LOCUS       NM_145551               4370 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium/glucose
            cotransporter), member 9 (Slc5a9), mRNA.
ACCESSION   NM_145551
VERSION     NM_145551.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4370)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4370)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   4  (bases 1 to 4370)
  AUTHORS   Tazawa,S., Yamato,T., Fujikura,H., Hiratochi,M., Itoh,F., Tomae,M.,
            Takemura,Y., Maruyama,H., Sugiyama,T., Wakamatsu,A., Isogai,T. and
            Isaji,M.
  TITLE     SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an
            essential transporter for mannose, 1,5-anhydro-D-glucitol, and
            fructose
  JOURNAL   Life Sci 76 (9), 1039-1050 (2005)
   PUBMED   15607332
  REMARK    GeneRIF: SGLT4 would have unique physiological functions (i.e.,
            absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition
            to Glc).
            Erratum:[Life Sci. 2010 Oct 9;87(15-16):514]
REFERENCE   5  (bases 1 to 4370)
  AUTHORS   Wiley,L.M., Lever,J.E., Pape,C. and Kidder,G.M.
  TITLE     Antibodies to a renal Na+/glucose cotransport system localize to
            the apical plasma membrane domain of polar mouse embryo blastomeres
  JOURNAL   Dev Biol 143 (1), 149-161 (1991)
   PUBMED   1702069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029158.1, AK033425.1, AK028743.1 and AI159731.1.
            
            On Jun 18, 2009 this sequence version replaced NM_145551.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2481              AK029158.1         2-2482
            2482-3464           AK033425.1         2412-3394
            3465-4262           AK028743.1         1971-2768
            4263-4370           AI159731.1         1-108               c
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.53 cM"
     gene            1..4370
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 9"
                     /db_xref="GeneID:230612"
                     /db_xref="MGI:MGI:2140201"
     exon            1..82
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            83..291
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2199
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /note="mSGLT4; solute carrier family 5 member 9;
                     Na(+)/glucose cotransporter 4"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 4"
                     /protein_id="NP_663526.3"
                     /db_xref="CCDS:CCDS18474.1"
                     /db_xref="GeneID:230612"
                     /db_xref="MGI:MGI:2140201"
                     /translation="MNTELVAMEPGVSRNGVRTETTTNPSLGLHTYDIVVVVIYFVFV
                     LAVGIWSSIRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLA
                     VGGFEWNATFLLLALGWIFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIF
                     TKISTDIFSGALFIQMALGWNLYLSTVILLVVTAVYTIAGGLTAVIYTDALQTVIMVG
                     GALVLMFLGFQEVGWYPGLQQLYRQAIPNTTVPNTTCHLPRPDAFHMLRDPVNGDIPW
                     PGLIFGLTVLATWCWCTDQVIVQRSLAAKNLSHAKGGSVLGGYLKILPMFFIVMPGMI
                     SRALYPDEVACVDPDICQRVCGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMS
                     SLTSIFNSSSTLFAIDVWQRFRRQASEQELMVVGRLFVVFLVVISILWIPIIQSSNSG
                     QLFDYIQSITSYLAPPITALFLLAIFCKRVNEPGAFWGLMFGLVVGILRMILEFSYSA
                     PACGEMDRRPAVLKDFHYLYFALLLCGLTAIIIVVISFFTEPIPDDKLARLTWWTRNC
                     AVSDLQKKTSVSVNNTEDDNSPGLAGRPVVEGPAGDEEEANTTQGPEQPGALHRSWGK
                     WLWNWFCGLSGAPQQALSPAEKAVLEQKLTSIEEEPLWRRVCNINAIILLAINIFLWG
                     YFA"
     exon            292..363
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            364..468
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..633
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..739
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            740..820
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1026
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1162
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1270
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1421
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1590
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1806
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1990
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..4360
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /note="hexamer: AATAAA"
     polyA_site      3465
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /note="major polyA site"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
                     /note="hexamer: AATAAA"
     polyA_site      4310
                     /gene="Slc5a9"
                     /gene_synonym="SGLT4"
ORIGIN      
        1 gttaaagacc atgccttggc actgaggagc ttgaagcttt gacactgagc ccaggaggtt
       61 ttgactaggc caggctgtgc aggaaaggaa tgaagccagc aggacatcaa agtccagact
      121 gctgagaacc atcagtttca gatgaacacg gagcttgtgg caatggaacc aggagtgtca
      181 aggaatggag tcagaactga gacaacaacg aacccaagcc tggggctaca tacctatgac
      241 atcgtggtgg tggtcatcta ttttgtcttt gttcttgctg tgggaatttg gtcatccatc
      301 cgtgcaagtc gagggaccgt tggtggctat ttcctggctg ggagatccat gacctggtgg
      361 ccaattggag catctctaat gtccagcaat gtgggcagtg gcttatttat cggcctggct
      421 ggaacagggg ctgctggagg ccttgctgtt ggtggctttg agtggaacgc aaccttcctg
      481 cttctagccc tgggctggat ctttgtccct gtgtacatag cagctggtgt ggtcaccatg
      541 ccacagtacc tgaagaaacg atttggggga cagaggatcc aggtgtacat gtcagttctt
      601 tctctcattc tctacatctt caccaagata tcgactgata tcttctctgg agccctcttc
      661 atccagatgg ccttgggctg gaatctctat ctctccacag tcatcttgct ggtggtgaca
      721 gctgtctaca ccattgcagg gggcctcaca gctgtgatct acacagatgc tctacagact
      781 gtgatcatgg ttgggggagc tctggtcctc atgtttctgg gctttcagga ggttggctgg
      841 tacccaggcc tgcagcagct ctatagacag gccatcccca ataccacagt tcccaatacc
      901 acctgtcacc tcccacggcc tgatgccttc cacatgcttc gagatcctgt gaatggagac
      961 atcccctggc caggtctcat ttttggcctc acagtcttgg ccacctggtg ttggtgcaca
     1021 gaccaggtga ttgtgcagag gtctctcgcg gccaagaatc tttcacatgc caagggaggc
     1081 tccgtgctag ggggctacct aaagatcctc ccaatgttct tcattgtcat gcctggcatg
     1141 atcagcaggg ccctgtaccc agatgaagtt gcctgtgtgg accctgacat ctgtcaaaga
     1201 gtgtgtgggg ccagagttgg atgctccaat attgcctacc ccaagctggt tatggctctc
     1261 atgcctgtgg ggctgcgagg cctgatgatt gctgtgatca tggctgccct catgagctca
     1321 ctcacctcta tcttcaacag cagtagcacc ctgtttgcca tagatgtgtg gcagcgcttc
     1381 cgcaggcagg catcggagca agagctgatg gtggtaggca ggttgttcgt agtcttcctg
     1441 gtagtcatca gcatcctctg gatccccatc atccagagct ccaatagtgg gcagctcttt
     1501 gactacatcc aatctatcac cagctactta gccccaccca tcacagccct cttcctgctg
     1561 gctatcttct gcaagagggt caacgagcct ggtgccttct ggggcctcat gtttggcctg
     1621 gtcgtcggaa tactgcgtat gattctggag ttctcatact cggccccagc ctgtggggag
     1681 atggacaggc ggccagctgt tctgaaggac ttccactacc tgtactttgc ccttctcctc
     1741 tgtggactga ccgcgatcat cattgtcgta atcagcttct tcacggagcc catccccgat
     1801 gacaagcttg ctcgcctgac ctggtggaca aggaactgtg ccgtatctga cctgcagaag
     1861 aaaacctctg tgagtgtgaa caacacagag gatgacaact ctccaggact ggcagggagg
     1921 ccagtggtag agggccctgc aggagatgag gaagaagcaa acaccactca ggggcctgaa
     1981 caaccaggag ccctacacag gtcctgggga aaatggctgt ggaactggtt ctgcggactc
     2041 tcaggagccc cacagcaagc cctgagccca gctgagaagg ctgtgttgga gcagaagctg
     2101 accagcatcg aggaggagcc gctctggaga cgtgtctgca acatcaacgc catcatcctg
     2161 ctagccatca acatctttct ctggggctat tttgcgtgac tccgcagact aggacttagt
     2221 tgaaatgagt aagaacccct gaaccctggt cagtccccaa gaccagaggc aggctctctt
     2281 tccaacttgc taggctaact gcagaccaca gaggctgagc gtgaaagagc ccgtgaggag
     2341 catccagtcc tatattcttg tcaagtagag atacaaagta ctagagcgat cactaggatc
     2401 tccccaggtc acacagtagg actcacactg ggtctccaat tccaactctc tttctactat
     2461 actgccctgt aatcctacct caaaaaaaaa attatcccct cagtttattc aacaatcttc
     2521 attgtatgtg tatcttctgg ttagacacat agttaaaaaa aaaatgggta gagagtttta
     2581 taaaaattat ccatgtacac tgggttttcc atttctctac ccttgttccc tttctgtttc
     2641 ctgtctccct ctctctttgc ctccttagct cccagtaaga tgagtccagt gaggagggtc
     2701 ttatcatgcc attggttgcc gttgtgcctg ccaatcccat tacagtgaag agcacaggta
     2761 tagagacaag tgctccaaga ccaggattct ccttggcata gctctaattc tgcttctctc
     2821 catattctag gagcctagag cccagctgta gaaataaaat gtattgaaaa caacaggaat
     2881 caaagagcct tatggagcag agcagacagc ctgggggtgg gcacaccatg gcccttatcc
     2941 ctctgccttt acttgccaag actccttcct tgaaatatac ctgagaccat gtccttaact
     3001 tcccaggaag atttccaaat tcctcacact gtgtcaaggt cccaatcagc ccccaccatg
     3061 catttgctat ctccttgtgg cccttaccac actgtcctgt agggctattt accttgtaga
     3121 gggtgcatgc ctaggagccg ggatcaatgg agatgcacaa cctgactttg tacctatcaa
     3181 caaaagaagg caatagatgc ttgttggatt ataacactct tacaggccct gtgccttttg
     3241 tgctctggat ggtggggaag agagttgtgg agttggcttc tggagagatg acattcaggt
     3301 atcagaagca gctgagtctc atgtgtgtag gctaaatgga acagatgaag ctgagaatgg
     3361 cccttctccc tcttctctgg tcctctgcaa tgtacttttg atcaccatgt caatgattgc
     3421 tcattctagc tgaagacaaa taaaactcca tttcattgat ctgcagacac agcagcatcc
     3481 ctgatccact catcttacag ctgcctccaa attttccctt cactgacttt ctgacctcac
     3541 taactctttg aatcagagag tgcactaagc tggcccatct gagaagctgt acctccagca
     3601 gtgtactgta agaactagaa cacttctaat tcggctctta taatgaagtc caaggtagtg
     3661 taaaggtaag agccccatgg tgggactcag gtcacctgag ttctgctccc agcactctag
     3721 atctaaagaa acgagaaaat tttaaaaact gcttgttcat gggatggtga ggttgtgagt
     3781 ggagtcggag tcagaggcaa acagtaaaat ggtgtggcaa gaagcttatg ggtgaatgtc
     3841 agctctgaaa agaacctcca gaaaaaaaga agccttcagt ggggttggga catagtcaga
     3901 atcctacagg gtgtcaacag ttaccatgat ccattgaaat aaaaggtgtt acacaggtga
     3961 tgagcaagtt ggctttgaca taggtaggtg tacagaatca tggagttagc ctggcctagc
     4021 tgccttgaga ggcctgagcc atgggttttt cagggtagag tccatggttc ctggtacaca
     4081 acgtaccttc catttcctga gagactgagg cactccctca ggcagtgaag ctttcaagct
     4141 tctttatgtt tctctgtatg ttcccttgga agttgaggaa gcatggaatt ctgataggac
     4201 aattggcttt agacattaat tttgtgtacc ctgtaaagtc tgcaaacatc attgtaatct
     4261 ggcaataaca actatgctga tcctttttta gaataaaggt ataaaatgtc tgattgcttt
     4321 caataaaact atcacagcct cagtcttgct gtggcccctc aaaaaaaaaa
//
