LOCUS       NM_001382268            2042 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium/glucose
            cotransporter), member 10 (Slc5a10), transcript variant 2, mRNA.
ACCESSION   NM_001382268 XM_017314221
VERSION     NM_001382268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Fukuzawa,T., Fukazawa,M., Ueda,O., Shimada,H., Kito,A.,
            Kakefuda,M., Kawase,Y., Wada,N.A., Goto,C., Fukushima,N.,
            Jishage,K., Honda,K., King,G.L. and Kawabe,Y.
  TITLE     SGLT5 reabsorbs fructose in the kidney but its deficiency
            paradoxically exacerbates hepatic steatosis induced by fructose
  JOURNAL   PLoS One 8 (2), e56681 (2013)
   PUBMED   23451068
  REMARK    GeneRIF: Data show fructose-induced hepatic steatosis was
            exacerbated in the SGLT5-deficient mice
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596209.13.
            
            On Apr 28, 2020 this sequence version replaced XM_017314221.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL596209.13        81961-82104
            145-216             AL596209.13        85630-85701
            217-321             AL596209.13        86164-86268
            322-381             AL596209.13        86623-86682
            382-486             AL596209.13        86806-86910
            487-592             AL596209.13        92250-92355
            593-673             AL596209.13        92587-92667
            674-879             AL596209.13        93947-94152
            880-1015            AL596209.13        97560-97695
            1016-1123           AL596209.13        123290-123397
            1124-1274           AL596209.13        125669-125819
            1275-1443           AL596209.13        127949-128117
            1444-1659           AL596209.13        128205-128420
            1660-1717           AL596209.13        128665-128722
            1718-2042           AL596209.13        128835-129159
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..2042
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 10"
                     /db_xref="GeneID:109342"
                     /db_xref="MGI:MGI:1926089"
     exon            1..144
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1824
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /note="sodium/glucose cotransporter 5; solute carrier
                     family 5 member 10; Na(+)/glucose cotransporter 5"
                     /codon_start=1
                     /product="sodium/mannose cotransporter SLC5A10"
                     /protein_id="NP_001369197.1"
                     /db_xref="GeneID:109342"
                     /db_xref="MGI:MGI:1926089"
                     /translation="MAGNSTGDAHVPGSQLSVTDIIVISVYFALNVAVGIWSACRANK
                     NTVSGYFLAGRDMAWWPIGASLFASSEGSGLFVGLAGSGAAGGLAVAGFEWNATYVLL
                     ALAWVFVPIYISSEIVTLPEYIQKRFGGQRIRTYLSVLSLMLSVFTKISIDLYAGALF
                     VHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTIIMVVGAVILAVKAFNQI
                     GGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFRDPSTGDLPWTGMTFGLTIMATW
                     YWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGMISRVLFPDDVGCVV
                     PSECLRACGAEIGCSNIAYPKLVMELMPIGLRGLMIAVMMAALLSSLTSIFNSSSTLF
                     TMDIWRQLRPSAGERELLLVGRLVIVVLIGVSVAWIPVLQGSNSGQLFIYMQSVTSSL
                     APPVTAIFILGIFWRRANEQGAFWGLMAGLVVGALRLVLEFLYPEPPCGQIDTRPAPL
                     RSLHYLHFAIALFLLTCAVMAAGSLLSPPPQQRQIENLTWWTLAPNWSLGTKTGDGQT
                     PQKRAFWARVCNVNAIFLMCVNIFFYAYFA"
     exon            145..216
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            217..321
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            322..381
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..486
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            487..592
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            593..673
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            674..879
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1015
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1123
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1274
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1443
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1659
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1717
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..2042
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /note="hexamer: AATATA"
     polyA_site      1984
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /note="major polyA site"
     polyA_site      2008
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
                     /note="hexamer: AACAAA"
     polyA_site      2042
                     /gene="Slc5a10"
                     /gene_synonym="C330021F16Rik; SGLT5"
ORIGIN      
        1 agtccctggg ctcggcacgg cgcttgctgc aggatggctg gcaattccac tggggatgcc
       61 catgttccag gatcccagct gagtgtcacg gacattattg tcatctctgt ctattttgcc
      121 ttgaatgtgg ccgtgggcat atggtcggct tgtcgagcca acaagaacac agtgagcggc
      181 tacttcctgg cgggccggga catggcttgg tggccgatcg gagcctcact ctttgcaagc
      241 agcgagggct ctggcctctt cgtaggattg gccggctcgg gtgctgccgg aggcctggct
      301 gtggctggct ttgagtggaa tgccacatat gtgcttttgg ctctggcatg ggtgtttgta
      361 cccatctaca tatcttcaga gatcgtcacc ttgcctgaat acattcagaa gcgctttggt
      421 ggccagcgca tccgcacgta cttatctgtc ctgtccctga tgctgtctgt cttcaccaag
      481 atatcgattg acctgtacgc aggagccctg tttgtccaca tctgcctggg ctggaacttc
      541 tacctgtcca ccatcctcac gctcgccatt acggccctgt acaccattgc agggggcctg
      601 gccactgtga tatacacaga tgccctgcag acaatcatca tggtggtggg tgctgtcatt
      661 ttggcagtca aagctttcaa ccagatcggt ggttatgagc agctggaggc ggcgtatgcc
      721 caggccatcc cctccaggac catccccaac accacctgcc acctgccgcg agcagacgcc
      781 atgcatatgt tccgggaccc ttccacagga gacctcccgt ggactgggat gacctttggt
      841 ctgaccatca tggccacctg gtactggtgc actgaccagg ttattgtgca gcggtccctg
      901 tctgcccgga acttgaacca tgccaaggca ggctccattc tagccagcta cctgaagatg
      961 cttcccatgg gcctgatgat catgccaggc atgatcagcc gagtactgtt cccagacgat
     1021 gtgggctgtg tggtaccatc cgagtgtctg cgagcctgtg gggctgagat tggctgctcc
     1081 aacattgcct acccgaagct ggtcatggag ctgatgccca taggtcttcg agggctgatg
     1141 atcgcagtaa tgatggctgc tctcctgtca tccctgacct ccatcttcaa cagcagcagc
     1201 acgcttttca ccatggacat ctggaggcag cttcggccca gcgcggggga gcgagagttg
     1261 ctgctggtgg gacggctggt catcgtggtg ctcatcggtg tgagtgtagc ctggatcccg
     1321 gtcctgcagg gctctaacag tggtcagctt ttcatctaca tgcagtcagt gaccagctcg
     1381 ctggcgcccc ctgtcaccgc catcttcatc ctgggcatct tctggaggag ggccaatgaa
     1441 cagggggcct tctggggcct gatggctggg ctggtggtgg gtgctctgag gctggtcctg
     1501 gaattcctgt acccggagcc cccgtgcggc caaatcgata cccggccagc ccccctccgc
     1561 agcctacatt acttgcactt tgccattgcc ctcttcctcc tcacctgtgc tgtgatggcc
     1621 gctgggagcc tactgagccc gccccctcag caaagacaga ttgaaaacct cacctggtgg
     1681 actctggctc caaactggtc cttaggaact aaaacaggtg atggccaaac accccagaaa
     1741 cgtgctttct gggcccgcgt gtgtaatgtc aacgccatct tcctcatgtg tgtcaacatt
     1801 ttcttctatg cctattttgc ctgatgctgc caccacacca gtgggaagac aggcgcttca
     1861 agttctcagg accaccttcc ttcctgggtt ggacatgaag gcctaaggaa tagaatgtgc
     1921 ccacagataa acagtggtca ataccaagtg tctggctgag ccagcagaca cggtgctctg
     1981 aaaatatagt ggagaatcat ttcaaaaata gcactttaaa caaagtcaga tatggggaga
     2041 aa
//
