LOCUS       NM_146198               2341 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium/glucose
            cotransporter), member 11 (Slc5a11), mRNA.
ACCESSION   NM_146198
VERSION     NM_146198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Walker,E.M., Thompson,C.A. and Battle,M.A.
  TITLE     GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation
            during development
  JOURNAL   Dev Biol 392 (2), 283-294 (2014)
   PUBMED   24929016
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Abbott,G.W., Tai,K.K., Neverisky,D.L., Hansler,A., Hu,Z.,
            Roepke,T.K., Lerner,D.J., Chen,Q., Liu,L., Zupan,B., Toth,M.,
            Haynes,R., Huang,X., Demirbas,D., Buccafusca,R., Gross,S.S.,
            Kanda,V.A. and Berry,G.T.
  TITLE     KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally
            regulating complexes that affect neuronal excitability
  JOURNAL   Sci Signal 7 (315), ra22 (2014)
   PUBMED   24595108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Fu,H., Li,B., Hertz,L. and Peng,L.
  TITLE     Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol
            uptake at different concentrations and pH
  JOURNAL   Neurochem Int 61 (2), 187-194 (2012)
   PUBMED   22564531
  REMARK    GeneRIF: At low concentration, where SMIT1/2 activity gains
            importance, myo-inositol uptake is reduced by ammonia-induced
            intracellular acidification
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Fenili,D., Weng,Y.Q., Aubert,I., Nitz,M. and McLaurin,J.
  TITLE     Sodium/myo-Inositol transporters: substrate transport requirements
            and regional brain expression in the TgCRND8 mouse model of amyloid
            pathology
  JOURNAL   PLoS One 6 (8), e24032 (2011)
   PUBMED   21887366
  REMARK    GeneRIF: For SMIT2, at all three ages both cortical and cerebellar
            SMIT2 levels were significantly higher than hippocampal levels
            (p<0.05) and at 4 and 6 months of age
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Buccafusca,R., Venditti,C.P., Kenyon,L.C., Johanson,R.A., Van
            Bockstaele,E., Ren,J., Pagliardini,S., Minarcik,J., Golden,J.A.,
            Coady,M.J., Greer,J.J. and Berry,G.T.
  TITLE     Characterization of the null murine sodium/myo-inositol
            cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is
            independent of expression of its cognate mitochondrial ribosomal
            protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels
            in neonatal brain
  JOURNAL   Mol Genet Metab 95 (1-2), 81-95 (2008)
   PUBMED   18675571
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Coady,M.J., Wallendorff,B., Gagnon,D.G. and Lapointe,J.Y.
  TITLE     Identification of a novel Na+/myo-inositol cotransporter
  JOURNAL   J Biol Chem 277 (38), 35219-35224 (2002)
   PUBMED   12133831
  REMARK    GeneRIF: Rabbit homologue acts as a low affinity Na/myo-inositol
            cotransporter.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC138364.8.
            
            On Nov 17, 2006 this sequence version replaced NM_146198.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031742.1, AK008219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC138364.8         113821-113952       c
            133-249             AC138364.8         95714-95830         c
            250-406             AC138364.8         93064-93220         c
            407-478             AC138364.8         90623-90694         c
            479-583             AC138364.8         89345-89449         c
            584-643             AC138364.8         88020-88079         c
            644-748             AC138364.8         80776-80880         c
            749-854             AC138364.8         78642-78747         c
            855-935             AC138364.8         76325-76405         c
            936-1141            AC138364.8         70259-70464         c
            1142-1277           AC138364.8         68176-68311         c
            1278-1385           AC138364.8         63522-63629         c
            1386-1536           AC138364.8         63081-63231         c
            1537-1705           AC138364.8         60901-61069         c
            1706-1921           AC138364.8         59580-59795         c
            1922-2090           AC138364.8         58809-58977         c
            2091-2341           AC138364.8         55567-55817         c
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.42 cM"
     gene            1..2341
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 11"
                     /db_xref="GeneID:233836"
                     /db_xref="MGI:MGI:1919316"
     exon            1..132
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..249
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..406
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2293
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 10; sodium-coupled cotransporter
                     KST1; sodium/glucose cotransporter KST1; na+/myo-inositol
                     cotransporter 2; solute carrier family 5 member 11;
                     sodium-dependent glucose cotransporter; Na(+)/myo-inositol
                     cotransporter 2; sodium/myo-inositol transporter 2"
                     /codon_start=1
                     /product="sodium/myo-inositol cotransporter 2"
                     /protein_id="NP_666310.1"
                     /db_xref="CCDS:CCDS21819.1"
                     /db_xref="GeneID:233836"
                     /db_xref="MGI:MGI:1919316"
                     /translation="MESATISPQPPQSDSLEAFPQKSMEPADIAVLVLYFLFVLAVGL
                     WSTVRTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAAVGISVAAYE
                     LNGLFSVLMLAWVFLPIYIAGQVTTMPEYLRRRFGGNRISITLAVLYLFIYIFTKISV
                     DMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIMLIGAFIL
                     MGYSFAAVGGMEGLKDQYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGILF
                     GMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFPGMVSRVLF
                     PDQVACAHPDICQRVCSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSI
                     FNSASTIFTMDLWNHIRPRASERELMIVGRIFVFALVLVSILWIPIVQASQGGQLFIY
                     IQSISSYLQPPVAMVFIMGCFWKRTNEKGAFSGLILGLLLGLVRLILDFVYAQPRCDQ
                     PDDRPAVVKDVHYLYFSMILSFTTLITVVTVSWFTETPSKEMVSRLTWFTRHEPVAQK
                     DSAPPETPLSLTLSQNGTTEAPGTSIQLETVQESTTKACGDGVSPRHSKVVRAILWLC
                     GMEKNKEEPPSKAEPVIVSLEENPLVKTLLDVNCIVCISCAIFLWGYFA"
     exon            407..478
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..583
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..643
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..748
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..854
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..935
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1141
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1277
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1385
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1536
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1705
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1921
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2090
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2341
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /note="hexamer: AATAAA"
     polyA_site      2341
                     /gene="Slc5a11"
                     /gene_synonym="2010013B02Rik; Kst1; RKST2; Slc5a10; SMIT2"
                     /note="major polyA site"
ORIGIN      
        1 gtctctgctg tcctctgctg ctccctgctg caaaggacag gacatcccag gggtctccct
       61 ttgcacagcc actgccttcg gcctctgaag tccccgagac cctagggcag tagagcctgc
      121 atcctgaaga agcacgccca ctggaagcct acctcttcag gattgcagtt tatacagagg
      181 gccagctgaa acacctagcc tcgtggaact agactcttgg acttcccatt tacagctgtc
      241 cattgttggg actagcggct cattcagcac catggagagt gccaccatca gccctcagcc
      301 cccacagtct gactccctgg aggcctttcc ccagaagagc atggagcctg cagacatcgc
      361 tgtcctagtt ctgtacttcc tctttgttct ggctgttgga ttatggtcca cagtgaggac
      421 caaacgagac acagtgaaag gctacttcct ggctggaggg gacatggtgt ggtggccagt
      481 gggtgcatcc ttgttcgcca gcaatgttgg aagtggacac ttcattggcc tcgctgggtc
      541 tggtgctgct gtgggcattt ctgtcgctgc ctatgagctt aatggcttgt tttctgtgct
      601 gatgctggcc tgggtcttcc ttcctatcta cattgctggc caggtaacca cgatgccaga
      661 atatctaagg cggcgctttg ggggcaacag gatctccatc accctggctg tgctctacct
      721 gttcatctac atcttcacca agatctcggt cgacatgtat gcaggggcca tcttcattca
      781 gcagtccttg catctggatc tgtacctggc catagtaggg ctgctggcaa tcacagctct
      841 gtacactgtt gcaggaggtc tggccgctgt gatctataca gatgctctgc agactgttat
      901 catgcttata ggagccttca tcctcatggg ctacagtttt gcagctgttg gtggaatgga
      961 aggcctgaag gaccagtact tcttagccct ggctagtaac cggagtgaga acagcagctg
     1021 tgggctaccc cgagaagatg ccttccacat cttccgagat ccattgacat ctgatctccc
     1081 ctggcctggg atcctgtttg gcatgtccat cccatctctc tggtattggt gtacagatca
     1141 ggtgattgtt cagcggagtc tggctgccaa gaacctgtct catgccaaag gcggctccct
     1201 gatggctgcg tacctgaaag tgcttcctct tttcctgatg gtgttccctg ggatggtcag
     1261 cagagtcctc ttcccagatc aagtagcctg tgcgcatcct gacatctgcc agagggtctg
     1321 tagcaacccc tctggctgtt cagacatcgc gtaccccaaa cttgtgctgg aacttctgcc
     1381 cacaggactc cgtgggctca tgatggctgt gatggtggcg gctctcatgt cctccctcac
     1441 ctccatcttt aacagtgcca gcaccatctt caccatggac ctgtggaacc acatccggcc
     1501 acgggcatct gaaagggagc tcatgattgt gggcaggata tttgtgtttg ccctggtgct
     1561 ggtctccatc ctctggatcc ccattgtgca ggccagccag ggagggcagc ttttcatcta
     1621 cattcaatcc atcagctcct acctgcagcc acctgtggcc atggtcttca tcatgggatg
     1681 tttctggaag cgtaccaatg aaaagggtgc cttctcaggc ctgatcttgg gcttgctgct
     1741 gggactggtc aggctgatcc tggactttgt ctacgcgcag cctcggtgtg accagcctga
     1801 tgaccggcca gctgtggtga aggatgtcca ctacctctac ttctccatga ttctgtcttt
     1861 taccaccctc atcactgtgg tcactgtgag ctggttcaca gagacaccct ccaaagagat
     1921 ggtcagccgc ctgacttggt tcactcgtca tgaacctgtg gcccagaagg actcagcacc
     1981 accagaaacc cccctgtctc taaccctttc tcagaatggg actacagagg cccctggcac
     2041 cagcatccag ctggagacag ttcaagaaag tacgaccaaa gcctgtggcg atggtgtgtc
     2101 tcccaggcat tccaaggtgg tgagggctat cctgtggctc tgtgggatgg aaaagaacaa
     2161 agaggagccc ccaagcaaag cggaacctgt catagtttcc ttggaggaaa atcccttggt
     2221 gaaaaccctg cttgacgtca actgcattgt gtgcatcagc tgcgccatct tcctttgggg
     2281 atacttcgca taactcaggg tgagccagga aacgacaata aagctgtgtc tgtttactgt
     2341 a
//
