LOCUS       NM_053248               2943 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 5 (sodium iodide symporter),
            member 5 (Slc5a5), mRNA.
ACCESSION   NM_053248
VERSION     NM_053248.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2943)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2943)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2943)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2943)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2943)
  AUTHORS   Kaspari,R.R., Reyna-Neyra,A., Jung,L., Torres-Manzo,A.P.,
            Hirabara,S.M. and Carrasco,N.
  TITLE     The paradoxical lean phenotype of hypothyroid mice is marked by
            increased adaptive thermogenesis in the skeletal muscle
  JOURNAL   Proc Natl Acad Sci U S A 117 (36), 22544-22551 (2020)
   PUBMED   32826330
REFERENCE   6  (bases 1 to 2943)
  AUTHORS   De Felice,M., Postiglione,M.P. and Di Lauro,R.
  TITLE     Minireview: thyrotropin receptor signaling in development and
            differentiation of the thyroid gland: insights from mouse models
            and human diseases
  JOURNAL   Endocrinology 145 (9), 4062-4067 (2004)
   PUBMED   15231702
  REMARK    Review article
REFERENCE   7  (bases 1 to 2943)
  AUTHORS   Lin,X., Ryu,K.Y. and Jhiang,S.M.
  TITLE     Cloning of the 5'-flanking region of mouse sodium/iodide symporter
            and identification of a thyroid-specific and TSH-responsive
            enhancer
  JOURNAL   Thyroid 14 (1), 19-27 (2004)
   PUBMED   15009910
  REMARK    GeneRIF: The high degree of homology in the 5'-flanking region
            between mouse and rat NIS suggests that mNIS and rNIS share similar
            mechanisms for transcriptional regulation in the thyroid.
REFERENCE   8  (bases 1 to 2943)
  AUTHORS   Postiglione,M.P., Parlato,R., Rodriguez-Mallon,A., Rosica,A.,
            Mithbaokar,P., Maresca,M., Marians,R.C., Davies,T.F., Zannini,M.S.,
            De Felice,M. and Di Lauro,R.
  TITLE     Role of the thyroid-stimulating hormone receptor signaling in
            development and differentiation of the thyroid gland
  JOURNAL   Proc Natl Acad Sci U S A 99 (24), 15462-15467 (2002)
   PUBMED   12432093
REFERENCE   9  (bases 1 to 2943)
  AUTHORS   Pinke,L.A., Dean,D.S., Bergert,E.R., Spitzweg,C., Dutton,C.M. and
            Morris,J.C.
  TITLE     Cloning of the mouse sodium iodide symporter
  JOURNAL   Thyroid 11 (10), 935-939 (2001)
   PUBMED   11716040
  REMARK    GeneRIF: Cloning of the mouse sodium iodide symporter.
            Erratum:[Thyroid 2001 Nov;11(11):1087]
REFERENCE   10 (bases 1 to 2943)
  AUTHORS   Perron,B., Rodriguez,A.M., Leblanc,G. and Pourcher,T.
  TITLE     Cloning of the mouse sodium iodide symporter and its expression in
            the mammary gland and other tissues
  JOURNAL   J Endocrinol 170 (1), 185-196 (2001)
   PUBMED   11431151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB645718.1, AC019302.14, AK046718.1 and CD741961.1.
            
            On Dec 8, 2007 this sequence version replaced NM_053248.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046718.1, BC137650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               BB645718.1         1-453
            454-519             AC019302.14        157888-157953
            520-2925            AK046718.1         521-2926
            2926-2943           CD741961.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.36 cM"
     gene            1..2943
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /note="solute carrier family 5 (sodium iodide symporter),
                     member 5"
                     /db_xref="GeneID:114479"
                     /db_xref="MGI:MGI:2149330"
     exon            1..453
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1953
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /note="sodium-iodide symporter; solute carrier family 5
                     member 5; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter"
                     /codon_start=1
                     /product="sodium/iodide cotransporter"
                     /protein_id="NP_444478.2"
                     /db_xref="CCDS:CCDS22385.1"
                     /db_xref="GeneID:114479"
                     /db_xref="MGI:MGI:2149330"
                     /translation="MEGAEAGARATFGPWDYGVFATMLLVSTGIGLWVGLARGGQRSA
                     DDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTA
                     LLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVT
                     GLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVMLMGGPWN
                     VLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRYVACHTER
                     KAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFE
                     DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPSLAPRKLVFISKGLSF
                     IYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLT
                     AGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMD
                     SGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQT
                     ASVAPKEDTTTLEDSLVKGPEDIPAATKKPPGFRPEAETHPLYLGHDAETNL"
     exon            454..519
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            520..571
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            572..639
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            640..794
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            795..935
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1065
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1154
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1267
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1338
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1425
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1607
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1732
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1848
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2928
                     /gene="Slc5a5"
                     /gene_synonym="NIS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgacggc ccagcaggaa ctcgcgctgc gacgacgctc gctctgagag tccccgacgt
       61 cctccgcatc ctctccgttc cgagttacct gtctccatgg agggcgcgga ggcaggggcc
      121 cgggccacct tcggcccctg ggactacggc gtgttcgcga ccatgctgct ggtgtccacg
      181 ggcatcggtc tgtgggtcgg cctggcccgc ggcggccagc gcagcgccga cgacttcttc
      241 accgggggcc ggcagctggc ggcagtgcct gtggggctgt cgctggccgc tagcttcatg
      301 tcggctgtgc aggtgctcgg ggtccccgcg gaggcagcgc gctacggtct caagtttctg
      361 tggatgtgcg tgggccagtt gctcaattcg ctgctcacag ccttgctctt cttgccgatc
      421 ttctaccgcc tgggccttac cagcacctac cagtacctag aactgcgctt cagccgagcg
      481 gtccggctct gcgggacgct gcagtacttg gtggccacga tgctgtatac tggcatcgtg
      541 atctacgcac ctgcgctcat cctgaaccaa gtgaccgggt tggacatctg ggcatcgctc
      601 ctgtccacag gaatcatctg caccttgtac acgaccgtgg gtggtatgaa ggccgtggtc
      661 tggacagatg tgttccaggt tgtggtaatg ctcgtcggct tctgggtgat cctggctcga
      721 ggtgtcatgc tcatgggggg cccctggaac gtgctcagtc tcgctcaaaa ccattcccgg
      781 atcaacctga tggactttga ccctgaccct cggagccgct acaccttctg gacatttgta
      841 gtaggtggct ccctggtgtg gctctccatg tatggtgtga accaagccca ggtgcagcgt
      901 tatgtggcct gtcacacgga gagaaaggcc aagcttgccc tgcttgtcaa ccagcttggc
      961 ctcttcctga ttgtggctag tgcagcttgc tgtggaattg tcatgtttgt ctactacaag
     1021 gactgcgacc ccctcctcac aggccgcatc gcagcccccg atcagtacat gccattgctc
     1081 gtgttggaca tttttgagga tctgcccgga gtccccgggc tcttcctggc ctgtgcctac
     1141 agtggcaccc tcagcaccgc gtccaccagt atcaacgcta tggcagctgt aactgtggaa
     1201 gacctcatca agcccaggat gcctagcctg gcaccccgga agctggtttt catctctaaa
     1261 gggctctcat tcatctatgg ctcaacctgc ctcactgtgg ctgctctgtc ctcgctgctg
     1321 ggaggtgggg tcctccaggg ctctttcacc gtgatgggtg tcatcagtgg gcctctcctt
     1381 ggcgctttca ccctcgggat gctgctccca gcctgcaaca cgccaggcgt cctctccggg
     1441 ctgacagcag gcttagctgt atccctgtgg gtggccgtgg gggccacgct gtacccgcct
     1501 ggagagcaga ccatgggggt gctgcccacc tcggctgcgg gatgcaccaa tgcctctgtc
     1561 ctcccgagcc cacccggagc tgccaacact tccagaggga tccccagttc tggaatggac
     1621 tcgggccgcc cagcctttgc cgacaccttt tatgctgtct cctatctcta ctacggggct
     1681 ctgggtactt tgaccactat gctttgtggt gctctcatca gctacctaac tggccccacc
     1741 aagcgcagct ccctgggccc cggattactg tggtgggacc tcgctcggca gacagcatct
     1801 gtggccccaa aggaggacac caccaccctg gaggacagcc tggttaaggg accggaagac
     1861 atccctgctg cgaccaagaa gccccctggc ttcaggccag aagccgagac ccaccccctg
     1921 tatctggggc acgatgctga gaccaacctc tgagggcgag gcccgagaaa gccaatcaca
     1981 ggcctcgggc cagcagcctc ctctctgaat ggttggacca tcacctgtac agaagcttgg
     2041 ctgatagagg ccctgcccgc cctgaagtcc ctgtgtccca cctgtgcccc ccaaaagagg
     2101 gttggttctc tatccaccaa ggaaaacatc tggaaccgca gtgaccttgt agattgcagt
     2161 aggcaactga gaacactcag cttctccaga ccgtgaggtt ttcccattta acaagcagag
     2221 aagctgaggg cggtcacccc aacgctggga aggtagaggc aagagattca ggaggtcaag
     2281 atcatccaca gctacaggct gagaccctgc ccacccccaa atatataaaa gtaatctggg
     2341 tgagccgcgt ggcttcgcga cagagggctt gcccagcaca cagaagaccc aaggcagagg
     2401 gagaaatggg atgtccacag aacacagagc cccaaggatt gtgaagcttc cgcgaagtgc
     2461 caagggacag attctcagag ccctcacaag acacggatgg acgagttgcc tcctcaaagg
     2521 gactgacggt ttgcagacta tcagagaaca tgttccttct gtgatcagcc acctaggctc
     2581 cgctaatgcg ttccagcttc caggagaccc tgcagacccc acctcccatg ctctctgccc
     2641 tttacccctg tgctttgtac acactaggca cctgctctac cactgaacct cacacctaca
     2701 cctccatttt tattttattt ttgacacagt gtcttaaggt agtctggctg atgtctggct
     2761 atcactcagc gctttttttg tatatcaata tttcattctt tttcattgcc aagtggtctt
     2821 gtaaagacat accacagtgt gtcatccatt cccagtgggt ggatgggtga atagctgcat
     2881 tgttttcagc ttttgtgtac accaataaaa ttgctgtagg tgttcagaaa aaaaaaaaaa
     2941 aaa
//
