LOCUS       NP_083919                450 aa            linear   ROD 28-APR-2025
DEFINITION  solute carrier family 52, riboflavin transporter, member 2 [Mus
            musculus].
ACCESSION   NP_083919
VERSION     NP_083919.1
DBSOURCE    REFSEQ: accession NM_029643.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 450)
  AUTHORS   Jin,C., Matsui,Y., Yonezawa,A., Imai,S., Ogihara,T., Itohara,K.,
            Nakagawa,S., Nakagawa,T. and Matsubara,K.
  TITLE     Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice
  JOURNAL   Biol Pharm Bull 44 (2), 283-286 (2021)
   PUBMED   33518683
  REMARK    GeneRIF: Complete Deletion of Slc52a2 Causes Embryonic Lethality in
            Mice.
REFERENCE   3  (residues 1 to 450)
  AUTHORS   Jin,C., Yonezawa,A., Yoshimatsu,H., Imai,S., Koyanagi,M.,
            Yamanishi,K., Nakagawa,S., Itohara,K., Omura,T., Nakagawa,T.,
            Nagai,J. and Matsubara,K.
  TITLE     Effect of riboflavin deficiency on development of the cerebral
            cortex in Slc52a3 knockout mice
  JOURNAL   Sci Rep 10 (1), 18443 (2020)
   PUBMED   33116204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 450)
  AUTHORS   Intoh,A., Suzuki,N., Koszka,K. and Eggan,K.
  TITLE     SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is
            essential for mouse development, but dispensable for motor neuron
            differentiation
  JOURNAL   Hum Mol Genet 25 (9), 1814-1823 (2016)
   PUBMED   26976849
REFERENCE   5  (residues 1 to 450)
  AUTHORS   Wu,A.M., Dedina,L., Dalvi,P., Yang,M., Leon-Cheon,J., Earl,B.,
            Harper,P.A. and Ito,S.
  TITLE     Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the
            mouse mammary gland during lactation
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (7), R578-R585 (2016)
   PUBMED   26791833
REFERENCE   6  (residues 1 to 450)
  AUTHORS   Yao,Y., Yonezawa,A., Yoshimatsu,H., Omura,T., Masuda,S. and
            Matsubara,K.
  TITLE     Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic
            homeostasis of riboflavin in mice
  JOURNAL   Eur J Pharmacol 714 (1-3), 281-287 (2013)
   PUBMED   23911957
  REMARK    GeneRIF: mRFVT2 was involved in hepatic riboflavin homeostasis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148057.1, AK029579.1 and AC157566.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029579.1, AK142597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.04 cM"
     Protein         1..450
                     /product="solute carrier family 52, riboflavin
                     transporter, member 2"
                     /note="riboflavin transporter 1; porcine endogenous
                     retrovirus A receptor 2 homolog; PERV-A receptor 2
                     homolog; G protein-coupled receptor 172B"
                     /calculated_mol_wt=46733
     Site            14..34
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            47..67
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            86..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            112..132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            147..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            178
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            201..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Region          227..264
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Region          278..376
                     /region_name="DUF1011"
                     /note="Protein of unknown function (DUF1011); pfam06237"
                     /db_xref="CDD:461856"
     Site            282..302
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            317..337
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            344..364
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            369..389
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     Site            409..429
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D8F3.1)"
     CDS             1..450
                     /gene="Slc52a2"
                     /gene_synonym="2010003P03Rik; D15Ertd747e; GPCR42;
                     Gpr172b; mRFT1; PAR2; RFT1; Rfvt2"
                     /coded_by="NM_029643.4:457..1809"
                     /db_xref="CCDS:CCDS27575.1"
                     /db_xref="GeneID:52710"
                     /db_xref="MGI:MGI:1289288"
ORIGIN      
        1 maapplgrlv lthllvalfg mgswaavngi wvelpvvvke lpegwslpsy lsvlvalgnl
       61 glllvtlwrr largkgeqvp irvvqglgiv gtgllaslwn hvapvagkpy svafltlafv
      121 lalaccasnv tflpflshlp ppflrsfflg qglsallpcv lalgqgvgrl eclhvpanrt
      181 tgppievspi nfperfsatt ffwvltallg tsaaafqgll lllpsptsep ttgtglrvet
      241 pgteeeeeee easplqeppg qvagivsspd pkahqlfssr sacllgllai tnaltngvlp
      301 avqsfsclpy grlayhlavv lgscanplac flamavlcrs laglcglsll gmllgsylmt
      361 laalspcppl vgtsagvvlv vlswvlcagt fsyikvaiss mlhsggrpal laagvaiqvg
      421 sllgavamfp ptsiyrvfrs gkdcvdqcgl
//
