LOCUS       NM_178933                488 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 51, beta subunit (Slc51b), mRNA.
ACCESSION   NM_178933
VERSION     NM_178933.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Christian,W.V. and Hinkle,P.M.
  TITLE     Global functions of extracellular, transmembrane and cytoplasmic
            domains of organic solute transporter beta-subunit
  JOURNAL   Biochem J 474 (12), 1981-1992 (2017)
   PUBMED   28455390
  REMARK    GeneRIF: Data suggest that transport of bile acid taurocholate is
            retained when OstB is truncated to contain only the transmembrane
            domain with 15 additional residues on each side and co-expressed
            with intact OstA (organic solute transporter alpha subunit);
            shorter fragments of OstB are inactive.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 488)
  AUTHORS   Ferrell,J.M., Boehme,S., Li,F. and Chiang,J.Y.
  TITLE     Cholesterol 7alpha-hydroxylase-deficient mice are protected from
            high-fat/high-cholesterol diet-induced metabolic disorders
  JOURNAL   J Lipid Res 57 (7), 1144-1154 (2016)
   PUBMED   27146480
REFERENCE   4  (bases 1 to 488)
  AUTHORS   Zhang,Y., Li,F., Wang,Y., Pitre,A., Fang,Z.Z., Frank,M.W.,
            Calabrese,C., Krausz,K.W., Neale,G., Frase,S., Vogel,P., Rock,C.O.,
            Gonzalez,F.J. and Schuetz,J.D.
  TITLE     Maternal bile acid transporter deficiency promotes neonatal demise
  JOURNAL   Nat Commun 6, 8186 (2015)
   PUBMED   26416771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 488)
  AUTHORS   Vergnes,L., Lee,J.M., Chin,R.G., Auwerx,J. and Reue,K.
  TITLE     Diet1 functions in the FGF15/19 enterohepatic signaling axis to
            modulate bile acid and lipid levels
  JOURNAL   Cell Metab 17 (6), 916-928 (2013)
   PUBMED   23747249
REFERENCE   6  (bases 1 to 488)
  AUTHORS   Zollner,G., Wagner,M., Moustafa,T., Fickert,P., Silbert,D.,
            Gumhold,J., Fuchsbichler,A., Halilbasic,E., Denk,H., Marschall,H.U.
            and Trauner,M.
  TITLE     Coordinated induction of bile acid detoxification and alternative
            elimination in mice: role of FXR-regulated organic solute
            transporter-alpha/beta in the adaptive response to bile acids
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 290 (5), G923-G932 (2006)
   PUBMED   16357057
  REMARK    GeneRIF: In conclusion, we identified Ost-alpha/Ost-beta as a novel
            FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-)
            animals may contribute to increased liver injury in these animals.
REFERENCE   7  (bases 1 to 488)
  AUTHORS   Lee,H., Zhang,Y., Lee,F.Y., Nelson,S.F., Gonzalez,F.J. and
            Edwards,P.A.
  TITLE     FXR regulates organic solute transporters alpha and beta in the
            adrenal gland, kidney, and intestine
  JOURNAL   J Lipid Res 47 (1), 201-214 (2006)
   PUBMED   16251721
  REMARK    GeneRIF: OSTalpha and OSTbeta mRNA levels were induced in the
            adrenals and kidneys of wild-type, but not FXR-/-, mice
REFERENCE   8  (bases 1 to 488)
  AUTHORS   Ballatori,N., Christian,W.V., Lee,J.Y., Dawson,P.A., Soroka,C.J.,
            Boyer,J.L., Madejczyk,M.S. and Li,N.
  TITLE     OSTalpha-OSTbeta: a major basolateral bile acid and steroid
            transporter in human intestinal, renal, and biliary epithelia
  JOURNAL   Hepatology 42 (6), 1270-1279 (2005)
   PUBMED   16317684
  REMARK    GeneRIF: the selective localization of OSTalpha and OSTbeta to the
            basolateral plasma membrane of epithelial cells responsible for
            bile acid and sterol reabsorption.
REFERENCE   9  (bases 1 to 488)
  AUTHORS   Dawson,P.A., Hubbert,M., Haywood,J., Craddock,A.L., Zerangue,N.,
            Christian,W.V. and Ballatori,N.
  TITLE     The heteromeric organic solute transporter alpha-beta,
            Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
  JOURNAL   J Biol Chem 280 (8), 6960-6968 (2005)
   PUBMED   15563450
  REMARK    GeneRIF: Co-expression of mouse Ostalpha-Ostbeta, but not the
            individual subunits, stimulated Na(+)-independent bile acid uptake
            and the apical-to-basolateral transport of taurocholate
REFERENCE   10 (bases 1 to 488)
  AUTHORS   Seward,D.J., Koh,A.S., Boyer,J.L. and Ballatori,N.
  TITLE     Functional complementation between a novel mammalian polygenic
            transport complex and an evolutionarily ancient organic solute
            transporter, OSTalpha-OSTbeta
  JOURNAL   J Biol Chem 278 (30), 27473-27482 (2003)
   PUBMED   12719432
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY279396.1.
            
            On Jun 3, 2003 this sequence version replaced NM_178933.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY279396.1, AK002463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.29 cM"
     gene            1..488
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /note="solute carrier family 51, beta subunit"
                     /db_xref="GeneID:330962"
                     /db_xref="MGI:MGI:3582052"
     exon            1..27
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /inference="alignment:Splign:2.1.0"
     exon            28..148
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..444
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /note="Ost beta; OST-beta; solute carrier family 51
                     subunit beta; organic solute transporter beta"
                     /codon_start=1
                     /product="organic solute transporter subunit beta"
                     /protein_id="NP_849264.1"
                     /db_xref="CCDS:CCDS23291.1"
                     /db_xref="GeneID:330962"
                     /db_xref="MGI:MGI:3582052"
                     /translation="MDHSAEKAAANAEVPQELLEEMLWYFRAEDAAPWNYSILVLAVL
                     VVMTSMFLLRRSILANRNRKKQPQDKETPEDLHLDDSIMKENNSQVFLRETLISEKPD
                     LAPGEPELKEKDSSLVFLPDPQETES"
     exon            149..239
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /inference="alignment:Splign:2.1.0"
     exon            240..488
                     /gene="Slc51b"
                     /gene_synonym="Ostb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaagtccca ggaatcccgg gtccagggcc agaaacatct caatcaggag cagaaacatg
       61 gaccacagtg cagagaaagc tgcagccaat gccgaggtgc cccaggaact gctggaagaa
      121 atgctttggt attttcgtgc agaagatgcg gctccttgga attattccat cctggtcctg
      181 gcagtcctgg tggtcatgac aagcatgttc ctcctgagaa ggagcatcct ggcaaacaga
      241 aatcgaaaga agcagccaca agacaaagaa acaccagaag acctgcatct tgatgactcc
      301 ataatgaaag agaacaacag ccaggtcttc ctaagagaga cattgatctc agagaaacca
      361 gacttggccc cgggggaacc tgagttgaaa gagaaagact catcacttgt ctttctgcca
      421 gacccacagg aaacagagag ctagggagcg ttgagagtac cccataacgc cccataacgc
      481 cgcctaac
//
