LOCUS       NM_017391              10918 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 5 (inositol transporters),
            member 3 (Slc5a3), mRNA.
ACCESSION   NM_017391
VERSION     NM_017391.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10918)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10918)
  AUTHORS   Cardenas,A.M., Fernandez-Olivares,P., Diaz-Franulic,I.,
            Gonzalez-Jamett,A.M., Shimahara,T., Segura-Aguilar,J., Caviedes,R.
            and Caviedes,P.
  TITLE     Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic
            and Glutamatergic Function in an Immortalized Cell Line Established
            from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal
            Model of Human Trisomy 21 (Down Syndrome)
  JOURNAL   Neurotox Res 32 (4), 614-623 (2017)
   PUBMED   28695546
  REMARK    GeneRIF: SMIT1 overexpression contributes to abnormal cholinergic
            and glutamatergic Ca(2+) signals in the trisomic condition
REFERENCE   3  (bases 1 to 10918)
  AUTHORS   Neverisky,D.L. and Abbott,G.W.
  TITLE     KCNQ-SMIT complex formation facilitates ion channel-solute
            transporter cross talk
  JOURNAL   FASEB J 31 (7), 2828-2838 (2017)
   PUBMED   28283543
REFERENCE   4  (bases 1 to 10918)
  AUTHORS   Van Steenbergen,A., Balteau,M., Ginion,A., Ferte,L., Battault,S.,
            Ravenstein,C.M., Balligand,J.L., Daskalopoulos,E.P., Gilon,P.,
            Despa,F., Despa,S., Vanoverschelde,J.L., Horman,S., Koepsell,H.,
            Berry,G., Hue,L., Bertrand,L. and Beauloye,C.
  TITLE     Sodium-myoinositol cotransporter-1, SMIT1, mediates the production
            of reactive oxygen species induced by hyperglycemia in the heart
  JOURNAL   Sci Rep 7, 41166 (2017)
   PUBMED   28128227
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10918)
  AUTHORS   Sade,Y., Toker,L., Kara,N.Z., Einat,H., Rapoport,S., Moechars,D.,
            Berry,G.T., Bersudsky,Y. and Agam,G.
  TITLE     IP3 accumulation and/or inositol depletion: two downstream
            lithium's effects that may mediate its behavioral and cellular
            changes
  JOURNAL   Transl Psychiatry 6 (12), e968 (2016)
   PUBMED   27922641
  REMARK    GeneRIF: Lithium affects the phosphatidylinositol signaling system
            in two ways: depleting inositol, consequently decreasing
            phosphoinositides; elevating inositol monophosphate levels followed
            by phosphoinositols accumulation. Each or both may mediate
            lithium-induced behavior
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10918)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 10918)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 10918)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   9  (bases 1 to 10918)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   10 (bases 1 to 10918)
  AUTHORS   McVeigh,K.E., Mallee,J.J., Lucente,A., Barnoski,B.L., Wu,S. and
            Berry,G.T.
  TITLE     Murine chromosome 16 telomeric region, homologous with human
            chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol
            cotransporter (SLC5A3) gene
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 153-158 (2000)
   PUBMED   10773690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144718.1, AC144408.3 and BF318171.1.
            
            On Nov 24, 2007 this sequence version replaced NM_017391.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144718.1, BB649023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2092              AK144718.1         2-2093
            2093-10428          AC144408.3         86886-95221
            10429-10918         BF318171.1         1-490               c
FEATURES             Location/Qualifiers
     source          1..10918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.44 cM"
     gene            1..10918
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /note="solute carrier family 5 (inositol transporters),
                     member 3"
                     /db_xref="GeneID:53881"
                     /db_xref="MGI:MGI:1858226"
     exon            1..159
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..10913
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..2653
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /note="solute carrier family 5, member 3; solute carrier
                     family 5, member alpha 3; sodium myo-inositol transporter
                     1; Na(+)/myo-inositol cotransporter"
                     /codon_start=1
                     /product="sodium/myo-inositol cotransporter"
                     /protein_id="NP_059087.2"
                     /db_xref="CCDS:CCDS37403.1"
                     /db_xref="GeneID:53881"
                     /db_xref="MGI:MGI:1858226"
                     /translation="MRAVLEAADIAVVALYFILVMCIGFFAMWKSNRSTVSGYFLAGR
                     SMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYI
                     RSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYV
                     SVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMVKIGGFEEVKRRYM
                     LASPDVASILLKYNLSNTNACMVHPKANALKMLRDPTDEDVPWPGFILGQTPASVWYW
                     CADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRIVFADEIACINPE
                     HCMQVCGSRAGCSNIAYPRLVMTLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTL
                     DVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTP
                     PVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFTYRAPECDQPDNRPGFIKD
                     IHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTLVTKESCSQKDEPYK
                     MQEKSILQCSENSEVISHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEA
                     ETPVDAYSNGQAALMGEREREKETENRSRYWKFIDWFCGFKSKSLSKRSLRDLMDEEA
                     VCLQMLEETPQVKVILNIGLFAVCSLGIFMFVYFSL"
     regulatory      10896..10901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /note="hexamer: AATAAA"
     polyA_site      10913
                     /gene="Slc5a3"
                     /gene_synonym="Smit1"
                     /note="major polyA site"
ORIGIN      
        1 gctttcgccg tccgggagct gaccggccgt gttcctctct cgtcttcctc tgcgccccgc
       61 gtccccgccc tcgcgacccc ggctctcctg gactcggcgc cgccaacctg ggcgatgccc
      121 cgctacgagt tggctttgat tctgaaagcc atgcggcggg gttggtacag taggcttcac
      181 tagacttagc tgcaactcag agcttctcct ccagcacctg agtaaatgct gatggtcttg
      241 tggagagtgg attaagagta cgagctaagt tctcaatccc aattgagaag cggaggaaat
      301 gtaaactgtc tccttccaag tttatcacag ccaccaccat caagacagca aaccaaagga
      361 caaagacttt gaactgctgt gttgctctgt gtagtccagt gcacgcatgg tttacagact
      421 tggctggggt tactaataag taaataaaaa gctggacgct tctgtcattc ggacatttca
      481 ttcaccagtt accagcatga gggctgtact ggaggcagca gacattgccg tagtggccct
      541 gtattttatc ctggtcatgt gcattggctt ttttgccatg tggaaatcta atagaagcac
      601 tgtgagtgga tacttcctgg ccgggcgctc tatgacctgg gtggcgattg gtgcctctct
      661 gtttgtgagc aatattggga gtgaacactt cattgggctg gcaggatctg gagcagcaag
      721 tggatttgca gtgggcgcat gggaattcaa tgccttactg ctcttgcaac ttctgggatg
      781 ggttttcatc cccatttaca tccggtcagg ggtatatacc atgcctgaat acttgtccaa
      841 gaggttcggt ggccatagga ttcaggtcta ttttgcagcc ttgtctctgc ttctctatat
      901 cttcaccaag ctctcagtgg atctgtattc aggggccctc tttatccagg agtccttggg
      961 ttggaacctt tatgtgtctg tcatcctgct cattggcatg actgctctgc tgactgtcac
     1021 cggaggcctt gttgcagtga tctacacaga cactctgcag gccctgctca tgatcattgg
     1081 ggcgctcaca cttatggtta ttagcatggt gaagattgga gggtttgagg aagttaagag
     1141 aaggtacatg ttggcctcac ctgatgttgc ttccattttg ttgaagtaca acctttccaa
     1201 cacaaatgct tgtatggtcc atcctaaggc gaatgcccta aaaatgttga gagacccaac
     1261 agatgaagat gttccatggc ctggattcat tcttgggcaa accccagcct cggtatggta
     1321 ctggtgtgct gaccaagtca tcgtacagag ggttctagca gccaaaaaca ttgctcatgc
     1381 caaaggctcc actctaatgg ctggcttctt gaagcttcta ccaatgttta tcatagttgt
     1441 accaggaatg atttccagga tagtgtttgc tgatgagata gcttgcatca acccagaaca
     1501 ctgcatgcaa gtgtgtggaa gcagagctgg ctgctccaat attgcttacc cacgcctggt
     1561 gatgaccttg gttcctgtgg gccttcgggg cctgatgatg gcagtgatga ttgcagctct
     1621 gatgagtgac ttggactcca tctttaacag cgccagtacc atattcaccc tcgatgtgta
     1681 caaacttatc cgcaagagtg caagctcccg ggaactaatg attgtgggca ggatatttgt
     1741 ggcttttatg gttgtcatca gcatagcatg ggtgccaatt attgtggaga tgcaaggagg
     1801 ccaaatgtac ctttacatcc aggaggtggc agattatctg actcctcccg tggcagccct
     1861 cttccttctg gcaattttct ggaaacgctg caatgagcaa ggggcttttt atggtggaat
     1921 ggcaggcttt gttcttggag ctgtccgttt gatactggct tttacctacc gtgctcctga
     1981 gtgtgatcaa cctgataaca ggccaggctt catcaaagac atccattata tgtacgtggc
     2041 tacggcatta ttttggatca caggactcat tactgtgatt gttagtcttc tcacaccacc
     2101 tcccacaaag gatcagattc gtaccactac cttttggtca aagaagaccc tggtgacaaa
     2161 ggagagctgt tctcagaaag acgaaccata caaaatgcaa gagaagagca tcctgcagtg
     2221 cagcgagaat agcgaagtca tcagccatac tattcccaac gggaagtctg aagacagcat
     2281 taagggactg caacctgaag acgttaatct gctggtgaca tgccgagaag agggcaaccc
     2341 agtggcttcc atgggtcatt cagaggcaga aacaccagta gatgcttatt ccaatgggca
     2401 agcagctctc atgggtgaga gagaaagaga gaaggaaacg gaaaatagaa gccggtattg
     2461 gaagttcata gactggtttt gtggctttaa gagtaaaagc cttagcaaga ggagcctcag
     2521 agacttgatg gatgaggagg ctgtgtgttt acaaatgtta gaagagactc cacaagttaa
     2581 agtgatccta aacattggac tttttgctgt gtgttcactt ggaattttca tgtttgttta
     2641 tttctcctta tgaacttaag gatacggtga gacacttaag agaaaatact ggtctttgaa
     2701 aacaaaaatg taactgtcgc acctcccagg cattgtttac gctgaaggtt ttagccaaat
     2761 tctccttagc agaaaaatca tctatttgta agactgtttt cccagagatg gggaaaacgt
     2821 aaatcttcaa cttacatgaa acagagcaga gtgaattgtg caaaaaatgt ggtttgagag
     2881 ttttctgtac caaagtaagg agagaccaat tattctcatg tatcacttag gacagaacat
     2941 gtgctaaggt atcgtgagta aagtgtcttg tctacattgc caaggcttgg tagaccctct
     3001 gctgaaggaa atttgctcat ttataaaggc ttttgtctct aatccctgct acagttaaaa
     3061 aatgaatttg tagagactgt atgattagtt aggtcctgaa agtctaatgt gttgtgtact
     3121 aatgacttga ggacaacttt gtgtgtgtgg ctggtcatta gcacgagtct acggattctg
     3181 cttgccaaga gaaaggaaga gcgttttcct gcaggtcctt ttgtactaca gcttgtatgg
     3241 aaatgtcagc agccgtgggg agcagacttg gtttccatct cttccctctc ttttttccta
     3301 cttaaactga atcatactcc acggactacc aagtctgtct ataattttgc ttttaattag
     3361 gggggaagta aatactgctg atgatcccca catttattga tcagataaga atattttaaa
     3421 atatagtttg agaattatca gctaccaggc aatgactgat atttaatgct aagtagatga
     3481 tgaatcattt ttttttttac ctgctttcta gctgcttctt tgtcatttta ctaacattcc
     3541 ttatttgcca aatgccttcc caaatgggtc ctattgtaag atgttcagta tcgtggagga
     3601 gcgtcaacac tacttgtgtg ccggggttgg cacttgctta gtttgtgaaa cgttgttaag
     3661 ttttagagga acagtctaat tccattcctt ataagttctc ttccttattt ctgtcttttt
     3721 tgaaggcttg ctgtgtatat acatctatgc tgttatagtc agttagcaca tgagtatgtt
     3781 tcattacgaa gtggctgtca gtcatagaac actcggcagt cttactgttg atgagagtag
     3841 attttctgta ggatggccag catgttcctc ggttgccacg aacagggact ttagggttta
     3901 gcagtgtgct tgtgggggat atcacacttg tggaggactc ttgatattga ccttagctta
     3961 gcttggtatc caactgccac attcatgggc agcagatctt tttttgtagg ctgtttctcc
     4021 ttattgaaga tagtgcagga ggaattcgag aaaaatccta gggatggtgt gtgtagtcct
     4081 atgtcttcat cactgcctct tctccattag agatgaagaa agcgaattct gtatctactt
     4141 tctttaggcc gataactttt taaattgcat gacttttatt aagccttgta cttaaggaga
     4201 attactactt ttatagatca ttttatagct tttcaatcaa actcagtcct gataaccaaa
     4261 acaaaacaat acctttcctt agtttttttt tttttttttt tttttttttt gtaatgcatc
     4321 gacttgtttg caggcgatgg acgtcatgag tccagtgctg ttagggatca cagattgtca
     4381 cacacagtct tcctatcttc tggagggttt ctgagggact gagtctggaa attgaaaaag
     4441 tcatctctgt atgaatagca tgcatttctg aagaacttag agtgccttgt acaatttttc
     4501 tcttagtttc tattttgaga tttataacct ggagccaagt agataggggc catccttttc
     4561 ttgagtggaa agttgagtta gttctccaaa tgtggactca gagtttgccc atgtgtttgg
     4621 atggatagct gtgctttgtg gctgtcttct cttaaacaat tctttttgag ataatctttc
     4681 agtctttgag aaagttacag aatattgggt tgtccaaatt tggattaagt tgtaggaatt
     4741 aacatttcct ttgaacacat tcctatgcaa gttagcagac attgacacat tggccaagtg
     4801 ggcttcctca tccttgtatg tatagcatag tgaataggag gtattatgtg aatttctccc
     4861 ttttatttag tgctgagtcc taataatttg gaatgctaga gtcctcttac cccctttttg
     4921 ttgacttata gtaagataca taatgtatac cgtaatgtgt ctatctgtgt gtaaatagct
     4981 gtaggtcaag tgtagagagc taataaataa ggaatagctt agcatatgca ttagatgtgt
     5041 attcttacca ctgcgaacat cactttattt agtctgaagt ttctaaagct tgtcttcctt
     5101 actgctttcc agtaatagat actgtgcttg aatacgtgtg tgatggcagc ctcatttcaa
     5161 ggaccagcct ttataggtca ttacagtggt tgttcttgga atgatacctg attttagact
     5221 agcaaaatgt tcatccttca catgcatatg agtcctaaaa gatggcatgg atctgtagac
     5281 atttacacat gtgtttttgt gtttgtccaa gctaagcttt ggaattgacc aagattacat
     5341 tgactaaaat agtgattaaa agtaaacgtg aggtaggtga ggctgttggt ctacagaggt
     5401 aggtgagaag tagttatcct ctgagtgata gccaagcttc tagatgattg tcttcccagg
     5461 cagttcttgc ttggatccag aaagggcttt ttaatttaat ttaattttat tttattttta
     5521 attttgcttt gcgccagtgg ctgggacaat gattgatggc tcttctgtgg ggtttctctt
     5581 tctctcagaa gattgtgtcc tgccatccta agagtaaaca actgggctgc tgttgttcta
     5641 ggaagtgatt gcttttgttt atagagaagc atcaggcagt agcagctgcc tttgactcag
     5701 attgagcgat ctcatcccca gggcttcctt tcaccagctc gaaggatcca ctcttgcaca
     5761 gagaggctga cctgggtagt ctatccgtga ctcttacggg tgtcaccata agtggtcaga
     5821 gatgctttgt gaaacttccc atttaagaac aggtcagtgg agttatgagt tctctgagtg
     5881 aggttaaaag ccttcttcag ggtcgctatg aatccttcaa ttcctacatc aggagtcttt
     5941 tttattccgg gtgcatggtc ttctcatctc caaataccat ttagtgtaat ctacagatga
     6001 gccttatttt ccaccacata agtatgcttt gtcattactc agtaaagaat taggtctaat
     6061 ttggctgata tactaagatg ccttcctccc tcatgcctca ctcccttgca cagctccttt
     6121 tggaggtgtg agtggaaagg gaccacatag gtttctattg taaacatctc accattctct
     6181 aggtttatgt tgaaagattt gcacaagacc attcctgttg aattatgtga ctgtagagcc
     6241 ttccttgttt gtgcacagat gctctaagaa gtaataataa aagcaaaatt tcaagatctg
     6301 accaatcccc atgagatcca gatgtgaaca gcaggggctg gagagatggc tcattggtta
     6361 agagtactgc tcttcccaag gacctgggtt cagttcccag cacccacatg gcagttgata
     6421 actgtctgta attctagctt cagaggatct gacaccctcg cacagacacc catggaggca
     6481 gagcccactg tatataaaat gaaacaaaac aaactgtaaa ggtaatagtc acattcttga
     6541 aatcccagaa acttgaagca tctgggctgt cagctggcgt aagcccctct ccagggagtc
     6601 aggcccagcc tgctaacttc tagtttaatg gtaagcagga gagacagatc tgttaacaga
     6661 atagaggcta aagtgcctga tacttagtat tgataattta gtaaaatgaa gctttaggct
     6721 tcattatctg taggcttgct cacgtcctaa gcagagtttc caagctctgt tcgggttctc
     6781 ttgtctccat tgctctgtag cctgctcttt atttcagtat tttctgatct cttgcgtagt
     6841 gcttggttta tctcacactg tcttgatgta ccaaagtctt cctttacccc aggattgagg
     6901 accaaataat aaccaaataa tgagttaaac agttaacttt taaacctatt atacctacgg
     6961 tagtagctta aaatgttatt gggaataaat gtttccagaa taattttctc agatttgtat
     7021 tggttaatag taaaagcact agtgttgtgg tcaggaaaca gtcagtagtg agttttcaca
     7081 gaagttgctt tgagatgatg gtgcctgcca cgtgatgcag aaagatcgag tttttttgtt
     7141 tttttttttt tttgttttcc atgagggtaa aggtttgatt tagttgctac aaagagaaac
     7201 acttgtaccg ttaaggtaca aggctggtgc ataagcagtg atggactgag acctttctca
     7261 tgaagaccat ctcctgatgt ggtactgttc cgttgcactg tcttgcacac tgtggctgct
     7321 cagctaactg ctttgactcc taggagtgcc gtgagcagag gttctgtgta agagcgtcac
     7381 tagtgccaag tcccacactt catcatgggt ttcaggtcaa gttctcactc tcctgtgctg
     7441 gcaataaggc tttactactg actgatcttg taacagtgtt gtgaaattga tcgttcatgt
     7501 ttctgtctcc gctcctttat aaaaggtaag gtttagtttg aatgtaagcc actcactttt
     7561 ctggcaacca gcaaccgttg acctgtagcc tttttctcag aaacaaagaa aagatgtgct
     7621 gtgtgtcttt actcgtcagc agtgcatgct gcatgtgctg cagatggcct gcttcctctg
     7681 tgtgtagagg agaggttttc tgtgccagga acggagctct gcgctggcac cccccccccc
     7741 ttgtttcacg tccagcagtg tgtgtctagg gaaatgctag tgattttcct gacaacacaa
     7801 gttgacagtg tacccacagc ataaatagat gaattcaccc tactttccta gtgctgctag
     7861 atatataaat ttatatataa ataacacaca tacatttaat gttcaattta tcaatatagc
     7921 ctaggcttct gaaaatagaa tgctattagt aacttttgtg tgtaagtggg tgcgtgcgta
     7981 atttggagat gaatcgggct cattgaaatc tttaaatggc agatgctggt atacaaggtt
     8041 ttctgtagta taatcaagtt ttgagattcg tgtttgggtt ggtgccttct gcttaccagt
     8101 attgatgcgc tagttcgcac ttgtcccttt cttagtagta agctttctct gttttaaact
     8161 tgcaactagt gaggggaaca agtacaaagt gcacatttct atacttttat gcagtctttt
     8221 ggttcaagga aacaaggcag ttgagtatct gtattaatgt tatttattca tctttatttg
     8281 cttttatatc tataattaaa atttaaagtg acattataaa ttcgtgtcta ttttaacttc
     8341 aatgtaggtt tgttaagggc atctgaagaa caatagttca tatttccatg tgtgaggaga
     8401 ggctagaggt ccattgaaag cacaaaaccg tgttcacgag tgtgtttcca cttgtgaaaa
     8461 gcacaaaatt taatagcatt cttactaacc cacaagtgcc agtcataaac ccacccaggc
     8521 tttgtcccaa gttgttagga agatcacagc ccagaaagcc tgggtggtga gcccactgtc
     8581 acagcccagt cctcagtgag atcctctgtc tgtatggctt tgatggagag agcaactggt
     8641 tgtatttggg ggttgcaagg gaaaatgagg cctggactca gatctaaagc tgaaacagag
     8701 agtcagggtt ctggtggacg gagtaggtgg cagctttgta agtagtaatt tgaacagttt
     8761 aaaaaaaaaa atctcattta gaagaaatat tacttgtcac cagtactcta aagacatgaa
     8821 aatattcaca ttaaatagtg caagtattat gttgatttat atagtttata taagatgaca
     8881 ttacctttgt tttctttatg tgcctaacta tactttttag taaaaagttg gatctctgtg
     8941 ttctgaacat tagactattt ctggatagat tcaaaatgac actgcttttc acagtggctt
     9001 tttaatctgt tccgttaact cctagactag atgactggaa aactgtaggt gtgcacacag
     9061 aaatgaagat ggcatctctt cccactcagc attgccttcc tccttgtttt tcttacctcc
     9121 agatagtccc atgtttacca ggagtgagaa tgagccctgt tggcttctgt ctaccttgta
     9181 agatgcagcc ctcagaaaag agagtgcggg agaggcttgg taacctctaa caaagatctt
     9241 agagggcata gaccagtgtt gctgagagag agacagacag acagacagaa acagagagag
     9301 agatatcaac aaggtcttgg tatatgatac atcttagaag agttcacatg aacactgatg
     9361 gaaagatttt tcccctccag caacaagcta ggcgtgtgta cccataacag aattttacag
     9421 caggtaacct ggaggttgca atgtgggggt gggagctgag ggtaggagtg tgtgaggagt
     9481 gtccttggct tagtaatgtg tgacagtgta gagcagttaa cctttcaggc ctaaagactg
     9541 tattctgtaa ctttaagagt ttattacaac tttatgaaat acttgttaaa atttctttgg
     9601 cagaaatgtt tttcgtggaa acctgcttta gttagactaa gtgaaatgta gttgtagcag
     9661 tgtaaatatg tataatttcc taatttcact gtgagatctc agacttttga gtggcaaaca
     9721 gatcactgag tcttttgcta atgacttgtc tgtggggtca gtaagatgta aactctttat
     9781 ttttgtttaa tagcgaccaa ctgtggtgct gtgggatgat ggtatggagc cattactcca
     9841 ctgcccttgt tggttttgct tcactttgag ggcctgcaaa gttcagaccc agcagggctt
     9901 cctgtccctt gctcagctgc ctttctttgt ctggaacggt tgctaatcac catataaact
     9961 cttaggcttt tctgctttgc tttgttgttg ttttgttctt ttcctttttt gacaagatgg
    10021 atatcaaaaa tagttgctgt gcaaaagtta gtagtcttct tcaagaagaa aacagttcct
    10081 tttctaatac tatcctgtga aattgcttca cccattcctt tattttaaag ccaaatgtca
    10141 gcagaatact gctgttttta tctaaataat tttaatatgt aagtattaat gcatttaaaa
    10201 agatgtctgc gttgagaaat acttcactag tgtactgcct gtgaaaactt tgttcagatt
    10261 tctggctaag acaccagtca gtatactggg gctgcacatt acatacatgt attattttag
    10321 tcaggtattg ttgtagacca agcctggtta taatagagta gactaacact agtttgttat
    10381 cagttaattt ttaattattt ccagtttact ctcttgtttt cctcatactc ttctcgtttt
    10441 cagattccat taatcgggtc catttcattg tgtaaggctt cagtttcaaa gaaaatagaa
    10501 tttgatataa gccaggttac ttccatcttg aaaggaaaac aattaaaact gtagatttaa
    10561 aatggttaat tatctgtgac aattttagcc tattctgtat acaactgatt tttaaaactg
    10621 tagactgtgt taagtgttac tgttgtttaa aaatggggaa aaaaacctga agcaaatctg
    10681 cttaaagagc tgttggttct cattgctgac cacaaacact atgttcatgt gtactcgtgt
    10741 tattttttga gctgctacat tagcctgcag acgtatttga aaatttaaga tgaatatatt
    10801 tcttgcaaag tccgttcctt tctgtggtat cttgtcctgt aactgaagtg tagttattat
    10861 tttatggaaa tgttagaact tctgtaccaa ctttgaataa aatgaaaact ttaaaaaa
//
