LOCUS       NM_145423               5346 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 5 (iodide transporter), member 8
            (Slc5a8), mRNA.
ACCESSION   NM_145423 XM_912680
VERSION     NM_145423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5346)
  AUTHORS   Schaefer,L., Hernandez,H., Coats,R.A., Yu,Z., Pflugfelder,S.C.,
            Britton,R.A. and de Paiva,C.S.
  TITLE     Gut-derived butyrate suppresses ocular surface inflammation
  JOURNAL   Sci Rep 12 (1), 4512 (2022)
   PUBMED   35296712
  REMARK    Erratum:[Sci Rep. 2022 Apr 21;12(1):6581. doi:
            10.1038/s41598-022-10856-y.. PMID: 35449441]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5346)
  AUTHORS   Gyawali,A., Latif,S., Choi,S.H., Hyeon,S.J., Ryu,H. and Kang,Y.S.
  TITLE     Monocarboxylate transporter functions and neuroprotective effects
            of valproic acid in experimental models of amyotrophic lateral
            sclerosis
  JOURNAL   J Biomed Sci 29 (1), 2 (2022)
   PUBMED   35012534
  REMARK    GeneRIF: Monocarboxylate transporter functions and neuroprotective
            effects of valproic acid in experimental models of amyotrophic
            lateral sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5346)
  AUTHORS   Jha,M.K., Ament,X.H., Yang,F., Liu,Y., Polydefkis,M.J., Pellerin,L.
            and Morrison,B.M.
  TITLE     Reducing monocarboxylate transporter MCT1 worsens experimental
            diabetic peripheral neuropathy
  JOURNAL   Exp Neurol 333, 113415 (2020)
   PUBMED   32717355
  REMARK    GeneRIF: Reducing monocarboxylate transporter MCT1 worsens
            experimental diabetic peripheral neuropathy.
REFERENCE   4  (bases 1 to 5346)
  AUTHORS   Yuri,T., Kono,Y. and Fujita,T.
  TITLE     Transport characteristics of 5-aminosalicylic acid into colonic
            epithelium: Involvement of sodium-coupled monocarboxylate
            transporter SMCT1-mediated transport system
  JOURNAL   Biochem Biophys Res Commun 524 (3), 561-566 (2020)
   PUBMED   32014250
  REMARK    GeneRIF: Transport characteristics of 5-aminosalicylic acid into
            colonic epithelium: Involvement of sodium-coupled monocarboxylate
            transporter SMCT1-mediated transport system.
REFERENCE   5  (bases 1 to 5346)
  AUTHORS   Srivastava,S., Nakagawa,K., He,X., Kimura,T., Fukutomi,T.,
            Miyauchi,S., Sakurai,H. and Anzai,N.
  TITLE     Identification of the multivalent PDZ protein PDZK1 as a binding
            partner of sodium-coupled monocarboxylate transporter SMCT1
            (SLC5A8) and SMCT2 (SLC5A12)
  JOURNAL   J Physiol Sci 69 (2), 399-408 (2019)
   PUBMED   30604288
REFERENCE   6  (bases 1 to 5346)
  AUTHORS   Thangaraju,M., Ananth,S., Martin,P.M., Roon,P., Smith,S.B.,
            Sterneck,E., Prasad,P.D. and Ganapathy,V.
  TITLE     c/ebpdelta Null mouse as a model for the double knock-out of slc5a8
            and slc5a12 in kidney
  JOURNAL   J Biol Chem 281 (37), 26769-26773 (2006)
   PUBMED   16873376
  REMARK    GeneRIF: slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a
            role in the renal handling of lactate and urate
REFERENCE   7  (bases 1 to 5346)
  AUTHORS   Takebe,K., Nio,J., Morimatsu,M., Karaki,S., Kuwahara,A., Kato,I.
            and Iwanaga,T.
  TITLE     Histochemical demonstration of a Na(+)-coupled transporter for
            short-chain fatty acids (slc5a8) in the intestine and kidney of the
            mouse
  JOURNAL   Biomed Res 26 (5), 213-221 (2005)
   PUBMED   16295698
  REMARK    GeneRIF: Data describe the cellular localization of Slc5a8 in the
            murine gastrointestinal tract and kidney by in situ hybridization
            and immunohistochemistry.
REFERENCE   8  (bases 1 to 5346)
  AUTHORS   Gopal,E., Fei,Y.J., Miyauchi,S., Zhuang,L., Prasad,P.D. and
            Ganapathy,V.
  TITLE     Sodium-coupled and electrogenic transport of B-complex vitamin
            nicotinic acid by slc5a8, a member of the Na/glucose co-transporter
            gene family
  JOURNAL   Biochem J 388 (Pt 1), 309-316 (2005)
   PUBMED   15651982
  REMARK    GeneRIF: SMCT functions not only as a Na+-coupled transporter for
            short-chain fatty acids and lactate but also as a Na+-coupled
            transporter for the water-soluble vitamin nicotinic acid.
REFERENCE   9  (bases 1 to 5346)
  AUTHORS   Hong,C., Maunakea,A., Jun,P., Bollen,A.W., Hodgson,J.G.,
            Goldenberg,D.D., Weiss,W.A. and Costello,J.F.
  TITLE     Shared epigenetic mechanisms in human and mouse gliomas inactivate
            expression of the growth suppressor SLC5A8
  JOURNAL   Cancer Res 65 (9), 3617-3623 (2005)
   PUBMED   15867356
  REMARK    GeneRIF: The shared epigenetic inactivation of mSLC5A8 in mouse
            gliomas indicates an additional degree of commonality in the origin
            and/or pathway to tumorigenesis between primary human tumors and
            these mouse models of gliomas.
REFERENCE   10 (bases 1 to 5346)
  AUTHORS   Gopal,E., Fei,Y.J., Sugawara,M., Miyauchi,S., Zhuang,L., Martin,P.,
            Smith,S.B., Prasad,P.D. and Ganapathy,V.
  TITLE     Expression of slc5a8 in kidney and its role in Na(+)-coupled
            transport of lactate
  JOURNAL   J Biol Chem 279 (43), 44522-44532 (2004)
   PUBMED   15322102
  REMARK    GeneRIF: slc5a8 is expressed abundantly in the kidney and plays a
            role in the active reabsorption of lactate
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY484428.1.
            
            On Jul 14, 2006 this sequence version replaced NM_145423.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY484428.1, BC017691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..5346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.34 cM"
     gene            1..5346
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="solute carrier family 5 (iodide transporter),
                     member 8"
                     /db_xref="GeneID:216225"
                     /db_xref="MGI:MGI:2384916"
     exon            1..666
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..2151
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="solute carrier family 5 member 8; electrogenic
                     sodium monocarboxylate cotransporter"
                     /codon_start=1
                     /product="sodium-coupled monocarboxylate transporter 1"
                     /protein_id="NP_663398.2"
                     /db_xref="CCDS:CCDS36026.1"
                     /db_xref="GeneID:216225"
                     /db_xref="MGI:MGI:2384916"
                     /translation="MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKD
                     FLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEV
                     FLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGF
                     DLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKIL
                     SDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHA
                     KLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKNY
                     PGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLY
                     GALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGF
                     AISLWVGIGAQLYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAE
                     RTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFD
                     VFKKRNHVLNYKLHPVEVGGTDNPAFNHVELNFTDHSGKINGTRL"
     exon            667..732
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            733..784
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            785..852
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1007
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1148
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1278
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1367
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1480
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1548
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1635
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1841
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1945
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2025
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..5331
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="hexamer: ATTAAA"
     polyA_site      2315
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="major polyA site"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="hexamer: ATTAAA"
     polyA_site      3095
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="major polyA site"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
                     /note="hexamer: AATAAA"
     polyA_site      3517
                     /gene="Slc5a8"
                     /gene_synonym="Ait; SMCT"
ORIGIN      
        1 tgcctaggca gtcgcagttg ggccacccgg ggccacacct ggtgagcgct cagcgctgcc
       61 ggcgcgactt ctccgggtcc cagggtgtca ggggcgcagc tggtgacagg ggtttccctg
      121 atccggtgat tggcaacagg tatttaggct cctactttct ggaggatcca cacctgcagg
      181 acgtacctga tctccgcggg acgccacgtc tgcctccaca gggagaaaaa aatcgagcgt
      241 cggcccgagg ctaaaaccac ctgtgctgct cctgccacca ccgtgcactc tgggcgcagg
      301 tcaccgaggg ggaccatgga cgcgtcgcgg gacatcggca gttttgtggt gtgggactac
      361 gtggtgttcg caggcatgct gctcatctcg gcggctatag gcatctatta cgccttcgcg
      421 gggggcggcc agcagacctc caaggacttt cttatgggcg gtcgcagtat gtccgccgtg
      481 cctgtggctc tgtccctcac cgccagcttc atgtccgctg tcactgtcct gggcactcct
      541 gccgaggtct accgttttgg ggcgatattc agcatctttg tcatcaccta cttttttgta
      601 gtggttatca gcgcggaggt cttccttcca gtgttctata ggctggggat caccagcacc
      661 tacgagtatt tggaacttcg atttaatcga tgcattcgtc tctgtggcac aatcctcttc
      721 atcgttcaaa caattctgta cactggaatt gtgatttatg cccctgctct ggctttgaat
      781 caagttacag gatttgatct gtggggcgca gtggtggcca caggggtggt ctgcacattc
      841 tactgcacac tgggcggtct taaagcagtt gtctggacag atgtttttca agttgggatc
      901 atggtggctg gatttgcatc cgtaattata caggcatcaa taactcaaca tggcatcaat
      961 aagattttaa gtgatgcttt taatggtgga agattaaact tctggaattt tgatcctaac
     1021 cctttgcaaa gacacacgtt ctggacaatt gtcattggag ggacttttac ctggaccacc
     1081 atctatggtg tcaaccagtc ccaagtgcag agatatattt cctgtaaaag cagactccat
     1141 gcaaaactgt ccctctatgt caaccttgtg ggcctctggg tgatcctcac ctgctccata
     1201 ttctgtgggc ttgccctgta ctccagatac cgtgaatgtg atccctggac atctaagaaa
     1261 gtgtcagcga ttgaccagct tatgccttat ttggtgttgg acattttgaa aaattaccct
     1321 ggtgttcccg gactttttgt ggcctgcgct tacagtggga cattaagcac agtgtcctcc
     1381 agtatcaatg ccttggcggc agtcaccgtg gaagatctca tcaaaccccg ctttaagtct
     1441 ctctcagaga agtctctgtc ttggatttcc caaggaatga gtgttctgta tggagctctg
     1501 tgcattggaa tggctgccct ggcatcgctg atgggagcct tgttacaggc agcactcagc
     1561 atattcggca tggttggtgg accacttctg ggcttgtttt ctttgggcat cttggtcccc
     1621 ttcgccaact cgattggagc actcactggt ctgttggctg gatttgccat ttccttatgg
     1681 gtaggaattg gagcccagct ttatcctccg cttcctgaga gaaccttacc attgcccctt
     1741 gaaacctatg gctgtaacat cacgcacaat gggtcggact ggatgtcaac cacagaaatg
     1801 ccattttcta ctagcgcttt tcaaatacat aatgcggaaa ggactccact gatggacaat
     1861 tggtattcat tatcatatct gtacttcagt actattggaa cgctgacaac actgtttgtg
     1921 gggatactta tcagcttatc aacaggagga agaaaacaga acttagatcc ccgattctta
     1981 ctaaccaaac aggacttttt atccaatttt gatgttttta agaaaaggaa tcatgtttta
     2041 aactataaat tgcatcctgt ggaagttggt ggaactgata accctgcctt caaccatgtt
     2101 gagctgaact tcacagatca cagtggcaag atcaatggga ctcgcttgtg aagcatctcc
     2161 agggctagat gacattgtat aatgtctgtt ttgtttttgt tttgcttttc tttaaacatg
     2221 ttttaggata gttggatcag atcagttttt tcctatcatg attgtttttg gaagatatat
     2281 tttattaaag ccaaatcccg atttggctca ctttatacac tggttgattg atgctatcct
     2341 ggagttagga gtttcaacac gagctctggt tgtggatgtt tataactaca tacatgtgtg
     2401 aaaggcaaat acagacatac acacatggtt cttgataatc aaaggcatat tcttacgttt
     2461 gggcattact gaaaacattt tacatgcctt tggtgctagt atatgtatat tctgggaact
     2521 ttactagaat aataaatctt ggaaagagat ttctttcctc cccctgaata tcctgtttct
     2581 aggcagcagg gacaggagga ggagtagagc acttctgtgg actttacttc tggatcagcc
     2641 catgctataa ccttgcctct gagtctgcct ctgaatgggt aaatagcagc atcctgccta
     2701 ggatacacta ggtacccaac gatcaagttc atctttaatg cattcttgtg cctgtttttc
     2761 ctctgctgag attcctgaca attgccaagt acagtgcttt tcatagacta ttgactatag
     2821 attatagacc attgactgta gactatcaac tatcgactat aatttttaat ctttattccc
     2881 aacttctgtt ctaataacct tgcttttgta gagcatgtta cctggactta actgttccag
     2941 cttcttgctt tttgccctgg gtttagatat gtcttgagac atccaatata aactatgtca
     3001 cctctttcct tcagtcccca gatcccatcc tgtgctaaca catgcttctt gtgtattggg
     3061 taacccaaga acattaaata tttgaaaacg gtgaagtccc atggagtcgc acaattgctt
     3121 ttaatgctgt taagttgaat tactaattca tatagttaaa gaacttcata gggaaatact
     3181 tctttatttt ttcacatgtt tcaggttatt aaatgcatgc tttttttcta ttttctaaga
     3241 tttcaagcag taatttcaaa gttcttagcc atttatttgg ctacattcat agctaaaact
     3301 tgtgttacag agtttcatca ataacttatt tttctatgat acccacatta gatattgctt
     3361 aaatttttaa aaagttttca atattttaag aaaagaaata ctgatatttt aaaaataatt
     3421 cataatttta tacatatttt tggtctatta tatttgaagg ctatactatt tacttttaaa
     3481 ggctcttaac tgataataaa aactaaaata tcaaaaatat tagcatttat ctgaaacaaa
     3541 gagatttata tgccatttga atcaactatg tattcatgta tttcttatgt atatagatct
     3601 atttattgat tactatattt gtaaacaaaa atcaagtttt gtgattatct tgcagtactc
     3661 taatgagcat ggttatgtaa ttttatatat gtaatcttat ataactatga tttgaagtat
     3721 agttatttat tagatgattc tgaaaaaaaa tatacatata catacacaca cacacacata
     3781 cacatgatgc ttcagttttg gcaatgagaa tcaggttatt tgattaactt tttctttgat
     3841 ctgactgcac aaaggttact caacgtgttc ttcatgagaa gtggtattcc aaacgagttt
     3901 gtcaacttcc tgtaagacaa agtatatcct tgtgagattt ggaaatacca ctgtcttatt
     3961 tttacaaatg cacaggaatg ccagatagaa ttcttaaagt caaaagatgt tgctattact
     4021 taaaaagtat ttatttttaa cttttaaaac atgggactaa tataaatatg agggatatgt
     4081 cagcatatta caatgtaaag taaataatct tttcttagtt ttattaaaac acaaaaacct
     4141 taatggaaga aaacaattgt acaggttgtc tgtcagtgtc ttgctgctga caagtatgcc
     4201 tttgactttg cccttaattt catttaatgc tgatataaga atgaggctgc ccacctcaaa
     4261 aaagtagtgt gaaagacctg agttttgaca gaccaggatt tcattaactc aagtgatttg
     4321 aggcaaatat tatttgctag gttttttttg aactaagaag aatctttact atcatgaagt
     4381 aaaaaaaaca aaacaaaaca aaaacaaaaa caaaaccctt ccctaaaaaa tatgtgccac
     4441 aggagtaaaa atacatttga gaatcaacag gaaagactat aaaccttaaa gaaagacatg
     4501 attcagtcct attcatccta cagagaggtg aaaactttat aggtcaggtg taaaacatca
     4561 cagagtcatg ttatcagtaa gtggattgtt tgcatgctct ctttttttct cttgagacca
     4621 gtagttacca gcatgggtca ttgtgtttct ctggtgacat gtggagacat ttaagtgtcc
     4681 ccaatgagat tgctggtgcc atgtatggaa ttaggttcag gaaagtacca ttagcactct
     4741 ggataatgac cacacacttt cagaggagtc tgaaatgtga acacattttc acaagtcgtg
     4801 ggtaattatt tagaccagtc tttggccagc tcagctcctt tacgtggttt ctaatatggc
     4861 cccacattag gatgttatga aatacatgac tactaagatc tctgaacttc atcttactta
     4921 tggaaagcac acgtcatgtg gtttgtttca tgaaataagc tgaacatatg atgtagacac
     4981 attgggtagg gctgagcttg agaaacactg aagaactctg tgaactgatt ccctctgaat
     5041 cttcccatga agattgttga taaggaggca accaaggtaa agggctgcgg ttcagcggta
     5101 aaactcttac tgagcttgtg caagatccta ggcttccttc ccagcatcac tgagaacggg
     5161 ggcaacctag tgcatgtccg tttagctctt aaaaacgcat tggatgcatt tagagtcaac
     5221 ttttgtacca ctgtttgtga aaatattggg aaagttgaat atttctatgt aaaatatggt
     5281 tacaaactta tttttttttc aatttgctga ttaaaatttc cataaaaatc aaaaaaaaaa
     5341 aaaaaa
//
