LOCUS       NM_022025               5198 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 5 (choline transporter), member
            7 (Slc5a7), mRNA.
ACCESSION   NM_022025
VERSION     NM_022025.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5198)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5198)
  AUTHORS   Vieira,J.R., Shah,B., Dupraz,S., Paredes,I., Himmels,P.,
            Schermann,G., Adler,H., Motta,A., Gartner,L., Navarro-Aragall,A.,
            Ioannou,E., Dyukova,E., Bonnavion,R., Fischer,A., Bonanomi,D.,
            Bradke,F., Ruhrberg,C. and Ruiz de Almodovar,C.
  TITLE     Endothelial PlexinD1 signaling instructs spinal cord
            vascularization and motor neuron development
  JOURNAL   Neuron 110 (24), 4074-4089 (2022)
   PUBMED   36549270
REFERENCE   3  (bases 1 to 5198)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5198)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5198)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   6  (bases 1 to 5198)
  AUTHORS   Okuda,T., Okamura,M., Kaitsuka,C., Haga,T. and Gurwitz,D.
  TITLE     Single nucleotide polymorphism of the human high affinity choline
            transporter alters transport rate
  JOURNAL   J Biol Chem 277 (47), 45315-45322 (2002)
   PUBMED   12237312
REFERENCE   7  (bases 1 to 5198)
  AUTHORS   Guermonprez,L., O'Regan,S., Meunier,F.M. and
            Morot-Gaudry-Talarmain,Y.
  TITLE     The neuronal choline transporter CHT1 is regulated by
            immunosuppressor-sensitive pathways
  JOURNAL   J Neurochem 82 (4), 874-884 (2002)
   PUBMED   12358793
REFERENCE   8  (bases 1 to 5198)
  AUTHORS   Marshall,K.E., Godden,E.L., Yang,F., Burgers,S., Buck,K.J. and
            Sikela,J.M.
  TITLE     In silico discovery of gene-coding variants in murine quantitative
            trait loci using strain-specific genome sequence databases
  JOURNAL   Genome Biol 3 (12), RESEARCH0078 (2002)
   PUBMED   12537567
REFERENCE   9  (bases 1 to 5198)
  AUTHORS   Apparsundaram,S., Ferguson,S.M. and Blakely,R.D.
  TITLE     Molecular cloning and characterization of a murine
            hemicholinium-3-sensitive choline transporter
  JOURNAL   Biochem Soc Trans 29 (Pt 6), 711-716 (2001)
   PUBMED   11709061
REFERENCE   10 (bases 1 to 5198)
  AUTHORS   Wang,Y., Cao,Z., Newkirk,R.F., Ivy,M.T. and Townsel,J.G.
  TITLE     Molecular cloning of a cDNA for a putative choline co-transporter
            from Limulus CNS
  JOURNAL   Gene 268 (1-2), 123-131 (2001)
   PUBMED   11368908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053063.1 and BC065089.1.
            
            On Apr 17, 2010 this sequence version replaced NM_022025.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034415.1, AK053063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4095              AK053063.1         3-4097
            4096-5198           BC065089.1         3613-4715
FEATURES             Location/Qualifiers
     source          1..5198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 28.23 cM"
     gene            1..5198
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /note="solute carrier family 5 (choline transporter),
                     member 7"
                     /db_xref="GeneID:63993"
                     /db_xref="MGI:MGI:1927126"
     exon            1..454
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..687
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..2252
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /note="CHT; solute carrier family 5 member 7;
                     hemicholinium-3-sensitive choline transporter"
                     /codon_start=1
                     /product="high affinity choline transporter 1"
                     /protein_id="NP_071308.2"
                     /db_xref="CCDS:CCDS28885.1"
                     /db_xref="GeneID:63993"
                     /db_xref="MGI:MGI:1927126"
                     /translation="MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNPEERSEAIIV
                     GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFF
                     AKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVD
                     VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFT
                     AVHAKYQSPWLGTIESVEVYTWLDNFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFL
                     AAFGCLVMALPAICIGAIGASTDWNQTAYGYPDPKTKEEADMILPIVLQYLCPVYISF
                     FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASA
                     TAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGG
                     EPYLYLQPLIFYPGYYSDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLP
                     PKLDVFDAVVARHSEENMDKTILVRNENIKLNELAPVKPRQSLTLSSTFTNKEALLDV
                     DSSPEGSGTEDNLQ"
     exon            688..801
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..957
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1106
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1250
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1404
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1622
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..5180
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /note="hexamer: ATTAAA"
     polyA_site      5180
                     /gene="Slc5a7"
                     /gene_synonym="CHT1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgaaatc ctccaagtcc attgctgtct tttgcaaccc agaaagataa agtgggcagg
       61 taggctggga aatgaccttt agtctggagt cctccattct agggtagcag acgacttgac
      121 ttgggatggg aacatgaact tgggcaagtg ctggatctga gcttggctgt tccctcgcac
      181 cccgggccac accagggcac agtccgcaac tcacgcccag caccactttg ttctgacgtc
      241 cttctccaga gctctgacga tcgcccccgc cttccgccct tataaagaga ctttttccaa
      301 tacccagatc gatcgcttca ccccctcgga gtcctcatcg ggctccttgc cggagccccc
      361 tccactcacc tcgagcctcc ctccctccgt gtccctcaca gcccggggct caaggggctc
      421 ctggacccct aaagcagctc cgggtgacgc aaagaagatt tgatgaagta gccctctgtg
      481 gaaggatctg cactgtaccc taaataaaaa tgtctttcca cgtagaagga ctggtagcta
      541 ttatcctctt ctacctcctt atatttctgg ttggaatatg ggctgcatgg aaaaccaaaa
      601 acagcggcaa cccagaagag cgcagtgaag ccatcatagt cgggggccgt gacattggtt
      661 tgttggttgg tggttttacc atgacagcca cctgggttgg aggaggctac atcaatggga
      721 cagcagaagc agtgtatggg ccaggttgtg gtctagcttg ggctcaggca cccattggat
      781 attctctgag tctaatttta ggtggtctgt tttttgcgaa acctatgcgt tccaagggat
      841 atgtgactat gttagaccca tttcaacaga tctatggaaa gcgcatgggt gggctgctct
      901 tcatccctgc actgatggga gagatgttct gggctgcagc aattttctct gcattagggg
      961 ccaccatcag cgtgatcatt gatgtggatg tgaacatatc ggtcattgtc tctgcactca
     1021 ttgccattct ttatacccta gtgggtgggc tctactctgt ggcatatact gatgttgtcc
     1081 agctattctg catttttata ggactgtgga tcagtgtccc ttttgccctg tcacatcctg
     1141 cagtcaccga catcggattc acagctgtgc atgctaaata ccagagtccc tggctgggaa
     1201 ccattgaatc agttgaagtc tacacctggc ttgataattt tctgttattg atgctgggtg
     1261 gaatcccatg gcaagcctac ttccagaggg tcctctcttc atcctcagcc acctatgctc
     1321 aggtactgtc cttcctggca gcttttgggt gcctggtgat ggctctaccc gccatatgca
     1381 taggagctat tggagcttcc acagactgga accagactgc ctacgggtat ccagatccca
     1441 agactaagga ggaagcagac atgattctcc cgatcgttct gcagtacctc tgccctgtgt
     1501 acatctcctt ctttgggctt ggtgctgttt cagctgctgt catgtcctca gctgactcgt
     1561 ccatcctgtc ggcgagttct atgtttgctc ggaatatcta ccagctttcc ttcagacaaa
     1621 atgcatcaga caaggaaatt gtgtgggtca tgaggatcac tgtgcttgtg ttcggagcat
     1681 ctgcaacagc catggctttg ctgacgaaga ctgtgtatgg gctctggtac ctgagctctg
     1741 accttgtcta catcatcatc ttcccacagc tgctctgtgt actcttcatc aaaggaacca
     1801 acacttatgg ggcagttgct ggttatattt ttggactatt cctgagaatt actggaggag
     1861 agccatatct atacttgcag cccttaatct tctaccctgg ttattactct gacaagaatg
     1921 gtatatacaa tcagaggttc ccatttaaaa ctctctccat ggttacctca ttctttacca
     1981 acatttgtgt ttcttatcta gccaagtatc tatttgaaag tggaaccttg cctccaaaat
     2041 tagatgtatt tgatgctgtt gtcgcaaggc acagtgaaga gaacatggac aagaccattc
     2101 tagtcagaaa tgaaaatatc aaattaaatg aacttgcacc tgtgaaacct cggcagagcc
     2161 taaccctcag ttcaactttc accaataagg aggccctcct tgatgttgat tccagtccgg
     2221 aggggtctgg gactgaagat aacttacaat gacccaatct aaaatataca gaagagggca
     2281 ttgctgtagg gtagtactgg aagaaaggct tggagcatat cttacacatg ttaaaatata
     2341 agtgtctaga gggaaatagt tttgcagaaa taaaataagt tatgacagat gagttcagaa
     2401 aaaataacaa ttgcacagtg agaaggaatc gagcatgaag ccaaaagctt tatctctcat
     2461 catagcactt ttaattttaa atagcattgt taagtgcata aaaatgcata aagccctagc
     2521 caaagaaggt ggccaaatat tacttatctt tattatggaa aaaaggggga tatatattag
     2581 ggagtctatg ggaaggagat tggctggtcc tgatcatcct cactggctaa tgcactggac
     2641 accattttaa ttactacaac gtggagttta tgcattcaat cccagtcact actgtggatg
     2701 atgcagtgag ttagccagtt gacttctctc catgggtagg ctgtcttgct cttgcctgat
     2761 ttgaactgtg gcttttactc atttttcaag gtgcgcttcc ttaccctttc ttgccatctt
     2821 gcatgtgtac tctctccacc atcccttcat ctatccatcc cctcctactc tctacttcct
     2881 ttcctttttt ctgcccttcc cctttctctt cttttcttcc ctttcctttt ctcttcatat
     2941 tttttttgag gtgctggaaa tctattgcac atgctgggta agaactctct tactgagcta
     3001 cattgcagcc ccacaatgat ttatttagtt tttcagtgat gccatacatt attctaagca
     3061 caagcaacac aaaccatatc ttacttaata gtgacatttt atgtgtaaat gatagaaaca
     3121 caatctatgt tggagttgga aaaaaagcac tgagttcttc aaatatatct aagattgcca
     3181 tctccacaaa gagaagggct tgacgccaag catgaaatgg ttgctggatg gcattacaga
     3241 aataagtcaa gaagaaaagt aaaggaagga gaagaagaaa aacagatttc tatctccagc
     3301 ttttagacat taaatactgt tacacattac aaatacaatg tcttggccta tcttctaagt
     3361 cagtgttgga ggcaaagatg agccatctgt aaagagagat ttctaacgtc tgttagaggt
     3421 ggcacttgct ttatcagcat gcgttcaatg tatatttatt accagcagct tccaaacacc
     3481 tcaccaagaa actggaaaac aaaccctgct tattttggac atttattaat ggaatagttt
     3541 agtgttcagg acctactctt gacactgttc cacataagcc atttttaggg actggacaga
     3601 tcacaacaag tatgtatatt gaatatcaaa tgtaatagaa agcaaacagt aaaaacaagt
     3661 catagaaaga agaagccatc atttttaata tctgttgtgt acatggattt caagaggtca
     3721 gtcattaaat gtagttttgc ttctctttgt cttgttcaga attgcacaca aaccttgtgc
     3781 ccccaaaccc tagaattctc tttataggtt acagttatta tctctcaaag tatcaaaagg
     3841 tggaagtcct ttgcttaaaa atgtgactta aaaattccta gtatgacttt taaaatttaa
     3901 agttaaataa ttttacatat tgtaatatcc tacttttcag tggtgtctca attcgtaggc
     3961 ctctttactg tatgtatatt acataagaaa gataattaat ttaccctcca gtctatctca
     4021 gaatcaactc actaactatg gactatttga aagtatggag tctgagatgc tcaaatgtgg
     4081 ggtgagaaaa gaatcaaaga aaaaagaaaa cacagattaa aaaatagaaa actttgggca
     4141 tgaaaaacta ctagtgacaa ggatgaaatt tctggtaaac atggtatttc agacccacaa
     4201 ggtctttcaa caaagacaaa agagtgaatt ttgcccaact catcatctgt gcccttccat
     4261 cggattgtta atgtgcgttc ttgaattatg aacatcatgg agtctcattc atactgtaga
     4321 ccttacagca aagcaggttc tttccatata caatatattt tgtaatgttc ttagtgaaca
     4381 actgcccaac taatcttata atatttaaag tgttaaaata gcaaaaaaga aaatgagaga
     4441 agaatcctaa agtatttatt tatgcatact ctggaatgaa ttcctcatga atttcaagca
     4501 agggatgatg cttcaaagta cggaaggtct actctgtatc agaatggtga catctctaag
     4561 tcattccaga ttcaggcagt agacgtcatt ttcaaatccc caatgaaatt aaaataacac
     4621 aactgtttca gcctcttgcc tgggaagtaa tatgtgtagc attggaacaa gataggagtt
     4681 tccctcccat atattaccaa tgattgtact atgtttctta ggtaagttgt gttcctctcc
     4741 acatattcag aacatcaagc ttgtaggtga aatgatatgt caacaagcta tcagatgctc
     4801 agtgccaaaa tccaatttca ttgttataaa taatgaattt ttgtgaatat tgtatgaaca
     4861 taagcttgaa attagtacat ttaatataac atgtgttgaa atttttattt gtaaataatg
     4921 aattaacata tattttaaac ataaatcatc actttccttt atgtctttct acaaaattta
     4981 ctctggtatc gtatgttata agtttgctat attgtatgtt tgctactgca taggtaaatg
     5041 catataatgg ttccaaaaca tatattttta tctgtcaaaa tattatacaa agttatactc
     5101 aaataagtag atttacaagt atacatgtat gtgttcaaat gtaataatac tgtattaaat
     5161 tattccactg aaattcagaa aaaaaaaaaa aaaaaaaa
//
