LOCUS       NM_023219               2132 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus solute carrier family 5 (neutral amino acid
            transporters, system A), member 4b (Slc5a4b), mRNA.
ACCESSION   NM_023219
VERSION     NM_023219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Yamazaki,Y., Harada,S. and Tokuyama,S.
  TITLE     Sodium-glucose transporter type 3-mediated neuroprotective effect
            of acetylcholine suppresses the development of cerebral ischemic
            neuronal damage
  JOURNAL   Neuroscience 269, 134-142 (2014)
   PUBMED   24699226
  REMARK    GeneRIF: Results suggest that activation of SGLT-3 in post-ischemic
            hyperglycemia may suppress the development of cerebral ischemic
            neuronal damage by releasing acetylcholine via its activation of
            cholinergic neurons
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Zukerman,S., Ackroff,K. and Sclafani,A.
  TITLE     Post-oral appetite stimulation by sugars and nonmetabolizable sugar
            analogs
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 305 (7), R840-R853 (2013)
   PUBMED   23926132
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Barcelona,S., Menegaz,D. and Diez-Sampedro,A.
  TITLE     Mouse SGLT3a generates proton-activated currents but does not
            transport sugar
  JOURNAL   Am J Physiol Cell Physiol 302 (8), C1073-C1082 (2012)
   PUBMED   22301059
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Diez-Sampedro,A. and Barcelona,S.
  TITLE     Sugar binding residue affects apparent Na+ affinity and transport
            stoichiometry in mouse sodium/glucose cotransporter type 3B
  JOURNAL   J Biol Chem 286 (10), 7975-7982 (2011)
   PUBMED   21187287
  REMARK    GeneRIF: Sugar binding residue affects apparent Na+ affinity and
            transport stoichiometry in mouse sodium/glucose cotransporter type
            3B.
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Aljure,O. and Diez-Sampedro,A.
  TITLE     Functional characterization of mouse sodium/glucose transporter
            type 3b
  JOURNAL   Am J Physiol Cell Physiol 299 (1), C58-C65 (2010)
   PUBMED   20392930
  REMARK    GeneRIF: Low sugar affinity and uncoupled sugar transport lead us
            to conclude that mSGLT3b likely functions as a physiological
            glucose sensor similar to hSGLT3.
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Tabatabai,N.M., Blumenthal,S.S., Lewand,D.L. and Petering,D.H.
  TITLE     Mouse kidney expresses mRNA of four highly related sodium-glucose
            cotransporters: regulation by cadmium
  JOURNAL   Kidney Int 64 (4), 1320-1330 (2003)
   PUBMED   12969150
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Tabatabai,N.M., Blumenthal,S.S., Lewand,D.L. and Petering,D.H.
  TITLE     Differential regulation of mouse kidney sodium-dependent
            transporters mRNA by cadmium
  JOURNAL   Toxicol Appl Pharmacol 177 (3), 163-173 (2001)
   PUBMED   11749115
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Pletcher,M.T., Roe,B.A., Chen,F., Do,T., Do,A., Malaj,E. and
            Reeves,R.H.
  TITLE     Chromosome evolution: the junction of mammalian chromosomes in the
            formation of mouse chromosome 10
  JOURNAL   Genome Res 10 (10), 1463-1467 (2000)
   PUBMED   11042146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140851.12, BC109133.1 and AV259402.1.
            
            On Nov 10, 2006 this sequence version replaced NM_023219.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144296.1, BC128465.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC140851.12        189166-189226
            62-2054             BC109133.1         1-1993
            2055-2132           AV259402.1         265-342
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.68 cM"
     gene            1..2132
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /note="solute carrier family 5 (neutral amino acid
                     transporters, system A), member 4b"
                     /db_xref="GeneID:64454"
                     /db_xref="MGI:MGI:1890478"
     exon            1..217
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2065
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /note="low affinity sodium-glucose cotransporter"
                     /codon_start=1
                     /product="solute carrier family 5 member 4B"
                     /protein_id="NP_075708.2"
                     /db_xref="CCDS:CCDS48603.1"
                     /db_xref="GeneID:64454"
                     /db_xref="MGI:MGI:1890478"
                     /translation="MASTLSPSITPQTEEPPVVPVRIQNAADISVIVIYFIVVLAVGL
                     WSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVE
                     WNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSS
                     IIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLIL
                     MGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVFRDPVTGDIPW
                     PGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMI
                     SRILYTDKVACVVPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMS
                     SLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVPLVQVSQNG
                     QLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVYGT
                     GSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNN
                     TEERIDLDAEELETQEEAGGALEEDSEQSRGCLKRACCLLCGLQNTGPKLTKEEEAAL
                     RQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA"
     exon            218..289
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            290..394
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            395..454
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            455..559
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            560..665
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            666..746
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            747..967
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1103
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1211
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1362
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1531
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1747
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1853
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2132
                     /gene="Slc5a4b"
                     /gene_synonym="2010104G07Rik; pSGLT2; SAAT1; SGLT3-b;
                     SGLT3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgagggtt gatcattaat ccagtgccta cataaagaca ggaggaggca tccttaggaa
       61 aggaccagaa cctcctgaag ccatggctag caccttaagt cccagcatca cgcctcagac
      121 tgaggagcct cctgtagtgc cagtgcgcat tcagaatgct gctgacatct ctgtcatcgt
      181 catctacttc atagtggtgc tagctgtggg gctgtggtca atggtgagaa gcaaccgtgg
      241 cactgttgga ggcttcttcc tggctggtca tgacatggcc tggtggccga tgggtgcctc
      301 tctctttgcc agtaacattg gcagcaatca cttcgtgggc ttggctggaa caggagcggc
      361 ttcaggaatc gctattgcag ctgtggaatg gaatgccctg cttatggtgc tggttcttgg
      421 ttgggtgttt ctccccatct acatcaaggc tggggtgttg accatgccag agtatctcag
      481 gaagcgcttc ggtgggaaga gactgcagat ctacctttct gtcctctccc tcttcatcat
      541 ggtggccctt caaacttcct caatcatatt ttccggagcc atattcattc aattggcctt
      601 gggattgaac ctctacctgg ctgtcttcat cctattggct atcactgctt tttacacggt
      661 ggctgggggt ttggcctcag tgatctacac agactctgtg cagactttca tcatgctgct
      721 tggctcctta attctcatgg ggtttgcatt tgctgaagtc ggaggctacg agagctttac
      781 cgagaagtat atgaatgcca tcccctctgt agtggagggg gacaacctga ccatcagccc
      841 caagtgctac actcctcagc ccgactcctt ccacgtcttc cgagatccag tcactggaga
      901 cattccatgg ccgggactga tatttggaat gaccatttta gccatctggt actggtgtgc
      961 cgatcaggtc atcgtacagc gctgcttatg tggtaagaac atgtcccacg tgaaggccgc
     1021 ctgcatcctg tgtggttacc tgaagctgct gcccatgttc ctcatggtga tgccgggcat
     1081 gatcagccgc attctgtaca cagataaggt ggcctgcgtt gtaccttctg agtgtgagaa
     1141 acagtgtggc actgcggtcg gctgcaccaa ctatgcctac cccaccctgg tgctggagtt
     1201 gatgcctgat ggactgcgag gcctgatgct gtcagtcatg ctggcttctc tcatgagctc
     1261 tctgacctcc atcttcaaca gcgccagcac cctcttcacc atcgacctgt acaccaagat
     1321 aaggaagaag gcatcagaga gagagctcat gatagccgga cggatatttg gcatggtcct
     1381 aatcgccgtc agcatcctgt gggtcccact ggtccaggtg tcacagaatg gacagctctt
     1441 ccactatatt ggctcagttt ctagctacct tgggcctccc cttggtgcag tcttcatgct
     1501 tgctatcttc ttcaaaaggg tcaatgagca gggagcattc tgggggctaa tggtcggact
     1561 tgtggtaggc cttattcgcc tgatcgctga gtttgtatac ggaacaggca gctgcgtggc
     1621 tcccagtaac tgtcccaaga ttatctgtgg agtgcactat atgtactttg ccatcatact
     1681 cttctttgtg tccataatag taatcctggg agtctccttc ctaacggagc cgattcctga
     1741 tgttcacctg taccgcctat gctggagtct ttggaacaac acagaggagc ggatagactt
     1801 ggatgcagaa gaattggaaa ctcaagaaga agctggtggt gctcttgaag aagattctga
     1861 gcaatcccgt ggctgtctca agagggcatg ctgcttattg tgtggtttgc agaatacagg
     1921 gcccaagctg accaaagaag aggaggcagc tctgaggcag aagttctcag acacatctga
     1981 gaagcccttg tggagaaccg tcatgaacat caatgccgtc ctcctcctgg gtgtggctgt
     2041 ctttgtccat gcctattttg cctgaaccct gaaggaagca gaaactattt gtactgagtt
     2101 ttcttttata aagttggctg tgtaacaaag gt
//
