LOCUS       NM_001360022            3159 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium-dependent vitamin
            transporter), member 6 (Slc5a6), transcript variant 4, mRNA.
ACCESSION   NM_001360022 XM_011240751
VERSION     NM_001360022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Sabui,S., Skupsky,J., Kapadia,R., Cogburn,K., Lambrecht,N.W.,
            Agrawal,A. and Said,H.M.
  TITLE     Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult
            mice leads to spontaneous inflammation: involvement of NF-kappaB,
            NLRP3, and gut microbiota
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 317 (4), G518-G530 (2019)
   PUBMED   31369292
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Sabui,S., Kapadia,R., Ghosal,A., Schneider,M., Lambrecht,N.W.G. and
            Said,H.M.
  TITLE     Biotin and pantothenic acid oversupplementation to conditional
            SLC5A6 KO mice prevents the development of intestinal mucosal
            abnormalities and growth defects
  JOURNAL   Am J Physiol Cell Physiol 315 (1), C73-C79 (2018)
   PUBMED   29669219
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Lakhan,R. and Said,H.M.
  TITLE     Lipopolysaccharide inhibits colonic biotin uptake via interference
            with membrane expression of its transporter: a role for a casein
            kinase 2-mediated pathway
  JOURNAL   Am J Physiol Cell Physiol 312 (4), C376-C384 (2017)
   PUBMED   28052864
  REMARK    GeneRIF: This study shows for the first time that LPS inhibits
            colonic biotin uptake via decreasing membrane expression of its
            transporter and that these effects likely involve a CK2-mediated
            pathway.
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Srinivasan,P., Kapadia,R., Biswas,A. and Said,H.M.
  TITLE     Chronic alcohol exposure inhibits biotin uptake by pancreatic
            acinar cells: possible involvement of epigenetic mechanisms
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 307 (9), G941-G949 (2014)
   PUBMED   25214397
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   Ghosal,A., Lambrecht,N., Subramanya,S.B., Kapadia,R. and Said,H.M.
  TITLE     Conditional knockout of the Slc5a6 gene in mouse intestine impairs
            biotin absorption
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (1), G64-G71 (2013)
   PUBMED   23104561
  REMARK    GeneRIF: These studies also provide evidence for a casual
            association between SMVT function and normal intestinal health
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Nabokina,S.M., Subramanian,V.S. and Said,H.M.
  TITLE     Association of PDZ-containing protein PDZD11 with the human
            sodium-dependent multivitamin transporter
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 300 (4), G561-G567 (2011)
   PUBMED   21183659
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Subramanian,V.S., Subramanya,S.B. and Said,H.M.
  TITLE     Chronic alcohol exposure negatively impacts the physiological and
            molecular parameters of the renal biotin reabsorption process
  JOURNAL   Am J Physiol Renal Physiol 300 (3), F611-F617 (2011)
   PUBMED   21209005
REFERENCE   10 (bases 1 to 3159)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109608.14.
            
            On Jan 25, 2018 this sequence version replaced XM_011240751.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1062601.1,
                                           SRR1660817.173428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC109608.14        111423-111536
            115-284             AC109608.14        111703-111872
            285-363             AC109608.14        114911-114989
            364-873             AC109608.14        116043-116552
            874-939             AC109608.14        116858-116923
            940-991             AC109608.14        117313-117364
            992-1059            AC109608.14        117891-117958
            1060-1214           AC109608.14        118204-118358
            1215-1355           AC109608.14        118704-118844
            1356-1485           AC109608.14        119011-119140
            1486-1574           AC109608.14        119660-119748
            1575-1687           AC109608.14        120086-120198
            1688-1755           AC109608.14        120493-120560
            1756-1842           AC109608.14        121402-121488
            1843-2021           AC109608.14        121610-121788
            2022-2125           AC109608.14        121990-122093
            2126-2241           AC109608.14        122284-122399
            2242-3159           AC109608.14        122549-123466
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.93 cM"
     gene            1..3159
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /note="solute carrier family 5 (sodium-dependent vitamin
                     transporter), member 6"
                     /db_xref="GeneID:330064"
                     /db_xref="MGI:MGI:2660847"
     exon            1..114
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            115..284
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            285..363
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            364..873
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2388
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /note="solute carrier family 5 member 6; Na(+)-dependent
                     multivitamin transporter"
                     /codon_start=1
                     /product="sodium-dependent multivitamin transporter"
                     /protein_id="NP_001346951.1"
                     /db_xref="CCDS:CCDS19169.1"
                     /db_xref="GeneID:330064"
                     /db_xref="MGI:MGI:2660847"
                     /translation="MSVASTAAPFHTTSGSSGAISTFSVVDYVVFGLLLVLSLVIGLY
                     HACRGWGHHTVGELLMADRKMGCLPVALSLLATFQSAVAILGAPAEIFRFGTQYWFLG
                     CSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFIFQMVIYMGVAL
                     YAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLVMFLGQLVVII
                     VGAARVGGLGHVWNVTSQHGLISGINLDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQ
                     VQRYLSSHSERAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYNMYSMSPELKQAAPDQ
                     LVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLTET
                     RAIMLSRGLAFAYGLVCLGMAYISSHLGSVLQAALSIFGMVGGPLLGLFCLGLFFPCA
                     NPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAVAPPPLNGSSSFLPANVTVAAVTTVMP
                     STLSKPTGLQHFYSLSYLWYSAHNSTTVIVVGLIVSLLTGGMRGRSLNPGTIYPVLPK
                     LLALLPLSCQKRLCWRSHSQDIPVIPNLFPEKMRNGVLQDSTDKERMAEDGLVHQPCS
                     PTYVVQETSL"
     exon            874..939
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            940..991
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1059
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1214
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1355
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1485
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1574
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1687
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1755
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1842
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2021
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2125
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2241
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..3159
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /note="hexamer: AATAAA"
     polyA_site      3159
                     /gene="Slc5a6"
                     /gene_synonym="E430023I20"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggggc ggggtgagcc tctcggtgtg ggctttgggg aaggtcttaa atactagtgc
       61 aaagtcgtgg gttcgccacg tgcggagaga aggggaaagc tgagccgaga gaggggggaa
      121 aaaccaatgc tggtttcgga aagaacgtag gaactttggt agccctggcc gaaccaccga
      181 cgcaaggcaa gcagaacagc agcaggtctg actggaaggg cgctgggaga gacccatcac
      241 acctaagggg acagctattg ctctgggtga cgactcctca aaagctactc acagaatcag
      301 tcggtgcctc tacctgtgtc ctgcccaggc agctctgccg cagaacaggg attgcttctc
      361 cagctgcccc tggaccatgt cactgggtag aagaggaacg ctgtgagact gaacgaggaa
      421 ccatctcgtg acagctcaga gcccaggagt accaagtcac tgcaaagcat cagcaccgtg
      481 aggatgagtg tggcgagcac tgcagctccc ttccatacaa cctcaggctc cagcggggct
      541 atttctacct tttctgttgt ggactatgtg gtatttggcc tgttgctggt cctctccctt
      601 gtcattgggc tctatcatgc ttgtcgtggc tggggccacc ataccgttgg tgaactgctg
      661 atggcagacc gcaaaatggg ctgtcttcct gtggcactgt ccttgctggc caccttccag
      721 tcagccgtgg ccatcctggg agcaccagct gagatcttcc gatttggaac ccagtattgg
      781 ttcctggggt gctcctactt cctggggctc ctgatccctg ctcacatctt catccctgtc
      841 ttctaccgtc tgcatctgac cagcgcctat gagtacctag agctccgctt caataaagca
      901 gttcggatct gtgggactgt gaccttcatc tttcagatgg tgatatacat gggagttgct
      961 ctctatgcac catccttggc cctcaatgca gtgactggat ttgatttatg gctgtcagtg
     1021 ctggccctag gaattgtctg caacatctac actgcactgg gtgggctgaa ggctgtcatc
     1081 tggacagatg tgttccaaac actggtcatg ttcctcgggc agctggtagt gatcattgta
     1141 ggagcagcca gagtgggtgg cttgggccat gtatggaatg tgacttccca gcatggcctc
     1201 atctctggga ttaacctgga tcctgacccc tttgtgcgtc atactttctg gactttggcc
     1261 tttggaggtg tcttcatgat gctctccttg tatggagtga atcaggctca ggtgcagcgc
     1321 tacctcagtt cccactcgga gagagctgct gtgctctcct gctatgcagt gttcccttgc
     1381 cagcaagtgg ccctctgcat gagctgcctc attggtctgg tcatgtttgc ctattataac
     1441 atgtatagca tgagccccga gctgaagcaa gcagcccctg accagttagt cctctatttt
     1501 gtgatggacc tcctgaaaga catgccaggg ctgcctgggc tcttcgttgc ctgtctcttc
     1561 agtggatctc tcagcaccat atcctctgca ttcaattcac tggcaactgt cacgatggaa
     1621 gacctgatcc agccctggtt cccacagttg actgaaactc gggccatcat gctttctcga
     1681 ggccttgcct ttgcctatgg gctagtttgc ctgggaatgg cctatatttc ctctcatctg
     1741 ggatcagtgc tccaggcagc actcagtatc tttggcatgg ttggagggcc actgctggga
     1801 ctcttctgcc ttggactgtt cttcccatgc gccaaccctc ttggtgccat tgtaggcctg
     1861 ttgacgggac tcaccatggc cttctggatc ggcattggga gcatagtaag caggatgagt
     1921 tctgctgtgg caccccctcc ccttaatgga tccagctcct tcctgcctgc caatgtaact
     1981 gtcgccgctg tgaccaccgt gatgccttct accctgtcca agcccacagg actgcagcac
     2041 ttctattccc tgtcctattt atggtacagc gcgcacaact ccaccacagt cattgtagtg
     2101 ggcctgattg tcagtctgct cactggggga atgcggggcc ggtccctgaa ccccggcacc
     2161 atttaccctg tgctgccaaa gctcctagca ctcctgcccc tatcctgcca gaagcggctt
     2221 tgctggagaa gccacagcca ggatatccct gtgatcccca acctgtttcc agagaagatg
     2281 aggaatgggg tgctgcagga cagcacagac aaagagagga tggctgaaga tggcctcgtc
     2341 caccagccgt gcagccctac ctacgttgtc caggagacct ccctgtgacc tggggcgtga
     2401 actctgccct cgctgcagac agcagccgga ggctattttg tagtgcagag atgactcact
     2461 cactccgtgt gttctacagt gctgaggtgg atgacctggc ctacagcaaa ggaccttgag
     2521 ctttaaagta tcacctccat ggaagcgggg gcatgcaagg gcgagacagt ttttcctcat
     2581 cccttgccaa gcttctctta ggattggttt gcagggtata gaatcccatc acgcgtggga
     2641 aaataaatga atacactaag aaaagggtgg catttgatta agtgaccagg gttctttgga
     2701 gtgagtagga acagcatttc ttacaaccgc cccaggacct gatttggcaa gactgactag
     2761 ctctctttag ccctctggtg attccttcac tatcatgtca acctggctta tcattgtgag
     2821 cccctgaggt ctttcgggtt ctctgtaata ctcaagtcct ctctcattct tacctacctc
     2881 gactcttgag agggaggctt tggtatcctt gggtctcagc atggacagtt atgtatatct
     2941 acttgtatag agggggacag ttttccacat cgatccttgc cctcttcagg cagtacttca
     3001 gggccctcac caggacccct tatgtagtgt gctatcctct aaactcctaa gctaagtcac
     3061 cctggtgtca ttctgtcatc tgtgcaacta ttatttcctt tgggagtttc ctcttcatgc
     3121 attttgttcc tagggaataa aaatagctgt tagacctgg
//
