LOCUS       NM_145932               1544 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus solute carrier family 51, alpha subunit (Slc51a),
            mRNA.
ACCESSION   NM_145932
VERSION     NM_145932.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Truong,J.K., Li,J., Li,Q., Pachura,K., Rao,A., Gumber,S.,
            Fuchs,C.D., Feranchak,A.P., Karpen,S.J., Trauner,M. and Dawson,P.A.
  TITLE     Active enterohepatic cycling is not required for the choleretic
            actions of 24-norUrsodeoxycholic acid in mice
  JOURNAL   JCI Insight 8 (6), e149360 (2023)
   PUBMED   36787187
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Zaufel,A., van de Wiel,S.M.W., Yin,L., Fauler,G., Chien,D.,
            Dong,X., Gilmer,J.F., Truong,J.K., Dawson,P.A., van de
            Graaf,S.F.J., Fickert,P. and Moustafa,T.
  TITLE     Secondary (iso)BAs cooperate with endogenous ligands to activate
            FXR under physiological and pathological conditions
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1867 (8), 166153 (2021)
   PUBMED   33895309
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Christian,W.V. and Hinkle,P.M.
  TITLE     Global functions of extracellular, transmembrane and cytoplasmic
            domains of organic solute transporter beta-subunit
  JOURNAL   Biochem J 474 (12), 1981-1992 (2017)
   PUBMED   28455390
  REMARK    GeneRIF: Data suggest that transport of bile acid taurocholate is
            retained when OstB (organic solute transporter beta subunit) is
            truncated to contain only the transmembrane domain with 15
            additional residues on each side and co-expressed with intact OstA;
            shorter fragments of OstB are inactive.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Zhang,Y., Li,F., Wang,Y., Pitre,A., Fang,Z.Z., Frank,M.W.,
            Calabrese,C., Krausz,K.W., Neale,G., Frase,S., Vogel,P., Rock,C.O.,
            Gonzalez,F.J. and Schuetz,J.D.
  TITLE     Maternal bile acid transporter deficiency promotes neonatal demise
  JOURNAL   Nat Commun 6, 8186 (2015)
   PUBMED   26416771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Hammond,C.L., Wheeler,S.G., Ballatori,N. and Hinkle,P.M.
  TITLE     Ostalpha-/- mice are not protected from western diet-induced weight
            gain
  JOURNAL   Physiol Rep 3 (1), e12263 (2015)
   PUBMED   25626867
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Zollner,G., Wagner,M., Moustafa,T., Fickert,P., Silbert,D.,
            Gumhold,J., Fuchsbichler,A., Halilbasic,E., Denk,H., Marschall,H.U.
            and Trauner,M.
  TITLE     Coordinated induction of bile acid detoxification and alternative
            elimination in mice: role of FXR-regulated organic solute
            transporter-alpha/beta in the adaptive response to bile acids
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 290 (5), G923-G932 (2006)
   PUBMED   16357057
  REMARK    GeneRIF: In conclusion, we identified Ost-alpha/Ost-beta as a novel
            FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-)
            animals may contribute to increased liver injury in these animals.
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Lee,H., Zhang,Y., Lee,F.Y., Nelson,S.F., Gonzalez,F.J. and
            Edwards,P.A.
  TITLE     FXR regulates organic solute transporters alpha and beta in the
            adrenal gland, kidney, and intestine
  JOURNAL   J Lipid Res 47 (1), 201-214 (2006)
   PUBMED   16251721
  REMARK    GeneRIF: OSTalpha and OSTbeta mRNA levels were induced in the
            adrenals and kidneys of wild-type, but not FXR-/-, mice
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Ballatori,N., Christian,W.V., Lee,J.Y., Dawson,P.A., Soroka,C.J.,
            Boyer,J.L., Madejczyk,M.S. and Li,N.
  TITLE     OSTalpha-OSTbeta: a major basolateral bile acid and steroid
            transporter in human intestinal, renal, and biliary epithelia
  JOURNAL   Hepatology 42 (6), 1270-1279 (2005)
   PUBMED   16317684
  REMARK    GeneRIF: the selective localization of OSTalpha and OSTbeta to the
            basolateral plasma membrane of epithelial cells responsible for
            bile acid and sterol reabsorption.
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   Dawson,P.A., Hubbert,M., Haywood,J., Craddock,A.L., Zerangue,N.,
            Christian,W.V. and Ballatori,N.
  TITLE     The heteromeric organic solute transporter alpha-beta,
            Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
  JOURNAL   J Biol Chem 280 (8), 6960-6968 (2005)
   PUBMED   15563450
  REMARK    GeneRIF: Co-expression of mouse Ostalpha-Ostbeta, but not the
            individual subunits, stimulated Na(+)-independent bile acid uptake
            and the apical-to-basolateral transport of taurocholate
REFERENCE   10 (bases 1 to 1544)
  AUTHORS   Seward,D.J., Koh,A.S., Boyer,J.L. and Ballatori,N.
  TITLE     Functional complementation between a novel mammalian polygenic
            transport complex and an evolutionarily ancient organic solute
            transporter, OSTalpha-OSTbeta
  JOURNAL   J Biol Chem 278 (30), 27473-27482 (2003)
   PUBMED   12719432
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK052725.1.
            
            On Apr 6, 2007 this sequence version replaced NM_145932.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052725.1, AK147155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1544              AK052725.1         2-1545
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.7 cM"
     gene            1..1544
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /note="solute carrier family 51, alpha subunit"
                     /db_xref="GeneID:106407"
                     /db_xref="MGI:MGI:2146634"
     exon            1..395
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            396..490
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            491..645
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            646..719
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            720..878
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            879..990
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1137
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1243
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1544
                     /gene="Slc51a"
                     /gene_synonym="D630035O19Rik; Osta; OSTalpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggaacat gaagttggaa ggaagggttg ggtagttcag ctacaaggtt gtgatcaacc
       61 gcatttgtct gaaagaggtg gaagggaccg cgcctaagct gtggggagga gtcaggagcc
      121 tgggcacagc acagaggatc aaattcctca ggggtgaact ctgagataaa aagcttgaca
      181 ctggaggctt gaggaggtaa tgaaacaggc gtggaggctc cgcttactgt ttagccttca
      241 cccagctctg aacaaggctc tgagagcctc aatacgggac agaaacctcg ccacccctca
      301 gtggctgtcc ctgcctgacc ctcctcgtcc tcagcgtctg cctgagagaa aagaaggatg
      361 gagccaggca ggactcatat caaacttgac cccaggtaca cagcagagct tctggaactt
      421 ctggagacca attacagcat ctcccctgcc tgcttctctc accctcccac cgcagcccag
      481 ctcctgagag cactgggccc agtggacata gccctcacca tcatcttgac ctttcttacc
      541 actggctcag ttgccatttt tctggaggat gctgtttacc tatacaagaa caccctttgc
      601 cccatcaaga agaggactct gatctggagt agctctgcac ccacggtggt atctgtgttc
      661 tgctgctttg gtctctggat tcctcgcgcc ctcacacttg tagaaatggc cataacctcg
      721 ttttatgccg tatgctttta cctgctgatg atggtcatgg tggaaggctt tggtgggaag
      781 aaagcagtac tgaggacact gaaggacacc ccgatgaggg tgcacacggg tccctgttgc
      841 tgctgctgtc cctgctgccc acctctcata cttaccagaa agaagctgca gctgctcctg
      901 ctgggccctt tccagtacgc cttcttcaag ataacgctga gcatagtggg cctgttcctc
      961 atccctgacg gcatctatga cccaggagaa atttctgaga agagcgcagc tctctggatc
     1021 aacaatctcc ttgctgtgtc tacccttctg gccctctggt ccctggccat ccttttccgt
     1081 caagccaaga tgcatctggg tgaacagaac atgggatcca agtttgctct gttccaggtg
     1141 cttgtcatcc tgaccgccct gcagcctgcc attttctcca tcttggctaa cagtgggcag
     1201 atcgcttgct cacctcccta ctcttctaaa atcaggtctc aagtgatgaa ctgccacatg
     1261 ctcatactgg agaccttcct gatgacagtg ctgacacgaa tgtactatcg aaggaaagac
     1321 gacaaggttg ggtatgaggc ttgttcgctg ccagacctgg actcagcact caaagcctga
     1381 ggagagtggc ttggaccctg gaagacatac tgtactcctc agaagagcag gaattctctt
     1441 ctgtccctca gccttatcag tggttaaggc tccccctggc agagcaggct ggcagcttcc
     1501 atgtgactat agggatgaag gtaaagtgca gtgggttgaa cctg
//
