LOCUS       NM_019810               3933 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus solute carrier family 5 (sodium/glucose
            cotransporter), member 1 (Slc5a1), mRNA.
ACCESSION   NM_019810
VERSION     NM_019810.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Takeyasu,M., Kozai,K. and Sugita,M.
  TITLE     Involvement of sodium-glucose cotransporter-1 activities in
            maintaining oscillatory Cl- currents from mouse submandibular
            acinar cells
  JOURNAL   J Comp Physiol B 194 (1), 21-32 (2024)
   PUBMED   38308715
  REMARK    GeneRIF: Involvement of sodium-glucose cotransporter-1 activities
            in maintaining oscillatory Cl[-] currents from mouse submandibular
            acinar cells.
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Numata,S., Oishee,M.J., McDermott,J., Koepsell,H., Vallon,V. and
            Blanco,G.
  TITLE     Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs
            mouse sperm movement
  JOURNAL   Mol Reprod Dev 91 (1), e23723 (2024)
   PUBMED   38282316
  REMARK    GeneRIF: Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1)
            impairs mouse sperm movement.
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Johnston,S.N., Silagi,E.S., Madhu,V., Nguyen,D.H., Shapiro,I.M. and
            Risbud,M.V.
  TITLE     GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells
            of the intervertebral disc
  JOURNAL   JCI Insight 8 (8), e164883 (2023)
   PUBMED   36917198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3933)
  AUTHORS   Anderson,M.J., Misaghian,S., Sharma,N., Perantoni,A.O. and
            Lewandoski,M.
  TITLE     Fgf8 promotes survival of nephron progenitors by regulating
            BAX/BAK-mediated apoptosis
  JOURNAL   Differentiation 130, 7-15 (2023)
   PUBMED   36527791
REFERENCE   5  (bases 1 to 3933)
  AUTHORS   Peritore-Galve,F.C., Kaji,I., Smith,A., Walker,L.M., Shupe,J.A.,
            Washington,M.K., Algood,H.M.S., Dudeja,P.K., Goldenring,J.R. and
            Lacy,D.B.
  TITLE     Increased intestinal permeability and downregulation of absorptive
            ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during
            Clostridioides difficile infection
  JOURNAL   Gut Microbes 15 (1), 2225841 (2023)
   PUBMED   37350393
  REMARK    GeneRIF: Increased intestinal permeability and downregulation of
            absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to
            diarrhea during Clostridioides difficile infection.
REFERENCE   6  (bases 1 to 3933)
  AUTHORS   Oesterreicher,T.J., Leeper,L.L., Finegold,M.J., Darlington,G.J. and
            Henning,S.J.
  TITLE     Intestinal maturation in mice lacking CCAAT/enhancer-binding
            protein alpha (C/EPBalpha)
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1165-1171 (1998)
   PUBMED   9494081
REFERENCE   7  (bases 1 to 3933)
  AUTHORS   Blumenthal,S.S., Ren,L., Lewand,D.L., Krezoski,S.K. and
            Petering,D.H.
  TITLE     Cadmium decreases SGLT1 messenger RNA in mouse kidney cells
  JOURNAL   Toxicol Appl Pharmacol 149 (1), 49-54 (1998)
   PUBMED   9512726
REFERENCE   8  (bases 1 to 3933)
  AUTHORS   Panayotova-Heiermann,M., Loo,D.D., Kong,C.T., Lever,J.E. and
            Wright,E.M.
  TITLE     Sugar binding to Na+/glucose cotransporters is determined by the
            carboxyl-terminal half of the protein
  JOURNAL   J Biol Chem 271 (17), 10029-10034 (1996)
   PUBMED   8626557
REFERENCE   9  (bases 1 to 3933)
  AUTHORS   Martin,M.G., Turk,E., Lostao,M.P., Kerner,C. and Wright,E.M.
  TITLE     Defects in Na+/glucose cotransporter (SGLT1) trafficking and
            function cause glucose-galactose malabsorption
  JOURNAL   Nat Genet 12 (2), 216-220 (1996)
   PUBMED   8563765
REFERENCE   10 (bases 1 to 3933)
  AUTHORS   Wiley,L.M., Lever,J.E., Pape,C. and Kidder,G.M.
  TITLE     Antibodies to a renal Na+/glucose cotransport system localize to
            the apical plasma membrane domain of polar mouse embryo blastomeres
  JOURNAL   Dev Biol 143 (1), 149-161 (1991)
   PUBMED   1702069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122203.4, AK033512.1, AK085602.1 and BE688659.1.
            
            On Oct 21, 2009 this sequence version replaced NM_019810.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208031.1, AK033512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC122203.4         247331-247345
            16-344              AK033512.1         2-330
            345-1095            AK085602.1         136-886
            1096-3834           AK033512.1         1082-3820
            3835-3933           BE688659.1         1-99                c
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.46 cM"
     gene            1..3933
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /note="solute carrier family 5 (sodium/glucose
                     cotransporter), member 1"
                     /db_xref="GeneID:20537"
                     /db_xref="MGI:MGI:107678"
     exon            1..373
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2236
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /note="solute carrier family 5, member 1; solute carrier
                     family 5, member alpha 1; high affinity sodium-glucose
                     cotransporter; Na(+)/glucose cotransporter 1"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 1"
                     /protein_id="NP_062784.3"
                     /db_xref="CCDS:CCDS19199.1"
                     /db_xref="GeneID:20537"
                     /db_xref="MGI:MGI:107678"
                     /translation="MDSSTLSPAVTATDAPIPSYERIRNAADISVIVIYFVVVMAVGL
                     WAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFE
                     WNALVLVVVLGWIFVPIYIKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISA
                     DIFSGAIFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFIL
                     TGFAFNEVGGYEAFMDKYMKAIPTKVSNGNFTAKEECYTPRADSFHIFRDPITGDMPW
                     PGLIFGLAILALWYWCTDQVIVQRCLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGMI
                     SRILYTEKIACVLPEECQKYCGTPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMS
                     SLTSIFNSASTLFTMDIYTKIRKKASEKELMIAGRLFILVLIGISIAWVPIVQSAQSG
                     QLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEQGAFWGLILGFLIGISRMITEFAYGT
                     GSCMEPSNCPKIICGVHYLYFAIILFVISVITILIISFLTKPIPDVHLYRLCWSLRNS
                     KEERIDLDAGEEEDIPEDSKDTIEIDTEAPQKKKGCFRRAYDLFCGLDQDKGPKMTKE
                     EEEAMKMKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA"
     exon            374..445
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..550
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..610
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..715
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..821
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..902
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1123
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1259
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1367
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1518
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1687
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1903
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2012
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3933
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2586
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /note="major polyA site"
     regulatory      3914..3919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /note="hexamer: AATAAA"
     polyA_site      3933
                     /gene="Slc5a1"
                     /gene_synonym="Sglt1"
                     /note="major polyA site"
ORIGIN      
        1 cgcccaggcg cccgcagact ctcttgagct ttgctcggtc ttcttaaggc actgcacacc
       61 taggagctgc ttcccgacgg tgcggtgcag cgcagcagca caggggccca gcgttcctgc
      121 cgcgcagccc cactgtcgcg ggtcccctcc ctcggggctg atcattaact caaaagcagt
      181 ataaggagtg agtggccccg gtgagcctgt gagccgagag ggactcgtcg ccaccgccat
      241 ggacagtagc accttgagcc ccgcggttac tgccaccgat gcacccatcc cgtcctacga
      301 gcgcattcgc aatgcggctg acatctcagt catcgtcatc tacttcgtgg tggtgatggc
      361 tgtcgggctg tgggccatgt tttccactaa tcgtggtacc gttggaggct tcttcctggc
      421 aggccgaagt atggtgtggt ggccgattgg agcctctctc tttgccagta acattggaag
      481 tggtcacttt gtggggctgg caggcacagg agcagccgca ggcattgcca tgggtggctt
      541 tgaatggaac gccttggttt tggtggttgt gctgggctgg atatttgtcc cgatttacat
      601 caaggccggg gtggtgacga tgccggagta tctgcggaag cggtttggag gcaagagaat
      661 tcagatctac ctttccgttc tgtccctgct cctctacatc ttcacaaaga tctctgcaga
      721 catcttctcc ggggctatat tcatcaatct agccttgggc ctggatatat acttggccat
      781 tttcatcctg ctagcaatca ctgcccttta tacaatcaca ggggggctgg cagctgtaat
      841 ttacacagat accctgcaga ccgcgatcat gctggtgggg tcttttatcc tgactgggtt
      901 tgctttcaat gaagtaggag gatatgaagc cttcatggac aagtacatga aagctattcc
      961 aactaaggtt tctaacggaa attttaccgc caaggaagaa tgctacacac cgagggctga
     1021 ctcattccac atattcagag accccattac tggagacatg ccgtggcctg ggctcatttt
     1081 tggcctggcc atcctcgccc tgtggtactg gtgtacggat caggtcattg tgcagcgatg
     1141 cctctcggcc aagaacatgt ctcacgtgaa ggctggctgt accctgtgtg gctatctgaa
     1201 gctactgccc atgttcctca tggtgatgcc aggaatgatc agccggattc tatatacaga
     1261 aaaaatcgcc tgtgtcctcc ctgaagaatg tcagaaatac tgcggcacac cagtgggctg
     1321 taccaacatc gcctacccca cgctcgtggt ggaactcatg cctaatggac tgcgaggcct
     1381 gatgctgtct gtcatgatgg cttccctcat gagctccttg acctccatct tcaacagcgc
     1441 cagtactctc ttcaccatgg acatctacac caagatccgg aagaaggcat ctgagaagga
     1501 gctcatgatt gcaggaaggt tgttcatcct cgtgctgatt ggcatcagca ttgcctgggt
     1561 acccattgta cagtctgctc aaagtgggca gctctttgat tacatccagt ctatcaccag
     1621 ttacctgggg ccgcccattg cagctgtctt cctgcttgcc attttctgca agagagtcaa
     1681 tgaacaagga gccttctggg gactgatcct gggcttcctg attggaatct cccgtatgat
     1741 cactgagttt gcctatggaa ctgggagctg catggagccc agcaactgcc ccaagatcat
     1801 ctgtggggtc cactatttgt actttgccat catcctcttc gtcatcagcg tcatcaccat
     1861 cttgatcatc tccttcctca ccaagcccat tccagacgtg cacctgtacc gtttgtgttg
     1921 gagtctacgc aacagcaagg aagagcgaat cgacctggat gcaggagagg aggaggacat
     1981 cccagaggac tccaaggaca caattgaaat agacacagaa gccccccaga agaagaaagg
     2041 atgcttcagg agagcatatg acctgttctg tgggctggac caggataaag gaccaaagat
     2101 gactaaggag gaggaggaag ccatgaagat gaagatgaca gacacttctg agaagccttt
     2161 gtggaggaca gtggtgaaca tcaacggtat tatcctgctg gcggtagctg tcttctgcca
     2221 tgcctatttt gcctgagccc tgccttctgg tgtagactcg gcaactctag cattgttctt
     2281 cccccttttg acccactctg tagtggcaag gggaagatgt ccacttgtaa atttcacgca
     2341 ttcggataaa aggtgtataa gtgtgattat aggcttgctg gaggaaagtg attacattgc
     2401 tgtgaactta tgcatttgaa gccagtgtgc cacactcatc tgccatgcca gagctttaga
     2461 agtgaagttg actcagatat aggaaaagtc atgccaagac acagaagccc tgtgttgtct
     2521 gatgtcactc tgtctcagct tgtaattatt gtttataatc cttaaatact attttttaaa
     2581 attgtagtct ggttcctgtc atttttctac ctaacccctc acctcttcct cctcctctta
     2641 ttttttttcc taaaagaaat tcccttgcca ttgcattcct ccctctagat ttttgttact
     2701 taaaaaaaaa atcaatttga caaatagaag aatacccgga agttgaggat aggaaccttg
     2761 tcctgtgaat ttgttcttta aagtgccagt atcaaggaga cagtatttac ttgaataggg
     2821 ttggggactc gcaccaatca ggggtacagc caaccttgag tactgagaac tttctggtct
     2881 ttaaaaaatg cccattgtgt gtctcctgga ttgttactca tctcgggggt cactgcacct
     2941 gaagtgtctt agccactcag gaatgttcgt tgactccata agtcgcatgt cacttattga
     3001 tgggtgctgc ctggcccttg cttagctttt attttatttt attttctatt tcattttttg
     3061 tacctgcaca aaatatacca gtggagtcta ttatggagtg gaatgcattt tctagtgtct
     3121 ctctctgcct cgtggtgctg atgttgacac acaatacagt cttagacgtt gacactactt
     3181 gataggacag agtaaatgcc cctgcaggga catctgcctt cctgatgcag cacactctcc
     3241 caggaatcat tgaaatcatt agcctgaggt cctctttccc atgtgtgcac atggccacaa
     3301 tgattggctt gtaatgggtc ttcacagggg gtcacccacc gaccaggcta aggcagccag
     3361 cctcagttct agatggcagg tgcttggtgg ttttagttgg aagaagactg tttatgttga
     3421 gctagttccc catgggaaaa taattttcat ttaatattaa attaattaat taactaatta
     3481 attaaaattg tactttcaaa atctcaatta tattgtaata ttatcccatt gaagctagga
     3541 aatcagcatg ttattgtaga atgatttcaa cttagcttag aaaagagctg agtgaggtgt
     3601 tgggcataga agtgtcttgg agtgtcaatg catggcttct tgttatagaa gaaagaaaat
     3661 ctggagagag ctgtttgagg tattttcttg ttccctgtaa gctgtgctga gaaaagggga
     3721 gattggggaa ccacccatgt ccagcacacg cagggcgtgg gctcagggtg tcaggctcag
     3781 gtggactttg tggtaagttg tgagtcttga gaagagaaag gcagggactg aagcttggga
     3841 aaggaaaagc aaagcaaact acctagattg ttttggtttc attgcatggc caatgattta
     3901 ttgtatatat tgtaataaat tattttatct gaa
//
