LOCUS       NM_001177624            5092 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium/glucose
            cotransporter), member 12 (Slc5a12), transcript variant 2, mRNA.
ACCESSION   NM_001177624
VERSION     NM_001177624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Naganuma,H., Miike,K., Ohmori,T., Tanigawa,S., Ichikawa,T.,
            Yamane,M., Eto,M., Niwa,H., Kobayashi,A. and Nishinakamura,R.
  TITLE     Molecular detection of maturation stages in the developing kidney
  JOURNAL   Dev Biol 470, 62-73 (2021)
   PUBMED   33197428
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Pucino,V., Certo,M., Bulusu,V., Cucchi,D., Goldmann,K.,
            Pontarini,E., Haas,R., Smith,J., Headland,S.E., Blighe,K.,
            Ruscica,M., Humby,F., Lewis,M.J., Kamphorst,J.J., Bombardieri,M.,
            Pitzalis,C. and Mauro,C.
  TITLE     Lactate Buildup at the Site of Chronic Inflammation Promotes
            Disease by Inducing CD4+ T Cell Metabolic Rewiring
  JOURNAL   Cell Metab 30 (6), 1055-1074 (2019)
   PUBMED   31708446
  REMARK    GeneRIF: Lactate Buildup at the Site of Chronic Inflammation
            Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Ohkubo,M., Ohta,K., Inoue,K. and Yuasa,H.
  TITLE     Nicotinate uptake by two kinetically distinct Na/-dependent
            carrier-mediated transport systems in the rat small intestine
  JOURNAL   Drug Metab Pharmacokinet 27 (2), 255-262 (2012)
   PUBMED   22123132
  REMARK    GeneRIF: A low affinity type of SMCT2-like transporter is in
            operation with high capacity throughout the small intestine,
            playing the role as the major intestinal nicotinate uptake
            transporter.
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Teramae,H., Yoshikawa,T., Inoue,R., Ushida,K., Takebe,K.,
            Nio-Kobayashi,J. and Iwanaga,T.
  TITLE     The cellular expression of SMCT2 and its comparison with other
            transporters for monocarboxylates in the mouse digestive tract
  JOURNAL   Biomed Res 31 (4), 239-249 (2010)
   PUBMED   20834181
  REMARK    GeneRIF: SMCT2 was localized in the brush border of enterocytes in
            the intestinal villi, and SMCT2 was localized in the brush border
            of is a jejunal type of SCMT.
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Gopal,E., Umapathy,N.S., Martin,P.M., Ananth,S.,
            Gnana-Prakasam,J.P., Becker,H., Wagner,C.A., Ganapathy,V. and
            Prasad,P.D.
  TITLE     Cloning and functional characterization of human SMCT2 (SLC5A12)
            and expression pattern of the transporter in kidney
  JOURNAL   Biochim Biophys Acta 1768 (11), 2690-2697 (2007)
   PUBMED   17692818
  REMARK    GeneRIF: low-affinity transporter SMCT2 initiates lactate
            absorption in the early parts of the proximal tubule followed by
            the participation of the high-affinity transporter SMCT1 in the
            latter parts of the proximal tubule.
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Martin,P.M., Dun,Y., Mysona,B., Ananth,S., Roon,P., Smith,S.B. and
            Ganapathy,V.
  TITLE     Expression of the sodium-coupled monocarboxylate transporters SMCT1
            (SLC5A8) and SMCT2 (SLC5A12) in retina
  JOURNAL   Invest Ophthalmol Vis Sci 48 (7), 3356-3363 (2007)
   PUBMED   17591909
  REMARK    GeneRIF: These data provide the first evidence for the expression
            of SMCT1 and SMCT2 in the retina and for the cell-type specific
            distribution of these transporters within the retina.
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Thangaraju,M., Ananth,S., Martin,P.M., Roon,P., Smith,S.B.,
            Sterneck,E., Prasad,P.D. and Ganapathy,V.
  TITLE     c/ebpdelta Null mouse as a model for the double knock-out of slc5a8
            and slc5a12 in kidney
  JOURNAL   J Biol Chem 281 (37), 26769-26773 (2006)
   PUBMED   16873376
  REMARK    GeneRIF: slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a
            role in the renal handling of lactate and urate
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Srinivas,S.R., Gopal,E., Zhuang,L., Itagaki,S., Martin,P.M.,
            Fei,Y.J., Ganapathy,V. and Prasad,P.D.
  TITLE     Cloning and functional identification of slc5a12 as a
            sodium-coupled low-affinity transporter for monocarboxylates
            (SMCT2)
  JOURNAL   Biochem J 392 (Pt 3), 655-664 (2005)
   PUBMED   16104846
  REMARK    GeneRIF: The cloning and characterization of slc5a12 (SMCT2) is
            reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732495.11, AK165419.1 and BX005257.9.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the 3' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128951.1, AK085356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL732495.11        126360-126367
            9-2413              AK165419.1         2-2406
            2414-5092           BX005257.9         13529-16207
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.75 cM"
     gene            1..5092
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 12"
                     /db_xref="GeneID:241612"
                     /db_xref="MGI:MGI:2138890"
     exon            1..642
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2163
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium-coupled monocarboxylate transporter 2; sodium
                     solute cotransporter; solute carrier family 5 member 12;
                     low-affinity sodium-lactate cotransporter; electroneutral
                     sodium monocarboxylate cotransporter"
                     /codon_start=1
                     /product="sodium-coupled monocarboxylate transporter 2
                     isoform 2"
                     /protein_id="NP_001171095.1"
                     /db_xref="CCDS:CCDS50656.1"
                     /db_xref="GeneID:241612"
                     /db_xref="MGI:MGI:2138890"
                     /translation="MRVKNFEAWDYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVG
                     GRQMSFGPVALSLTASFMSAVTVLGTPAEVYRFGASFFLFLISYVFVVFFTSELFLPV
                     FYRSGITSTYEYLQLRFNKPVRYAATIIYIVQTILYTGVVVYAPALALNQVTGFNLWA
                     SVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSNHVGGFNNVLEKAG
                     NGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCISCKTEKHAKLAL
                     YFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATMPGLP
                     GLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDKLSTWISKGLCILFGIMC
                     TSMAVVASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSF
                     WVAIGSFIYPAPESKTLPLPLSTEHCVELNITTTVAPQISSRPVLADTWYSLSYLYFS
                     AVGCLGCIAAGIIISFLTGKQRGKDIDPLLIRPVCNLFCFWSKKYKTLCWCGVQHDRE
                     TEQDYLDSGSAWKQGVESGLQNGLKQDTLAQIPGYNPKEKSYSNSVPEKTTYF"
     exon            643..708
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..760
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..828
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..983
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1124
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1254
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1343
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1456
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1524
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1611
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1778
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1882
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2010
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..5092
                     /gene="Slc5a12"
                     /gene_synonym="D630015G19; SMCT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctactccct ctacccccca gaaacttcag gagtcttctg tcagatgttg cagaagaaac
       61 gcagacagct agtggccaga atctgatccc aatttgtcat tttttccccc ttggtgtcag
      121 tttcacagcc agctttagag aactttgagg actgttgagt atctgaaaac ttagacatgg
      181 atggatgatc ttcaactctt cagagaacca aattcttcct tccatctgaa aaaagttttg
      241 gctgttggaa atatctcagt gagccctgct tgaaagagac tctcttgtgt tccacttcca
      301 agcatgaggg tgaagaactt tgaagcttgg gattatgttg tgtttgcagg tctcttcgtc
      361 atttcctctg gaattggcgt gttctttgcc ataaaggaga gaaaaaagac aacatctcgg
      421 gaattcttag taggaggaag gcaaatgagc tttggccctg tagctttgtc tctgacagcc
      481 agcttcatgt cagctgtcac tgtcctgggg actcctgctg aagtctaccg ctttggggca
      541 tccttcttcc ttttcctcat ttcatatgta tttgtggtct ttttcacatc tgagctcttt
      601 cttcctgtgt tctacaggtc tggcatcaca agcacctatg agtacttaca gctacgattc
      661 aacaagccag ttcgatatgc agcaaccatt atctacatcg tacagacgat tctctatact
      721 ggagtcgtgg tctacgcccc tgctctggct ctcaaccaag tgactggttt taatctatgg
      781 gcctctgtgt ttgcaacagg aatcgtttgc acattctact gtagtttggg gggtttaaaa
      841 gcagtggtgt ggacagatgc atttcagatg gttgtcatga ttgtgggctt cttaacagtc
      901 cttatccaag gatcaaatca tgttggtggc ttcaacaatg tgttagaaaa agcaggaaac
      961 ggatcccggc tacacattgt tgactttgat gtagatcctc taagacggca cactttttgg
     1021 acaattacaa taggaggaac ttttacttgg cttggagtct atggagtgaa ccaatcaacc
     1081 atccagagat gcatctcttg caaaacagaa aagcatgcta agcttgcctt gtactttaac
     1141 ttgttgggtc tctggataat tgtggcgtgt gccgtcttct ctggcttgat catgtactcc
     1201 cacttcaagg attgtgaccc ttggacttct ggtgttattt cagcaccaga ccagctgatg
     1261 ccatattttg tcatggagat ttttgcaact atgccagggc tgccaggact ttttgtggct
     1321 tgtgccttta gtggaactct gagcacagtg gctgccagca tcaatgcctt agcaacagtg
     1381 acctttgagg attttgtcaa gagctgtttt ccacacctct ccgacaaact gagtacctgg
     1441 atcagtaaag gcttatgtat ccttttcggt attatgtgta cctccatggc tgtggttgca
     1501 tccctcatgg ggagtgttgt acaggctgcc ctcagcatcc atggcatgtg tgggggaccg
     1561 atgctaggtt tattcacttt gggactcgtg tttccttttg taaactggaa gggtgctcta
     1621 ggaggacttc ttactggaat cacgttgtca ttctgggtgg ccattggatc tttcatttac
     1681 cctgcaccag aatccaagac attaccttta cctctatcaa cagagcattg tgtagaacta
     1741 aatataacaa caacagtagc cccacagatt tccagcagac ctgtcctagc tgacacatgg
     1801 tactcactct cctaccttta cttcagtgct gtgggctgcc tgggatgtat cgctgctgga
     1861 ataatcatca gtttcctcac aggcaagcaa agaggcaaag acattgatcc acttttaata
     1921 agacctgttt gcaatttatt ttgcttttgg tctaagaaat acaaaactct gtgctggtgt
     1981 ggagttcagc atgaccggga aacagagcag gattaccttg acagtggcag tgcctggaaa
     2041 caaggggttg aatctggcct acagaatgga ctcaagcaag acaccttggc tcagattcca
     2101 ggctacaacc ctaaagaaaa aagctacagc aacagtgtgc cggagaagac cacttatttc
     2161 taggacaata catgcgacag atatctttac acacatgcat gcatgtactt catgtcactt
     2221 cttgttatag ccttgtgtac agattcttgt cagaaaagag ggatgtccag tacctattta
     2281 tacttattta tagaagtgat atgactcagg atgttctttg ggaagaccaa attcaggtga
     2341 gaaaaatcag ctaaggcctg aagtgcttcg tgccacataa ctcaacagga ctgagtttga
     2401 ttgtgatgaa aggagttaaa gtttccttga ttcttgtcaa attagaactc tgggtttatt
     2461 gtctatttat ttgtaggctt ttgttttgtt ttggtgctga gaattaagca caggtccttg
     2521 ctcttgcaaa atatctgcct gaccacttac cctagtctac cttctaaagt tttaaccatc
     2581 agaacatcgt ggtgagttag aggacaaaca taaatgggaa tctgcacctt caatgctgct
     2641 ctgacaaggc tgataaaata ggaatgacat cttctcaaag ctcacatctc acatgtatgt
     2701 cgacatgtag acagaaccat gcccaccttg tggccacagc tagaacactt tacttctctg
     2761 agtatcctca cagtgcctct gttatgcatt ccattagtca tttctgctga gctattatga
     2821 ccacacttta agggcaattg cactaaatac aaggggagaa aaatgagttt tcacagtggg
     2881 agccatcaca tataaatata ctattcactt tgtgttgtta aagcaatgtt tcttaatttc
     2941 tgtcatttaa aaatgataaa ttggagctgg acagatggct cagcagttag gagaacttgt
     3001 tactcttccc aaggacctgt gttcaattcc cagcacctaa gttgagtagc ttataactgc
     3061 ccataatggt agctctcgag gtaatctgat atctttttgt gaccttcctt gacattcaca
     3121 ttcctgtgca catacttgca catagatgca tatacataat aaataattaa aacattttaa
     3181 gtggaaaaag tctatgcata tccagaagtt aagaatcgca tatacaaagt ttaataaagg
     3241 ggaagtcggg aagtcatgct ttattgaaag ctgtgaggtc agacagtata ttttaaacga
     3301 accctgaaag aacatatcat ttacagcaga gatcattagc catagagtct tacaaattat
     3361 ccaaagaact catccaggtc acatatgcaa gcttaagtca caccctcaga tgcaagcact
     3421 atattagttt tagtctgtat aacaacttca aagttctgga gcagaactca tccaaactga
     3481 acaaatatgc ctttatgtag gagcagaggg aaatttgaaa aaaaccaaaa aaaaacccca
     3541 aaaaaatcca aaaccatatt gtacaggtct gggaactgta ttagtcgtgt ggtgaagtgg
     3601 aagaaaacta cgaagtgtac agtcaattgg ctcagcaagt accaacatct tcctttcctt
     3661 actctcaaaa tggcagctca ggatggtgtt acagggccac attcagtgta aatggattaa
     3721 atatgggtct attttgccat agagtgtccg gagacttctc aatacattgt tgtgtgagtg
     3781 gtgagattct agacatggaa actagccttt gtgccttttg tgcatgattg tagactctgg
     3841 tgaggataag aatgtctatt tcactaaact catttagatg attgacattt gtcatttttt
     3901 ggaccaaaaa agtatagttt cttggttgac agaaggtatc tgaatcaaat ggcttagact
     3961 caaacatgag ttctaacaga aattatctgg ttgtttggag gaaagacttt aaaagtatta
     4021 gcttattttc caattaaaag gaatagaaac tatttttatt taatggaatt attgtgagaa
     4081 cttaacccag tgactggcca attgccattg tgtagtgcat gaaaaactgg tgttcatttt
     4141 gactgaaatt gtttcaccat ttctctttga tggcattgac ttcgaacatg ttttactagg
     4201 gtgctgtgaa aaaaaaaaag aactgataag ataaatatag ttacaagtca aaaacaatgt
     4261 cctgaattcc catgctctgg attttatgct agagtatcca taaaacatca ttaaaatgtc
     4321 ccacattttc caaaatggga tggatcttat catatccaca agttcatgac tggaaacaac
     4381 atgctctatt gtggttcaag tcttacactg gtaaattcta accttaagca aacatcccaa
     4441 actacgttag taactcagta cccagaagcg agggtgaatc ttaaaagagg cagggccatg
     4501 gggtttactt ttgtgtaatt taaacagcat tttttgcata attttactat cttgtgacta
     4561 cagtgcttca acaagaatag caaagcccac aagctgtgat gctttcacac agtatttaaa
     4621 aacaagtatg agcaaaatgt tttataactt gctcagaaca tcagaaaata caatgcatgt
     4681 catgcaaagt ctgagctttc tctcatctgt tcagattttt ttttttcagg atagtttaga
     4741 aaaaattcag aatttgtata gtgtctgttt gtatatttac agattccatg tatttcaaaa
     4801 tcagttgtag ctttcgatta atagatcact gctgggttat ttctatttat agttcttgga
     4861 aagattaagt gctacagttt catactactg aggaagtcaa taaaaattcg caaacatgta
     4921 aatgacactc aaaggtgtac ttttccaata cattattttt ggggtttgat gtatcagaag
     4981 tcttcaaaat agatttacac tcatttatat atagctactt aatagaaata taactgtttg
     5041 gtttcgaacc cagggacaag ggactgaata aagtgcttat tttacacacc aa
//
