LOCUS       NM_001164819            2630 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier protein family 52, member 3 (Slc52a3),
            transcript variant 2, mRNA.
ACCESSION   NM_001164819
VERSION     NM_001164819.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Jin,C., Yonezawa,A., Yoshimatsu,H., Imai,S., Koyanagi,M.,
            Yamanishi,K., Nakagawa,S., Itohara,K., Omura,T., Nakagawa,T.,
            Nagai,J. and Matsubara,K.
  TITLE     Effect of riboflavin deficiency on development of the cerebral
            cortex in Slc52a3 knockout mice
  JOURNAL   Sci Rep 10 (1), 18443 (2020)
   PUBMED   33116204
  REMARK    GeneRIF: Effect of riboflavin deficiency on development of the
            cerebral cortex in Slc52a3 knockout mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Yoshimatsu,H., Yonezawa,A., Yamanishi,K., Yao,Y., Sugano,K.,
            Nakagawa,S., Imai,S., Omura,T., Nakagawa,T., Yano,I., Masuda,S.,
            Inui,K. and Matsubara,K.
  TITLE     Disruption of Slc52a3 gene causes neonatal lethality with
            riboflavin deficiency in mice
  JOURNAL   Sci Rep 6, 27557 (2016)
   PUBMED   27272163
  REMARK    GeneRIF: our knowledge, this is the first report to indicate that
            Rfvt3 contributes to placental riboflavin transport, and that
            disruption of Slc52a3 gene caused neonatal mortality with
            hyperlipidemia and hypoglycemia owing to riboflavin deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Intoh,A., Suzuki,N., Koszka,K. and Eggan,K.
  TITLE     SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is
            essential for mouse development, but dispensable for motor neuron
            differentiation
  JOURNAL   Hum Mol Genet 25 (9), 1814-1823 (2016)
   PUBMED   26976849
  REMARK    GeneRIF: Loss of Slc52a3 gene is associated with Brown-Vialetto-van
            Laere syndrome.
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Subramanian,V.S., Lambrecht,N., Lytle,C. and Said,H.M.
  TITLE     Conditional (intestinal-specific) knockout of the riboflavin
            transporter-3 (RFVT-3) impairs riboflavin absorption
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (4), G285-G293 (2016)
   PUBMED   26660539
  REMARK    GeneRIF: the RFVT-3 system is the main transporter involved in
            carrier-mediated riboflavin uptake in the native mouse small and
            large intestine
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047618.1, AK029091.1 and CF424499.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_001164819.2.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon
            and encodes the same isoform, as compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047618.1, SRR5189685.142430.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1164              AK047618.1         2-1165
            1165-2399           AK029091.1         1210-2444
            2400-2589           AK047618.1         2400-2589
            2590-2630           CF424499.1         355-395
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2630
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /note="solute carrier protein family 52, member 3"
                     /db_xref="GeneID:69698"
                     /db_xref="MGI:MGI:1916948"
     exon            1..73
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..700
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..1188
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1312
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2625
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /note="hexamer: ATTAAA"
     polyA_site      2353
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /note="major polyA site"
     polyA_site      2625
                     /gene="Slc52a3"
                     /gene_synonym="2310046K01Rik; RFT2"
                     /note="major polyA site"
ORIGIN      
        1 accagggcgg ggacagacag gtgccgccac agacttttgg agtcaccgtg caggcagacc
       61 tccttgactc tcggtgtcct ccaccagtcc ctctgcagcc tgacctggag gacaggatat
      121 cgtctggcct gggctgccca caatggcctt cctgacacac ctactggtct gcgtctttgg
      181 catgggctcc tgggtggcca tcaatgggct ctgggtggag ctgcccctgc tggtgactga
      241 gttgcccgag gcctggtacc tgccttctta cctcactgtg gtcatccagc tggccaacat
      301 aggccccctc ctggtcaccc tgatgcaccg cttccgaccc ggctgcctgt ctgaggtgcc
      361 tgtgatcttc cttatcctgt gcgtaggcac ggctgcctgc attctcctag ccttcctgtg
      421 gaacgtgacc tcctggatac agggtggaca gcatagtgtg gccttcatcg tcctcacctt
      481 cttcctggcc ctggtggact gcacctcttc tgtcaccttc ttgcccttca tgagccagct
      541 gcctacgtac tatcttacca ccttcttcat aggcgagggg ctcagtggcc tcctgcctgc
      601 cctggtggcc cttgtccaag gctccggtat caccacctgt gtcaatgtca cggagacacc
      661 agggaccacc ttgaacacta tggagactcc catcactcag ggaaacctta gcccttccct
      721 gccgtcgccc agctggcacc aggagagccg ctacctggcc cctcgcttct cgccactgct
      781 cttcttccta ctgctgtctt tcctgacagg ctgctgtctg gtggccttct tcctcctgca
      841 gaggcagccc tggggacggc aaggctccat agaggacctc ctccactccc aggtcaccct
      901 gcactctatc aggccccgag acacagagga caccagctcc ctgggtgccc ctgtgagcag
      961 cccaggcaag ggatcagtgg aagccagtgt ggcttcgctc cgcccagccc agctggcctt
     1021 catctactcc gtggtggcct ttgtcaatgc actcaccaat ggcgttctgc cctccgtgca
     1081 gacctactcc tgcctgcctt atgggcctgt tgcctaccac ctgtctgcca ccctcagctc
     1141 cgtggccagc cccctcgcct gcttcctccc catcttcctg cctaacaggt cgctgttatt
     1201 cctgggggtg ctcacagtgt tggggaccgg ctttggggcc tacaatatgg ccatggctgc
     1261 tatgagcccc tgccctgtcc tgcagggtca ctggggtgga gaagtcctta tcgtgctctc
     1321 ctgggtgctg tttgcagcct gtctcagcta tgtcaaggtg atgctgggtg tgatcttgcg
     1381 tgaccggagt cgcagtgccc tcttgtggtg tggggcagcg gtgcagctgg gctctctgat
     1441 tggtgccctg ctcatgttcc cactggttaa tgtactgaaa ctcttctcat ctgccgacta
     1501 ctgcagcctg gactgctccg tgtaggctca cttggccacc tcaggacacc aggtaccccc
     1561 atcggtgaag gtaaaagcca gaagagccca gcgacactaa ggataacaac cctttgctcc
     1621 atttttcatc cccatcctcc acacccccac tccaaccttg catggtcata gatcggggtc
     1681 tggggagctg ttaggccagg cctgagcttt ttaacacaaa ggcctccttc caacctggag
     1741 ttgcactgtg cagcccctcc tccagcacag tgcccgttgc ttatgagccc cagttgcaga
     1801 ctttgttctc tgtcttcgga gagatccgtt tgtagcattc agttggaggc agcctaagga
     1861 tgttagggga agactcctgg gaggtttagc tgcctcttgc ttactgtgag accttaggga
     1921 agtttcgtga ttctctaggc ctctgtttgc tcgattaaag gaggggtata gtaaacagcc
     1981 tttcgcttgt aggcttaggc atctatcagg ttctcctaga ccctgtcctg catggacacc
     2041 cttcttaata caacctggaa gtgatcggag gacttgggag ggaccccgcc tccattcctt
     2101 ttctgcatcc caagcctgtt gttggtcctg ggtcccagta cagccctctg ccttccctgt
     2161 ctcccagaat ggtgagaccc tgagatgagt tgaagggggt cctgcgtgca tctgagtgaa
     2221 ccccaccagg acacacagtg gacagtgcgg acctcaaaag gggtagctca ggcaggatga
     2281 gtttcgtctg taattattat tttgttttgc attttgtttc tttttgtaaa aattaaagct
     2341 gtctatgctt ttacatgatg ggctgtgtac acacaagaag cctggtgagg gctacactgt
     2401 atcagcctaa ttctaatcca ttttcagtca aggtcgagaa ccaaggaagc aagagcagag
     2461 agaggcctga tgcccaccca ctttttttta gactgttgtc ttactggctt gtactacctt
     2521 gcactcctct ttattcttaa agtagggctg gagagattgt ccagctgttt aaggcaaagt
     2581 cccatgacca aaaatcaaac tacttaaacg gtgcttatcc aggtaaaaaa
//
