITLE     Up-regulating GABA transporter-3 in the zona incerta prevents
            surgery-induced memory impairment in mice
  JOURNAL   Neuropharmacology 257, 110034 (2024)
   PUBMED   38878858
  REMARK    GeneRIF: Up-regulating GABA transporter-3 in the zona incerta
            prevents surgery-induced memory impairment in mice.
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Ying,Y., Liu,W., Wang,H., Shi,J., Wang,Z. and Fei,J.
  TITLE     GABA transporter mGat4 is involved in multiple neural functions in
            mice
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (5), 119740 (2024)
   PUBMED   38697303
  REMARK    GeneRIF: GABA transporter mGat4 is involved in multiple neural
            functions in mice.
REFERENCE   3  (bases 1 to 4066)
  AUTHORS   Roberts,B.M., Doig,N.M., Brimblecombe,K.R., Lopes,E.F.,
            Siddorn,R.E., Threlfell,S., Connor-Robson,N., Bengoa-Vergniory,N.,
            Pasternack,N., Wade-Martins,R., Magill,P.J. and Cragg,S.J.
  TITLE     GABA uptake transporters support dopamine release in dorsal
            striatum with maladaptive downregulation in a parkinsonism model
  JOURNAL   Nat Commun 11 (1), 4958 (2020)
   PUBMED   33009395
  REMARK    GeneRIF: GABA uptake transporters support dopamine release in
            dorsal striatum with maladaptive downregulation in a parkinsonism
            model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4066)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4066)
  AUTHORS   Nishimura,T., Higuchi,K., Yoshida,Y., Sugita-Fujisawa,Y.,
            Kojima,K., Sugimoto,M., Santo,M., Tomi,M. and Nakashima,E.
  TITLE     Hypotaurine Is a Substrate of GABA Transporter Family Members
            GAT2/Slc6a13 and TAUT/Slc6a6
  JOURNAL   Biol Pharm Bull 41 (10), 1523-1529 (2018)
   PUBMED   30270321
REFERENCE   6  (bases 1 to 4066)
  AUTHORS   Jursky,F. and Nelson,N.
  TITLE     Developmental expression of the neurotransmitter transporter GAT3
  JOURNAL   J Neurosci Res 55 (3), 394-399 (1999)
   PUBMED   10348670
REFERENCE   7  (bases 1 to 4066)
  AUTHORS   Street,V.A., McKee-Johnson,J.W., Fonseca,R.C., Tempel,B.L. and
            Noben-Trauth,K.
  TITLE     Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in
            deafwaddler mice
  JOURNAL   Nat Genet 19 (4), 390-394 (1998)
   PUBMED   9697703
REFERENCE   8  (bases 1 to 4066)
  AUTHORS   McKee-Johnson,J.W., Street,V.A., Erford,S.K., Robinson,L.C. and
            Tempel,B.L.
  TITLE     Physical and genetic maps of the deafwaddler region on distal mouse
            Chr 6
  JOURNAL   Genomics 49 (3), 371-377 (1998)
   PUBMED   9615221
REFERENCE   9  (bases 1 to 4066)
  AUTHORS   Evans,J.E., Frostholm,A. and Rotter,A.
  TITLE     Embryonic and postnatal expression of four gamma-aminobutyric acid
            transporter mRNAs in the mouse brain and leptomeninges
  JOURNAL   J Comp Neurol 376 (3), 431-446 (1996)
   PUBMED   8956109
REFERENCE   10 (bases 1 to 4066)
  AUTHORS   Liu,Q.R., Lopez-Corcuera,B., Mandiyan,S., Nelson,H. and Nelson,N.
  TITLE     Molecular characterization of four pharmacologically distinct
            gamma-aminobutyric acid transporters in mouse brain [corrected]
  JOURNAL   J Biol Chem 268 (3), 2106-2112 (1993)
   PUBMED   8420981
  REMARK    Erratum:[J Biol Chem 1993 Apr 25;268(12):9156]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153587.2 and
            AC155719.11.
            
            On May 2, 2007 this sequence version replaced NM_172890.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053078.1, AK140423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC153587.2         126877-127153
            278-412             AC153587.2         130235-130369
            413-553             AC153587.2         130486-130626
            554-644             AC153587.2         134537-134627
            645-777             AC153587.2         157677-157809
            778-912             AC153587.2         190247-190381
            913-1016            AC153587.2         221459-221562
            1017-1141           AC153587.2         225673-225797
            1142-1254           AC153587.2         231436-231548
            1255-1392           AC155719.11        43708-43845
            1393-1495           AC155719.11        49215-49317
            1496-1596           AC155719.11        50159-50259
            1597-1767           AC155719.11        50955-51125
            1768-4066           AC155719.11        52937-55235
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.98 cM"
     gene            1..4066
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, GABA), member 11"
                     /db_xref="GeneID:243616"
                     /db_xref="MGI:MGI:95630"
     exon            1..277
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1920
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /note="gamma-aminobutyric acid (GABA-A) transporter 4;
                     GAT-3; GAT-4; solute carrier family 6 member 11; sodium-
                     and chloride-dependent GABA transporter 4"
                     /codon_start=1
                     /product="sodium- and chloride-dependent GABA transporter
                     3"
                     /protein_id="NP_766478.1"
                     /db_xref="CCDS:CCDS39597.1"
                     /db_xref="GeneID:243616"
                     /db_xref="MGI:MGI:95630"
                     /translation="MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHE
                     RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLE
                     TALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTE
                     LPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGN
                     LRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEG
                     IKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCC
                     LNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWAT
                     LFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVML
                     TEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIK
                     WCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFI
                     KLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKE
                     THF"
     exon            278..412
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..553
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            554..644
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..777
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            778..912
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1016
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1141
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1254
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1392
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1495
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1596
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1767
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..4066
                     /gene="Slc6a11"
                     /gene_synonym="D930045G19Rik; E130202I16Rik; Gabt4; Gat3;
                     GAT4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgggg ccggcgcacg aggcggcagg gcggccatga ctgcggagca agcgctgccc
       61 ctgggcaacg ggaaagcggc cgaggaggcg cgggggtccg agacgctggg cggcggcggc
      121 gggggcgcgg cggggacgcg cgaggcgcgc gacaaggctg tccacgagcg cggccactgg
      181 aacaacaagg tggagttcgt gttgagcgta gctggagaga tcatcggact gggcaacgtg
      241 tggcgctttc cctacctgtg ctacaaaaac ggcggagggg cattcctgat tccttacgtg
      301 gtgtttttca tctgctgcgg aatccccgtc ttcttcctgg aaacggctct ggggcagttc
      361 acgagcgagg gtggcatcac gtgctggagg agggtctgcc ctttatttga aggcattggc
      421 tatgcaacac aggtgatcga ggcacacctc aatgtctact acatcatcat cctggcgtgg
      481 gccatcttct acctaagcaa ttgcttcacc accgagctcc cctgggccac ctgtgggcac
      541 gagtggaaca cagagaaatg tgtggagttc cagaagctga acttcagcaa ctacagtcat
      601 gtgtccctgc agaatgccac ctccccggtc atggagttct gggaacgccg ggtcttggct
      661 atatccgatg gcattgagca cattgggaac ctccgttggg aactggcatt atgtctcctg
      721 gcggcctgga ccatctgcta cttctgcata tggaagggta ctaagtcgac tggaaaggtc
      781 gtgtatgtca ctgcaacctt cccctacatc atgctgctga tcctcctgat ccgaggggtc
      841 acgttgccag gcgcctctga aggcatcaag ttctatctgt accctgacct ctcccggctc
      901 tctgacccac aggtgtgggt ggacgctggg acgcagatct ttttctccta tgccatctgc
      961 ctgggctgcc taaccgctct ggggagttac aacaactata acaacaactg ctacagggac
     1021 tgcattatgc tctgctgtct aaacagtggc accagcttcg tggctgggtt tgccatcttc
     1081 tcagtcctgg gcttcatggc atacgagcag ggtgtgccta ttgccgaggt ggcagagtca
     1141 ggtcctggac tggctttcat cgcctacccc aaggctgtca ctatgatgcc cctctctcca
     1201 ctgtgggcca ccttgttctt catgatgctc atcttcctgg gcctggacag tcagtttgtg
     1261 tgcgtggaga gtcttgtgac agccgtggta gacatgtacc ctaaggtctt ccggcggggc
     1321 taccggcgag aactgctcat cctggccctg tccatcatct cctatttcct aggcctggtg
     1381 atgctgaccg agggaggcat gtacatcttc cagctttttg actcatacgc cgccagtggc
     1441 atgtgcttgc tctttgtggc catctttgag tgtgtctgca tcggctgggt atatggaagc
     1501 aaccggttct atgacaatat tgaggatatg attggttacc ggccactgtc actcatcaag
     1561 tggtgctgga aagtcgtgac ccctgggatc tgtgcgggca tcttcatctt ctttctggtc
     1621 aagtacaaac cgctcaagta caacaatgtg tacacatatc ctgcttgggg ctacggcatc
     1681 ggctggctca tggctctgtc ctccatgctg tgtatcccac tctggatctt cattaagctg
     1741 tggaagacag agggcacact gcccgagaaa ttacagaagt tgacagtccc cagcgccgat
     1801 ctgaaaatgc ggggcaagct tggggccagc ccacggacgg tgaccgttaa tgactgtgag
     1861 gccaaggtca agggcgacgg caccatctct gccatcacag agaaggagac acacttctga
     1921 gtccccacca gccatttgga tgcggctcca accttccttc cctgcgtgta aatgaatcct
     1981 gaacctcgta cttcacctaa tgttaggggc ttgctcgtct gcacaggact tattaacaag
     2041 ttaactccca gccggccact gtgtgccctg tacccttgcc tcttcccagt gatagtgggc
     2101 atatccacct caccaagata attctgtaca gtgactagca gatcctggcc tagggtggct
     2161 cagccggtgt tttctagagt ccttgtatta tatactgtca actcgtatgc tgggggcagg
     2221 tggagtgggg gagcggtgcc catctgcctc tgatgttcag tcattcctgg ttttatctct
     2281 gaacttccct ggccaccctc ctctgtgccc tgggaccagt ttgttttatt ttattttttt
     2341 ttcttttggt cttccccttt tcctagtgac accttccaca tgtcaatgtc gtaagacaga
     2401 gagcaaagcc tcccaccatc gttaggactc ctgagtaacc aggagttgct gactgtccct
     2461 tcaagtgact gtggctcctt tctctccctg gcccctagtt tctccatctc ccagaccaag
     2521 ggggcgaggg ggttgagtgg agtcttccct tcaaagcagg gaagaatacc tgactcgttg
     2581 cttcgcagag ctgctttgac ctgcagagac ttgtagacct cttctcttct ctgtcccctt
     2641 ggttaccacc tacccacctt gcctatttta agtgaaactt accaccaatg atgtggggaa
     2701 gtgtgtttcc ctaacaactg gagttttagc ctaaccctga tcccttaact ggtgcacccc
     2761 agcccccgtg ttcggggctc ccaccatctg tccagccttc ttggccacca gctctgtccc
     2821 tccttcctag atagggatga tcagaaggta gccatctctt cttgcagctg cctggccagg
     2881 atctatggct taggatctat ggccacccct gcaggggagc tacagtgagg cctggggctg
     2941 gattccaccc acagtccctt ccctgtgcac cctgctttgt cccctgcctt gtcccctgct
     3001 ctctcttcta cctacctgcc tacccctgca gatcctgtgg gcagacacct tactctggag
     3061 ccattccacc tgcctgtcac ctgggtctga gaagccttca cttccacttg ccagagggaa
     3121 gaactggcca cccatctgtc aggctcttcc ttggaaacga agagcagagg tggtctctag
     3181 ggggaggctg gtgccattcc ctcctgcctg gctcagacct cttagactgg tctctcttcc
     3241 tcagctgctg ggttctttgt ctgcccagct attggaggat gggaagtgga gggagggtca
     3301 ctctttccct cttactgtag tttcctagat ttatctgagg aaaagtgaga tgtcttcacg
     3361 ctaaggctcc agtgttctgt cagagacctg aatgctctat ttgcccaatg cttccagact
     3421 cttagctgtt ctgcccagcc cccgtcccgc tcccacctaa agcctgagtt ggctgagcca
     3481 aatgcccagc actgccccca cctaactggg cacttgtcta gggcacacca cccccagctg
     3541 ctcacacaca gaccacatat tccttctggg aaggccagca tcatcctgaa gatgacctgt
     3601 ggggttggtc cttgatggct gtcccctcca ccctacccct gagaagggaa gctgcccgtt
     3661 gctgctactg cacctcacca ccaactccct catggacaga cagatccctg atgtctgtca
     3721 ctatagacac acgtgttgta catgtggccc ttaacacttg acactcttaa cactactcat
     3781 ggggctgggt agagggaggc ttgtggtttg gggggttgtt attttttgct ttcttttctt
     3841 cctttctttt ttctttttgt ctttttttgt aatttcatac tagtatttgg gtaactgtag
     3901 ggaggagggg agggtaagtg ggggcaagtg ggggcaaggg gacatatcat tgtgacaact
     3961 tttttgatat ttactagaaa tgatgcaata tatcctttct gagatattta cagtattatt
     4021 aaagggttgg gctgttttgc ataacaaact ttttattggc ataccc
//
